Normal Human Microbial Flora Quiz

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Questions and Answers

The normal microbial flora in the human body develops chaotically after birth.

False (B)

Breast-fed infants tend to have a predominance of gram-negative bacteria in their gastrointestinal tract.

False (B)

Moisture and temperature are factors that influence the composition of the normal flora on the skin.

True (A)

The skin's normal microbiota helps prevent the colonization of transient microbes.

<p>True (A)</p> Signup and view all the answers

Gram-negative bacilli are more commonly found in drier areas of the skin.

<p>False (B)</p> Signup and view all the answers

An infant's type of diet does not affect the composition of its normal flora.

<p>False (B)</p> Signup and view all the answers

Acne can occur when Propionibacterium, normally present on the skin, becomes trapped in hair follicles.

<p>True (A)</p> Signup and view all the answers

Normal flora can aid the host by producing nutrients that the host can utilize.

<p>True (A)</p> Signup and view all the answers

Staphylococcus epidermidis is a common species found in the normal flora of the conjunctiva.

<p>True (A)</p> Signup and view all the answers

The upper respiratory tract does not contain a significant amount of microbiota.

<p>False (B)</p> Signup and view all the answers

Only Gram-negative bacteria are found in the population of the gastrointestinal tract.

<p>False (B)</p> Signup and view all the answers

The normal flora of the oral cavity includes species from the Viridans Group Streptococci.

<p>True (A)</p> Signup and view all the answers

Pathogens like Neisseria gonorrhoeae are typically found in high numbers in the conjunctiva.

<p>False (B)</p> Signup and view all the answers

The large intestine is populated primarily by aerobic bacteria.

<p>False (B)</p> Signup and view all the answers

Propionibacterium acnes is one of the dominant bacteria in the normal conjunctiva.

<p>True (A)</p> Signup and view all the answers

Hemophilus sp. and Neisseria sp. are commonly found in the upper respiratory tract flora.

<p>True (A)</p> Signup and view all the answers

Anaerobic Bacteriodes are the only species found in the colon of humans.

<p>False (B)</p> Signup and view all the answers

The presence of anaerobic methanogens in the human colon is an example of archaea as normal flora.

<p>True (A)</p> Signup and view all the answers

Lactic acid produced by Lactobacillus acidophilus helps maintain a low pH in the vaginal epithelium.

<p>True (A)</p> Signup and view all the answers

Urine in a healthy individual is typically contaminated with various microorganisms.

<p>False (B)</p> Signup and view all the answers

Some bacteria in the colon can produce carcinogenic metabolites that may increase the incidence of colon cancer.

<p>True (A)</p> Signup and view all the answers

Staphylococcus epidermidis is an example of normal microflora in the vagina.

<p>False (B)</p> Signup and view all the answers

Antibiotics can lead to alterations in gut flora and gastrointestinal disease.

<p>True (A)</p> Signup and view all the answers

E. coli is found only in the intestines and never contaminates urine samples.

<p>False (B)</p> Signup and view all the answers

Flashcards

Normal Flora

Refers to the group of microorganisms that naturally inhabit a specific body part, like the skin, conjunctiva, oral cavity, or gastrointestinal tract.

Staphylococcus epidermidis

A type of bacteria commonly found on the skin and often present in the conjunctiva, usually harmless.

Conjunctiva

The thin, transparent membrane lining the inner surface of the eyelid and covering the front part of the eyeball.

Oral Cavity & Upper Respiratory Tract

The mouth and the back of the throat, containing a diverse collection of bacteria.

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Viridans Group Streptococci (VGS)

A group of bacteria commonly found in the mouth, often associated with dental health.

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Stomach

The stomach, the first part of the digestive system, where food is mixed with gastric juices.

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Duodenum

The first part of the small intestine, where the breakdown of food continues.

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Ileum

The last part of the small intestine, where nutrient absorption is significant.

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Normal Human Microbial Flora

The diverse community of microorganisms that live on and within the human body. This includes bacteria, viruses, fungi, and other microbes.

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Benefits of Normal Flora

The normal flora can help the host by competing for resources with pathogens, producing beneficial substances, and stimulating the immune system.

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Factors Affecting Microbial Flora

Factors like temperature, pH, oxygen levels, and nutrient availability influence the types of microbes that can thrive in a specific body region.

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Microbial Colonization (Succession)

The process of how microbes take up residence in a specific body region, starting from birth and eventually leading to a stable population of microbes in adulthood.

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Variations in Skin Flora

Skin flora varies greatly depending on the microenvironment. Areas with more moisture and occlusion, like the armpits and toe webs, harbor more microbes than drier areas like the arms and legs.

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Protective Role of Skin Flora

The natural microbiota of the skin helps prevent colonization by harmful pathogens by producing antimicrobial substances and out-competing them for space and resources.

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Influence of Occlusion on Skin Flora

Areas of the skin with more moisture and occlusion tend to be more frequently colonized by Gram-negative bacteria, while drier areas have more Gram-positive microbes.

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Skin Flora and Acne

A non-pathogenic bacterium like Propionibacterium can become harmful if it becomes trapped in a hair follicle and multiplies rapidly, leading to inflammation and acne.

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Anaerobic bacteria in the colon

These are the primary bacteria found in the human colon. They are known for their anaerobic nature and crucial role in maintaining gut health.

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Methanogens in the colon

These archaea, though present in the colon, are not as abundant as other bacteria. Their association with human gut flora is unique among archaea.

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Normal flora of the colon

These diverse bacteria, found in the colon, aid in various processes, including bile acid conversion and vitamin K production.

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Disruption of gut flora

A shift in the balance of bacteria in the colon, often caused by poor nutrition or antibiotics, can disrupt normal functioning and lead to gastrointestinal problems.

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Normal flora of the urethra

Staphylococcus epidermidis, Enterococcus faecalis, and alpha-hemolytic streptococci are commonly found on the skin and in the anterior urethra, typically not causing harm.

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Contaminants in urine samples

E. coli, Proteus, and corynebacteria, sometimes found in urine samples, are contaminants from the skin, vulva, or rectum. They are not considered normal residents of the urinary tract.

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Normal flora of the vagina

The vagina has a unique environment due to Lactobacillus acidophilus. This bacterium produces lactic acid, lowering the pH and inhibiting the growth of potentially harmful Candida albicans.

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Role of estrogen in the vaginal flora

The vaginal flora is influenced by estrogen levels, particularly from puberty to menopause. Estrogen promotes glycogen production, used by Lactobacillus to produce lactic acid.

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Study Notes

Normal Human Microbial Flora

  • The human body harbors microbes from birth, affecting anatomy, physiology, susceptibility to pathogens, and morbidity.
  • Normal flora helps by competing for resources, producing nutrients, and protecting against pathogens.
  • Flora development follows a sequence, establishing stable populations after birth.
  • Environmental factors (temperature, pH, etc.) influence microbial community composition in different body regions.
  • Birth canal exposure introduces organisms; breast-feeding favors Bifidobacteria and Lactobacilli. Bottle-feeding leads to a different flora.
  • Immunoglobulins and breast milk components contribute to maintaining the flora.

Skin Flora

  • Skin microbial communities vary across sites, influenced by moisture, occlusion, and temperature.
  • Skin microbes (e.g., Staphylococci, Micrococci, Corynebacterium) often inhibit transient pathogens.
  • Gram-negative bacilli colonize partially occluded areas more than drier regions.
  • Skin commensals can cause problems (e.g., inflammation, acne) when conditions change (e.g., trapped in hair follicles).

Conjunctiva Flora

  • Tears and blinking wash away foreign objects, limiting microbial colonization.
  • Low microbial counts are usually observed on the conjunctiva, with Staphylococcus epidermidis, Propionibacterium acnes being prominent, along with occasional presence of other bacteria like Staphylococcus aureus, some streptococci and Hemophilus sp. Neisseria sp.
  • Pathogens like Neisseria gonorrhoeae and Chlamydia trachomatis can attach to the conjunctiva.

Oral Cavity and Upper Respiratory Tract

  • Oral cavity and upper respiratory tract are exposed to the external environment.
  • Abundant and diverse microbiota inhabit these areas.
  • Common bacteria include Staphylococcus epidermis, Viridans Group Streptococci (VGS), Streptococcus, Haemophilus, and Neisseria (pharynx).
  • Lower respiratory tract has fewer microbes, predominantly containing Pseudomonas, Streptococcus, Prevotella, and Veillonella.

Gastrointestinal Tract Flora

  • Stomach acid keeps numbers low.
  • Duodenum has sparse flora mostly Gram-positive lactobacilli and Enterococcus faecalis.
  • Ileum has a moderately mixed flora.
  • Large intestine is heavily populated by anaerobes (bacteriodes, lactobacilli, bifidobacteria).
  • Some anaerobic methanogens may also be present.
  • Bacteria in the colon can aid in bile acid processing, vitamin K production, ammonia production, and can also influence carcinogenesis or be influenced by nutrition and antibiotics.

Urogenital Tract Flora

  • Staphylococcus epidermidis, Enterococcus faecalis, and some alpha-hemolytic streptococci are present in the anterior urethra.
  • Skin and fecal contaminants (E.coli, Proteus, Corynebacteria) may be present.
  • Urine washes away microbes, making interior urogenital areas relatively free of microbes.
  • Estrogen-influenced glycogen metabolism by Lactobacillus acidophilus creates an acidic environment in the vagina, preventing Candida albicans growth.

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