10 Questions
What allows rapid formation of solid blood clots to seal rupture or injury to blood vessels?
Adequacy and function of platelets
What is the primary function of endothelial injury in haemostasis?
Exposing thrombogenic subendothelial extracellular matrix
What is the role of thrombin in secondary haemostasis?
Conversion of fibrinogen into fibrin
What initiates the coagulation pathway in secondary haemostasis?
Synthesis of tissue factor by endothelium
What causes the brief period of vasoconstriction at the site of injury?
Reflux neurogenic mechanisms
What is the primary function of haemostatic mechanisms?
To allow rapid formation of solid blood clots to seal rupture or injury to blood vessels
What is the primary role of the endothelial injury in primary haemostasis?
To expose highly thrombogenic subendothelial extracellular matrix, allowing platelet adhesion and activation
What is the function of thrombin in secondary haemostasis?
Converts fibrinogen into fibrin to form a stable blood clot
What initiates the coagulation pathway in secondary haemostasis?
Synthesis of tissue factor by endothelium
What is the brief period of vasoconstriction at the site of injury due to?
Reflux neurogenic mechanisms (endothelin release)
Test your knowledge on the normal mechanisms that maintain blood in a fluid state and allow for rapid clot formation to seal ruptures or injuries to blood vessels. Explore the sequence of events at the site of injury and understand the importance of vessel wall integrity, platelet function, and the coagulation system.
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