11 Questions
What is the primary mechanism for termination of noradrenaline (NA) at the nerve terminal?
Nerve terminal actively reuptakes NA (Uptake 1)
Which of the following drugs inhibits the Uptake 1 mechanism for termination of NA?
Cocaine and tricyclic antidepressants (TCAs)
What is the enzyme responsible for the conversion of dopamine to noradrenaline in the cytoplasm?
Dopamine-$\beta$-hydroxylase
Which of the following drugs inhibits the storage of noradrenaline in vesicles?
Reserpine
What is the mechanism of action of guanethidine, a sympatholytic drug?
Blocks the adrenergic receptors and reduces the effects of NA
Which of the following accurately describes the actions of alpha-1 (α1) receptors?
Vasoconstriction, mydriasis, and excitation/contraction of effector organs
Which receptor type is associated with the inhibition of noradrenaline release and insulin release from the pancreas?
Alpha-2 (α2) receptors
Which receptor type is associated with chronotropic, inotropic, and dromotropic effects on the heart, as well as renin release from the kidney and lipolysis in fat cells?
Beta-1 (β1) receptors
Which of the following actions is NOT associated with beta-2 (β2) receptors?
Vasoconstriction
Which receptor type is associated with the relaxation of the detrusor muscle of the bladder wall, leading to urinary retention, as well as glycogenolysis and gluconeogenesis in the liver?
Beta-2 (β2) receptors
Which of the following accurately describes the actions associated with the Gs receptor type?
Chronotropic, inotropic, and dromotropic effects on the heart, renin release from the kidney, and lipolysis in fat cells
Test your knowledge on the synthesis and metabolism of noradrenaline with Assoc. Prof. Dr. Dayang Fredalina Basri. Explore topics such as the site of Noradrenaline synthesis in the brain, storage mechanisms, and the steps involved in Dopamine-β-hydroxylase pathway.
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