Nondihydropyridine CCB Side Effects Quiz

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Questions and Answers

What is the arterial blood pressure value that represents the peak achieved during cardiac contraction?

  • Systolic BP (correct)
  • Diastolic BP
  • Mean Arterial Pressure
  • None of the above

Which of the following drug classes could contribute to developing elevated blood pressure?

  • Erythropoiesis-stimulating agents (correct)
  • Antihistamines
  • Antibiotics
  • Nonsteroidal anti-inflammatory drugs

What is the arterial blood pressure value that represents the minimum achieved after cardiac contraction?

  • Systolic BP
  • Diastolic BP (correct)
  • Mean Arterial Pressure
  • None of the above

Which of the following substances could potentially impact arterial blood pressure?

<p>Ethanol (C)</p> Signup and view all the answers

What is the average pressure throughout the cardiac cycle known as?

<p>Mean Arterial Pressure (D)</p> Signup and view all the answers

Which of the following situations could potentially lead to drug-induced elevation of blood pressure?

<p>Abrupt discontinuation of β-blocker or centrally acting α-agonists (C)</p> Signup and view all the answers

What is the primary physical finding of hypertension?

<p>Elevated blood pressure (B)</p> Signup and view all the answers

Why is hypertension referred to as the silent killer?

<p>It has no symptoms in most patients (A)</p> Signup and view all the answers

How many elevated BP measurements are required for diagnosing hypertension?

<p>The average of two or more measurements taken during two or more clinical encounters (C)</p> Signup and view all the answers

What is recommended for diagnostic confirmation of hypertension before starting antihypertensive therapy?

<p>Ambulatory and self-blood pressure monitoring (C)</p> Signup and view all the answers

Which condition is NOT mentioned as a hypertension-related complication in the text?

<p>Diabetes mellitus (DM) (B)</p> Signup and view all the answers

Why is it important to estimate future risk of cardiovascular disease and clinical ASCVD for patients without certain medical histories?

<p>To guide treatment decisions even without specific medical histories (A)</p> Signup and view all the answers

Which factor determines the choice of initial antihypertensive drug therapy?

<p>Compelling indications (B)</p> Signup and view all the answers

What is recommended for patients with stage 1 hypertension?

<p>First-line antihypertensive drug (D)</p> Signup and view all the answers

When is combination drug therapy recommended?

<p>For patients with more severe BP elevation (stage 2 HTN) (D)</p> Signup and view all the answers

Which class of antihypertensive agents are preferred as first-line agents for most patients?

<p>ACEIs, ARBs, CCBs, or thiazides (C)</p> Signup and view all the answers

When should beta-blocker therapy be reserved according to the text?

<p>To treat compelling indications only (A)</p> Signup and view all the answers

Which drugs are considered alternative drug classes that may be used in select patients after first-line agents?

<p>Other antihypertensive drug classes (C)</p> Signup and view all the answers

Which type of calcium channel blockers (CCBs) do not alter conduction through the AV node and are not effective agents in supraventricular tachyarrhythmias?

<p>Dihydropyridines (B)</p> Signup and view all the answers

Which side effect is unique to verapamil compared to diltiazem?

<p>Constipation (B)</p> Signup and view all the answers

Which calcium channel blocker (CCB) is associated with negative inotropic effects but to a lesser extent than verapamil?

<p>Diltiazem (C)</p> Signup and view all the answers

What is the main reason behind cardiac conduction abnormalities associated with diltiazem and verapamil?

<p>Preexisting cardiac conduction abnormalities (C)</p> Signup and view all the answers

What effect may dihydropyridines cause due to their potent peripheral vasodilating effects?

<p>Tachycardia (D)</p> Signup and view all the answers

Which cytochrome P450 isoenzyme system do verapamil and diltiazem inhibit?

<p>CYP3A4 (B)</p> Signup and view all the answers

Why are immediate-release nifedipine not approved for the treatment of hypertension?

<p>Linked to increased incidence of adverse CV effects (B)</p> Signup and view all the answers

What is the most common gastrointestinal side effect associated with verapamil and diltiazem?

<p>Constipation (B)</p> Signup and view all the answers

Which side effects occur more frequently with dihydropyridines compared to non-DHP CCBs?

<p>Peripheral edema and dizziness (C)</p> Signup and view all the answers

Which type of CCBs are very effective in older patients with isolated systolic hypertension?

<p>Dihydropyridine CCBs (B)</p> Signup and view all the answers

Why should verapamil and diltiazem be given cautiously with a β-blocker?

<p>Increased risk of heart block (D)</p> Signup and view all the answers

Which type of grapefruit juice ingestion can inhibit the hepatic metabolism of certain CCBs?

<p>$5(7 + 3)$ quantities or more daily (D)</p> Signup and view all the answers

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