Nondihydropyridine CCB Side Effects Quiz
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Questions and Answers

What is the arterial blood pressure value that represents the peak achieved during cardiac contraction?

  • Systolic BP (correct)
  • Diastolic BP
  • Mean Arterial Pressure
  • None of the above
  • Which of the following drug classes could contribute to developing elevated blood pressure?

  • Erythropoiesis-stimulating agents (correct)
  • Antihistamines
  • Antibiotics
  • Nonsteroidal anti-inflammatory drugs
  • What is the arterial blood pressure value that represents the minimum achieved after cardiac contraction?

  • Systolic BP
  • Diastolic BP (correct)
  • Mean Arterial Pressure
  • None of the above
  • Which of the following substances could potentially impact arterial blood pressure?

    <p>Ethanol</p> Signup and view all the answers

    What is the average pressure throughout the cardiac cycle known as?

    <p>Mean Arterial Pressure</p> Signup and view all the answers

    Which of the following situations could potentially lead to drug-induced elevation of blood pressure?

    <p>Abrupt discontinuation of β-blocker or centrally acting α-agonists</p> Signup and view all the answers

    What is the primary physical finding of hypertension?

    <p>Elevated blood pressure</p> Signup and view all the answers

    Why is hypertension referred to as the silent killer?

    <p>It has no symptoms in most patients</p> Signup and view all the answers

    How many elevated BP measurements are required for diagnosing hypertension?

    <p>The average of two or more measurements taken during two or more clinical encounters</p> Signup and view all the answers

    What is recommended for diagnostic confirmation of hypertension before starting antihypertensive therapy?

    <p>Ambulatory and self-blood pressure monitoring</p> Signup and view all the answers

    Which condition is NOT mentioned as a hypertension-related complication in the text?

    <p>Diabetes mellitus (DM)</p> Signup and view all the answers

    Why is it important to estimate future risk of cardiovascular disease and clinical ASCVD for patients without certain medical histories?

    <p>To guide treatment decisions even without specific medical histories</p> Signup and view all the answers

    Which factor determines the choice of initial antihypertensive drug therapy?

    <p>Compelling indications</p> Signup and view all the answers

    What is recommended for patients with stage 1 hypertension?

    <p>First-line antihypertensive drug</p> Signup and view all the answers

    When is combination drug therapy recommended?

    <p>For patients with more severe BP elevation (stage 2 HTN)</p> Signup and view all the answers

    Which class of antihypertensive agents are preferred as first-line agents for most patients?

    <p>ACEIs, ARBs, CCBs, or thiazides</p> Signup and view all the answers

    When should beta-blocker therapy be reserved according to the text?

    <p>To treat compelling indications only</p> Signup and view all the answers

    Which drugs are considered alternative drug classes that may be used in select patients after first-line agents?

    <p>Other antihypertensive drug classes</p> Signup and view all the answers

    Which type of calcium channel blockers (CCBs) do not alter conduction through the AV node and are not effective agents in supraventricular tachyarrhythmias?

    <p>Dihydropyridines</p> Signup and view all the answers

    Which side effect is unique to verapamil compared to diltiazem?

    <p>Constipation</p> Signup and view all the answers

    Which calcium channel blocker (CCB) is associated with negative inotropic effects but to a lesser extent than verapamil?

    <p>Diltiazem</p> Signup and view all the answers

    What is the main reason behind cardiac conduction abnormalities associated with diltiazem and verapamil?

    <p>Preexisting cardiac conduction abnormalities</p> Signup and view all the answers

    What effect may dihydropyridines cause due to their potent peripheral vasodilating effects?

    <p>Tachycardia</p> Signup and view all the answers

    Which cytochrome P450 isoenzyme system do verapamil and diltiazem inhibit?

    <p>CYP3A4</p> Signup and view all the answers

    Why are immediate-release nifedipine not approved for the treatment of hypertension?

    <p>Linked to increased incidence of adverse CV effects</p> Signup and view all the answers

    What is the most common gastrointestinal side effect associated with verapamil and diltiazem?

    <p>Constipation</p> Signup and view all the answers

    Which side effects occur more frequently with dihydropyridines compared to non-DHP CCBs?

    <p>Peripheral edema and dizziness</p> Signup and view all the answers

    Which type of CCBs are very effective in older patients with isolated systolic hypertension?

    <p>Dihydropyridine CCBs</p> Signup and view all the answers

    Why should verapamil and diltiazem be given cautiously with a β-blocker?

    <p>Increased risk of heart block</p> Signup and view all the answers

    Which type of grapefruit juice ingestion can inhibit the hepatic metabolism of certain CCBs?

    <p>$5(7 + 3)$ quantities or more daily</p> Signup and view all the answers

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