Podcast
Questions and Answers
What is the function of presynaptic boutons?
What is the function of presynaptic boutons?
- Store neurotransmitters in synaptic vesicles (correct)
- Clustering of ion channels
- Anchor postsynaptic receptors
- Regulate synapse function
What is the role of presynaptic active zones?
What is the role of presynaptic active zones?
- Contain electron dense proteins
- Anchor postsynaptic receptors
- Regulate synapse function
- Fuse with synaptic vesicles (correct)
Which component of the synapse is involved in clustering postsynaptic receptors and ion channels at high density?
Which component of the synapse is involved in clustering postsynaptic receptors and ion channels at high density?
- Presynaptic bouton
- Presynaptic active zone
- Synaptic cleft
- Postsynaptic density (correct)
What is the specialized content of the synaptic cleft?
What is the specialized content of the synaptic cleft?
During which phase of synapse formation does target selection occur?
During which phase of synapse formation does target selection occur?
Which drug specifically inhibits action potentials by blocking sodium channels that depolarize neurons?
Which drug specifically inhibits action potentials by blocking sodium channels that depolarize neurons?
What is the role of the postsynaptic denisity (PSD) in a synapse?
What is the role of the postsynaptic denisity (PSD) in a synapse?
How do drugs like tetrodotoxin typically affect the first phase of synapse formation?
How do drugs like tetrodotoxin typically affect the first phase of synapse formation?
Which phase of synapse formation involves remodeling the initial course distribution of synaptic connections?
Which phase of synapse formation involves remodeling the initial course distribution of synaptic connections?
What is the role of Agrin in neuromuscular junctions?
What is the role of Agrin in neuromuscular junctions?
What happens in MuSK knockout mice?
What happens in MuSK knockout mice?
Which molecule is an intracellular adaptor protein for AChRs?
Which molecule is an intracellular adaptor protein for AChRs?
What is the main excitatory neurotransmitter in CNS synapses?
What is the main excitatory neurotransmitter in CNS synapses?
Which synapses can be axo-dendritic, axo-somatic, or axo-axonic?
Which synapses can be axo-dendritic, axo-somatic, or axo-axonic?
What is the function of netrin-1 in synapses?
What is the function of netrin-1 in synapses?
Which molecule promotes excitatory glutamatergic synapse formation when overexpressed in cortex neurons?
Which molecule promotes excitatory glutamatergic synapse formation when overexpressed in cortex neurons?
What is a key difference between CNS and PNS synapses in terms of neurotransmitter release?
What is a key difference between CNS and PNS synapses in terms of neurotransmitter release?
In what way does Rapsyn knockout mice phenotype differ from MuSK knockout mice phenotype?
In what way does Rapsyn knockout mice phenotype differ from MuSK knockout mice phenotype?
What is the role of the intracellular domain of cadherins in synaptic terminals?
What is the role of the intracellular domain of cadherins in synaptic terminals?
What is the role of Ephrins in axon guidance?
What is the role of Ephrins in axon guidance?
What effect does disrupting cadherins have on synaptic function?
What effect does disrupting cadherins have on synaptic function?
What is the primary neurotransmitter at the mammalian Neuromuscular Junction (NMJ)?
What is the primary neurotransmitter at the mammalian Neuromuscular Junction (NMJ)?
What change in AChR subunits occurs after innervation of myotubes?
What change in AChR subunits occurs after innervation of myotubes?
In knockout mice lacking gephrin, what is the impact on post-synaptic clustering?
In knockout mice lacking gephrin, what is the impact on post-synaptic clustering?
What is the function of heterophilic synaptic adhesion molecules like beta-neurexin and neuroligin?
What is the function of heterophilic synaptic adhesion molecules like beta-neurexin and neuroligin?
What triggers the differentiation of both presynaptic and post-synaptic elements during synapse formation?
What triggers the differentiation of both presynaptic and post-synaptic elements during synapse formation?
What is the role of PDZ domains in synaptic organization?
What is the role of PDZ domains in synaptic organization?
Which protein activates the receptor tyrosine kinase erbB on the post-synaptic membrane of myotubes?
Which protein activates the receptor tyrosine kinase erbB on the post-synaptic membrane of myotubes?
Which proteins contain PDZ domains involved in synaptic function?
Which proteins contain PDZ domains involved in synaptic function?
What is one of the mechanisms that contribute to AChR clustering?
What is one of the mechanisms that contribute to AChR clustering?
What does experiment A, denervating a mature NMJ, suggest about AChR clustering?
What does experiment A, denervating a mature NMJ, suggest about AChR clustering?
What is the role of the active zones in synaptic terminals?
What is the role of the active zones in synaptic terminals?
What is the proposed function of a presynaptic active zone precursor vesicle?
What is the proposed function of a presynaptic active zone precursor vesicle?
What are Ephrins and Eph receptors responsible for directing?
What are Ephrins and Eph receptors responsible for directing?
What is one outcome of synapse formation involving recognition and adhesive interaction?
What is one outcome of synapse formation involving recognition and adhesive interaction?
How do CNS neurons differ in response compared to NMJ neurons?
How do CNS neurons differ in response compared to NMJ neurons?
What is the effect of expressing neuroligin by a non-neuronal cell on an axon that contacts it?
What is the effect of expressing neuroligin by a non-neuronal cell on an axon that contacts it?
