Podcast
Questions and Answers
What is the generic name of the drug with trade names Procardia and Adalat?
What is the generic name of the drug with trade names Procardia and Adalat?
What classification does nifedipine belong to?
What classification does nifedipine belong to?
Antianginal, antihypertensive, calcium channel blocker
What is the FDA category for nifedipine?
What is the FDA category for nifedipine?
C
What is the mechanism of action of nifedipine?
What is the mechanism of action of nifedipine?
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What is the therapeutic indication of nifedipine?
What is the therapeutic indication of nifedipine?
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What is the dosage for treating angina in adults?
What is the dosage for treating angina in adults?
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Which of the following are possible side effects of nifedipine? (Select all that apply)
Which of the following are possible side effects of nifedipine? (Select all that apply)
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What are some drug interactions associated with nifedipine?
What are some drug interactions associated with nifedipine?
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What nursing consideration is essential while administering nifedipine?
What nursing consideration is essential while administering nifedipine?
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Patients should swallow the ER tablet _____ and avoid _____ juice.
Patients should swallow the ER tablet _____ and avoid _____ juice.
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What should patients report while taking nifedipine?
What should patients report while taking nifedipine?
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Study Notes
Nifedipine Overview
- Generic name: Nifedipine; Trade names include Procardia and Adalat.
- Classified as an antianginal, antihypertensive, and a calcium channel blocker.
- FDA pregnancy category C.
Mechanism of Action
- Reduces arterial blood pressure through peripheral arterial vasodilation.
- Inhibits calcium influx into vascular smooth muscle by binding to voltage-dependent and receptor-operated channels.
Therapeutic Uses
- Indicated for vasopastic angina and angina of effort.
- Often used in combination with a beta blocker to mitigate reflexive heart stimulation.
- Long-term use associated with reduced rates of heart failure, coronary bypass surgery, but not necessarily stroke, myocardial infarction, or mortality.
- Also used to treat essential hypertension.
Pharmacology
- Well absorbed orally but undergoes significant first-pass metabolism; only around 50% reaches systemic circulation.
- Completely metabolized before excretion in urine.
Dosage Information
- Angina treatment: 10 mg orally, three times daily (tid), with a range of 10 to 20 mg tid, maximum 180 mg/day.
- Hypertension treatment: 30 to 60 mg/day of extended-release (ER) tablet, with a maximum of 90 to 120 mg/day.
Side Effects
- Possible side effects include angina, asthenia, AV block, constipation, cough, dizziness, fatigue, flushing, headache, hypotension, lightheadedness, mood changes, nasal congestion, nervousness, nausea/vomiting, peripheral edema, tremor, and weakness.
Drug Interactions
- May interact with beta blockers, cimetidine, CYP3A inhibitors and inducers, digoxin, and grapefruit juice.
Nursing Considerations
- Close monitoring is required while adjusting the dosage to ensure patient safety and drug efficacy.
Patient Teaching
- Instruct to swallow the ER tablet whole and to avoid grapefruit juice.
- Educate about possible CNS effects and to report any irregular heartbeat or swelling in hands/feet.
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Description
Test your knowledge on Nifedipine with these flashcards. Learn about its classification, FDA category, and mechanism of action. Perfect for medical students or anyone interested in pharmacology!
