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Questions and Answers
What is the mechanism of sensitization to nickel?
What is the mechanism of sensitization to nickel?
- Nickel directly induces activation of non-specific T lymphocytes and macrophages
- Contact with allergen causes direct activation of antigen-specific T cells in the skin
- Dendritic cells in the skin internalize and process epicutaneously applied hapten and migrate to the lymph nodes (correct)
- Keratinocytes and langrhans cells directly activate antigen-specific T cells at the site of contact
What is the consequence of asbestos fibers diffusing into the pulmonary alveoli?
What is the consequence of asbestos fibers diffusing into the pulmonary alveoli?
- Secretion of IL1, IL6, and TNF-α leading to chronic inflammation
- Disruption of MARK activity involved in regulation of mesothelium cell proliferation
- Release of ROS including OH. from H2O2 by Fenton Reaction (correct)
- Activation of NF-kB in alveolar rnacrophage and rnesothelial cell
How do asbestos fibers damage DNA?
How do asbestos fibers damage DNA?
- Through ROS reactions producing hydroxyl bases and causing mutations (correct)
- By causing mutations in alveolar macrophages
- Directly through physical interaction with DNA strands
- Indirectly through activation of specific T lymphocytes
What is the main effect of asbestos on mesothelium cell proliferation?
What is the main effect of asbestos on mesothelium cell proliferation?
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What is the result of asbestos inhalation on lung health?
What is the result of asbestos inhalation on lung health?
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Which biotechnology-based medicine is associated with autoimmune aplasia?
Which biotechnology-based medicine is associated with autoimmune aplasia?
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Which medicine is linked to autoimmune hepatitis?
Which medicine is linked to autoimmune hepatitis?
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Which autoimmune reaction is associated with Etanercept, infliximab, and adalimumab?
Which autoimmune reaction is associated with Etanercept, infliximab, and adalimumab?
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