Nickel Hypersensitivity and Contact Dermatitis Quiz

Nickel directly induces activation of non-specific T lymphocytes and macrophages

Contact with allergen causes direct activation of antigen-specific T cells in the skin

Dendritic cells in the skin internalize and process epicutaneously applied hapten and migrate to the lymph nodes (correct)

Keratinocytes and langrhans cells directly activate antigen-specific T cells at the site of contact

Secretion of IL1, IL6, and TNF-α leading to chronic inflammation

Disruption of MARK activity involved in regulation of mesothelium cell proliferation

Release of ROS including OH. from H2O2 by Fenton Reaction (correct)

Activation of NF-kB in alveolar rnacrophage and rnesothelial cell

Through ROS reactions producing hydroxyl bases and causing mutations (correct)

By causing mutations in alveolar macrophages

Directly through physical interaction with DNA strands

Indirectly through activation of specific T lymphocytes

<p>Disruption of MARK activity involved in regulation of cell proliferation</p> Signup and view all the answers

<p>Lung fibrosis, lung carcinoma, or mesothelioma</p> Signup and view all the answers

<p>Recombinant human erythropoietin</p> Signup and view all the answers

<p>Anti-TNF-α</p> Signup and view all the answers

<p>Lupus syndrome</p> Signup and view all the answers