Neutropenia in Adults Quiz

<p>5-135 hours (C)</p> Signup and view all the answers

<p>Collagen vascular disorders (D)</p> Signup and view all the answers

<p>Neutropenia with decreased BM reserve (A)</p> Signup and view all the answers

<p>Apoptosis of precursors (B)</p> Signup and view all the answers

<p>Neutropenia with normal BM reserve (C)</p> Signup and view all the answers

<p>Autosomal Recessive (A)</p> Signup and view all the answers

<p>Myelodysplastic syndromes (MDS) (A)</p> Signup and view all the answers

<p>1.5 to 7.0×10^9/L (B)</p> Signup and view all the answers

<p>Chronic nutritional deficiency (D)</p> Signup and view all the answers

<p>Neonates (B)</p> Signup and view all the answers

<p>&lt; 2.5×10^9/L (D)</p> Signup and view all the answers

<p>African American children/adults (C)</p> Signup and view all the answers

<p>Cyclic neutropenia (D)</p> Signup and view all the answers

<p>Microbiology (A)</p> Signup and view all the answers

<p>By absolute neutrophil count (D)</p> Signup and view all the answers

<p>HIV (D)</p> Signup and view all the answers

<p>Infection-related neutropenia (A)</p> Signup and view all the answers

<p>Adenosine deaminase deficiency (A)</p> Signup and view all the answers

<p>Low birth weight (A)</p> Signup and view all the answers

<p>Autosomal dominant (D)</p> Signup and view all the answers

<p>90% (C)</p> Signup and view all the answers

<p>Myelokathexis (B)</p> Signup and view all the answers

<p>It is commonly self-limited. (A)</p> Signup and view all the answers

<p>SBDS mutation (B)</p> Signup and view all the answers

<p>Recurrent fever every 21 days (A)</p> Signup and view all the answers

<p>Recurrent pyogenic infections (A)</p> Signup and view all the answers

<p>Up to 80% (D)</p> Signup and view all the answers

<p>Non-immune reaction (B)</p> Signup and view all the answers

<p>Autosomal recessive (A)</p> Signup and view all the answers

<p>Type of drug (D)</p> Signup and view all the answers

<p>Decreased myelopoiesis (B)</p> Signup and view all the answers

<p>Chediak-Higashi syndrome (B)</p> Signup and view all the answers

<p>Bone marrow biopsy (A)</p> Signup and view all the answers

A condition characterized by an abnormally low neutrophil count.

The absolute neutrophil count (ANC) for adults ranges from 1.5 to 7.0×10^9/L.

Neutropenia is classified based on absolute neutrophil count into three groups.

In infants, neutropenia is defined as ANC < 2.5×10^9/L.

These include benign conditions, autoimmune disorders, and infections.

These arise from external factors like medications or infections.

Causes differ by age: common in neonates and children due to infections, autoimmune issues.

Ethnicity can affect normal ANC ranges; for example, lower limits for African Americans.

Neutropenia can be caused by various factors including drug reactions and infections.

Circulating neutrophils survive around 5-135 hours in the bloodstream.

95% of neutrophils are stored as maturing granulocytes in the bone marrow.

Therapies that destroy bone marrow to treat certain conditions, leading to temporary neutropenia.

Neutropenia can arise as a secondary effect of autoimmune disorders or conditions like collagen vascular disorders.

A type of neutropenia where the bone marrow has a reduced ability to produce neutrophils.

Neutropenia caused by intrinsic defects in granulopoiesis.

Neutropenia due to suppression of normal granulopoiesis by external factors.

A rare genetic disorder causing severe congenital neutropenia.

Common causes include viral infections, B12 deficiency, and certain congenital conditions.

Certain viral infections (like EBV, CMV, HIV) can cause immune-mediated neutropenia.

The patient's clinical history is key to determining the cause and degree of neutropenia.

Severe neutropenia carries significant risks, especially in infants, such as high infection risk.

Includes myelokathexis, reticular dysgenesis, and dyskeratosis congenita, often resulting in mild neutropenia.

Antenatal care can reduce risks of infections in neonates, especially in hypertensive mothers.

Diagnosis involves blood tests and possibly bone marrow analysis to assess neutrophil production.

A genetic disorder causing recurrent fever and infections every 21 days due to apoptosis of neutrophil precursors.

A rare genetic disorder marked by recurrent pyogenic infections and giant granules in many cells due to a mutation in the LYST gene.

Secretory function involving the release of substances (like sweat) through ducts to external force.

Common side effect of chemotherapy due to direct toxicity to neutrophils, leading to increased infection risk.

A non-immune suppression of neutrophils caused by certain drugs, potentially fatal in 25% of cases.

Study of the shape and structure of granulocytes in bone marrow, like maturation arrest at the promyelocyte stage.

Severe form of neutropenia present from birth, often resulting in frequent bacterial infections and complications.

Symptoms that occur every 21 days in conditions like cyclic neutropenia, indicating immune challenges.

Protein involved in apoptosis, its increase in lymphocytes is linked to secondary leukemia.

A form of malnutrition characterized by inadequate protein and calorie intake, causing ineffective hematopoiesis.