Neurotransmitter Release Types
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Questions and Answers

What type of NT release occurs randomly and is thought to play a part in maintaining basal neurotransmitter levels and modulating synaptic strength?

  • Calcium-independent
  • Asynchronous
  • Synchronous
  • Spontaneous (correct)
  • What is the role of synaptotagmin-1 in vesicle fusion?

  • To regulate vesicle docking
  • To recycle vesicles
  • To inhibit vesicle fusion
  • To promote vesicle fusion (correct)
  • What is the purpose of positional priming in vesicle release?

  • To regulate calcium entry
  • To allow vesicle docking
  • To move vesicles towards docking sites (correct)
  • To fuse vesicles with the plasma membrane
  • Which type of NT release can persist for a longer duration after cessation of action potentials?

    <p>Asynchronous</p> Signup and view all the answers

    What is the role of SNARE proteins in vesicle release?

    <p>To allow vesicle docking</p> Signup and view all the answers

    What is the term for the simultaneous release of multiple neurotransmitters from the same presynaptic terminal?

    <p>Co-release</p> Signup and view all the answers

    What precedes vesicle fusion in the process of synchronous NT release?

    <p>Calcium entry</p> Signup and view all the answers

    What is the primary function of spontaneous NT release?

    <p>To maintain basal neurotransmitter levels and modulate synaptic strength</p> Signup and view all the answers

    Which type of NT release is most closely associated with the movement of vesicles towards docking sites?

    <p>Positional priming</p> Signup and view all the answers

    What is the primary mechanism by which vesicle fusion occurs in synchronous NT release?

    <p>The binding of synaptotagmin-1 to the SNARE complex</p> Signup and view all the answers

    Which type of NT release is most closely associated with the release of neurotransmitters from the vesicle?

    <p>Synchronous NT release</p> Signup and view all the answers

    What is the primary function of molecular priming in vesicle release?

    <p>To promote the fusion of vesicles with the presynaptic membrane</p> Signup and view all the answers

    Which type of NT release is most closely associated with the release of multiple neurotransmitters from the same presynaptic terminal?

    <p>Co-release</p> Signup and view all the answers

    What is the primary function of SNARE proteins in vesicle release?

    <p>To promote the fusion of vesicles with the presynaptic membrane</p> Signup and view all the answers

    Study Notes

    Types of Neurotransmitter Release

    • Spontaneous neurotransmitter release occurs in the absence of action potentials or external stimuli, happening randomly and thought to play a part in maintaining basal neurotransmitter levels and modulating synaptic strength.

    Asynchronous Neurotransmitter Release

    • Asynchronous release occurs following neuronal activity and can persist for a longer duration after cessation of action potentials.

    Synchronous Neurotransmitter Release

    • Synchronous release occurs in response to a single action potential, involving:
      • Presynaptic depolarisation
      • Calcium entry
      • Vesicle movement and priming
        • Positional priming: movement of vesicle towards docking sites
        • Molecular priming: molecular changes that allow docking and fusion

    Vesicle Docking and Fusion

    • Vesicle docking involves the use of SNARE proteins:
      • Synaptobrevin on synaptic vesicles
      • Syntaxin and SNAP-25 on presynaptic membrane
    • These proteins join together, allowing vesicle docking

    Vesicle Fusion and Recycling

    • Vesicle fusion is triggered by the influx of Ca2+, leading to synaptotagmin-1 binding to the SNARE complex, promoting vesicle fusion
    • Vesicle recycling is necessary for further neurotransmitter release

    Co-Release

    • Co-release is the simultaneous release of multiple neurotransmitters from the same presynaptic terminal, used to control the size of the action potential generated

    Types of Neurotransmitter Release

    • Spontaneous neurotransmitter release occurs in the absence of action potentials or external stimuli, happening randomly and thought to play a part in maintaining basal neurotransmitter levels and modulating synaptic strength.

    Asynchronous Neurotransmitter Release

    • Asynchronous release occurs following neuronal activity and can persist for a longer duration after cessation of action potentials.

    Synchronous Neurotransmitter Release

    • Synchronous release occurs in response to a single action potential, involving:
      • Presynaptic depolarisation
      • Calcium entry
      • Vesicle movement and priming
        • Positional priming: movement of vesicle towards docking sites
        • Molecular priming: molecular changes that allow docking and fusion

    Vesicle Docking and Fusion

    • Vesicle docking involves the use of SNARE proteins:
      • Synaptobrevin on synaptic vesicles
      • Syntaxin and SNAP-25 on presynaptic membrane
    • These proteins join together, allowing vesicle docking

    Vesicle Fusion and Recycling

    • Vesicle fusion is triggered by the influx of Ca2+, leading to synaptotagmin-1 binding to the SNARE complex, promoting vesicle fusion
    • Vesicle recycling is necessary for further neurotransmitter release

    Co-Release

    • Co-release is the simultaneous release of multiple neurotransmitters from the same presynaptic terminal, used to control the size of the action potential generated

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    Description

    This quiz covers the different types of neurotransmitter release, including spontaneous, asynchronous, synchronous, and calcium-independent release, and their characteristics.

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