Neuroscience: Retrograde Degeneration

What is the primary change observed in nerve cells during chromatolysis?

What happens to the volume of the perikaryon during chromatolysis?

Which of the following structures are likely to disappear in the process of chromatolysis?

What is indicated by the migration of the nucleus to a peripheral position in a neuron?

Which cellular change is commonly associated with retrograde degeneration?

Retrograde Degeneration

Occurs in nerve cells and the proximal part of nerve fibers following trauma.
Characterized by significant changes in the structure and function of the neuron.
Chromatolysis:
- Disappearance of Nissl bodies, granular structures in neurons responsible for protein synthesis.
- Decrease in basophilia, the staining property of the neuron's cytoplasm.
Perikaryon (Cell Body):
- Increases in volume.
- Experiences loss of dendrites, the branching extensions that receive signals from other neurons.
- Becomes globular in shape.
Nucleus:
- Migrates to the periphery of the cell body.
Organelles:
- Disappearance of Golgi bodies, involved in packaging and transporting molecules within the cell.
- Disappearance of mitochondria, which provide energy for the cell.
Neurofibrils:
- Fragmentation of neurofibrils, these are thread-like structures that provide structural support to the neuron and help transport molecules.
Lysosomes:
- Increase in number: Lysosomes are responsible for breaking down cellular debris. This increase suggest an attempt by the cell to remove damaged components.

Explore the processes and changes that occur in nerve cells during retrograde degeneration following trauma. This quiz covers key concepts like chromatolysis, alterations in the perikaryon, nucleus migration, and organelle disappearance. Test your understanding of these vital neurological phenomena.