Neuroscience Quiz on Neurons and Glial Cells
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Questions and Answers

What is the primary function of the axon hillock?

  • To receive synaptic input from other neurons.
  • To make synaptic contacts with other neurons.
  • To integrate multiple inputs and modify the signal before passing it on.
  • To initiate the action potential. (correct)
  • Which type of neuron is most abundant in the CNS and receives thousands of axodendritic synaptic inputs?

  • Unipolar
  • Multipolar (correct)
  • Bipolar
  • Pseudounipolar
  • What role do postsynaptic densities play in synaptic transmission?

  • They serve as scaffolding and organize neurotransmitter receptors and ion channels. (correct)
  • They form synapses with other neurons.
  • They are involved in the synthesis of neurotransmitters.
  • They release neurotransmitters into the synaptic cleft.
  • What is the function of myelin sheaths produced by oligodendrocytes?

    <p>They help to speed up the transmission of action potentials. (D)</p> Signup and view all the answers

    Which type of glial cell is responsible for maintaining homeostasis around neurons and taking up excess neurotransmitters at the synapse?

    <p>Astrocytes (B)</p> Signup and view all the answers

    Which type of synapse is most common in the CNS and involves an axon contacting a dendrite?

    <p>Axodendritic (C)</p> Signup and view all the answers

    Which glial cell type is found primarily in the white matter of the CNS?

    <p>Fibrous astrocytes (D)</p> Signup and view all the answers

    Which of the following is NOT a function of astrocytes?

    <p>Myelinating axons in the CNS. (D)</p> Signup and view all the answers

    Which type of neuron is found in the spinal dorsal root ganglia and relays sensory information to the CNS without modifying the signal?

    <p>Pseudounipolar (A)</p> Signup and view all the answers

    What is the function of the nodes of Ranvier?

    <p>They create gaps in the myelin sheath that allow for saltatory conduction. (A)</p> Signup and view all the answers

    What is the primary component found within the epidural space?

    <p>Fatty tissue and vertebral venous plexus (D)</p> Signup and view all the answers

    Which type of hematoma results from the separation of the dura mater from the skull due to arterial bleeding?

    <p>Epidural hematoma (A)</p> Signup and view all the answers

    Which condition is characterized by impaired production, circulation, or absorption of cerebrospinal fluid (CSF)?

    <p>Hydrocephalus (C)</p> Signup and view all the answers

    What primarily causes a subdural hematoma in situations such as shaken baby syndrome?

    <p>Severing of bridging veins (D)</p> Signup and view all the answers

    What is typically found in the subarachnoid space?

    <p>Cerebrospinal fluid, cerebral arteries, and veins (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of noncommunicating hydrocephalus?

    <p>Increased production of CSF (D)</p> Signup and view all the answers

    What is the primary function of the peripheral nervous system?

    <p>To connect the brain and spinal cord with the rest of the body (D)</p> Signup and view all the answers

    Which of the following is NOT a type of nerve fiber classified by its conduction velocity?

    <p>D (A)</p> Signup and view all the answers

    Which of the following is TRUE regarding the structure of a muscle spindle?

    <p>It is composed of intrafusal muscle fibers (A)</p> Signup and view all the answers

    What is the function of the gamma reflex loop?

    <p>To regulate the sensitivity of muscle spindles (D)</p> Signup and view all the answers

    Which type of afferent nerve fiber innervates the middle portion of all intrafusal fibers?

    <p>Type Ia (A)</p> Signup and view all the answers

    Which of the following scenarios would cause an increase in afferent nerve firing frequency from a muscle spindle?

    <p>Muscle stretching (C)</p> Signup and view all the answers

    What is the main function of alpha-gamma coactivation?

    <p>To maintain the sensitivity of muscle spindles during muscle contraction (C)</p> Signup and view all the answers

    Which of the following is a characteristic of muscles that require precise movements?

    <p>High density of muscle spindles (C)</p> Signup and view all the answers

    What type of sensory nerve endings are found within Golgi tendon organs?

    <p>Type Ib (D)</p> Signup and view all the answers

    What is the primary function of the phospholipid bilayer in terms of ion movement?

    <p>It creates a barrier that prevents the free movement of ions. (A)</p> Signup and view all the answers

    What is the key characteristic of a voltage-gated ion channel?

    <p>It opens in response to changes in membrane potential. (A)</p> Signup and view all the answers

    Which of the following reflexes is an example of a monosynaptic reflex?

    <p>Myotatic-stretch reflex (B)</p> Signup and view all the answers

    What is the role of reciprocal innervation in the myotatic-stretch reflex?

    <p>To inhibit the contraction of the antagonist muscle (A)</p> Signup and view all the answers

    What is the role of the threshold potential in the generation of an action potential?

    <p>It represents the minimum depolarization required to open voltage-gated sodium channels. (B)</p> Signup and view all the answers

    What is the primary function of the refractory period following an action potential?

    <p>To prevent the generation of another action potential immediately after the previous one. (D)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding the classification of peripheral nerve fibers based on axon diameter?

    <p>It is only used for sensory fibers (C)</p> Signup and view all the answers

    Which of the following is a characteristic of visceral sensory (visceral afferents) fibers?

    <p>They carry information from the body core (thoracic, abdominal, pelvic organs) (A)</p> Signup and view all the answers

    Which of the following accurately describes temporal summation?

    <p>A single presynaptic neuron repeatedly releases neurotransmitters onto a postsynaptic neuron. (C)</p> Signup and view all the answers

    Which type of ion channel is directly activated by neurotransmitters?

    <p>Ligand-gated ion channels (C)</p> Signup and view all the answers

    What is the primary function of the sympathetic nervous system?

    <p>To prepare the body for 'fight or flight' responses (C)</p> Signup and view all the answers

    What is the primary difference between ionotropic and metabotropic receptors?

    <p>Ionotropic receptors directly open ion channels, while metabotropic receptors require second messengers. (C)</p> Signup and view all the answers

    What is the function of the neurotransmitter glutamate in the central nervous system?

    <p>It excites postsynaptic neurons by inducing depolarization. (D)</p> Signup and view all the answers

    Which of the following describes saltatory conduction?

    <p>The rapid propagation of action potentials by jumping from one node of Ranvier to the next. (B)</p> Signup and view all the answers

    How does increasing the diameter of an axon affect the speed of action potential conduction?

    <p>It increases the number of voltage-gated sodium channels. (A)</p> Signup and view all the answers

    How does myelination affect the efficiency of action potential transmission?

    <p>Myelination reduces the number of action potentials required for signal transmission. (D)</p> Signup and view all the answers

    What is the primary function of the astrocyte process in a chemical synapse?

    <p>It removes excess neurotransmitters from the synaptic cleft. (D)</p> Signup and view all the answers

    What type of ion channel opening is responsible for an excitatory postsynaptic potential (EPSP)?

    <p>Influx of sodium ions (Na+) (A)</p> Signup and view all the answers

    What is the key characteristic of an electrical synapse?

    <p>It allows for direct ion flow between adjacent neurons through gap junctions. (D)</p> Signup and view all the answers

    What is the primary difference between the generation of an action potential and the initiation of a postsynaptic potential?

    <p>Action potentials are generated by the opening of voltage-gated ion channels, while postsynaptic potentials are generated by the binding of neurotransmitters to receptors. (C)</p> Signup and view all the answers

    What is the role of calcium ions (Ca2+) in synaptic transmission?

    <p>They trigger the release of neurotransmitters from vesicles in the presynaptic terminal. (D)</p> Signup and view all the answers

    What is the primary function of astrocytes in relation to neurotransmitters?

    <p>They help in converting glutamate to glutamine. (D)</p> Signup and view all the answers

    Which cells are primarily involved in the immune response within the brain?

    <p>Microglia (A)</p> Signup and view all the answers

    What process do polydendrocytes primarily contribute to during demyelinating disorders?

    <p>Remyelination as oligodendrocyte precursors (B)</p> Signup and view all the answers

    Which structure lines the ventricles and produces cerebrospinal fluid (CSF)?

    <p>Ependymal cells (C)</p> Signup and view all the answers

    How do substances cross the blood-brain barrier?

    <p>Only small lipophilic molecules can diffuse through. (D)</p> Signup and view all the answers

    Which of the following is NOT a component of the blood-brain barrier's protective layers?

    <p>Demyelinated axons (B)</p> Signup and view all the answers

    What role does the tripartite synapse play in neuronal communication?

    <p>It involves the interaction of the presynaptic neuron, postsynaptic neuron, and astrocyte. (A)</p> Signup and view all the answers

    What is the primary source of cerebrospinal fluid (CSF)?

    <p>Choroid plexus (B)</p> Signup and view all the answers

    What distinguishes stem cells in the peripheral nervous system (PNS) from those in the central nervous system (CNS)?

    <p>CNS stem cells are less active in replacing damaged cells. (C)</p> Signup and view all the answers

    What is the main functionality of radial glia in neural development?

    <p>They provide structural support for migrating neurons. (B)</p> Signup and view all the answers

    Where do sensory cell bodies reside in the spinal cord?

    <p>Dorsal root ganglion (B)</p> Signup and view all the answers

    Which structure serves to connect the spinal cord to the coccyx?

    <p>Filum terminale (B)</p> Signup and view all the answers

    What type of fibers travel with somatic afferents through the posterior root?

    <p>Afferent autonomic fibers (B)</p> Signup and view all the answers

    Which spinal region has 8 segments innervating the arm?

    <p>Cervical (B)</p> Signup and view all the answers

    Which layer of the spinal meninges is the innermost?

    <p>Pia mater (C)</p> Signup and view all the answers

    Which structure emerges from the intervertebral foramen?

    <p>Anterior rami (A), Posterior rami (B)</p> Signup and view all the answers

    What is the role of the substantia gelatinosa in the spinal cord?

    <p>Pain modulation (C)</p> Signup and view all the answers

    Where is the anterior median fissure located?

    <p>Entirity of the anterior surface of the spinal cord (B)</p> Signup and view all the answers

    What type of neurons does the anterior horn of the spinal cord primarily contain?

    <p>Motor neurons (A)</p> Signup and view all the answers

    What does the term 'myotome' refer to?

    <p>The sum of all muscle fibers supplied by a single spinal nerve (B)</p> Signup and view all the answers

    Which layer of the spinal meninges forms the dural sac, surrounding the entire spinal cord?

    <p>Dura mater (B)</p> Signup and view all the answers

    What pairs of nerve fibers were mentioned as traveling through the lumbar cistern?

    <p>Posterior and anterior roots (C)</p> Signup and view all the answers

    What is primarily found in the posterior horn of the spinal cord?

    <p>Sensory neurons (A)</p> Signup and view all the answers

    What is the role of anterior roots in the spinal cord?

    <p>Provide motor control to muscles (C)</p> Signup and view all the answers

    Flashcards

    Dendrites

    Protrusions on neurons where synaptic input occurs.

    Axon

    Long projection of a neuron that transmits signals away from the cell body.

    Multipolar neurons

    Most abundant neuron type in CNS with multiple dendrites and one axon.

    Pseudounipolar neurons

    Neuron type that bypasses the cell body to relay sensory info to the CNS.

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    Bipolar neurons

    Neurons with one main dendrite and axon, involved in sensory processing.

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    Axodendritic synapses

    Common synaptic contacts between an axon and a dendrite.

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    Axosomatic synapses

    Synapses where an axon contacts the soma of another neuron.

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    Axoaxonic synapses

    Synapses formed when one axon contacts another axon, affecting signal strength.

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    Oligodendroglia

    CNS cells that myelinate multiple axons, providing support and protection.

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    Schwann cells

    PNS myelinating cells that myelinate only a single axon.

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    Epidural Space

    The potential space between the dura mater and the periosteum in the skull, filled with fatty tissue and venous plexus.

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    Epidural Hematoma

    A collection of blood between the skull and dura due to arterial bleeding typically after a skull fracture.

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    Subdural Space

    The potential space between the dura mater and arachnoid mater, affected by bridging veins.

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    Subarachnoid Space

    A true space containing cerebrospinal fluid (CSF), cerebral arteries, and veins.

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    Hydrocephalus

    A condition characterized by an excessive accumulation of CSF in the brain due to impaired production, circulation, or absorption.

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    Glutamate conversion

    The process where glutamate is taken up and converted to glutamine by astrocytes.

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    Blood-brain barrier (BBB)

    A protective barrier separating blood from nervous tissue, maintained by astrocyte end-feet.

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    Tripartite synapse

    A synapse consisting of a presynaptic neuron, postsynaptic neuron, and astrocyte facilitating communication.

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    Role of astrocytes in synapse

    Astrocytes release neurotransmitters and have receptors, enhancing synaptic signaling.

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    Radial glia

    Cells that provide direction and scaffolding for migrating axons during development.

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    Polydendrocytes

    Stem cells in the CNS that can produce glial cells and neurons and respond to synaptic input.

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    Microglia

    The immune cells of the brain, derived from monocyte-macrophages, involved in protecting and cleaning up.

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    Ependymal cells

    Cells that line the brain’s ventricles and separate cerebrospinal fluid (CSF) from nervous tissue.

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    Choroid plexus

    A structure that produces cerebrospinal fluid (CSF) within the ventricles of the brain.

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    Components of BBB protection

    The three protective layers of the BBB: endothelial tight junctions, continuous basement membrane, and astrocyte end-feet.

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    Phospholipid bilayer

    A membrane that maintains differential ion concentrations inside and outside of the cell.

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    Electrochemical gradient

    The difference in ion concentrations across a membrane that creates a potential energy difference.

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    Membrane potential

    The sum of all ion gradients that creates electrical potential across a membrane.

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    Voltage-gated ion channels

    Channels that open or close in response to changes in membrane potential.

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    Action Potential (AP)

    A rapid wave of depolarization that travels along a neuron.

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    Threshold potential

    The critical level to which a membrane must be depolarized to initiate an AP.

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    Refractory period

    The recovery time after an action potential when the neuron cannot fire another AP.

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    Passive current

    Charge shuttling along a neuron without active ion transport.

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    Saltatory conduction

    AP that jumps from one node of Ranvier to another in myelinated axons.

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    Synaptic transmission

    The process of communication between neurons via synapses.

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    Excitatory postsynaptic potential (EPSP)

    A small depolarization causing the postsynaptic neuron to become more positive.

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    Inhibitory postsynaptic potential (IPSP)

    A small hyperpolarization making the postsynaptic neuron less likely to fire an AP.

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    Ionotropic receptors

    Receptors that directly open ion channels when activated by neurotransmitters.

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    Metabotropic receptors

    Receptors that initiate cellular signaling cascades, requiring second messengers.

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    Neurotransmitters

    Chemicals like glutamate and GABA that transmit signals across synapses.

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    Noncommunicating hydrocephalus

    Condition where CSF can't flow between ventricles and subarachnoid space, causing ventricle enlargement.

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    Treatment for hydrocephalus

    Involves restoring normal CSF cycle using a shunt to drain into the peritoneal cavity.

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    Peripheral Nervous System (PNS)

    Network of cranial and spinal nerves linking the CNS with the body.

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    Somatic components

    Parts of PNS carrying sensory and motor signals to/from the skeletal muscles.

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    Visceral components

    Parts of PNS that transmit sensory and motor commands to/from internal organs.

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    Ganglia

    Aggregations of nerve cell bodies located outside the CNS.

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    Epineurium

    The outermost connective tissue layer surrounding peripheral nerves.

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    Muscle Spindles

    Proprioceptors that detect muscle length and stretch.

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    Golgi Tendon Organs

    Receptors that detect muscle tension at the tendon junction.

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    Myotatic-reflex

    A monosynaptic reflex that causes contraction of the stretched muscle.

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    Alpha-gamma coactivation

    Simultaneous activation of alpha and gamma motor neurons to maintain muscle spindle function.

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    Proprioceptors

    Sensory receptors detecting body position and movement.

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    Type Ia afferents

    Sensory nerve fibers innervating the central region of intrafusal muscle fibers.

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    Reciprocal innervation

    Process where activation of one muscle triggers inhibition of its antagonist.

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    CNS communication

    Peripheral nerves carry sensory input to the CNS and motor output from the CNS.

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    Dorsal root ganglion

    Cluster of sensory neuron cell bodies located near the spinal cord.

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    Anterior motor roots

    Motor fibers that exit the spinal cord to control muscle movement.

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    Lower Motor Neurons (LMNs)

    Neurons located in the anterior horn of the spinal cord, controlling skeletal muscles.

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    Efferent autonomic fibers

    Nerve fibers that carry commands from the central nervous system to autonomic targets.

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    Posterior roots

    Sensory roots of spinal nerves carrying information to the spinal cord.

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    Anterior rami

    Branches of spinal nerves that supply the front of the body.

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    Cauda equina

    Bundle of spinal nerves below the spinal cord, resembling a horse's tail.

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    Conus medullaris

    The tapering end of the spinal cord.

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    Anterior median fissure

    Longitudinal groove on the anterior surface of the spinal cord.

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    Dermatomes

    Skin areas innervated by specific spinal nerve segments.

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    Myotome

    Group of muscles innervated by a single spinal nerve.

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    Posteromedial sulcus

    Groove at the back of the spinal cord separating two halves.

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    Rexed Laminae

    Classification of gray matter regions in the spinal cord.

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    Study Notes

    Central Nervous System (CNS)

    • CNS includes the brain and spinal cord
    • The CNS receives and processes information from the environment and generates commands for the body.

    Peripheral Nervous System (PNS)

    • The PNS consists of all nerves and their components outside the CNS
    • It receives and transmits information to and from the CNS.

    Afferent Neurons

    • Sensory neurons that receive and transmit information from the environment to the CNS
    • They carry sensory information like input from sensory organs, skin, muscles, joints, and viscera.

    Efferent Neurons

    • Motor neurons that transmit information generated in the CNS to the periphery
    • These neurons travel to glands, smooth muscles, and skeletal muscles.

    Cellular Components of the Nervous System: Neurons

    • Excitable cells of the nervous system organized in circuits
    • They process conscious and non-conscious information in brain and spinal cord.
    • Signal propagation occurs via action potentials
    • Neurons connect to each other via synapses having 3 components:
      • Axon terminal
      • Dendrite of the receiving cell
      • Glial cell process
      • A synaptic cleft

    Functional Organization of Neurons

    • Soma/perikaryon = cell body containing the nucleus

    • Where all proteins, hormones, and neurotransmitters are produced

    • Nissl substance = a halo of endoplasmic reticulum

    • High metabolic rate of neurons, that stains intensely blue.

    • Microtubules are used for axonal transport

    • Anterograde transport is from perikaryon to synapse

    • Retrograde transport is from synaptic terminal to perikaryon

    • Helpful for shuttling of trophic factors e.g. neurotrophins.

    • Neurons depend on trophic substances from peripheral targets for survival.

    Different Neuron Types

    • Multipolar neurons: the most abundant type in CNS, dendritic branches are direct off the cell body.
    • Pseudounipolar neurons: located in dorsal root ganglion, a dendritic axon receives sensory info and transmits to spinal cord bypassing the cell body.
    • Bipolar neurons: have a single main dendrite and an axon, relay info in the retina and olfactory epithelium.

    Types of Synapses

    • Axodendritic synapses – most common synaptic contacts in the CNS, between an axon and a dendrite.
    • Axosomatic synapses – axon contacts another neuron directly on the cell soma; less common in the CNS.
    • Axoaxonic synapses – axon contacts an axon.

    Glia

    • Glia cells support and protect neurons
    • Oligodendrocytes- myelinate axons in the CNS
    • Schwann cells- myelinate axons in the PNS
    • Astroglia- blood-brain barrier, ion homeostasis, nutritive functions
    • Muller cells- found in the retina
    • Functions include: taking up and recycling excess NTs (e.g., glutamate), maintaining homeostasis around neurons.

    Blood Brain Barrier

    • Astrocyte end feet, form boundary between the blood and nervous tissue.
    • The barrier maintains homeostasis by shuttling excess ions into the bloodstream.
    • Tripartite synapse, includes presynaptic neurons, postsynaptic neurons, and astrocytes.
    • Astrocytes release NTs into the synaptic cleft to strengthen signals.

    Microglia

    • Immune cells in the brain
    • Similar to macrophages
    • Activated in areas of neuronal damage
    • Involved in antigen presentation

    Ependymal Cells

    • Line the ventricles of the brain
    • Separates CSF from the neuropil

    Choroid Plexus

    • Produces CSF

    Ion Movements and Action Potentials

    • Phospholipid bilayer maintains differential ion concentrations inside vs. outside of the cell
    • Movement of ions generates an electrochemical gradient for each ion
    • Membrane potential is the sum of all ion gradients
    • Voltage-gated ion channels, regulate by membrane potential, open the channel pore.

    Synaptic Transmission

    • Electrical Synapse – ions flow through gap junctions, coupling 2 neurons
    • Chemical Synapse – Communication via neurotransmitters
      • Charge and ions don't directly move between cells
      • AP arrives at presynaptic terminal
      • Voltage-gated Ca2+ channels open; influx of Ca2+
      • NT filled vesicles fuse w/ membrane; NT diffuses across synaptic cleft
      • NT binds to postsynaptic receptors and ion channels open
      • Influx of Na+ → EPSP
      • Influx of Cl- → IPSP
      • Efflux of K+ → IPSP

    Neurotransmitters

    • Glutamate − excitatory NT in CNS
    • GABA − inhibitory NT in CNS
    • Acetylcholine − excitatory or inhibitory NT, used in PNS (ganglia of visceral motor system), CNS (forebrain), neuromuscular junctions.

    Types of Neurotransmitter Receptors

    • Ionotropic receptors – NT receptor coupled with an ion channel (direct effect)
    • Metabotropic receptors – NT receptor coupled with intracellular signaling cascades (indirect effect)

    Multiple Sclerosis

    • Chronic neurological disease affecting young adults
    • Pathology: loss of myelin sheath around axons

    Saltatory Conduction

    • More rapid method of AP propagation along myelinated axons
    • APs jump from node to node

    Continuous Conduction

    • APs are regenerated across the entire length of axon
    • Slower method of AP propagation in unmyelinated axons

    Sensory Receptors (Spindles and Golgi)

    • Muscle spindles: detect muscle length/stretch; found throughout skeletal muscles
    • Golgi tendon organs (GTOs): monitor muscle strength, tension; found tendon-muscles junctions

    Spinal Reflexes

    • Sensory stimulus initiates motor response directly
    • Example: withdrawal reflex (stepping on a sharp object)
    • Myotatic reflex (stretch reflex or deep tendon reflex): contraction of quadriceps muscle when patellar ligament is tapped
    • Important for posture

    Myotatic or Stretch Reflex

    • Monosynaptic nerve pathway
    • The stretch reflex is triggered by muscle spindle receptors and results in contraction of that muscle.

    Inverse Myotatic Reflex

    • Polysynaptic nerve pathway
    • The GTO detects excessive muscle tension and inhibits the alpha-motor neurons that innervate the same muscles.

    Flexion and Crossed-Extension Reflex

    • Initiated by a painful stimulus or injury, resulting in flexion of the affected limb and extension of the opposite limb.

    Cerebrum (Brain)

    • The largest part of the brain that is responsible for sensory input, higher-order processes, voluntary movements.

    Brainstem

    • A collection of neural tissues in the CNS that connects the cerebrum, cerebellum, and spinal cord.

    Cerebellum

    • Structures within the brainstem that control the movement of the body.

    Spinal Cord

    • Provides communication between the brain and the body, also integrates sensory information and sends motor commands.

    Meninges

    • Membranes that surround the brain and spinal cord
    • Dura mater
    • Arachnoid mater
    • Pia mater
    • Contains venous sinuses that collect venous blood

    Cerebral Ventricles

    • Fluid-filled cavities in the brain
    • CSF is produced there and circulates through the ventricles and into the subarachnoid space.

    Hydrocephalus

    • Too much CSF, resulting in enlarged ventricles, and damage to brain tissue.

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