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Questions and Answers
What is the primary function of the axon hillock?
What is the primary function of the axon hillock?
Which type of neuron is most abundant in the CNS and receives thousands of axodendritic synaptic inputs?
Which type of neuron is most abundant in the CNS and receives thousands of axodendritic synaptic inputs?
What role do postsynaptic densities play in synaptic transmission?
What role do postsynaptic densities play in synaptic transmission?
What is the function of myelin sheaths produced by oligodendrocytes?
What is the function of myelin sheaths produced by oligodendrocytes?
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Which type of glial cell is responsible for maintaining homeostasis around neurons and taking up excess neurotransmitters at the synapse?
Which type of glial cell is responsible for maintaining homeostasis around neurons and taking up excess neurotransmitters at the synapse?
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Which type of synapse is most common in the CNS and involves an axon contacting a dendrite?
Which type of synapse is most common in the CNS and involves an axon contacting a dendrite?
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Which glial cell type is found primarily in the white matter of the CNS?
Which glial cell type is found primarily in the white matter of the CNS?
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Which of the following is NOT a function of astrocytes?
Which of the following is NOT a function of astrocytes?
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Which type of neuron is found in the spinal dorsal root ganglia and relays sensory information to the CNS without modifying the signal?
Which type of neuron is found in the spinal dorsal root ganglia and relays sensory information to the CNS without modifying the signal?
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What is the function of the nodes of Ranvier?
What is the function of the nodes of Ranvier?
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What is the primary component found within the epidural space?
What is the primary component found within the epidural space?
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Which type of hematoma results from the separation of the dura mater from the skull due to arterial bleeding?
Which type of hematoma results from the separation of the dura mater from the skull due to arterial bleeding?
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Which condition is characterized by impaired production, circulation, or absorption of cerebrospinal fluid (CSF)?
Which condition is characterized by impaired production, circulation, or absorption of cerebrospinal fluid (CSF)?
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What primarily causes a subdural hematoma in situations such as shaken baby syndrome?
What primarily causes a subdural hematoma in situations such as shaken baby syndrome?
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What is typically found in the subarachnoid space?
What is typically found in the subarachnoid space?
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Which of the following is NOT a characteristic of noncommunicating hydrocephalus?
Which of the following is NOT a characteristic of noncommunicating hydrocephalus?
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What is the primary function of the peripheral nervous system?
What is the primary function of the peripheral nervous system?
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Which of the following is NOT a type of nerve fiber classified by its conduction velocity?
Which of the following is NOT a type of nerve fiber classified by its conduction velocity?
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Which of the following is TRUE regarding the structure of a muscle spindle?
Which of the following is TRUE regarding the structure of a muscle spindle?
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What is the function of the gamma reflex loop?
What is the function of the gamma reflex loop?
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Which type of afferent nerve fiber innervates the middle portion of all intrafusal fibers?
Which type of afferent nerve fiber innervates the middle portion of all intrafusal fibers?
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Which of the following scenarios would cause an increase in afferent nerve firing frequency from a muscle spindle?
Which of the following scenarios would cause an increase in afferent nerve firing frequency from a muscle spindle?
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What is the main function of alpha-gamma coactivation?
What is the main function of alpha-gamma coactivation?
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Which of the following is a characteristic of muscles that require precise movements?
Which of the following is a characteristic of muscles that require precise movements?
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What type of sensory nerve endings are found within Golgi tendon organs?
What type of sensory nerve endings are found within Golgi tendon organs?
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What is the primary function of the phospholipid bilayer in terms of ion movement?
What is the primary function of the phospholipid bilayer in terms of ion movement?
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What is the key characteristic of a voltage-gated ion channel?
What is the key characteristic of a voltage-gated ion channel?
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Which of the following reflexes is an example of a monosynaptic reflex?
Which of the following reflexes is an example of a monosynaptic reflex?
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What is the role of reciprocal innervation in the myotatic-stretch reflex?
What is the role of reciprocal innervation in the myotatic-stretch reflex?
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What is the role of the threshold potential in the generation of an action potential?
What is the role of the threshold potential in the generation of an action potential?
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What is the primary function of the refractory period following an action potential?
What is the primary function of the refractory period following an action potential?
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Which of the following statements is TRUE regarding the classification of peripheral nerve fibers based on axon diameter?
Which of the following statements is TRUE regarding the classification of peripheral nerve fibers based on axon diameter?
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Which of the following is a characteristic of visceral sensory (visceral afferents) fibers?
Which of the following is a characteristic of visceral sensory (visceral afferents) fibers?
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Which of the following accurately describes temporal summation?
Which of the following accurately describes temporal summation?
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Which type of ion channel is directly activated by neurotransmitters?
Which type of ion channel is directly activated by neurotransmitters?
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What is the primary function of the sympathetic nervous system?
What is the primary function of the sympathetic nervous system?
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What is the primary difference between ionotropic and metabotropic receptors?
What is the primary difference between ionotropic and metabotropic receptors?
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What is the function of the neurotransmitter glutamate in the central nervous system?
What is the function of the neurotransmitter glutamate in the central nervous system?
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Which of the following describes saltatory conduction?
Which of the following describes saltatory conduction?
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How does increasing the diameter of an axon affect the speed of action potential conduction?
How does increasing the diameter of an axon affect the speed of action potential conduction?
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How does myelination affect the efficiency of action potential transmission?
How does myelination affect the efficiency of action potential transmission?
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What is the primary function of the astrocyte process in a chemical synapse?
What is the primary function of the astrocyte process in a chemical synapse?
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What type of ion channel opening is responsible for an excitatory postsynaptic potential (EPSP)?
What type of ion channel opening is responsible for an excitatory postsynaptic potential (EPSP)?
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What is the key characteristic of an electrical synapse?
What is the key characteristic of an electrical synapse?
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What is the primary difference between the generation of an action potential and the initiation of a postsynaptic potential?
What is the primary difference between the generation of an action potential and the initiation of a postsynaptic potential?
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What is the role of calcium ions (Ca2+) in synaptic transmission?
What is the role of calcium ions (Ca2+) in synaptic transmission?
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What is the primary function of astrocytes in relation to neurotransmitters?
What is the primary function of astrocytes in relation to neurotransmitters?
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Which cells are primarily involved in the immune response within the brain?
Which cells are primarily involved in the immune response within the brain?
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What process do polydendrocytes primarily contribute to during demyelinating disorders?
What process do polydendrocytes primarily contribute to during demyelinating disorders?
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Which structure lines the ventricles and produces cerebrospinal fluid (CSF)?
Which structure lines the ventricles and produces cerebrospinal fluid (CSF)?
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How do substances cross the blood-brain barrier?
How do substances cross the blood-brain barrier?
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Which of the following is NOT a component of the blood-brain barrier's protective layers?
Which of the following is NOT a component of the blood-brain barrier's protective layers?
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What role does the tripartite synapse play in neuronal communication?
What role does the tripartite synapse play in neuronal communication?
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What is the primary source of cerebrospinal fluid (CSF)?
What is the primary source of cerebrospinal fluid (CSF)?
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What distinguishes stem cells in the peripheral nervous system (PNS) from those in the central nervous system (CNS)?
What distinguishes stem cells in the peripheral nervous system (PNS) from those in the central nervous system (CNS)?
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What is the main functionality of radial glia in neural development?
What is the main functionality of radial glia in neural development?
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Where do sensory cell bodies reside in the spinal cord?
Where do sensory cell bodies reside in the spinal cord?
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Which structure serves to connect the spinal cord to the coccyx?
Which structure serves to connect the spinal cord to the coccyx?
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What type of fibers travel with somatic afferents through the posterior root?
What type of fibers travel with somatic afferents through the posterior root?
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Which spinal region has 8 segments innervating the arm?
Which spinal region has 8 segments innervating the arm?
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Which layer of the spinal meninges is the innermost?
Which layer of the spinal meninges is the innermost?
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Which structure emerges from the intervertebral foramen?
Which structure emerges from the intervertebral foramen?
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What is the role of the substantia gelatinosa in the spinal cord?
What is the role of the substantia gelatinosa in the spinal cord?
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Where is the anterior median fissure located?
Where is the anterior median fissure located?
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What type of neurons does the anterior horn of the spinal cord primarily contain?
What type of neurons does the anterior horn of the spinal cord primarily contain?
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What does the term 'myotome' refer to?
What does the term 'myotome' refer to?
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Which layer of the spinal meninges forms the dural sac, surrounding the entire spinal cord?
Which layer of the spinal meninges forms the dural sac, surrounding the entire spinal cord?
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What pairs of nerve fibers were mentioned as traveling through the lumbar cistern?
What pairs of nerve fibers were mentioned as traveling through the lumbar cistern?
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What is primarily found in the posterior horn of the spinal cord?
What is primarily found in the posterior horn of the spinal cord?
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What is the role of anterior roots in the spinal cord?
What is the role of anterior roots in the spinal cord?
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Flashcards
Dendrites
Dendrites
Protrusions on neurons where synaptic input occurs.
Axon
Axon
Long projection of a neuron that transmits signals away from the cell body.
Multipolar neurons
Multipolar neurons
Most abundant neuron type in CNS with multiple dendrites and one axon.
Pseudounipolar neurons
Pseudounipolar neurons
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Bipolar neurons
Bipolar neurons
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Axodendritic synapses
Axodendritic synapses
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Axosomatic synapses
Axosomatic synapses
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Axoaxonic synapses
Axoaxonic synapses
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Oligodendroglia
Oligodendroglia
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Schwann cells
Schwann cells
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Epidural Space
Epidural Space
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Epidural Hematoma
Epidural Hematoma
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Subdural Space
Subdural Space
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Subarachnoid Space
Subarachnoid Space
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Hydrocephalus
Hydrocephalus
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Glutamate conversion
Glutamate conversion
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Blood-brain barrier (BBB)
Blood-brain barrier (BBB)
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Tripartite synapse
Tripartite synapse
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Role of astrocytes in synapse
Role of astrocytes in synapse
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Radial glia
Radial glia
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Polydendrocytes
Polydendrocytes
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Microglia
Microglia
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Ependymal cells
Ependymal cells
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Choroid plexus
Choroid plexus
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Components of BBB protection
Components of BBB protection
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Phospholipid bilayer
Phospholipid bilayer
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Electrochemical gradient
Electrochemical gradient
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Membrane potential
Membrane potential
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Voltage-gated ion channels
Voltage-gated ion channels
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Action Potential (AP)
Action Potential (AP)
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Threshold potential
Threshold potential
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Refractory period
Refractory period
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Passive current
Passive current
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Saltatory conduction
Saltatory conduction
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Synaptic transmission
Synaptic transmission
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Excitatory postsynaptic potential (EPSP)
Excitatory postsynaptic potential (EPSP)
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Inhibitory postsynaptic potential (IPSP)
Inhibitory postsynaptic potential (IPSP)
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Ionotropic receptors
Ionotropic receptors
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Metabotropic receptors
Metabotropic receptors
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Neurotransmitters
Neurotransmitters
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Noncommunicating hydrocephalus
Noncommunicating hydrocephalus
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Treatment for hydrocephalus
Treatment for hydrocephalus
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Peripheral Nervous System (PNS)
Peripheral Nervous System (PNS)
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Somatic components
Somatic components
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Visceral components
Visceral components
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Ganglia
Ganglia
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Epineurium
Epineurium
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Muscle Spindles
Muscle Spindles
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Golgi Tendon Organs
Golgi Tendon Organs
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Myotatic-reflex
Myotatic-reflex
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Alpha-gamma coactivation
Alpha-gamma coactivation
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Proprioceptors
Proprioceptors
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Type Ia afferents
Type Ia afferents
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Reciprocal innervation
Reciprocal innervation
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CNS communication
CNS communication
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Dorsal root ganglion
Dorsal root ganglion
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Anterior motor roots
Anterior motor roots
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Lower Motor Neurons (LMNs)
Lower Motor Neurons (LMNs)
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Efferent autonomic fibers
Efferent autonomic fibers
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Posterior roots
Posterior roots
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Anterior rami
Anterior rami
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Cauda equina
Cauda equina
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Conus medullaris
Conus medullaris
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Anterior median fissure
Anterior median fissure
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Dermatomes
Dermatomes
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Myotome
Myotome
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Posteromedial sulcus
Posteromedial sulcus
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Rexed Laminae
Rexed Laminae
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Study Notes
Central Nervous System (CNS)
- CNS includes the brain and spinal cord
- The CNS receives and processes information from the environment and generates commands for the body.
Peripheral Nervous System (PNS)
- The PNS consists of all nerves and their components outside the CNS
- It receives and transmits information to and from the CNS.
Afferent Neurons
- Sensory neurons that receive and transmit information from the environment to the CNS
- They carry sensory information like input from sensory organs, skin, muscles, joints, and viscera.
Efferent Neurons
- Motor neurons that transmit information generated in the CNS to the periphery
- These neurons travel to glands, smooth muscles, and skeletal muscles.
Cellular Components of the Nervous System: Neurons
- Excitable cells of the nervous system organized in circuits
- They process conscious and non-conscious information in brain and spinal cord.
- Signal propagation occurs via action potentials
- Neurons connect to each other via synapses having 3 components:
- Axon terminal
- Dendrite of the receiving cell
- Glial cell process
- A synaptic cleft
Functional Organization of Neurons
-
Soma/perikaryon = cell body containing the nucleus
-
Where all proteins, hormones, and neurotransmitters are produced
-
Nissl substance = a halo of endoplasmic reticulum
-
High metabolic rate of neurons, that stains intensely blue.
-
Microtubules are used for axonal transport
-
Anterograde transport is from perikaryon to synapse
-
Retrograde transport is from synaptic terminal to perikaryon
-
Helpful for shuttling of trophic factors e.g. neurotrophins.
-
Neurons depend on trophic substances from peripheral targets for survival.
Different Neuron Types
- Multipolar neurons: the most abundant type in CNS, dendritic branches are direct off the cell body.
- Pseudounipolar neurons: located in dorsal root ganglion, a dendritic axon receives sensory info and transmits to spinal cord bypassing the cell body.
- Bipolar neurons: have a single main dendrite and an axon, relay info in the retina and olfactory epithelium.
Types of Synapses
- Axodendritic synapses – most common synaptic contacts in the CNS, between an axon and a dendrite.
- Axosomatic synapses – axon contacts another neuron directly on the cell soma; less common in the CNS.
- Axoaxonic synapses – axon contacts an axon.
Glia
- Glia cells support and protect neurons
- Oligodendrocytes- myelinate axons in the CNS
- Schwann cells- myelinate axons in the PNS
- Astroglia- blood-brain barrier, ion homeostasis, nutritive functions
- Muller cells- found in the retina
- Functions include: taking up and recycling excess NTs (e.g., glutamate), maintaining homeostasis around neurons.
Blood Brain Barrier
- Astrocyte end feet, form boundary between the blood and nervous tissue.
- The barrier maintains homeostasis by shuttling excess ions into the bloodstream.
- Tripartite synapse, includes presynaptic neurons, postsynaptic neurons, and astrocytes.
- Astrocytes release NTs into the synaptic cleft to strengthen signals.
Microglia
- Immune cells in the brain
- Similar to macrophages
- Activated in areas of neuronal damage
- Involved in antigen presentation
Ependymal Cells
- Line the ventricles of the brain
- Separates CSF from the neuropil
Choroid Plexus
- Produces CSF
Ion Movements and Action Potentials
- Phospholipid bilayer maintains differential ion concentrations inside vs. outside of the cell
- Movement of ions generates an electrochemical gradient for each ion
- Membrane potential is the sum of all ion gradients
- Voltage-gated ion channels, regulate by membrane potential, open the channel pore.
Synaptic Transmission
- Electrical Synapse – ions flow through gap junctions, coupling 2 neurons
- Chemical Synapse – Communication via neurotransmitters
- Charge and ions don't directly move between cells
- AP arrives at presynaptic terminal
- Voltage-gated Ca2+ channels open; influx of Ca2+
- NT filled vesicles fuse w/ membrane; NT diffuses across synaptic cleft
- NT binds to postsynaptic receptors and ion channels open
- Influx of Na+ → EPSP
- Influx of Cl- → IPSP
- Efflux of K+ → IPSP
Neurotransmitters
- Glutamate − excitatory NT in CNS
- GABA − inhibitory NT in CNS
- Acetylcholine − excitatory or inhibitory NT, used in PNS (ganglia of visceral motor system), CNS (forebrain), neuromuscular junctions.
Types of Neurotransmitter Receptors
- Ionotropic receptors – NT receptor coupled with an ion channel (direct effect)
- Metabotropic receptors – NT receptor coupled with intracellular signaling cascades (indirect effect)
Multiple Sclerosis
- Chronic neurological disease affecting young adults
- Pathology: loss of myelin sheath around axons
Saltatory Conduction
- More rapid method of AP propagation along myelinated axons
- APs jump from node to node
Continuous Conduction
- APs are regenerated across the entire length of axon
- Slower method of AP propagation in unmyelinated axons
Sensory Receptors (Spindles and Golgi)
- Muscle spindles: detect muscle length/stretch; found throughout skeletal muscles
- Golgi tendon organs (GTOs): monitor muscle strength, tension; found tendon-muscles junctions
Spinal Reflexes
- Sensory stimulus initiates motor response directly
- Example: withdrawal reflex (stepping on a sharp object)
- Myotatic reflex (stretch reflex or deep tendon reflex): contraction of quadriceps muscle when patellar ligament is tapped
- Important for posture
Myotatic or Stretch Reflex
- Monosynaptic nerve pathway
- The stretch reflex is triggered by muscle spindle receptors and results in contraction of that muscle.
Inverse Myotatic Reflex
- Polysynaptic nerve pathway
- The GTO detects excessive muscle tension and inhibits the alpha-motor neurons that innervate the same muscles.
Flexion and Crossed-Extension Reflex
- Initiated by a painful stimulus or injury, resulting in flexion of the affected limb and extension of the opposite limb.
Cerebrum (Brain)
- The largest part of the brain that is responsible for sensory input, higher-order processes, voluntary movements.
Brainstem
- A collection of neural tissues in the CNS that connects the cerebrum, cerebellum, and spinal cord.
Cerebellum
- Structures within the brainstem that control the movement of the body.
Spinal Cord
- Provides communication between the brain and the body, also integrates sensory information and sends motor commands.
Meninges
- Membranes that surround the brain and spinal cord
- Dura mater
- Arachnoid mater
- Pia mater
- Contains venous sinuses that collect venous blood
Cerebral Ventricles
- Fluid-filled cavities in the brain
- CSF is produced there and circulates through the ventricles and into the subarachnoid space.
Hydrocephalus
- Too much CSF, resulting in enlarged ventricles, and damage to brain tissue.
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Description
Test your knowledge on the functions and types of neurons and glial cells in the central nervous system. This quiz covers topics such as synaptic transmission, myelin sheaths, and the role of astrocytes. Challenge yourself with questions that delve into the anatomy and physiology of the nervous system.