Neuroscience Quiz: MRI and Spinal Cord Functions
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Questions and Answers

What primarily differentiates functional magnetic resonance imaging (fMRI) from traditional MRI?

  • fMRI is used exclusively for spinal cord analysis.
  • fMRI measures brain structure.
  • fMRI provides a static image of the brain.
  • fMRI detects changes associated with blood flow. (correct)
  • Which structure is responsible for serving as a link between the brain and the rest of the body?

  • Peripheral nerves
  • Cerebellum
  • Spinal cord (correct)
  • Cerebrum
  • Which components of the spinal cord carry signals from the brain to the spinal nerves?

  • Ascending tracts
  • Descending tracts (correct)
  • Cervical nerves
  • Efferent fibers
  • What is the primary function of afferent fibers in the spinal cord?

    <p>To transmit signals from peripheral tissues to the spinal cord. (B)</p> Signup and view all the answers

    Which statement about nerves and neurons is accurate?

    <p>A nerve is a bundle of neuronal axons enclosed by connective tissue. (C)</p> Signup and view all the answers

    What structure is mainly responsible for the formation of the blood-brain barrier (BBB)?

    <p>Astrocytes (A)</p> Signup and view all the answers

    Where is the gray matter located in the spinal cord?

    <p>Interior of the spinal cord (D)</p> Signup and view all the answers

    What is the role of cerebrospinal fluid (CSF)?

    <p>To facilitate exchange of materials and protect the brain (B)</p> Signup and view all the answers

    Which type of neuron has a single axon and is often fused with its dendrite?

    <p>Pseudounipolar neuron (C)</p> Signup and view all the answers

    Which area of the brain is primarily involved in language comprehension?

    <p>Wernicke's area (C)</p> Signup and view all the answers

    Which of the following components are part of the protective structures of the central nervous system?

    <p>Meninges and cerebrospinal fluid (B)</p> Signup and view all the answers

    What type of fluid is found in the brain's ventricles and protects the brain during sudden movements?

    <p>Cerebrospinal fluid (CSF) (C)</p> Signup and view all the answers

    What term describes the uneven distribution of sensory and motor cortex areas depicted in the homunculus?

    <p>Cortical plasticity (C)</p> Signup and view all the answers

    Which type of glial cell is primarily involved in the maintenance and repair of neural tissue?

    <p>Microglia (B)</p> Signup and view all the answers

    Which division of the peripheral nervous system is responsible for voluntary actions?

    <p>Somatic nervous system (B)</p> Signup and view all the answers

    What is the main function of the cerebellum?

    <p>Subconscious coordination of motor activity (A)</p> Signup and view all the answers

    What is the primary role of oligodendrocytes in the nervous system?

    <p>Myelinating axons (D)</p> Signup and view all the answers

    What is a major characteristic of the cerebral cortex?

    <p>It is highly convoluted (A)</p> Signup and view all the answers

    What is temporal summation primarily characterized by?

    <p>A single presynaptic neuron firing multiple times in close succession (A)</p> Signup and view all the answers

    Which process involves multiple presynaptic inputs influencing a single postsynaptic neuron?

    <p>Spatial summation (A)</p> Signup and view all the answers

    What is the outcome of long-term potentiation (LTP)?

    <p>Strengthening of synaptic connections (B)</p> Signup and view all the answers

    In which scenario would a decrease in neurotransmitter release likely occur?

    <p>During high frequency stimulation causing desensitization (A)</p> Signup and view all the answers

    Which type of memory lasts the longest?

    <p>Long-term memory (A)</p> Signup and view all the answers

    What role does the process of consolidation play in memory?

    <p>Transfers short-term memory into long-term storage (B)</p> Signup and view all the answers

    What characterizes the divergent pathway in neuronal processing?

    <p>Single neuron connecting with multiple postsynaptic neurons (D)</p> Signup and view all the answers

    What structural change can occur during memory formation?

    <p>Formation of new synapses (D)</p> Signup and view all the answers

    What initiates the action potential in a neuron?

    <p>Axon hillock activation (C)</p> Signup and view all the answers

    What is primarily affected in multiple sclerosis?

    <p>Myelin sheath integrity (C)</p> Signup and view all the answers

    Which change occurs at an excitatory synapse?

    <p>Depolarization leading to an action potential (B)</p> Signup and view all the answers

    What happens to Na+ ions during saltatory conduction?

    <p>They reinforce depolarization at the nodes of Ranvier. (B)</p> Signup and view all the answers

    What type of membrane potential change occurs during an inhibitory synapse?

    <p>Small hyperpolarization (B)</p> Signup and view all the answers

    How does cocaine affect neurotransmitter transmission?

    <p>Inhibits dopamine breakdown at the synaptic cleft. (B)</p> Signup and view all the answers

    What is the primary function of the axon in a neuron?

    <p>Conducting action potentials to other cells (A)</p> Signup and view all the answers

    Which type of ion channels are always open and allow potassium ions to move freely across the membrane?

    <p>Leaky channels (D)</p> Signup and view all the answers

    What is the primary event that triggers the generation of an action potential in a neuron?

    <p>Membrane depolarization (A)</p> Signup and view all the answers

    Which mechanism terminates synaptic transmission?

    <p>Endocytosis of neurotransmitter receptors (C)</p> Signup and view all the answers

    What is a key characteristic of graded potentials?

    <p>Their amplitude diminishes with distance. (B)</p> Signup and view all the answers

    Which ion primarily causes the depolarization phase of an action potential?

    <p>Na^+ (D)</p> Signup and view all the answers

    During which phase of an action potential does potassium ion efflux primarily occur?

    <p>Repolarization (B)</p> Signup and view all the answers

    What distinct feature does a synapse have?

    <p>Specific neurotransmitter release (C)</p> Signup and view all the answers

    What is the state called when a neuron cannot generate another action potential immediately after one has occurred?

    <p>Absolute refractory period (D)</p> Signup and view all the answers

    What characterizes a graded potential compared to an action potential?

    <p>It is dependent on the strength of the trigger. (C)</p> Signup and view all the answers

    Which of the following neurotoxins blocks voltage-gated sodium channels?

    <p>Tetrodotoxin (TTX) (C)</p> Signup and view all the answers

    Which structure in the neuron contributes to the formation of synapses?

    <p>Dendritic spine (C)</p> Signup and view all the answers

    What is the primary role of myelin in neurons?

    <p>Insulate axons and speed up conduction (C)</p> Signup and view all the answers

    During the hyperpolarization phase of an action potential, which ion channel closes slowly?

    <p>K^+ channel (B)</p> Signup and view all the answers

    What effect does tetrodotoxin (TTX) have on neuronal function?

    <p>Prevents generation of action potentials (B)</p> Signup and view all the answers

    What change occurs in the membrane potential during depolarization?

    <p>Decreased negativity (B)</p> Signup and view all the answers

    Which ion movement is responsible for the repolarization phase of the action potential?

    <p>K^+ efflux (B)</p> Signup and view all the answers

    In which type of conduction does the action potential jump from node to node?

    <p>Saltatory conduction (A)</p> Signup and view all the answers

    Flashcards

    Central Nervous System (CNS)

    The brain and spinal cord; the control center of the body.

    Peripheral Nervous System (PNS)

    Nerves outside the CNS; connects the CNS to the rest of the body.

    Astrocytes

    Star-shaped glial cells that support neurons structurally and metabolically. Form the Blood-Brain Barrier.

    Blood-Brain Barrier (BBB)

    A barrier created by astrocytes that regulates the passage of substances from the blood into the brain tissue.

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    Grey matter

    Area of the CNS containing densely packed neuron cell bodies.

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    White matter

    Area of the CNS containing myelinated axons.

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    Cerebrospinal Fluid (CSF)

    Fluid filling the ventricles of the brain and the spinal cord; cushions the CNS.

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    Meninges

    Protective membranes surrounding the brain and spinal cord, including dura mater, arachnoid mater, and pia mater.

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    Cerebral Cortex

    Outer layer of the cerebrum; responsible for higher-level functions like decision-making.

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    Cerebellum

    Part of the brain involved in coordinating motor activity.

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    Hypothalamus

    Brain region controlling homeostasis and basic drives

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    Neuron

    Cell that transmits nerve impulses.

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    Oligodendrocytes

    Glial cells that produce myelin in the CNS.

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    Broca's area

    Brain region controlling language production.

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    Wernicke's area

    Brain region responsible for understanding language.

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    Spinal Cord Function

    Connects the brain to the body, enabling information transmission and reflex actions.

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    Spinal Nerve Types

    Spinal nerves emerge from the spinal cord in different regions (cervical, thoracic, lumbar, sacral, coccygeal), relating to the vertebrae they exit from.

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    Ascending/Descending Tracts

    Nerve pathways in the spinal cord that carry information up (to the brain) and down (from the brain).

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    Afferent vs Efferent Fibers

    Afferent fibers carry sensory information to the spinal cord, while efferent fibers carry motor commands from the spinal cord.

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    Nerve vs Neuron

    A nerve is a bundle of axons, while a neuron is a single nerve cell. Nerves are bundles of axons that follow a path; neurons are individual cells and are part of the nerve.

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    Membrane Potential

    The voltage difference across a cell membrane, usually negative in neurons due to excess anions inside and cations outside.

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    Resting Membrane Potential

    The stable, negative voltage difference across the neuronal membrane when the neuron is not actively transmitting signals. Around -70mV.

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    What maintains the resting membrane potential?

    The Na+/K+ pump actively transports sodium ions out of the cell and potassium ions in, while leaky potassium channels allow some potassium to leak out, creating the negative charge inside.

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    Depolarization

    A reduction in the membrane potential, making it more positive, due to an influx of positive ions (usually Na+).

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    Hyperpolarization

    An increase in the membrane potential, making it more negative, due to an efflux of positive ions (usually K+) or influx of negative ions.

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    Graded Potential

    A localized, temporary change in membrane potential, can be depolarizing or hyperpolarizing. The magnitude varies with the strength of the stimulus.

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    Action Potential

    A rapid, short-lasting, all-or-none electrical signal that travels along the axon of a neuron. Propagated by the opening and closing of voltage-gated Na+ and K+ channels.

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    Threshold Potential

    The minimum membrane potential change required to trigger an action potential, typically around -55mV.

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    How is an action potential generated?

    A graded potential that reaches the threshold potential triggers the opening of voltage-gated Na+ channels, allowing Na+ influx and rapid depolarization. This positive feedback further opens more Na+ channels, creating a self-propagating wave of depolarization.

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    Repolarization

    The return of the membrane potential to its resting state after an action potential, due to the closing of Na+ channels and the opening of K+ channels.

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    Refractory Period

    The time period after an action potential when a new action potential cannot be generated. Divided into absolute refractory and relative refractory periods.

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    Contiguous Conduction

    The spread of action potential along the axon of a non-myelinated neuron, involving the sequential activation of adjacent membrane patches.

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    Saltatory Conduction

    The rapid propagation of action potential along myelinated axons, where the signal jumps from one node of Ranvier to the next. Faster than contiguous conduction.

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    Tetrodotoxin (TTX)

    A potent neurotoxin that blocks voltage-gated Na+ channels, preventing action potential generation. Found in pufferfish and other animals.

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    How does myelination increase conduction speed?

    Myelin acts as an insulator, preventing the leakage of current and concentrating ion channels at the nodes of Ranvier. This allows for faster saltatory conduction, where the signal jumps between nodes.

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    Nodes of Ranvier

    Gaps in the myelin sheath along an axon, where action potentials are generated.

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    Action Potential (AP)

    A rapid electrical signal that travels along an axon, transmitting information in the nervous system.

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    Graded potential (GP)

    A change in membrane potential that can vary in size and duration, depending on the strength of the stimulus.

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    Multiple sclerosis (MS)

    An autoimmune condition where the body's immune system attacks the myelin sheath of axons, affecting nerve impulse transmission.

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    Axon

    The long, slender projection of a neuron that conducts nerve impulses away from the cell body.

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    Dendrite

    Branched projections of a neuron that receive signals from other neurons.

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    Synapse

    The junction between two neurons, where nerve impulses are transmitted from one neuron to another.

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    Neurotransmitter

    A chemical messenger released by a neuron that transmits signals across a synapse.

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    Synaptic transmission

    The process of transmitting a signal from one neuron to another across a synapse.

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    Temporal Summation

    Multiple EPSPs from a single presynaptic neuron firing in rapid succession. This leads to an increased likelihood of the postsynaptic neuron firing.

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    Spatial Summation

    Multiple EPSPs arriving simultaneously from different presynaptic neurons. This allows the postsynaptic neuron to reach threshold and fire.

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    IPSP - EPSP Cancellation

    Inhibitory postsynaptic potentials (IPSPs) can counteract excitatory postsynaptic potentials (EPSPs) resulting in a decrease in the likelihood of the postsynaptic neuron firing

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    Divergent Pathway

    A single presynaptic neuron branches out to affect many postsynaptic neurons, spreading information widely.

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    Convergent Pathway

    Many presynaptic neurons converge onto a single postsynaptic neuron, integrating several inputs.

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    Frequency of Action Potential

    The frequency of action potentials determines the strength of stimulus. A higher frequency of action potentials indicates a stronger stimulus.

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    Consolidation

    The process of transferring a short-term memory into a long-term memory.

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    Long-Term Potentiation (LTP)

    Repetitive stimulation of a synapse strengthens that synaptic connection over time. This is a major mechanism for learning and memory.

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    Study Notes

    Human Physiology BIOL3205 - Nervous System I - Structure

    •  The nervous system comprises three components: central, peripheral, and enteric.
    •  The central nervous system (CNS) consists of the brain and spinal cord.
    •  The peripheral nervous system (PNS) encompasses both afferent and efferent divisions.
    •  The somatic nervous system controls voluntary actions.
    •  The autonomic nervous system regulates involuntary actions, which are further divided into sympathetic and parasympathetic systems.
    •  The enteric nervous system manages digestion and is part of the autonomic system.

    Nervous System Structure I - Cells

    • Glial cells account for 90% of brain volume, supporting neurons structurally and metabolically.
    • Astrocytes, star-shaped cells, maintain the spatial relationships within the CNS.
    • Astrocytes create the blood-brain barrier (BBB), transferring nutrients from the blood to neurons and clearing toxic byproducts.
    • Oligodendrocytes produce the myelin sheath, crucial for nerve impulse transmission.
    • Microglia are inactive cells that remove foreign invaders or tissue debris, playing roles in neurodegenerative diseases.
    • Ependymal cells form the lining of the ventricles and create cerebrospinal fluid (CSF).

    Nervous System Structure I - Gray and White Matter

    • Grey matter contains densely packed cell bodies (non-myelinated).
    • White matter comprises myelinated axons.
    • The brain's superior region contains grey matter, while the interior has white matter.
    • The spinal cord has superior white matter and interior grey matter.
    • Impulse transmission speed varies based on myelination.

    Nervous System Structure I - Protection

    • The CNS is protected by the cranium (skull) and vertebral column.
    • Protective membranes called meninges (dura mater, arachnoid mater, pia mater) surround the brain and spinal cord.
    • Cerebrospinal fluid (CSF) cushions the CNS and maintains a consistent environment.
    • The blood-brain barrier (BBB) selectively regulates the substances entering the brain.

    Nervous System Structure I - Brain

    • The brain begins as a hollow tube during embryonic development, retaining this structure throughout formation.
    • The brain contains four interconnected ventricles (two lateral ventricles, third ventricle, and fourth ventricle).
    • The fourth ventricle extends into the spinal cord as a central canal, containing cerebrospinal fluid.

    Nervous System Structure I - Cerebral Spinal Fluid (CSF)

    • CSF volume is approximately 150 ml.
    • CSF has a similar density to the brain, enabling it to float or suspend brain tissues.
    • CSF is manufactured by choroid plexuses, specialized structures in the brain's ventricles.
    • CSF flows through the ventricles and into the spinal cord's central canal.
    • CSF is reabsorbed into the subarachnoid space.
    • CSF safeguards the brain from impact damage.

    Nervous System Structure I - Brain Injury

    •  Coup injuries occur when the brain strikes the skull on the same side of impact.
    •  Contrecoup injuries occur when the brain strikes the opposite side of the skull from impact.
    •  Shaken baby syndrome can cause neurological damage.

    Nervous System Structure I - Cerebral Spinal Fluid Composition

    • Cerebrospinal fluid (CSF) contains substances like Na+, K+, Ca2+, Cl-, HCO3−, PCO2, differing from blood composition.
    •  Lower K+ levels exist in CSF in comparison to blood.
    • CSF contains smaller amounts of protein.
    • CSF facilitates ion transport, crucial for neural impulses.

    Nervous System Structure I - Brain Organization

    • Brainstem is responsible for vegetative functions.
    • Cerebellum manages subconscious coordination of motor activity.
    • Forebrain components include the diencephalon (hypothalamus for homeostasis, thalamus for sensory processing) and the cerebrum (basal nuclei for coordinating movement and cerebral cortex for decision-making).

    Nervous System Structure I - Functional Areas of the Cortex

    • Divided into distinctive areas like frontal lobe, parietal lobe, occipital lobe, and temporal lobe.
    • Subdivided further by specific functions, such as primary motor cortex, somatosensory cortex.

    Nervous System Structure I - Homunculus

    • Depicts the location and relative amount of cortical area dedicated to sensory input and motor output.
    • Distribution within the brain is uneven.
    • Sensitivity and movement precision are unevenly distributed.
    • The homunculus varies among individuals, adaptable (plasticity).

    Nervous System Structure I - Neuron vs. Nerve

    • Nerves are bundles of peripheral neuronal axons encased by connective tissue.
    • Nerves have a similar pathway.
    • Nerves do not contain complete neurons.
    • Fibers within a nerve don't influence each other.
    • Nerves in the CNS are called tracts, lacking the same structure as peripheral nerves.

    Nervous System Structure I - Renewal of Neurons

    • Most neurons are generated during embryonic development and remain throughout life.
    • Ependymal cells are neural stem cells.
    • New neurons are produced in the hippocampus.
    • Neurogenesis occurs in the hippocampus, new neurons actively formed, die and are replaced, part of the neurogenesis process.

    Nervous System Structure I - Lecture Summary

    • The aim of the lecture series is to elucidate the structure and functions of the central and peripheral nervous systems, encompassing the cellular mechanisms, protective mechanisms (like the blood-brain barrier), and functions of brain regions.  This includes neuron vs. nerve, regeneration, and methods for identifying active brain regions in terms of correlation and fMRI or MRI.

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    Human Physiology BIOL3205 PDF

    Description

    Test your knowledge on the differences between functional magnetic resonance imaging (fMRI) and traditional MRI, as well as the roles of various structures in the spinal cord. This quiz covers key concepts related to neural communication and the anatomy of the nervous system. Challenge yourself and enhance your understanding of neuroscience!

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