Neuroscience Chapter on Synapses and Receptors
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Questions and Answers

What is the primary function of the nicotinic acetylcholine receptors in the brain?

  • Enhance the release of serotonin
  • Block the reuptake of dopamine
  • Increase the release of dopamine (correct)
  • Inhibit the release of dopamine
  • What is the mechanism of action of curare?

  • It stimulates the release of acetylcholine
  • It increases the sensitivity of the acetylcholine receptor
  • It blocks the reuptake of acetylcholine
  • It binds to and blocks the acetylcholine receptor (correct)
  • Which of these drugs acts by blocking the reuptake of a neurotransmitter?

  • Nicotine
  • Morphine
  • Curare
  • Cocaine (correct)
  • How does the action of nerve gas (sarin) differ from that of cocaine?

    <p>Sarin inhibits the release of neurotransmitters, while cocaine blocks their reuptake. (B)</p> Signup and view all the answers

    What is the underlying cause of myasthenia gravis?

    <p>Auto-antibodies bind to and block acetylcholine receptors on muscle fibers. (C)</p> Signup and view all the answers

    Which of the following correctly describes the effect of the auto-antibodies in Graves disease?

    <p>They stimulate the production and release of thyroid hormone. (D)</p> Signup and view all the answers

    The text focuses on the role of synapses in various processes. How does the potential of a synaptic event compare to that of a muscle fiber?

    <p>Synaptic potentials are generally weaker than those of muscle fibers. (A)</p> Signup and view all the answers

    Why is it important that the postsynaptic neuron integrates signals from all of its inputs?

    <p>To filter out irrelevant signals and ensure a specific response. (D)</p> Signup and view all the answers

    What is the term used to describe the spread of information from one neuron to several neurons?

    <p>Divergence (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of divergence in neural circuits?

    <p>Involves the integration of multiple inputs onto a single neuron (C)</p> Signup and view all the answers

    What is the term for the process where several neurons synapse on the same postsynaptic neuron?

    <p>Convergence (A)</p> Signup and view all the answers

    What is an example of convergence in the nervous system?

    <p>The control of the diaphragm by both conscious and subconscious processes (B)</p> Signup and view all the answers

    Which of the following is a characteristic of serial processing?

    <p>Information is relayed from one neuron to another in a stepwise fashion (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of parallel processing?

    <p>Involves the integration of multiple inputs onto a single neuron (C)</p> Signup and view all the answers

    How does parallel processing enable multiple responses to occur simultaneously?

    <p>By distributing information to different neuronal pools that process it simultaneously (B)</p> Signup and view all the answers

    Which of the following is an example of parallel processing?

    <p>The response to stepping on a sharp object, involving multiple sensory and motor pathways (C)</p> Signup and view all the answers

    What is the primary function of the Golgi Tendon Organ (GTO)?

    <p>To detect changes in muscle tension and initiate muscle relaxation (D)</p> Signup and view all the answers

    Which type of mechanoreceptor is responsible for detecting high-frequency vibrations?

    <p>Pacinian corpuscles (B)</p> Signup and view all the answers

    Which of the following receptors is NOT a tactile receptor?

    <p>Free nerve endings in joint capsules (A)</p> Signup and view all the answers

    Which receptor type is responsible for detecting continuous touch and pressure?

    <p>Ruffini corpuscles (B)</p> Signup and view all the answers

    What is the role of the lateral corticospinal tract?

    <p>Control muscles in the limbs for precise and skilled movements. (A)</p> Signup and view all the answers

    Which of the following is a characteristic of rapidly adapting receptors?

    <p>They respond only to the onset of a stimulus and quickly adapt, ceasing to fire. (B)</p> Signup and view all the answers

    Which of the following statements about kinesthetic receptors is TRUE?

    <p>They are involved in providing information about body position and movement. (B)</p> Signup and view all the answers

    Which statement is TRUE about the corticospinal tracts?

    <p>They control voluntary movements by directly stimulating skeletal muscle fibers. (C)</p> Signup and view all the answers

    Which of these is NOT a characteristic of the direct motor pathways?

    <p>They are involved in regulating reflexes and involuntary muscle contractions. (B)</p> Signup and view all the answers

    Which of the following is a characteristic of the Ruffini corpuscles?

    <p>They are sensitive to skin stretching and pressure. (D)</p> Signup and view all the answers

    Which type of receptor is responsible for detecting movements on the skin surface that disturb hairs?

    <p>Hair root plexuses (C)</p> Signup and view all the answers

    What percentage of upper motor neuron fibers decussate in the medulla to form the lateral corticospinal tract?

    <p>90% (D)</p> Signup and view all the answers

    Which of these is a primary function of the anterior corticospinal tract?

    <p>Control muscles involved in posture and balance. (A)</p> Signup and view all the answers

    Which of the following is NOT a type of somatic sensory modality?

    <p>Taste sensations (B)</p> Signup and view all the answers

    What is the primary function of receptors in sensation?

    <p>To convert stimuli into electrical signals (B)</p> Signup and view all the answers

    Which of these examples best illustrates the concept of perception?

    <p>Recognizing the melody of a familiar song (C)</p> Signup and view all the answers

    What distinguishes one sensory modality from another?

    <p>The type of receptor that detects the stimulus (B)</p> Signup and view all the answers

    Which of the following is an example of a visceral sensation?

    <p>Experiencing a feeling of fullness in your stomach (C)</p> Signup and view all the answers

    What is the primary difference between sensation and perception?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of these types of stimuli can be detected by our senses?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the main function of proprioception?

    <p>To maintain balance and coordination (B)</p> Signup and view all the answers

    Which type of receptor provides information about body position and movement?

    <p>Proprioceptors (C)</p> Signup and view all the answers

    What type of receptor detects changes in temperature?

    <p>Thermoreceptors (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of interoceptors?

    <p>Convey visual, smell, taste, touch, pressure, vibration, thermal, and pain sensations (C)</p> Signup and view all the answers

    What type of receptor is responsible for detecting chemicals in the mouth and nose?

    <p>Chemoreceptors (A)</p> Signup and view all the answers

    Which of the following is an example of a tonic receptor?

    <p>Nociceptors (A)</p> Signup and view all the answers

    Adaptation is the tendency for the generator or receptor potential to decrease in amplitude during a maintained constant stimulus. Which of these is NOT a consequence of adaptation?

    <p>Increased responsiveness of a receptor (B)</p> Signup and view all the answers

    What type of receptor adapts rapidly to a stimulus, leading to a quick and short-lived response?

    <p>Phasic receptor (A)</p> Signup and view all the answers

    Which of the following statements is TRUE about adaptation?

    <p>Adaptation is a mechanism that helps our sensory systems focus on changes in the environment. (B)</p> Signup and view all the answers

    Flashcards

    Types of transmitters

    Neurotransmitters can be inhibitory or excitatory and vary in type.

    Synaptic potential

    The change in voltage in a neuron due to synaptic transmission, often smaller than muscle action potentials.

    Integration in neurons

    Post-synaptic neurons combine multiple inputs to determine output action potentials.

    Nicotine effects

    Nicotine activates nicotinic acetylcholine receptors, releasing dopamine, leading to euphoria.

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    Curare function

    Curare blocks acetylcholine receptors, paralyzing muscle function.

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    Cocaine mechanism

    Cocaine inhibits dopamine reuptake, prolonging its action in the synaptic cleft.

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    Myasthenia gravis

    An autoimmune disease where antibodies block acetylcholine receptors, causing muscle fatigue.

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    Graves disease

    An autoimmune disorder where antibodies stimulate thyroid receptors, increasing hormone production.

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    Neural Circuit

    A 'wiring diagram' of neuronal interactions that reveals functional characteristics.

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    Divergence

    The spread of information from one neuron to several neurons or pools.

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    Convergence

    Several neurons synapse onto the same postsynaptic neuron, combining multiple signals.

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    Serial Processing

    Information relayed in a stepwise fashion from one neuron to another or from pools.

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    Parallel Processing

    When several neurons or pools process the same information simultaneously.

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    Postsynaptic Neuron

    The neuron that receives signals from presynaptic neurons in convergence.

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    Sensory Neurons

    Neurons responsible for bringing information into the CNS from sensory inputs.

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    Neuronal Pools

    Groups of interconnected neurons that process specific information or responses.

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    Sensation

    Any stimulus the body is aware of, detected by receptors.

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    Perception

    The conscious awareness and interpretation of a sensation.

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    Sensory Modality

    The property by which one sensation is distinguished from another.

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    General Senses

    Includes somatic and visceral senses providing info about body and organs.

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    Somatic Sensations

    Include tactile, thermal, pain, and proprioceptive sensations.

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    Proprioceptive Sensations

    Sensations regarding the position and movement of limbs and body parts.

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    Receptors

    Specialized cells that detect specific types of sensory stimuli.

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    Unawareness of Stimuli

    Stimuli like X-rays that we cannot sense or perceive.

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    Exteroceptors

    Sensory receptors located at or near the body surface, sensitive to external stimuli.

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    Interoceptors

    Receptors located in blood vessels and organs that monitor internal stimuli.

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    Proprioceptors

    Receptors in muscles and joints providing information about body position and movement.

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    Mechanoreceptors

    Receptors that detect mechanical stimuli like touch, pressure, and vibration.

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    Nociceptors

    Receptors that respond to painful stimuli from tissue damage.

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    Tonic receptors

    Receptors that adapt slowly and maintain action potentials during a stimulus.

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    Phasic receptors

    Receptors that adapt rapidly and diminish their response quickly.

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    Adaptation in receptors

    The process where receptors decrease in sensitivity to a constant stimulus over time.

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    Golgi Tendon Organ

    A sensory receptor located at the junction of tendon and muscle, detecting tension.

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    Function of GTO

    Generates nerve impulses when muscle tension increases, signaling the CNS.

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    Kinesthetic Receptors

    Sensory receptors located in joints, providing awareness of body position and movement.

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    Meissner Corpuscles

    Tactile receptors responding to light touch and low-frequency vibrations.

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    Hair Root Plexuses

    Free nerve endings around hair follicles detecting movement on the skin.

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    Ruffini Corpuscles

    Cutaneous mechanoreceptors responding to skin stretching and sustained pressure.

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    Pacinian Corpuscles

    Mechanoreceptors that respond to high-frequency vibrations.

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    Itch and Tickle Receptors

    Free nerve endings in the skin responsible for itching and tickling sensations.

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    Direct Motor Pathways

    Also known as pyramidal pathways, involved in voluntary movement transmission.

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    Upper Motor Neurons (UMN)

    Neurons in the cerebral cortex that initiate voluntary movements.

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    Decussation

    The crossing over of nerve fibers, important for brain control of opposite body sides.

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    Lateral Corticospinal Tract

    Pathway for 90% of UMN fibers that decussate, controlling skilled limb movements.

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    Corticobulbar Tracts

    Pathways connecting UMNs to cranial nerve nuclei for facial and neck muscle control.

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    Study Notes

    Synapse

    • The point of connection between a nerve cell and another cell.
    • A specialized junction where a neuron communicates with a target cell.
    • Target cells include nerves, muscles, and glands.

    Electrical Synapses

    • Relatively rare in vertebrates.
    • Membranes of the two cells are in close contact.
    • Enables a rapid and reliable transmission of nerve impulses.

    Chemical Synapses

    • More complex than electrical synapses.
    • Presynaptic and postsynaptic cells are separated by a synaptic cleft.
    • Transmission is accomplished by neurotransmitters released from synaptic vesicles.

    Neurotransmitter Release

    • The presynaptic nerve terminal contains vesicles filled with neurotransmitter molecules.
    • When an action potential arrives, voltage-gated calcium channels open.
    • Calcium influx triggers the release of neurotransmitters into the synaptic cleft.
    • Diffuse across the cleft and bind to receptors on the postsynaptic membrane.

    Neurotransmitter Receptor Interactions

    • Neurotransmitter molecules have specific shapes that fit the shapes of their receptors.
    • Binding of the neurotransmitter changes the receptor's shape, opening ion channels.
    • Excitatory neurotransmitters cause depolarization of the postsynaptic membrane (e.g., sodium influx).
    • Inhibitory neurotransmitters cause hyperpolarization (e.g., chloride influx).

    Excitatory Postsynaptic Potential (EPSP)

    • A local depolarization of the postsynaptic membrane.
    • The amplitude is determined by the number of vesicles released.
    • If sufficiently large, it initiates an action potential in the postsynaptic cell.

    Inhibitory Postsynaptic Potential (IPSP)

    • A local hyperpolarization of the postsynaptic membrane.
    • Makes the postsynaptic membrane more negative.
    • Decreases the likelihood of an action potential.

    Details of a Synapse

    • Synaptic vesicles, full of neurotransmitters, are positioned at the presynaptic terminal.

    Action of neurotransmitters

    • Neurotransmitters activate receptors, causing changes in the postsynaptic cell.
    • Some neurotransmitters activate ion channels directly.
    • Other neurotransmitters activate second messengers inside the postsynaptic cell.

    Types of Neurotransmitters

    • Acetylcholine: crucial at neuromuscular junctions and some synapses between neurons.
    • Glutamate: the main excitatory neurotransmitter in the central nervous system (CNS).
    • GABA: the main inhibitory neurotransmitter in the CNS.

    Synaptic Transmission (steps)

    • Step 1: Action potential arrives at the axon terminal.
    • Step 2: Calcium channels open, triggering neurotransmitter release.
    • Step 3: Neurotransmitters bind to receptors on the postsynaptic membrane.
    • Step 4: Neurotransmitters diffuse away from the receptors and are removed from the synaptic cleft.

    Neurotransmitter Action

    • Neurotransmitters are synthesized from precursors.
    • They are stored inside vesicles.
    • They are released when they are triggered.
    • They are inactivated by degradation or reuptake.

    Classification of neurotransmitter

    • By chemical structure.
    • By function (excitatory or inhibitory).
    • Acetylcholine
    • Amino acids
    • Monoamines
    • Neuropeptides

    Neural Circuits

    • Neurons and circuit organization, including convergence and divergence.

    Types of Neural Circuits

    • Divergence (one neuron to many).
    • Convergence (many neurons to one).
    • Serial processing (step-by-step).
    • Parallel processing (multiple pathways simultaneously).
    • Reverberating (feedback loops).

    Sensory Functions

    • Levels of sensation and pathways, from body-to-brain, brain-to-body.
    • Integration of sensation as a process involved in wakefulness & sleep.
    • Sensory integration involves receiving, sorting, interpreting, and storing sensory information.

    Sensory Receptors

    • Structures and types of sensory receptors, including free nerve endings and encapsulated nerve endings.
    • Types of stimulus they detect;
    • Type of response to a stimulus;
    • Location of receptors & origin of stimuli;

    Tactile Receptors

    • Touch—crude touch & discrimination.
    • Types of rapidly adapting touch receptors, including Meissner corpuscles and hair root plexuses.
    • Two types of slowly adapting touch receptors, including Type I cutaneous mechanoreceptors (Merkel discs) & Type II cutaneous mechanoreceptors (Ruffini corpuscles).
    • Pressure.
    • Vibration.

    Pain

    • Fast pain (acute) vs. slow pain (chronic).
    • Sensory adaptation to pain.
    • Causes of pain including, initial stimulus & referred pain.
    • The modulation of pain involves the CNS as well as the PNS.

    Sensation (as a process)

    • The mechanisms for stimulus transduction into action potentials.

    Sensory Modalities

    • How one sensation can be distinguished from another. This reflects the types of stimuli detected by sensory receptors.

    Proprioception

    • Information about body position & movement.
    • The importance of proprioceptors in maintaining posture, balance, & coordination.
    • Types of proprioceptors, including muscle spindles & tendon organs.
    • How proprioceptors detect changes in muscle length/tension.
    • The adaptive nature of proprioceptive receptors & the importance of the brain's role in sensory integration.

    Other Receptors

    • The various types of sensory receptors that detect a variety of stimuli.

    Receptor Potentials

    • The way that stimuli are changed into electrical signals.

    Sensory Pathways

    • Somatic Sensory—The pathways for sensory information.
    • The processes/pathways that involve first-, second-, and third-order neurons.
    • Trigeminothalamic pathways.

    Memory

    • A process in which knowledge or skills acquired through instruction or experience are retained over time.
    • Stages of memory.
    • Types of memory (immediate, short-term, and long-term).
    • Amnesia

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