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Questions and Answers
What is the primary function of the nicotinic acetylcholine receptors in the brain?
What is the primary function of the nicotinic acetylcholine receptors in the brain?
What is the mechanism of action of curare?
What is the mechanism of action of curare?
Which of these drugs acts by blocking the reuptake of a neurotransmitter?
Which of these drugs acts by blocking the reuptake of a neurotransmitter?
How does the action of nerve gas (sarin) differ from that of cocaine?
How does the action of nerve gas (sarin) differ from that of cocaine?
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What is the underlying cause of myasthenia gravis?
What is the underlying cause of myasthenia gravis?
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Which of the following correctly describes the effect of the auto-antibodies in Graves disease?
Which of the following correctly describes the effect of the auto-antibodies in Graves disease?
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The text focuses on the role of synapses in various processes. How does the potential of a synaptic event compare to that of a muscle fiber?
The text focuses on the role of synapses in various processes. How does the potential of a synaptic event compare to that of a muscle fiber?
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Why is it important that the postsynaptic neuron integrates signals from all of its inputs?
Why is it important that the postsynaptic neuron integrates signals from all of its inputs?
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What is the term used to describe the spread of information from one neuron to several neurons?
What is the term used to describe the spread of information from one neuron to several neurons?
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Which of the following is NOT a characteristic of divergence in neural circuits?
Which of the following is NOT a characteristic of divergence in neural circuits?
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What is the term for the process where several neurons synapse on the same postsynaptic neuron?
What is the term for the process where several neurons synapse on the same postsynaptic neuron?
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What is an example of convergence in the nervous system?
What is an example of convergence in the nervous system?
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Which of the following is a characteristic of serial processing?
Which of the following is a characteristic of serial processing?
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Which of the following is NOT a characteristic of parallel processing?
Which of the following is NOT a characteristic of parallel processing?
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How does parallel processing enable multiple responses to occur simultaneously?
How does parallel processing enable multiple responses to occur simultaneously?
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Which of the following is an example of parallel processing?
Which of the following is an example of parallel processing?
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What is the primary function of the Golgi Tendon Organ (GTO)?
What is the primary function of the Golgi Tendon Organ (GTO)?
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Which type of mechanoreceptor is responsible for detecting high-frequency vibrations?
Which type of mechanoreceptor is responsible for detecting high-frequency vibrations?
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Which of the following receptors is NOT a tactile receptor?
Which of the following receptors is NOT a tactile receptor?
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Which receptor type is responsible for detecting continuous touch and pressure?
Which receptor type is responsible for detecting continuous touch and pressure?
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What is the role of the lateral corticospinal tract?
What is the role of the lateral corticospinal tract?
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Which of the following is a characteristic of rapidly adapting receptors?
Which of the following is a characteristic of rapidly adapting receptors?
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Which of the following statements about kinesthetic receptors is TRUE?
Which of the following statements about kinesthetic receptors is TRUE?
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Which statement is TRUE about the corticospinal tracts?
Which statement is TRUE about the corticospinal tracts?
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Which of these is NOT a characteristic of the direct motor pathways?
Which of these is NOT a characteristic of the direct motor pathways?
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Which of the following is a characteristic of the Ruffini corpuscles?
Which of the following is a characteristic of the Ruffini corpuscles?
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Which type of receptor is responsible for detecting movements on the skin surface that disturb hairs?
Which type of receptor is responsible for detecting movements on the skin surface that disturb hairs?
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What percentage of upper motor neuron fibers decussate in the medulla to form the lateral corticospinal tract?
What percentage of upper motor neuron fibers decussate in the medulla to form the lateral corticospinal tract?
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Which of these is a primary function of the anterior corticospinal tract?
Which of these is a primary function of the anterior corticospinal tract?
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Which of the following is NOT a type of somatic sensory modality?
Which of the following is NOT a type of somatic sensory modality?
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What is the primary function of receptors in sensation?
What is the primary function of receptors in sensation?
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Which of these examples best illustrates the concept of perception?
Which of these examples best illustrates the concept of perception?
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What distinguishes one sensory modality from another?
What distinguishes one sensory modality from another?
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Which of the following is an example of a visceral sensation?
Which of the following is an example of a visceral sensation?
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What is the primary difference between sensation and perception?
What is the primary difference between sensation and perception?
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Which of these types of stimuli can be detected by our senses?
Which of these types of stimuli can be detected by our senses?
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What is the main function of proprioception?
What is the main function of proprioception?
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Which type of receptor provides information about body position and movement?
Which type of receptor provides information about body position and movement?
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What type of receptor detects changes in temperature?
What type of receptor detects changes in temperature?
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Which of the following is NOT a characteristic of interoceptors?
Which of the following is NOT a characteristic of interoceptors?
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What type of receptor is responsible for detecting chemicals in the mouth and nose?
What type of receptor is responsible for detecting chemicals in the mouth and nose?
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Which of the following is an example of a tonic receptor?
Which of the following is an example of a tonic receptor?
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Adaptation is the tendency for the generator or receptor potential to decrease in amplitude during a maintained constant stimulus. Which of these is NOT a consequence of adaptation?
Adaptation is the tendency for the generator or receptor potential to decrease in amplitude during a maintained constant stimulus. Which of these is NOT a consequence of adaptation?
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What type of receptor adapts rapidly to a stimulus, leading to a quick and short-lived response?
What type of receptor adapts rapidly to a stimulus, leading to a quick and short-lived response?
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Which of the following statements is TRUE about adaptation?
Which of the following statements is TRUE about adaptation?
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Flashcards
Types of transmitters
Types of transmitters
Neurotransmitters can be inhibitory or excitatory and vary in type.
Synaptic potential
Synaptic potential
The change in voltage in a neuron due to synaptic transmission, often smaller than muscle action potentials.
Integration in neurons
Integration in neurons
Post-synaptic neurons combine multiple inputs to determine output action potentials.
Nicotine effects
Nicotine effects
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Curare function
Curare function
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Cocaine mechanism
Cocaine mechanism
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Myasthenia gravis
Myasthenia gravis
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Graves disease
Graves disease
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Neural Circuit
Neural Circuit
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Divergence
Divergence
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Convergence
Convergence
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Serial Processing
Serial Processing
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Parallel Processing
Parallel Processing
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Postsynaptic Neuron
Postsynaptic Neuron
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Sensory Neurons
Sensory Neurons
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Neuronal Pools
Neuronal Pools
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Sensation
Sensation
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Perception
Perception
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Sensory Modality
Sensory Modality
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General Senses
General Senses
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Somatic Sensations
Somatic Sensations
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Proprioceptive Sensations
Proprioceptive Sensations
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Receptors
Receptors
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Unawareness of Stimuli
Unawareness of Stimuli
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Exteroceptors
Exteroceptors
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Interoceptors
Interoceptors
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Proprioceptors
Proprioceptors
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Mechanoreceptors
Mechanoreceptors
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Nociceptors
Nociceptors
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Tonic receptors
Tonic receptors
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Phasic receptors
Phasic receptors
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Adaptation in receptors
Adaptation in receptors
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Golgi Tendon Organ
Golgi Tendon Organ
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Function of GTO
Function of GTO
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Kinesthetic Receptors
Kinesthetic Receptors
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Meissner Corpuscles
Meissner Corpuscles
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Hair Root Plexuses
Hair Root Plexuses
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Ruffini Corpuscles
Ruffini Corpuscles
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Pacinian Corpuscles
Pacinian Corpuscles
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Itch and Tickle Receptors
Itch and Tickle Receptors
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Direct Motor Pathways
Direct Motor Pathways
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Upper Motor Neurons (UMN)
Upper Motor Neurons (UMN)
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Decussation
Decussation
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Lateral Corticospinal Tract
Lateral Corticospinal Tract
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Corticobulbar Tracts
Corticobulbar Tracts
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Study Notes
Synapse
- The point of connection between a nerve cell and another cell.
- A specialized junction where a neuron communicates with a target cell.
- Target cells include nerves, muscles, and glands.
Electrical Synapses
- Relatively rare in vertebrates.
- Membranes of the two cells are in close contact.
- Enables a rapid and reliable transmission of nerve impulses.
Chemical Synapses
- More complex than electrical synapses.
- Presynaptic and postsynaptic cells are separated by a synaptic cleft.
- Transmission is accomplished by neurotransmitters released from synaptic vesicles.
Neurotransmitter Release
- The presynaptic nerve terminal contains vesicles filled with neurotransmitter molecules.
- When an action potential arrives, voltage-gated calcium channels open.
- Calcium influx triggers the release of neurotransmitters into the synaptic cleft.
- Diffuse across the cleft and bind to receptors on the postsynaptic membrane.
Neurotransmitter Receptor Interactions
- Neurotransmitter molecules have specific shapes that fit the shapes of their receptors.
- Binding of the neurotransmitter changes the receptor's shape, opening ion channels.
- Excitatory neurotransmitters cause depolarization of the postsynaptic membrane (e.g., sodium influx).
- Inhibitory neurotransmitters cause hyperpolarization (e.g., chloride influx).
Excitatory Postsynaptic Potential (EPSP)
- A local depolarization of the postsynaptic membrane.
- The amplitude is determined by the number of vesicles released.
- If sufficiently large, it initiates an action potential in the postsynaptic cell.
Inhibitory Postsynaptic Potential (IPSP)
- A local hyperpolarization of the postsynaptic membrane.
- Makes the postsynaptic membrane more negative.
- Decreases the likelihood of an action potential.
Details of a Synapse
- Synaptic vesicles, full of neurotransmitters, are positioned at the presynaptic terminal.
Action of neurotransmitters
- Neurotransmitters activate receptors, causing changes in the postsynaptic cell.
- Some neurotransmitters activate ion channels directly.
- Other neurotransmitters activate second messengers inside the postsynaptic cell.
Types of Neurotransmitters
- Acetylcholine: crucial at neuromuscular junctions and some synapses between neurons.
- Glutamate: the main excitatory neurotransmitter in the central nervous system (CNS).
- GABA: the main inhibitory neurotransmitter in the CNS.
Synaptic Transmission (steps)
- Step 1: Action potential arrives at the axon terminal.
- Step 2: Calcium channels open, triggering neurotransmitter release.
- Step 3: Neurotransmitters bind to receptors on the postsynaptic membrane.
- Step 4: Neurotransmitters diffuse away from the receptors and are removed from the synaptic cleft.
Neurotransmitter Action
- Neurotransmitters are synthesized from precursors.
- They are stored inside vesicles.
- They are released when they are triggered.
- They are inactivated by degradation or reuptake.
Classification of neurotransmitter
- By chemical structure.
- By function (excitatory or inhibitory).
- Acetylcholine
- Amino acids
- Monoamines
- Neuropeptides
Neural Circuits
- Neurons and circuit organization, including convergence and divergence.
Types of Neural Circuits
- Divergence (one neuron to many).
- Convergence (many neurons to one).
- Serial processing (step-by-step).
- Parallel processing (multiple pathways simultaneously).
- Reverberating (feedback loops).
Sensory Functions
- Levels of sensation and pathways, from body-to-brain, brain-to-body.
- Integration of sensation as a process involved in wakefulness & sleep.
- Sensory integration involves receiving, sorting, interpreting, and storing sensory information.
Sensory Receptors
- Structures and types of sensory receptors, including free nerve endings and encapsulated nerve endings.
- Types of stimulus they detect;
- Type of response to a stimulus;
- Location of receptors & origin of stimuli;
Tactile Receptors
- Touch—crude touch & discrimination.
- Types of rapidly adapting touch receptors, including Meissner corpuscles and hair root plexuses.
- Two types of slowly adapting touch receptors, including Type I cutaneous mechanoreceptors (Merkel discs) & Type II cutaneous mechanoreceptors (Ruffini corpuscles).
- Pressure.
- Vibration.
Pain
- Fast pain (acute) vs. slow pain (chronic).
- Sensory adaptation to pain.
- Causes of pain including, initial stimulus & referred pain.
- The modulation of pain involves the CNS as well as the PNS.
Sensation (as a process)
- The mechanisms for stimulus transduction into action potentials.
Sensory Modalities
- How one sensation can be distinguished from another. This reflects the types of stimuli detected by sensory receptors.
Proprioception
- Information about body position & movement.
- The importance of proprioceptors in maintaining posture, balance, & coordination.
- Types of proprioceptors, including muscle spindles & tendon organs.
- How proprioceptors detect changes in muscle length/tension.
- The adaptive nature of proprioceptive receptors & the importance of the brain's role in sensory integration.
Other Receptors
- The various types of sensory receptors that detect a variety of stimuli.
Receptor Potentials
- The way that stimuli are changed into electrical signals.
Sensory Pathways
- Somatic Sensory—The pathways for sensory information.
- The processes/pathways that involve first-, second-, and third-order neurons.
- Trigeminothalamic pathways.
Memory
- A process in which knowledge or skills acquired through instruction or experience are retained over time.
- Stages of memory.
- Types of memory (immediate, short-term, and long-term).
- Amnesia
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Description
Test your knowledge on synaptic functions and the role of various neurotransmitters in the brain. This quiz covers important concepts such as the mechanisms of drugs, the actions of receptors, and the effects of diseases like myasthenia gravis and Graves' disease. Evaluate your understanding of how neural circuits operate and their significance in brain function.