Neuroscience Chapter on Action Potentials and Synapses

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Questions and Answers

What is the primary function of the refractory period in the context of action potential propagation?

  • To regulate the frequency of action potential generation by controlling the opening and closing of voltage-gated ion channels.
  • To maintain a continuous flow of action potentials along the axon.
  • To ensure rapid propagation of the action potential down the axon.
  • To prevent the action potential from reversing direction and traveling back up the axon. (correct)

Which of the following statements accurately describes the role of neurotransmitters in synaptic transmission?

  • Neurotransmitters are released by the presynaptic neuron and bind to receptors on the postsynaptic neuron, leading to changes in membrane potential. (correct)
  • Neurotransmitters are synthesized and stored within the postsynaptic neuron and released upon arrival of an action potential at the synapse.
  • Neurotransmitters are released by the postsynaptic neuron and bind to receptors on the presynaptic neuron, initiating an action potential.
  • Neurotransmitters are primarily involved in the generation of action potentials within the presynaptic neuron, ensuring rapid transmission of nerve impulses.

What is the primary difference between chemically regulated ion channels and voltage-regulated ion channels in the context of synaptic transmission?

  • Chemically regulated channels are involved in the release of neurotransmitters, while voltage-regulated channels are involved in the reuptake of neurotransmitters.
  • Chemically regulated channels are found on the presynaptic neuron, while voltage-regulated channels are found on the postsynaptic neuron.
  • Chemically regulated channels are opened by neurotransmitters, while voltage-regulated channels are opened by changes in membrane potential. (correct)
  • Chemically regulated channels are responsible for generating action potentials, while voltage-regulated channels are responsible for synaptic transmission.

Why is the synapse considered a directional structure in nerve impulse transmission?

<p>The neurotransmitter receptors are only present on the postsynaptic side of the synapse, limiting the direction of signal transmission. (C)</p> Signup and view all the answers

Which of the following is a direct consequence of an excitatory postsynaptic potential (EPSP) in a postsynaptic neuron?

<p>The neuron becomes more likely to generate an action potential, increasing the probability of signal transmission. (A)</p> Signup and view all the answers

What is the primary difference between a synapse and a neuromuscular junction?

<p>A synapse occurs between two neurons, while a neuromuscular junction connects a neuron to a muscle fiber. (D)</p> Signup and view all the answers

What is the significance of the tiny cleft, approximately 10 nm in size, between the presynaptic and postsynaptic cells at a synapse?

<p>This cleft allows for rapid diffusion of neurotransmitters across the synapse, ensuring efficient signal transmission. (D)</p> Signup and view all the answers

What is the primary characteristic of myotonia, as described in the content?

<p>A prolonged state of muscle relaxation following voluntary contraction or electrical stimulation. (A)</p> Signup and view all the answers

Which neurotransmitter is primarily associated with cholinergic transmission?

<p>Acetylcholine (D)</p> Signup and view all the answers

Which type of nerve fibers most commonly release norepinephrine?

<p>Sympathetic nerve fibers (B)</p> Signup and view all the answers

Which of the following conditions is suggested to cause dysautonomia?

<p>Brain injury (C)</p> Signup and view all the answers

What characteristic lesion is associated with Borrelia burgdorferi infection?

<p>Circular lesion (A)</p> Signup and view all the answers

Which type of autonomic nervous system fibers are responsible for controlling heart rate and blood pressure?

<p>Sympathetic fibers (D)</p> Signup and view all the answers

Which form of synesthesia allows individuals to perceive musical notes as colors?

<p>Chromesthesia (D)</p> Signup and view all the answers

In what way does Lyme disease affect the immune response?

<p>Disrupts local immune response (B)</p> Signup and view all the answers

Which nervous system is responsible for the transmission of involuntary bodily functions such as digestion and sweating?

<p>Autonomic Nervous System (C)</p> Signup and view all the answers

What taste is experienced when listening to a major third musical tone interval?

<p>Sweet (D)</p> Signup and view all the answers

Which musical tone interval corresponds with the taste of cream?

<p>Minor sixth (A)</p> Signup and view all the answers

What was the primary achievement of Shigeru Kondo and Alexander Yee?

<p>Calculating Pi to 10 trillion decimal places (C)</p> Signup and view all the answers

What taste does a minor second musical tone interval trigger?

<p>Sour (D)</p> Signup and view all the answers

What is the ratio expressed by the mathematical constant π?

<p>Circumference to diameter of a circle (D)</p> Signup and view all the answers

What taste is experienced from the tritone musical tone interval?

<p>Disgust (A)</p> Signup and view all the answers

How long would it take an average person to recite every digit of Pi calculated by Kondo and Yee?

<p>158,000 years (C)</p> Signup and view all the answers

What taste does a major seventh musical tone interval elicit?

<p>Sour (C)</p> Signup and view all the answers

What type of molecules can primarily cross the cell membrane through simple diffusion?

<p>Small uncharged molecules (B)</p> Signup and view all the answers

What characteristic of ion channels allows some to facilitate the passage of ions across the membrane?

<p>Some are leaky, allowing ions to flow in or out as needed. (B)</p> Signup and view all the answers

Which of the following processes requires metabolic energy to transport substances across the cell membrane?

<p>Active transport (B)</p> Signup and view all the answers

What role does cholesterol play in the fluid mosaic model of the cell membrane?

<p>It stabilizes the structure of the membrane. (A)</p> Signup and view all the answers

Which type of diffusion is utilized by charged molecules to move through the cell membrane?

<p>Facilitated diffusion (C)</p> Signup and view all the answers

What distinguishes voltage-gated ion channels from other types of channels?

<p>They open or close in response to changes in membrane potential. (C)</p> Signup and view all the answers

What is a key feature of the phospholipid bilayer in the cell membrane?

<p>It has hydrophilic heads and hydrophobic tails. (D)</p> Signup and view all the answers

Which mechanism does simple diffusion NOT employ to facilitate molecular transport?

<p>Energy consumption (D)</p> Signup and view all the answers

Which of the following cellular processes is most directly affected by the mutation in the muscle chloride channel causing myotonia?

<p>Potassium ion efflux (D)</p> Signup and view all the answers

The text describes myotonic goats as having a "wonderful disposition" and being "very loving pets." What does this information suggest about the impact of myotonia on the goats' behavior?

<p>Myotonia has no significant effect on their behavior. (A)</p> Signup and view all the answers

The text states that myotonic goats have a higher meat-to-bone ratio than normal goats. This suggests that myotonia has a direct impact on

<p>Muscle fiber growth and development (B)</p> Signup and view all the answers

The text mentions "The present that your brain comprehends is around 500 milliseconds behind what is actually "happening.". This means the brain processes information in a

<p>Delayed and asynchronous manner. (A)</p> Signup and view all the answers

Based on the information provided, why are myotonic goats considered a part of "Slow Food Ark of Taste?"

<p>Their meat is considered a delicacy due to its unique texture and flavor. (D)</p> Signup and view all the answers

What is the primary function of the Na+/K+ ATPase?

<p>Maintains the electrochemical gradient by moving Na+ out and K+ in (C)</p> Signup and view all the answers

How does active transport differ from passive transport in the context of cell membranes?

<p>Active transport directly consumes ATP, whereas passive transport relies on concentration gradients (C)</p> Signup and view all the answers

What is the significance of voltage-gated ion channels in neurons?

<p>They regulate the flow of ions necessary for changing the membrane potential (C)</p> Signup and view all the answers

What charge does the inside of a neuron typically have at resting membrane potential?

<p>-70 mV (B)</p> Signup and view all the answers

Which ion is typically found in greater concentration outside the neuron at rest?

<p>Na+ (A)</p> Signup and view all the answers

What role does ATP play in the operation of the Na+/K+ ATPase?

<p>It provides the energy required for the active transport of ions (A)</p> Signup and view all the answers

Which of the following processes would NOT be categorized as a form of active transport?

<p>Facilitated diffusion of glucose (D)</p> Signup and view all the answers

What occurs during the action potential in relation to ion flow?

<p>Na+ ions flow into the cell after the membrane is depolarized (B)</p> Signup and view all the answers

Flashcards

What is the neurotransmitter released at autonomic ganglia?

The neurotransmitter acetylcholine (ACh) is released at synapses between preganglionic and postganglionic neurons in both the sympathetic and parasympathetic nervous systems.

What is the neurotransmitter released by most parasympathetic postganglionic fibers?

The neurotransmitter acetylcholine (ACh) is released by most parasympathetic postganglionic fibers at their synapses with effector cells.

What is the neurotransmitter released by most sympathetic postganglionic fibers?

The neurotransmitter norepinephrine (NE) is released by most sympathetic postganglionic fibers at their synapses with effector cells.

What is Dysautonomia?

A condition affecting the autonomic nervous system (ANS), which controls involuntary functions like heart rate, blood pressure, and digestion.

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What is Lyme disease?

Lyme disease is a multisystem illness caused by the bacterium Borrelia burgdorferi. It is transmitted to humans through the bite of infected blacklegged ticks.

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What is Autonomic Nervous System Function?

The process of the autonomic nervous system (ANS) controlling involuntary functions like heart rate, blood pressure, and digestion.

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What is Synesthesia?

A condition where a particular sensory input triggers an automatic, involuntary experience in a different sensory modality.

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What is Grapheme-Color Synesthesia?

A form of synesthesia where numbers or letters are perceived as having inherent colors.

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Synesthesia

A condition where one sense triggers another, causing a subjective experience; for example, hearing a musical tone can trigger a taste perception.

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Working Memory

The ability to hold information in mind for a short period, usually around 7 items.

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Pi (Ï€)

The ratio of a circle's circumference to its diameter, approximately 3.14159.

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Musical Tone Interval

The difference in pitch between two notes, often defined by intervals like 'major third' or 'minor second'.

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Taste Synesthesia

A subjective experience of taste triggered by auditory stimuli, such as musical tone intervals.

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Taste Perception

A subjective experience of taste, such as sour, bitter, salty, sweet, or umami.

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Synesthete

An individual with synesthesia who experiences taste triggered by auditory stimuli.

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Auditory Perception

The subjective experience of hearing, such as recognizing different musical tones.

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Refractory period & Directional Action Potential

The refractory period, a temporary state of reduced excitability, ensures that action potentials travel in one direction down the axon.

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Saltatory Conduction

Myelinated axons have a sheath of myelin that insulates the axon, allowing action potentials to jump between gaps called nodes of Ranvier.

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Synapse

The junction between a neuron and another cell, where communication occurs via neurotransmitters.

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Presynaptic Neuron

The neuron that releases neurotransmitters into the synaptic cleft.

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Postsynaptic Neuron

The neuron that receives the neurotransmitters released by the presynaptic neuron.

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Neurotransmitters

Chemicals released by the presynaptic neuron that bind to receptors on the postsynaptic neuron, stimulating a response.

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EPSP (Excitatory Postsynaptic Potential)

A type of postsynaptic potential that depolarizes the membrane, making it more likely to fire an action potential.

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Myotonia

A group of neuromuscular disorders characterized by delayed muscle relaxation after contraction due to faulty neuromuscular transmission.

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Na+/K+ ATPase

A protein embedded within the cell membrane that actively transports sodium ions (Na+) out of the cell and potassium ions (K+) into the cell, requiring energy from ATP.

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Active Transport

A type of cell transport that requires energy, typically from ATP, to move substances against their concentration gradient.

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Membrane Potential

The difference in electrical charge across a cell membrane.

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Resting Membrane Potential

The membrane potential of a neuron when it is not actively transmitting a signal.

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Voltage-Gated Ion Channel

A special type of ion channel that opens and closes in response to changes in the membrane potential.

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Action Potential

A rapid electrical signal that travels along the axon of a neuron.

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Ion Movement

The movement of ions across the cell membrane through specialized proteins called ion channels.

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Electrical Activity in Axons

The process of generating and transmitting electrical signals in neurons, which is essential for communication in the nervous system.

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What is the cell membrane?

The cell membrane is a selectively permeable barrier that separates the cell's internal environment from its external surroundings. It is composed of a phospholipid bilayer, with hydrophilic heads facing outward and hydrophobic tails facing inward.

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What is the fluid mosaic model?

The fluid mosaic model describes the cell membrane as a dynamic structure, where phospholipids and proteins move freely within the bilayer. This fluidity allows the membrane to adjust to changing conditions.

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What is simple diffusion?

Simple diffusion is a passive transport process where molecules move from an area of high concentration to an area of low concentration without requiring cellular energy. This occurs across the cell membrane for small, uncharged molecules and ions.

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How do small, uncharged molecules cross the membrane?

Small, uncharged molecules like steroid hormones can pass directly through the phospholipid bilayer of the cell membrane due to their lipid solubility.

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How do small, charged molecules cross the membrane?

Small, charged molecules like ions can cross the cell membrane through water-filled channels called pores. These pores are formed by proteins embedded within the membrane.

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What are ion channels?

Ion channels are protein-based structures that act as selective gates for the passage of specific ions, such as sodium, potassium, or calcium. Some ion channels are always open, while others are voltage-gated, opening only in response to changes in membrane potential.

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What is active transport?

Active transport is a process that requires cellular energy (ATP) to move molecules against their concentration gradient, from an area of low concentration to an area of high concentration. This is essential for maintaining cell function and intracellular gradients.

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Why is active transport important?

Active transport is important for maintaining cell function and intracellular gradients by ensuring the proper concentration of essential ions and molecules is maintained within the cell.

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Myotonic 'Fainting' Goat

A brief involuntary muscle stiffening in goats, often triggered by surprise or excitement.

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Acetylcholine (ACh) in Autonomic Ganglia

A neurotransmitter released at synapses between preganglionic and postganglionic neurons in both the sympathetic and parasympathetic nervous systems.

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Brain's Processing Delay

The time delay between an event occurring and our brain registering it, approximately 500 milliseconds.

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Study Notes

Nervous System Overview

  • The nervous system has two main divisions: Central Nervous System (CNS) and Peripheral Nervous System (PNS).
  • The CNS consists of the brain and spinal cord.
  • The PNS consists of peripheral nerves and ganglia.

Autonomic Nervous System

  • The autonomic nervous system is part of the PNS, controlling involuntary functions.
  • It has two branches: sympathetic and parasympathetic, which often have opposing effects.

Somatic Nervous System

  • The somatic nervous system is part of the PNS, controlling voluntary movements.
  • It involves a single neuron carrying signals from the CNS to skeletal muscles.

Neurophysiology Learning Outcomes

  • Understanding neurophysiology concepts.
  • Categorizing neurons based on function and structure.
  • Describing the blood-brain barrier, its importance and how it works.
  • Learning about the organization of the nervous system.
  • Applying critical thinking skills.

Neurons and Synapses

  • Neurons are the basic unit of the nervous system.
  • Dendrites receive signals and pass them to the cell body.
  • Axons carry signals from the cell body to other neurons or effectors, like muscle.
  • Neurons communicate with other neurons at synapses.

Functional Classification of Neurons

  • Sensory neurons carry signals to the central nervous system (CNS).
  • Motor neurons carry signals from the central nervous system (CNS) to effector organs.
  • Interneurons connect sensory and motor neurons.

Supporting Cells

  • Schwann cells form myelin sheaths in the peripheral nervous system (PNS).
  • Oligodendrocytes form myelin sheaths in the central nervous system (CNS).
  • Astrocytes provide support to neurons.

Blood-Brain Barrier

  • The blood-brain barrier prevents many substances from entering the brain from the bloodstream.
  • Nonpolar molecules (such as O2 and CO2) can pass through.
  • Other substances must use specific transport mechanisms.
  • Astrocytes play a role in this barrier.

Organization of the Nervous System

  • The nervous system is structured in a hierarchical manner, with the CNS at the top.
  • The PNS is divided into somatic (voluntary) and autonomic (involuntary) branches.
  • The autonomic nervous system has sympathetic (fight-or-flight) and parasympathetic (rest-and-digest) divisions.

Action Potentials

  • Action potentials are rapid changes in membrane potential, serving as signals in neurons.
  • Ion channels (e.g., voltage-gated Na+ and K+ channels) are crucial for propagating action potentials.
  • The movement of ions across the membrane, leads to depolarization and repolarization.
  • This rapid process allows for signals to travel quickly in the nervous system.

The Synapse

  • Synapses are the junctions between neurons.
  • Neurotransmitters released at the synapse allow communication between neurons or from neurons to effector organs (muscle or glands).
  • Voltage-gated calcium channels are involved in neurotransmitter release.
  • Neurotransmitters bind to receptors on post-synaptic cells and affect whether or not an action potential is generated, either exciting or inhibiting the target cell.

Review of Learning Outcomes

  • Cell membranes act as barriers but also have specialized proteins that facilitate transport across membranes.
  • Action potentials are electrical signals that propagate rapidly along axons, vital for nerve function.
  • Neurotransmitters relay signals between neurons at synapses.
  • The blood-brain barrier protects the brain from harmful substances.

Other Information

  • Neurological disorders like Alzheimer's disease, Brain tumors, Ischaemic, hemorrhagic stroke can affect brain functioning.
  • Certain nerve disorders (Myotonia) cause delayed muscle relaxation.
  • Brain injury can cause dysfunction in the autonomic nervous system.
  • There's a variety of Neurotransmitters in the nervous system.
  • Individuals with synesthesia experience unusual sensory perceptions.
  • The human brain holds approximately 7 digits of information in working memory.
  • The human brain, even while comprehending the present, actually processes information at a slower rate.

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