Neuroscience Chapter: Action Potentials and CNS

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Questions and Answers

What drives the movement of ions across the cell membrane when channels are open?

  • Concentration gradient and magnetic fields
  • Electric charge alone
  • Chemical energy only
  • Concentration gradient and electrostatic pressure (correct)

What is the threshold membrane potential required to initiate an action potential?

  • -50 mV (correct)
  • -70 mV
  • -30 mV
  • -90 mV

Which ion is primarily responsible for both passive diffusion out of the cell and electrostatic pressure into the cell in terms of equilibrium potential?

  • Chloride (Cl-)
  • Calcium (Ca+)
  • Potassium (K+) (correct)
  • Sodium (Na+)

What occurs during the absolute refractory period?

<p>No action potential can be generated because Na+ channels are locked. (A)</p> Signup and view all the answers

What happens to the membrane during the relative refractory period?

<p>It becomes hyperpolarized due to excessive K+ leaving. (C)</p> Signup and view all the answers

Which two divisions make up the central nervous system (CNS)?

<p>Brain and Spinal Cord (C)</p> Signup and view all the answers

What function does the hypothalamus primarily serve in the limbic system?

<p>Hormone Regulation and Sleep Control (C)</p> Signup and view all the answers

Which neurotransmitters are primarily associated with the ventral tegmental area (VTA)?

<p>Dopamine and Glutamate (C)</p> Signup and view all the answers

What is the primary role of the association cortices in the nervous system?

<p>Integration of Information from Different Modalities (D)</p> Signup and view all the answers

Which part of the limbic system is primarily involved in motivation and voluntary motion?

<p>Basal Ganglia (C)</p> Signup and view all the answers

Which cells are primarily involved in the electrical transmission within a neuron?

<p>Neurons (C)</p> Signup and view all the answers

What is the primary function of the sympathetic division of the autonomic nervous system?

<p>Increase Heart Rate and Blood Flow (C)</p> Signup and view all the answers

Which of the following structures is involved in processing fear and reward?

<p>Nucleus Accumbens (C)</p> Signup and view all the answers

What is the primary function of glial cells in the nervous system?

<p>Provide metabolic support and protection for neurons. (B)</p> Signup and view all the answers

Which type of neuron is responsible for converting physical stimuli into electrical signals?

<p>Sensory neuron (A)</p> Signup and view all the answers

Which type of glial cell is specifically responsible for producing myelin in the central nervous system?

<p>Oligodendrocytes (C)</p> Signup and view all the answers

What part of a neuron is primarily responsible for receiving information from other cells?

<p>Dendrites (D)</p> Signup and view all the answers

What role do interneurons play in the nervous system?

<p>They facilitate communication between sensory and motor neurons. (C)</p> Signup and view all the answers

Which component of the neuron conducts electrical signals from the cell body to the terminal buttons?

<p>Axon (B)</p> Signup and view all the answers

What is the main function of neurotransmitter receptors located on dendrites?

<p>Receive signals and trigger excitatory or inhibitory effects. (A)</p> Signup and view all the answers

Which glial cell type is responsible for cleaning up debris in the nervous system?

<p>Microglia (A)</p> Signup and view all the answers

What role do dendritic spines play in neuron structure?

<p>They increase surface area for synaptic transmission. (B)</p> Signup and view all the answers

What is the primary function of the axon in a neuron?

<p>To conduct electrical signals to the axon terminals. (C)</p> Signup and view all the answers

Which of the following statements about the myelin sheath is true?

<p>It consists of a fatty insulation created by layers of glial cells. (A)</p> Signup and view all the answers

What are the Nodes of Ranvier responsible for?

<p>They are sites where action potentials are regenerated. (C)</p> Signup and view all the answers

In convergent pathways, how is information processed?

<p>Information is converged from multiple sources into a single neuron. (C)</p> Signup and view all the answers

What characteristic of the cell membrane allows for the action of neurotransmitters?

<p>Specific receptors located on the membrane. (D)</p> Signup and view all the answers

Which statement best describes the structure of a phospholipid in a cell membrane?

<p>It includes a negatively charged head and two hydrophobic tails. (B)</p> Signup and view all the answers

What type of glial cells myelinate nerves in the peripheral nervous system?

<p>Schwann cells (C)</p> Signup and view all the answers

What is the primary role of receptor proteins in cell membranes?

<p>Bind neurotransmitters, hormones, and drugs (A)</p> Signup and view all the answers

Which type of ion channel opens in response to changes in electrical potential across the membrane?

<p>Voltage-gated channel (D)</p> Signup and view all the answers

What describes the resting membrane potential of a neuron?

<p>The inside of the cell is more negative than the outside (B)</p> Signup and view all the answers

What process is referred to when a phosphate group is added or removed from an intracellular protein affecting ion channel activity?

<p>Phosphorylation (D)</p> Signup and view all the answers

Which statement about ion channels is true when they are open?

<p>They allow ions to move passively along their concentration gradient (B)</p> Signup and view all the answers

What ions are typically more concentrated outside a neuron at resting membrane potential?

<p>Sodium ions (Na+) (D)</p> Signup and view all the answers

Which type of transporter protein primarily uses energy to move molecules across the membrane?

<p>Active transporter (A)</p> Signup and view all the answers

Which of the following correctly identifies the state of the cell membrane during resting membrane potential?

<p>The membrane is polarized with negative ions inside (C)</p> Signup and view all the answers

What initiates the hyperpolarization seen in inhibitory postsynaptic potentials (IPSPs)?

<p>K+ leaving the cell (C)</p> Signup and view all the answers

Which type of cell forms myelin sheaths in the central nervous system (CNS)?

<p>Oligodendrocytes (B)</p> Signup and view all the answers

What is true about action potentials in neurons?

<p>They exhibit an 'all or none' response. (A)</p> Signup and view all the answers

What does saltatory conduction refer to in myelinated neurons?

<p>Conduction that jumps between nodes of Ranvier (D)</p> Signup and view all the answers

Which statement about local potentials is correct?

<p>They can result in graded changes in membrane potential. (B)</p> Signup and view all the answers

What is the role of the Na+/K+ pump in neuron function?

<p>To maintain resting membrane potential (B)</p> Signup and view all the answers

What effect does local anesthesia like Novocain have on nerve cells?

<p>It blocks voltage-gated Na+ channels. (B)</p> Signup and view all the answers

Which type of summation involves the addition of multiple stimuli occurring at different locations?

<p>Spatial Summation (D)</p> Signup and view all the answers

Flashcards

Cell Membrane Proteins

Proteins embedded in the cell membrane that perform specific functions like signaling and transport.

Ion Channels

Proteins that create channels allowing specific ions to passively move across the membrane.

Gated Channels

Ion channels that open in response to signals: ligand-binding or changes in membrane potential.

Resting Membrane Potential (RMP)

The electrical charge difference between the inside and outside of a cell, typically around -70 mV.

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Ion Distribution

The unequal distribution of ions inside and outside the cell that contributes to RMP.

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Phosphorylation

The addition or removal of a phosphate group that can change the opening of ion channels.

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Localized Potentials

Small changes in membrane potential that occur in response to stimuli.

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Action Potential

A rapid change in voltage across the membrane, allowing for long-distance signal transmission in neurons.

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Central Nervous System (CNS)

The part of the nervous system consisting of the brain and spinal cord.

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Peripheral Nervous System (PNS)

The part of the nervous system outside the CNS that connects it to limbs and organs.

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Autonomic Nervous System

The branch of the PNS that controls involuntary functions like heartbeat and digestion.

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Sympathetic Division

Part of the autonomic nervous system that prepares the body for 'fight or flight.'

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Parasympathetic Division

Part of the autonomic nervous system that conserves energy and restores the body to a calm state.

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Limbic System

A group of structures in the brain involved in emotions, memory, and arousal.

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Ventral Tegmental Area (VTA)

A midbrain structure involved in the reward system and releases dopamine.

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Hippocampus

A brain structure crucial for forming new memories and learning.

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Dendrites

Extensions of a neuron that receive signals from other neurons.

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Dendritic spines

Small protrusions on dendrites that increase surface area for synapses.

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Axon

Long projection that transmits electrical signals away from the soma to axon terminals.

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Myelin sheath

Fatty insulation around axons that speeds up electrical transmission.

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Nodes of Ranvier

Breaks in the myelin sheath where action potentials are regenerated.

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Axon terminal

End of an axon where neurotransmitters are released into the synapse.

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Convergent pathways

Neural pathways where multiple inputs converge onto one neuron.

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Cell membrane

Barrier made of phospholipids controlling passage of substances into and out of the neuron.

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Na+/K+ Pump

A protein that moves K+ into and Na+ out of cells, resetting RMP.

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Action Potential (AP)

A rapid rise and fall in membrane potential, triggered by Na+ influx.

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Refractory Periods

Times when a neuron can't fire (absolute) or can fire with strong stimuli (relative).

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Saltatory Conduction

AP jumps between nodes of Ranvier, speeding up signal propagation in myelinated neurons.

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Local Potentials

Small temporary changes in RMP; can be depolarizing or hyperpolarizing.

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Excitatory vs. Inhibitory Potentials

EPSPs make the inside less negative; IPSPs make it more negative.

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Summation of Local Potentials

Combining small local changes to create a larger potential change at the axon hillock.

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Diffusion

The process where ions move from high to low concentration areas.

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Electrostatic Pressure

The force that causes oppositely charged ions to attract each other.

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Equilibrium Potential for K+

The state where K+ ions move equally in and out of the cell.

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Glial Cells

Cells that provide support, protection, and insulation for neurons.

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Types of Glial Cells

Includes Oligodendrocytes, Astrocytes, Microglia, and Schwann cells.

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Sensory Neurons

Neurons that convert physical stimuli into electrical signals.

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Interneurons

Neurons found in the CNS that create circuits for processing information.

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Motor Neurons

Neurons that send signals to muscles for movement.

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Neuron Structure

Includes soma, dendrites, axon, and axon terminal.

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Soma

The central part of a neuron containing the nucleus.

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Study Notes

Module 1: Foundations

  • This module covers principles of pharmacology, the structure and function of the nervous system, and chemical signaling of neurotransmitters.

Structure and Function of the Nervous System

  • Organization:

    • Central Nervous System (CNS) and Peripheral Nervous System (PNS)
    • Development of the nervous system
    • Divisions of the nervous system
  • Cells:

    • Types of cells
    • Features of neurons
      • Types of neurons (Sensory, Interneurons, Motor)
      • Structure of neurons (Soma, Dendrites, Axon, Axon Terminal, Myelin sheath, Nodes of Ranvier)
      • Pathways (Convergent and Divergent)
    • Cell membrane
      • Characteristics—selectively permeable
      • Receptors (binding sites for neurotransmitters, hormones, drugs)
      • Transporters
      • Ion Channels
    • Glial cells:
      • Types, functions, properties
  • Electrical Transmission:

    • Resting membrane potential (RMP)
    • Ion distribution & RMP
    • Ion movement
    • The Action Potential (AP)
      • Rapid depolarization
      • Absolute & Relative refractory periods
      • Propagation of the AP
    • Myelin Sheath
      • Composition (oligodendrocytes, Schwann cells)
    • Localized Potentials
      • Graded potentials
      • Types of local potentials (Depolarization, Hyperpolarization), Summation
    • Application—local anesthesia

Nervous System Divisions

  • CNS and PNS

  • Brain development stages (e.g., 25 days, 35 days, 40 days, 50 days, 100 days)

  • Divisions of the adult CNS (Forebrain, Midbrain, Hindbrain)

  • Limbic system components (e.g., Hippocampus, Amygdala, Hypothalamus, Basal Ganglia, Cingulate Gyrus)

  • Pathways: Mesolimbic & Mesocortical

  • Ventral tegmental area (VTA)

  • Nucleus Accumbens (NAcc)

  • Dopamine & Glutamate

  • Mesolimbic Pathway: reward pathway.

Nervous System Models

  • Rats are widely used.
  • Brain structures are highly conserved across mammals (e.g., humans).

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