NUR 425 Week 9 - Mental Health Lecture

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Questions and Answers

What are the three components of neurons?

  • Cell body, dendrites, axons (correct)
  • Soma, myelin, synapse
  • Dendrites, glial cells, synapse
  • Cell body, synapse, neurotransmitters

What is the resting membrane potential of a neuron?

  • -70 mV (correct)
  • +30 mV
  • 0 mV
  • -90 mV

During an action potential, which ion enters the neuron first?

  • Sodium (Na+) (correct)
  • Potassium (K+)
  • Calcium (Ca2+)
  • Chloride (Cl-)

What is the small gap between two neurons where communication occurs called?

<p>Synaptic cleft (A)</p> Signup and view all the answers

Which neurotransmitter is known as the primary inhibitory neurotransmitter in the CNS?

<p>GABA (C)</p> Signup and view all the answers

Which neurotransmitter is associated with the fight or flight response?

<p>Norepinephrine (C)</p> Signup and view all the answers

Which neurotransmitter is primarily involved in mood regulation and sleep cycles?

<p>Serotonin (A)</p> Signup and view all the answers

Which neurotransmitter is associated with Alzheimer's disease due to a decrease in its secreting neurons?

<p>Acetylcholine (C)</p> Signup and view all the answers

Which neurotransmitter is known as the 'feel good' neurotransmitter?

<p>Dopamine (B)</p> Signup and view all the answers

Which neurotransmitter is primarily excitatory and involved in learning and memory?

<p>Glutamate (C)</p> Signup and view all the answers

Which neurotransmitter is involved in muscle movement and autonomic functions?

<p>Acetylcholine (C)</p> Signup and view all the answers

Which neurotransmitter is associated with the positive symptoms of schizophrenia?

<p>Dopamine (A)</p> Signup and view all the answers

Which neurotransmitter is involved in the regulation of mood, appetite, and digestion?

<p>Serotonin (B)</p> Signup and view all the answers

Which neurotransmitter is involved in the regulation of the sleep-wake cycle and memory?

<p>Serotonin (B), Norepinephrine (D)</p> Signup and view all the answers

Which neurotransmitter is involved in the prevention of seizures by inhibiting excessive neuronal firing?

<p>GABA (C)</p> Signup and view all the answers

Which neurotransmitter is involved in pain perception and mood regulation?

<p>Glutamate (B)</p> Signup and view all the answers

Which neurotransmitter is involved in the fight-or-flight response and increases heart rate and blood pressure?

<p>Norepinephrine (D)</p> Signup and view all the answers

Which neurotransmitter is associated with the calming effect and reduction in anxiety?

<p>GABA (C)</p> Signup and view all the answers

Which neurotransmitter is involved in the regulation of muscle tone and sleep cycles?

<p>GABA (D)</p> Signup and view all the answers

Neurons generate and conduct electrical and chemical impulses by selectively changing the electrical potential of their plasma membranes and influencing other nearby neurons by the release of neurotransmitters. (True or false)

<p>True (A)</p> Signup and view all the answers

During an action potential, neurons send information down the axon, and this action potential is created by a depolarizing current. (T or F)

<p>True (A)</p> Signup and view all the answers

When the depolarization reaches around -55 millivolts, neurons will fire an action potential. The main ions involved are sodium and potassium.

<p>True (A)</p> Signup and view all the answers

Which neurotransmitter is primarily associated with the positive symptoms of schizophrenia?

<p>Dopamine (A)</p> Signup and view all the answers

What is a common prenatal stressor that increases the risk of developing schizophrenia?

<p>Maternal malnutrition (A), Viral infections during pregnancy (D)</p> Signup and view all the answers

Which of the following is a neuroanatomic alteration commonly seen in individuals with schizophrenia? (SATA)

<p>Enlargement of ventricles (A), Reduced gray matter volume (C), Lower brain volumes (B)</p> Signup and view all the answers

Which neurotransmitter dysregulation is associated with schizophrenia and involves altered levels that decrease more rapidly with age?

<p>Glutamate (A)</p> Signup and view all the answers

What are some positive symptoms of schizophrenia? (SATA)

<p>Hallucinations (A), Delusions (B)</p> Signup and view all the answers

What are some negative symptoms of schizophrenia? (Select all that apply)

<p>Inability to experience pleasure or joy (anhedonia) (A), Poverty of thought (alogia) (C), Loss of motivation (avolition) (D)</p> Signup and view all the answers

What pharmacologic management options are used for schizophrenia? (Select all that apply)

<p>First-generation antipsychotics (FGAs) (A), Second-generation antipsychotics (SGAs) (B), Long-acting injectable antipsychotics (LAIs) (C)</p> Signup and view all the answers

What are the two categories of mood disorders?

<p>Unipolar or major depressive disorders (A), Bipolar disorder (C)</p> Signup and view all the answers

Which of the following is a characteristic of bipolar I disorder?

<p>Presence of at least one manic episode (A)</p> Signup and view all the answers

What is the heritability percentage of major depressive disorder?

<p>40-50% (B)</p> Signup and view all the answers

Which neurotransmitters are initially thought to be the main ones involved in major depressive disorder?

<p>Serotonin and norepinephrine (A)</p> Signup and view all the answers

Which hormone is produced by the hypothalamus and stimulates the secretion of ACTH in the anterior pituitary?

<p>Corticotropin-releasing hormone (CRH) (A)</p> Signup and view all the answers

What is a major stress hormone that is involved in the hypothalamic-pituitary-adrenal axis?

<p>Cortisol (A)</p> Signup and view all the answers

Which tool is commonly used to assess the severity of depression?

<p>PHQ-9 (B)</p> Signup and view all the answers

Which medication is considered the first-line therapy for bipolar disorder?

<p>Lithium (A)</p> Signup and view all the answers

Which type of therapy is especially effective in combination with stabilized anti-psychotic medications for schizophrenia?

<p>Cognitive Behavioral Therapy (CBT) (A)</p> Signup and view all the answers

Which of the following is a common environmental factor that can contribute to major depressive disorder? (SATA)

<p>Chronic stress (A), Childhood trauma (C)</p> Signup and view all the answers

What is the concordance rate for bipolar disorder in identical twins?

<p>70% (A)</p> Signup and view all the answers

Which neurotransmitter imbalances are associated with bipolar disorder?

<p>Serotonin, dopamine, norepinephrine (A)</p> Signup and view all the answers

Which of the following is a characteristic of hypomanic episodes in Bipolar II disorder?

<p>Elevated or irritable mood (A)</p> Signup and view all the answers

SATA: Which of these are clinical manifestations of manic episodes in Bipolar I disorder?

<p>Extreme euphoria or irritability (A), Decreased need for sleep (B), Engaging in risky behaviours (D)</p> Signup and view all the answers

Which of the following methods can be used to manage bipolar disorder? (Select all that apply)

<p>Mood stabilizers (A), Atypical antipsychotic medications (B), Psychotherapy (C)</p> Signup and view all the answers

Which neurotransmitter imbalances contribute to anxiety disorders? (Select all that apply)

<p>Serotonin (A), Norepinephrine (B), GABA (C), Dopamine (D)</p> Signup and view all the answers

Which anxiety disorder is characterized by recurring, severe panic attacks?

<p>Panic Disorder (C)</p> Signup and view all the answers

Which tool is helpful in assessing the severity of anxiety in Generalized Anxiety Disorder (GAD)?

<p>GAD-7 (B)</p> Signup and view all the answers

Which of the following is a common treatment for Panic Disorder?

<p>Cognitive Behavioral Therapy (CBT) (A), Antidepressant medications (SSRIs and SNRIs) (B)</p> Signup and view all the answers

What brain changes occur in PTSD? (SATA)

<p>Increased NE levels (C), Decreased volume of the hippocampus (D)</p> Signup and view all the answers

Which anxiety disorder is characterized by exposure to a stressful or terrifying event and includes symptoms such as intrusive flashbacks and nightmares?

<p>Post-Traumatic Stress Disorder (C)</p> Signup and view all the answers

Which anxiety disorder involves repetitive, intrusive thoughts (obsessions) and/or compulsions?

<p>Obsessive-Compulsive Disorder (C)</p> Signup and view all the answers

What other mental disorders are associated with OCD? (Select all that apply)

<p>Depression (A), Panic disorder (C), General Anxiety Disorder (D)</p> Signup and view all the answers

What medications are commonly used to treat Obsessive-Compulsive Disorder (OCD)?

<p>Selective Serotonin Reuptake Inhibitors (SSRIs) (A)</p> Signup and view all the answers

Which medication is used for the treatment of major depressive disorder and works by blocking the reuptake of norepinephrine and serotonin?

<p>Duloxetine (B)</p> Signup and view all the answers

Which medication is used for the treatment of major depressive disorder and works by blocking the reuptake of serotonin?

<p>Fluoxetine (A)</p> Signup and view all the answers

Which type of medication should be avoided in patients with dementia due to an increased rate of mortality?

<p>All of the above (D)</p> Signup and view all the answers

Which type of medication is administered every 2-6 weeks and reduces the likelihood of relapse in patients with schizophrenia?

<p>Long-acting injectable antipsychotics (B)</p> Signup and view all the answers

Which type of medication works by enhancing the response to GABA and is used for short-term relief of anxiety?

<p>Benzodiazepines (B)</p> Signup and view all the answers

Which medication is often used with SSRIs/SNRIs for chronic anxiety and has no CNS depressant effects or abuse potential?

<p>Buspirone (A)</p> Signup and view all the answers

Which antiseizure medication is used for bipolar disorder and is less effective at treating and preventing depression compared to lithium?

<p>Valproate (A)</p> Signup and view all the answers

Which medication is considered the first-line therapy for bipolar disorder and requires regular monitoring of blood levels?

<p>Lithium (A)</p> Signup and view all the answers

Which medication is used for depression and sometimes OCD and anxiety, and works by increasing the release of serotonin and norepinephrine?

<p>Mirtazapine (B)</p> Signup and view all the answers

Which medication is used for smoking cessation and has an unclear mechanism of action?

<p>Bupropion (A)</p> Signup and view all the answers

Which type of antidepressant works by blocking the reuptake of serotonin and norepinephrine?

<p>Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) (B)</p> Signup and view all the answers

Which medication is considered the most effective agent for schizophrenia but is used for patients who have not responded to safer alternatives due to its side effects?

<p>Clozapine (A)</p> Signup and view all the answers

Which type of drug is used to block receptors for both dopamine and serotonin?

<p>Second-Generation Antispychotics (A)</p> Signup and view all the answers

Which medication mimics endorphins by binding to opioid receptors, providing pain relief?

<p>Morphine (A)</p> Signup and view all the answers

Which medication prevents the breakdown of monoamine neurotransmitters by inhibiting the enzyme monoamine oxidase?

<p>Monoamine oxidase inhibitors (MAOIs) (C)</p> Signup and view all the answers

What are Monoamine oxidase inhibitors (MAOIs) primarily used to treat?

<p>Depression (A)</p> Signup and view all the answers

What are Tricyclic Antidepressants (TCAs) used to treat?

<p>Depressive Disorders, Bipolar disorder, Pain management (B)</p> Signup and view all the answers

What are the clinical manifestations of serotonin syndrome? (Select all that apply)

<p>Altered mental status (agitation, confusion, hallucinations) (A), Neuromuscular manifestations (incoordination, myoclonus, hyperreflexia, tremor) (B), Autonomic instability (excessive sweating, fever, shivering, tachycardia, HTN) (C)</p> Signup and view all the answers

What is Neonatal Abstinence Syndrome (NAS)?

<p>A condition affecting newborns exposed to drugs in utero. (A)</p> Signup and view all the answers

Which medication blocks the reuptake of serotonin into presynaptic neurons, increasing its availability in the synaptic cleft?

<p>All of the above (D)</p> Signup and view all the answers

What are the 4 types of extrapyramidal symptoms seen in the use of First-Generation Antipsychotics (FGAs)?

<p>Acute dystonia, Parkinsonism, Akathisia, Tardive dyskinesia (A)</p> Signup and view all the answers

A patient is experiencing dry mouth, blurred vision, orthostatic hypotension, and menstrual irregularities. What type of antipsychotic drug is causing these adverse effects?

<p>First-Generation Antipsychotics (FGAs) (A)</p> Signup and view all the answers

Which medication inhibits the release of acetylcholine at neuromuscular junctions, leading to muscle relaxation?

<p>Botulinum toxin (B)</p> Signup and view all the answers

Which medication is used to increase dopamine synthesis in the treatment of Parkinson's disease?

<p>Levodopa (A)</p> Signup and view all the answers

Which type of drug is used to block dopamine, acetylcholine, histamine, and norepinephrine to varying degrees?

<p>First-Generation Antipsychotics (FGAs) (A)</p> Signup and view all the answers

Flashcards

Neuron components

Neurons have a cell body, dendrites, and axons.

Resting membrane potential

The electrical charge difference across a neuron's membrane when not firing.

Action potential trigger

Sodium (Na+) ions rush into the neuron during an action potential.

Synaptic cleft

The gap between two neurons.

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Primary inhibitory neurotransmitter

GABA is the primary inhibitory neurotransmitter.

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Fight-or-flight neurotransmitter

Norepinephrine is associated with the fight-or-flight response.

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Mood regulation neurotransmitter

Serotonin is involved in mood and sleep regulation.

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Alzheimer's neurotransmitter

Acetylcholine is linked to Alzheimer's disease due to neuron loss.

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'Feel-good' neurotransmitter

Dopamine is often associated with feelings of pleasure.

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Learning & memory neurotransmitter

Glutamate is primarily excitatory and involved in learning and memory.

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Muscle movement neurotransmitter

Acetylcholine is involved in muscle movement and autonomic functions.

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Schizophrenia positive symptom neurotransmitter

Dopamine is associated with positive symptoms of schizophrenia.

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Schizophrenia neuroanatomic alteration

Enlarged ventricles are a common neuroanatomic change in schizophrenia.

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Action Potential Mechanism

Neurons send information via depolarizing action potentials down axons.

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Action Potential Threshold

Neurons fire an action potential at ~-55mV.

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Bipolar I Disorder

Characterized by at least one manic episode.

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Major Depressive Disorder heritability

40-50% heritability.

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Major Depressive Disorder neurotransmitters

Initially thought to involve serotonin and norepinephrine imbalances.

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Corticotropin-releasing hormone (CRH)

Hypothalamic hormone that stimulates ACTH.

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Major stress hormone

Cortisol, part of the HPA axis.

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Panic Disorder

Anxiety disorder with recurring panic attacks.

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PTSD

Anxiety disorder triggered by traumatic events.

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