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Questions and Answers
During the rising phase of the action potential, what is the primary ion movement?
During the rising phase of the action potential, what is the primary ion movement?
What is the function of the voltage-gated sodium channels (Na+v) during the rising phase of an action potential?
What is the function of the voltage-gated sodium channels (Na+v) during the rising phase of an action potential?
Why does the action potential reach a peak and then begin to fall?
Why does the action potential reach a peak and then begin to fall?
What is the role of potassium leak channels during the action potential?
What is the role of potassium leak channels during the action potential?
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Which of the following events is NOT directly associated with the falling phase of the action potential?
Which of the following events is NOT directly associated with the falling phase of the action potential?
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What triggers exocytosis at the axon terminal?
What triggers exocytosis at the axon terminal?
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What initiates the release of neurotransmitters from synaptic vesicles?
What initiates the release of neurotransmitters from synaptic vesicles?
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Which statement accurately describes the function of neurotransmitters?
Which statement accurately describes the function of neurotransmitters?
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Which of the following statements about neurotransmitter release is true?
Which of the following statements about neurotransmitter release is true?
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What happens to neurotransmitters in the synaptic cleft after their release?
What happens to neurotransmitters in the synaptic cleft after their release?
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What role do vesicles play in neurotransmitter release?
What role do vesicles play in neurotransmitter release?
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What allows for the integration of multiple presynaptic inputs in a postsynaptic neuron?
What allows for the integration of multiple presynaptic inputs in a postsynaptic neuron?
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Which receptor type is directly associated with ligand-gated ion channels?
Which receptor type is directly associated with ligand-gated ion channels?
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Which neurophysiological process is influenced by both ionotropic and metabotropic receptors?
Which neurophysiological process is influenced by both ionotropic and metabotropic receptors?
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How do some neurotransmitters operate as first messengers?
How do some neurotransmitters operate as first messengers?
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How does acetylcholine affect cardiac muscle contraction?
How does acetylcholine affect cardiac muscle contraction?
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What was concluded from the experimental research involving two hearts and the vagus nerve?
What was concluded from the experimental research involving two hearts and the vagus nerve?
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What defines ionotropic receptors compared to metabotropic receptors?
What defines ionotropic receptors compared to metabotropic receptors?
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What process is used for neurotransmitter release into the synaptic cleft?
What process is used for neurotransmitter release into the synaptic cleft?
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Which ions are primarily involved in the binding of neurotransmitters to postsynaptic receptors?
Which ions are primarily involved in the binding of neurotransmitters to postsynaptic receptors?
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What role do Ca2+ ions play in the process of exocytosis?
What role do Ca2+ ions play in the process of exocytosis?
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What is the primary function of myelin in the context of action potential conduction?
What is the primary function of myelin in the context of action potential conduction?
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What is the primary advantage of saltatory conduction?
What is the primary advantage of saltatory conduction?
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How does the conduction of action potentials in myelinated axons differ from conduction in unmyelinated axons?
How does the conduction of action potentials in myelinated axons differ from conduction in unmyelinated axons?
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What is the primary reason for the rapid conduction of action potentials in myelinated axons?
What is the primary reason for the rapid conduction of action potentials in myelinated axons?
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Why does the refractory period prevent backpropagation of the action potential in an unmyelinated axon?
Why does the refractory period prevent backpropagation of the action potential in an unmyelinated axon?
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What role does the axon hillock play in the conduction of action potentials in myelinated axons?
What role does the axon hillock play in the conduction of action potentials in myelinated axons?
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What is the role of the axon hillock in the initiation and propagation of action potentials?
What is the role of the axon hillock in the initiation and propagation of action potentials?
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Why is the concentration of sodium and potassium ions important at the nodes of Ranvier in myelinated axons?
Why is the concentration of sodium and potassium ions important at the nodes of Ranvier in myelinated axons?
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How does the diameter of an unmyelinated axon affect the speed of action potential conduction?
How does the diameter of an unmyelinated axon affect the speed of action potential conduction?
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What is the primary reason for the faster conduction velocity of action potentials in myelinated axons compared to unmyelinated axons?
What is the primary reason for the faster conduction velocity of action potentials in myelinated axons compared to unmyelinated axons?
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Which of the following is NOT a characteristic of action potential propagation in myelinated axons?
Which of the following is NOT a characteristic of action potential propagation in myelinated axons?
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Why is it important that the concentration of potassium voltage-gated channels is reduced in dendrites and the cell body?
Why is it important that the concentration of potassium voltage-gated channels is reduced in dendrites and the cell body?
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How does the initial depolarization trigger the opening of sodium voltage-gated channels, leading to the rising phase of the action potential?
How does the initial depolarization trigger the opening of sodium voltage-gated channels, leading to the rising phase of the action potential?
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In what way does the presence of myelin influence the energy expenditure of the neuron during action potential conduction?
In what way does the presence of myelin influence the energy expenditure of the neuron during action potential conduction?
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What is meant by the statement "The Hodgkin-Huxley Cycle is Positive Feedback"?
What is meant by the statement "The Hodgkin-Huxley Cycle is Positive Feedback"?
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In the context of action potential propagation, what does it mean for the current to spread along the membrane toward the terminals?
In the context of action potential propagation, what does it mean for the current to spread along the membrane toward the terminals?
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Flashcards
Depolarization
Depolarization
The process during an action potential where the membrane potential becomes more positive due to Na+ influx.
Voltage-gated Na+ channels
Voltage-gated Na+ channels
Channels that open when a threshold is reached, allowing Na+ ions to flow into the cell, leading to depolarization.
Falling Phase of Action Potential
Falling Phase of Action Potential
Phase where K+ channels open, allowing K+ to exit, causing repolarization of the membrane back to resting potential.
Repolarization
Repolarization
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Refractory Period
Refractory Period
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Hodgkin-Huxley Cycle
Hodgkin-Huxley Cycle
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Positive Feedback in AP
Positive Feedback in AP
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AP Propagation
AP Propagation
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Axon Hillock
Axon Hillock
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Unmyelinated Axon Conduction
Unmyelinated Axon Conduction
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Myelinated Axon
Myelinated Axon
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Saltatory Conduction
Saltatory Conduction
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Myelin Insulation
Myelin Insulation
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Nodes of Ranvier
Nodes of Ranvier
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Presynaptic Cell
Presynaptic Cell
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Postsynaptic Cell
Postsynaptic Cell
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Electrical Synapse
Electrical Synapse
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Chemical Synapse
Chemical Synapse
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Ions between cells
Ions between cells
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Neurotransmitter Release
Neurotransmitter Release
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Calcium Influx
Calcium Influx
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Postsynaptic Binding
Postsynaptic Binding
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First Messenger
First Messenger
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Integration of Inputs
Integration of Inputs
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G-protein–coupled receptors
G-protein–coupled receptors
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Exocytosis
Exocytosis
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Neurotransmitter removal
Neurotransmitter removal
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Acetylcholine (ACh)
Acetylcholine (ACh)
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Nicotinic receptor
Nicotinic receptor
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Muscarinic receptor
Muscarinic receptor
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Ionotropic receptors
Ionotropic receptors
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Metabotropic receptors
Metabotropic receptors
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Calcium ions (Ca2+)
Calcium ions (Ca2+)
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Study Notes
Depolarization - Rising Phase of Action Potential (AP)
- Action potentials (APs) rely on ion currents and voltage-gated channels
- Sodium (Na+) channels are voltage-gated
- Potassium (K+) channels are voltage-gated
- K+ leak channels are always open (important note!)
- At time zero (t=0), voltage-gated Na+ and K+ channels are closed
- Stimulus opens the channels
- Na+ channels open, sodium flows in, causing depolarization
- Na+ channels close and inactivate, stopping Na+ influx
- Peak depolarization is reached
- This is the rising or depolarizing phase for AP
Falling Phase of Action Potential (AP)
- The falling phase of the AP depends on voltage-gated channels
- K+ channels open, potassium flows out
- This creates repolarization
- K+ channels remain open after the membrane reaches resting potential
- This causes a brief hyperpolarization
- Na+/K+ pump returns ions to their original concentrations
- Refractory period follows
The Hodgkin-Huxley Cycle
- The rising phase of the AP is positive feedback
- Initial depolarization triggers opening of Na+ channels, increasing membrane permeability to Na
- Increased Na+ flow results in further membrane depolarization, driving the positive feedback cycle
Action Potential Propagation Along Axon
- Action potentials begin at the axon hillock, rich in Na+ channels
- Action potentials travel unchanged along the axon membrane towards terminals
- Dendrites and cell bodies have high K+ channel concentration, reducing backpropagation into the soma (cell body).
Propagation of Action Potential
- Action potentials travel along axons as depolarization spreads from one segment to the next
- This occurs in both myelinated and unmyelinated axons
Action Potential Conduction in Unmyelinated Axon
- Threshold is reduced at the axon hillock (spike initiating zone)
- High concentration of Na+ channels is present
- Current spreads along the membrane towards terminals (creating new APs)
Action Potential Conduction in Unmyelinated Axon (Time = 1)
- Adjacent (downstream) Na+ channels reach threshold from the large depolarization
- Refractory period is crucial, preventing backpropagation
Action Potential Conduction in Unmyelinated Axon (Time = 2)
- Next adjacent (downstream) Na+ channels reach threshold
- Axon diameter determines conduction speed (larger = faster, up to 40 m/s)
- This is typical of most invertebrates
Saltatory Conduction
- In myelinated axons, ions flow across the plasma membrane only at nodes where the myelin sheath is interrupted
- Action potentials rapidly skip from node to node
- Saltatory conduction allows many fast-transmitting axons to be packed into a smaller diameter
Action Potential Conduction in Myelinated Axon
- Myelin (protein and lipid) prevents ion flow across the membrane, reducing current loss
- Concentration of Na+ and K+ channels is at the nodes
- This enables ions to cross the membrane
Action Potential Conduction in Myelinated Axon (Time = 0)
- Active node at peak of action potential
- Adjacent inactive node is spreading depolarization, soon reaching threshold
- Other nodes are still at resting potential.
Action Potential Conduction in Myelinated Axon (Time = 1)
- Previous active node returns to resting potential, in refractory period
- Adjacent node was brought to threshold by local current flow and is now active, at peak of action potential
- New adjacent inactive node is spreading depolarization, will soon reach threshold
Action Potential Conduction in Myelinated Axon (Time = 2)
- Previous active node returns to resting potential and is in a longer refractory period
- Adjacent node that was brought to threshold (by local current flow) is now active at peak of action potential
- Saltatory (jumping) conduction, from node to node, eventually reaches terminals.
- Higher conduction velocities (up to 100 m/s) are characteristic of vertebrates
Synaptic Transmission
- Synapses are the sites where neurons communicate with other neurons or effectors
- Presynaptic cells send signals, postsynaptic receive them
- Electrical and chemical synapses are the two types
- The chemical synapses use neurotransmitters and a neurotransmitter receptor
- Neurotransmitters that bind to ligand-gated ion channels, cause rapid effects (e.g., Na+,K+,Cl-)
- neurotransmitters that bind to G-protein-coupled receptors, initiate slower, more complex cellular responses (e.g. second messenger cascades)
- Summation is either excitory or inhibitory, adding effects
- Neurotransmitter release stops when action potentials cease arriving, neurotransmitters are removed from synaptic cleft
- Neurotransmitters are broken down by enzymes or taken up by the axon terminal or glial cells
Experimental Research: Demonstration of Chemical Transmission of Nerve Impulses
- Heart experiments demonstrate chemical transmission
- Heart 1 connected to vagus nerve , Stimulating Heart 1 shows rapid reaction
- Heart 2 not connected to vagus nerve, receives the solution, shows delayed reaction (same as heart 1).
Neurotransmitters Work in Two Ways
- Some neurotransmitters bind directly to ligand-gated ion channels in the postsynaptic membrane, opening or closing the channels rapidly
- Other neurotransmitters work more slowly, acting as first messengers, binding to G-protein-coupled receptors to initiate intracellular signaling cascades; leading to the opening or closing of gated channels, triggering a second messenger
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Description
Test your knowledge on the depolarization and falling phases of action potentials. Explore the role of voltage-gated sodium and potassium channels and understand the Hodgkin-Huxley cycle. Perfect for students studying neuroscience or physiology.