Neuroscience Action Potential Quiz
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Questions and Answers

During the rising phase of the action potential, what is the primary ion movement?

  • Sodium ions (Na+) flow into the cell. (correct)
  • Potassium ions (K+) flow out of the cell.
  • Sodium ions (Na+) flow out of the cell.
  • Potassium ions (K+) flow into the cell.
  • What is the function of the voltage-gated sodium channels (Na+v) during the rising phase of an action potential?

  • They open to allow potassium ions (K+) out of the cell.
  • They remain closed throughout the rising phase.
  • They open to allow sodium ions (Na+) into the cell. (correct)
  • They close to prevent sodium ions (Na+) from entering the cell.
  • Why does the action potential reach a peak and then begin to fall?

  • The cell membrane becomes impermeable to both sodium and potassium ions.
  • Voltage-gated potassium channels (K+v) open, allowing potassium ions to flow out of the cell. (correct)
  • The sodium-potassium pump actively pumps sodium ions out of the cell.
  • The influx of calcium ions into the cell triggers a cascade of events that lead to repolarization.
  • What is the role of potassium leak channels during the action potential?

    <p>They help to maintain the resting membrane potential. (C)</p> Signup and view all the answers

    Which of the following events is NOT directly associated with the falling phase of the action potential?

    <p>The activation of the sodium-potassium pump. (C)</p> Signup and view all the answers

    What triggers exocytosis at the axon terminal?

    <p>Entry of Ca2+ ions (B)</p> Signup and view all the answers

    What initiates the release of neurotransmitters from synaptic vesicles?

    <p>Ca2+ influx through voltage-gated Ca2+ channels (A)</p> Signup and view all the answers

    Which statement accurately describes the function of neurotransmitters?

    <p>They can either depolarize or hyperpolarize the postsynaptic membrane. (C)</p> Signup and view all the answers

    Which of the following statements about neurotransmitter release is true?

    <p>It stops when action potentials cease arriving. (C)</p> Signup and view all the answers

    What happens to neurotransmitters in the synaptic cleft after their release?

    <p>They are broken down by enzymes. (A)</p> Signup and view all the answers

    What role do vesicles play in neurotransmitter release?

    <p>They store neurotransmitters until an action potential triggers their release. (B)</p> Signup and view all the answers

    What allows for the integration of multiple presynaptic inputs in a postsynaptic neuron?

    <p>Summed postsynaptic excitation or inhibition (D)</p> Signup and view all the answers

    Which receptor type is directly associated with ligand-gated ion channels?

    <p>Nicotinic receptors (A)</p> Signup and view all the answers

    Which neurophysiological process is influenced by both ionotropic and metabotropic receptors?

    <p>Post-synaptic cell response (A)</p> Signup and view all the answers

    How do some neurotransmitters operate as first messengers?

    <p>They trigger second messengers via G-protein–coupled receptors. (D)</p> Signup and view all the answers

    How does acetylcholine affect cardiac muscle contraction?

    <p>It inhibits contraction via muscarinic receptors. (D)</p> Signup and view all the answers

    What was concluded from the experimental research involving two hearts and the vagus nerve?

    <p>Heart 2 received a chemical signal from Heart 1. (D)</p> Signup and view all the answers

    What defines ionotropic receptors compared to metabotropic receptors?

    <p>Direct influence on ion current. (A)</p> Signup and view all the answers

    What process is used for neurotransmitter release into the synaptic cleft?

    <p>Exocytosis from synaptic vesicles (D)</p> Signup and view all the answers

    Which ions are primarily involved in the binding of neurotransmitters to postsynaptic receptors?

    <p>Na+, K+, and Cl- (B)</p> Signup and view all the answers

    What role do Ca2+ ions play in the process of exocytosis?

    <p>They trigger the opening of ion channels. (B)</p> Signup and view all the answers

    What is the primary function of myelin in the context of action potential conduction?

    <p>Myelin decreases the resistance of the membrane to ion flow, speeding up action potential conduction. (B)</p> Signup and view all the answers

    What is the primary advantage of saltatory conduction?

    <p>Saltatory conduction speeds up the transmission of action potentials by allowing them to &quot;jump&quot; between nodes of Ranvier. (D)</p> Signup and view all the answers

    How does the conduction of action potentials in myelinated axons differ from conduction in unmyelinated axons?

    <p>Myelinated axons use a specialized mechanism to generate action potentials called saltatory conduction, while unmyelinated axons use continuous conduction. (D)</p> Signup and view all the answers

    What is the primary reason for the rapid conduction of action potentials in myelinated axons?

    <p>Myelin sheaths act as insulators, preventing ion leakage and allowing faster propagation. (C)</p> Signup and view all the answers

    Why does the refractory period prevent backpropagation of the action potential in an unmyelinated axon?

    <p>The refractory period reduces the permeability of sodium channels, preventing depolarization of the previously activated segment. (B)</p> Signup and view all the answers

    What role does the axon hillock play in the conduction of action potentials in myelinated axons?

    <p>The axon hillock initiates action potential generation, similar to unmyelinated axons, but the action potential travels differently in myelinated axons. (D)</p> Signup and view all the answers

    What is the role of the axon hillock in the initiation and propagation of action potentials?

    <p>The axon hillock has a high concentration of sodium channels, making it the primary site of action potential initiation. (B)</p> Signup and view all the answers

    Why is the concentration of sodium and potassium ions important at the nodes of Ranvier in myelinated axons?

    <p>The concentration gradient of these ions allows for the rapid diffusion of ions across the membrane at the nodes, enabling action potential propagation. (D)</p> Signup and view all the answers

    How does the diameter of an unmyelinated axon affect the speed of action potential conduction?

    <p>A larger axon diameter increases conduction speed by decreasing the internal resistance to ion flow. (D)</p> Signup and view all the answers

    What is the primary reason for the faster conduction velocity of action potentials in myelinated axons compared to unmyelinated axons?

    <p>The presence of myelin reduces the resistance to ion flow, allowing for faster action potential propagation. (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of action potential propagation in myelinated axons?

    <p>Action potential propagation is continuous along the entire length of the axon. (C)</p> Signup and view all the answers

    Why is it important that the concentration of potassium voltage-gated channels is reduced in dendrites and the cell body?

    <p>To prevent the backpropagation of action potentials into the soma, ensuring unidirectional signal flow. (D)</p> Signup and view all the answers

    How does the initial depolarization trigger the opening of sodium voltage-gated channels, leading to the rising phase of the action potential?

    <p>The initial depolarization causes a conformational change in sodium channels, opening them up to allow sodium influx. (D)</p> Signup and view all the answers

    In what way does the presence of myelin influence the energy expenditure of the neuron during action potential conduction?

    <p>Myelin significantly decreases the energy expenditure due to the reduced number of membrane regions that need to be repolarized during an action potential. (D)</p> Signup and view all the answers

    What is meant by the statement "The Hodgkin-Huxley Cycle is Positive Feedback"?

    <p>The opening of sodium channels is a positive feedback loop, leading to further depolarization and more sodium channel opening. (C)</p> Signup and view all the answers

    In the context of action potential propagation, what does it mean for the current to spread along the membrane toward the terminals?

    <p>The current carries the depolarization signal along the axon membrane, initiating new action potentials in the subsequent segments. (C)</p> Signup and view all the answers

    Flashcards

    Depolarization

    The process during an action potential where the membrane potential becomes more positive due to Na+ influx.

    Voltage-gated Na+ channels

    Channels that open when a threshold is reached, allowing Na+ ions to flow into the cell, leading to depolarization.

    Falling Phase of Action Potential

    Phase where K+ channels open, allowing K+ to exit, causing repolarization of the membrane back to resting potential.

    Repolarization

    Restoration of the membrane potential to a negative value after depolarization due to K+ efflux.

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    Refractory Period

    The period after an action potential when a neuron cannot fire another action potential, ensuring one-way transmission.

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    Hodgkin-Huxley Cycle

    A model describing how action potentials are generated in neurons through ion channel interactions and positive feedback.

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    Positive Feedback in AP

    A process where initial depolarization triggers more Na+ channels to open, accelerating the depolarization.

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    AP Propagation

    The process by which action potentials travel along an axon from the axon hillock to the terminals without losing strength.

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    Axon Hillock

    The part of the neuron where action potentials are initiated due to a high concentration of Na+ channels.

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    Unmyelinated Axon Conduction

    Action potentials travel along unmyelinated axons, relying on a sequential opening of Na+ channels.

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    Myelinated Axon

    An axon covered with myelin sheath that allows faster action potential propagation through saltatory conduction.

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    Saltatory Conduction

    A fast mode of action potential propagation in myelinated axons where impulses jump between nodes of Ranvier.

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    Myelin Insulation

    Layer of protein and lipid that prevents ion crossing the membrane, reducing current loss.

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    Nodes of Ranvier

    Gaps in myelin sheath where ion exchange occurs, allowing action potentials to jump between them.

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    Presynaptic Cell

    The neuron that sends the signal in a synapse, releasing neurotransmitters.

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    Postsynaptic Cell

    The neuron that receives a signal in a synapse, responding to neurotransmitters.

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    Electrical Synapse

    A type of synapse where ions pass directly between cells, allowing for rapid communication.

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    Chemical Synapse

    A synapse where neurotransmitters are released from presynaptic to postsynaptic cells across a gap.

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    Ions between cells

    Ions flow rapidly between cells, creating current.

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    Neurotransmitter Release

    Neurotransmitters are released from vesicles into the synaptic cleft through exocytosis.

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    Calcium Influx

    Action potentials cause Ca2+ to enter the presynaptic neuron, triggering neurotransmitter release.

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    Postsynaptic Binding

    Neurotransmitter binds to postsynaptic receptors, leading to depolarization or hyperpolarization.

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    First Messenger

    Some neurotransmitters bind to receptors to act as messengers, leading to cellular responses.

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    Integration of Inputs

    A postsynaptic neuron can integrate signals from multiple presynaptic neurons for a combined effect.

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    G-protein–coupled receptors

    Receptors that bind neurotransmitters and activate second messengers for cellular effects.

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    Exocytosis

    Process where neurotransmitters are released into the synaptic cleft after Ca2+ entry.

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    Neurotransmitter removal

    Neurotransmitters are cleared from synaptic cleft after action potentials stop.

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    Acetylcholine (ACh)

    A neurotransmitter that can stimulate or inhibit muscles depending on the receptor.

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    Nicotinic receptor

    An ionotropic receptor type that is a Na+ channel, leading to muscle contraction.

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    Muscarinic receptor

    A metabotropic receptor that can inhibit cardiac muscle contraction via G-proteins.

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    Ionotropic receptors

    Ligand-gated ion channels that respond directly to neurotransmitter binding.

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    Metabotropic receptors

    Receptors that affect post-synaptic cells via second messengers, causing complex responses.

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    Calcium ions (Ca2+)

    Ions that trigger neurotransmitter release when they enter the cytoplasm of axon terminals.

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    Study Notes

    Depolarization - Rising Phase of Action Potential (AP)

    • Action potentials (APs) rely on ion currents and voltage-gated channels
    • Sodium (Na+) channels are voltage-gated
    • Potassium (K+) channels are voltage-gated
    • K+ leak channels are always open (important note!)
    • At time zero (t=0), voltage-gated Na+ and K+ channels are closed
    • Stimulus opens the channels
    • Na+ channels open, sodium flows in, causing depolarization
    • Na+ channels close and inactivate, stopping Na+ influx
    • Peak depolarization is reached
    • This is the rising or depolarizing phase for AP

    Falling Phase of Action Potential (AP)

    • The falling phase of the AP depends on voltage-gated channels
    • K+ channels open, potassium flows out
    • This creates repolarization
    • K+ channels remain open after the membrane reaches resting potential
    • This causes a brief hyperpolarization
    • Na+/K+ pump returns ions to their original concentrations
    • Refractory period follows

    The Hodgkin-Huxley Cycle

    • The rising phase of the AP is positive feedback
    • Initial depolarization triggers opening of Na+ channels, increasing membrane permeability to Na
    • Increased Na+ flow results in further membrane depolarization, driving the positive feedback cycle

    Action Potential Propagation Along Axon

    • Action potentials begin at the axon hillock, rich in Na+ channels
    • Action potentials travel unchanged along the axon membrane towards terminals
    • Dendrites and cell bodies have high K+ channel concentration, reducing backpropagation into the soma (cell body).

    Propagation of Action Potential

    • Action potentials travel along axons as depolarization spreads from one segment to the next
    • This occurs in both myelinated and unmyelinated axons

    Action Potential Conduction in Unmyelinated Axon

    • Threshold is reduced at the axon hillock (spike initiating zone)
    • High concentration of Na+ channels is present
    • Current spreads along the membrane towards terminals (creating new APs)

    Action Potential Conduction in Unmyelinated Axon (Time = 1)

    • Adjacent (downstream) Na+ channels reach threshold from the large depolarization
    • Refractory period is crucial, preventing backpropagation

    Action Potential Conduction in Unmyelinated Axon (Time = 2)

    • Next adjacent (downstream) Na+ channels reach threshold
    • Axon diameter determines conduction speed (larger = faster, up to 40 m/s)
    • This is typical of most invertebrates

    Saltatory Conduction

    • In myelinated axons, ions flow across the plasma membrane only at nodes where the myelin sheath is interrupted
    • Action potentials rapidly skip from node to node
    • Saltatory conduction allows many fast-transmitting axons to be packed into a smaller diameter

    Action Potential Conduction in Myelinated Axon

    • Myelin (protein and lipid) prevents ion flow across the membrane, reducing current loss
    • Concentration of Na+ and K+ channels is at the nodes
    • This enables ions to cross the membrane

    Action Potential Conduction in Myelinated Axon (Time = 0)

    • Active node at peak of action potential
    • Adjacent inactive node is spreading depolarization, soon reaching threshold
    • Other nodes are still at resting potential.

    Action Potential Conduction in Myelinated Axon (Time = 1)

    • Previous active node returns to resting potential, in refractory period
    • Adjacent node was brought to threshold by local current flow and is now active, at peak of action potential
    • New adjacent inactive node is spreading depolarization, will soon reach threshold

    Action Potential Conduction in Myelinated Axon (Time = 2)

    • Previous active node returns to resting potential and is in a longer refractory period
    • Adjacent node that was brought to threshold (by local current flow) is now active at peak of action potential
    • Saltatory (jumping) conduction, from node to node, eventually reaches terminals.
    • Higher conduction velocities (up to 100 m/s) are characteristic of vertebrates

    Synaptic Transmission

    • Synapses are the sites where neurons communicate with other neurons or effectors
    • Presynaptic cells send signals, postsynaptic receive them
    • Electrical and chemical synapses are the two types
    • The chemical synapses use neurotransmitters and a neurotransmitter receptor
    • Neurotransmitters that bind to ligand-gated ion channels, cause rapid effects (e.g., Na+,K+,Cl-)
    • neurotransmitters that bind to G-protein-coupled receptors, initiate slower, more complex cellular responses (e.g. second messenger cascades)
    • Summation is either excitory or inhibitory, adding effects
    • Neurotransmitter release stops when action potentials cease arriving, neurotransmitters are removed from synaptic cleft
    • Neurotransmitters are broken down by enzymes or taken up by the axon terminal or glial cells

    Experimental Research: Demonstration of Chemical Transmission of Nerve Impulses

    • Heart experiments demonstrate chemical transmission
    • Heart 1 connected to vagus nerve , Stimulating Heart 1 shows rapid reaction
    • Heart 2 not connected to vagus nerve, receives the solution, shows delayed reaction (same as heart 1).

    Neurotransmitters Work in Two Ways

    • Some neurotransmitters bind directly to ligand-gated ion channels in the postsynaptic membrane, opening or closing the channels rapidly
    • Other neurotransmitters work more slowly, acting as first messengers, binding to G-protein-coupled receptors to initiate intracellular signaling cascades; leading to the opening or closing of gated channels, triggering a second messenger

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    Test your knowledge on the depolarization and falling phases of action potentials. Explore the role of voltage-gated sodium and potassium channels and understand the Hodgkin-Huxley cycle. Perfect for students studying neuroscience or physiology.

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