Neuroplasticity and Recovery Mechanisms
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Questions and Answers

Which of the following is NOT a characteristic of experience-dependent plasticity?

  • Involved with learning and memory
  • Involves persistent, long-lasting changes in the strength of synapses between neurons and within neural networks
  • Can only occur in the central nervous system (correct)
  • Requires synthesis of new proteins, growth of new synapses, and modifications of existing synapses
  • What is the main difference between recovery and compensation in the context of neural plasticity?

  • Recovery is always better than compensation.
  • Recovery is faster than compensation.
  • Recovery involves restoring damaged tissue, while compensation involves using unaffected systems to perform tasks. (correct)
  • Compensation is only possible in the peripheral nervous system.
  • Which of the following is a cellular method of change related to neural plasticity?

  • Changes in blood flow to the brain
  • Long-term potentiation (LTP) (correct)
  • Hormonal changes
  • Increased production of neurotransmitters
  • How does long-term potentiation (LTP) affect the postsynaptic membrane?

    <p>It increases the surface area of the postsynaptic membrane. (C)</p> Signup and view all the answers

    What role does glutamate play in long-term potentiation (LTP)?

    <p>Glutamate binds to NMDA receptors, leading to an influx of calcium ions (Ca2+) into the postsynaptic neuron. (A)</p> Signup and view all the answers

    Which of the following is an example of a maladaptive change related to neural plasticity?

    <p>The development of phantom limb pain after an amputation (A)</p> Signup and view all the answers

    What happens to synapses during long-term depression (LTD)?

    <p>They are weakened and less likely to fire. (A)</p> Signup and view all the answers

    What does the phrase "neural plasticity is not always a positive thing" mean in the context of the provided text?

    <p>Neural plasticity can lead to negative outcomes like maladaptive recovery or phantom limb pain. (D)</p> Signup and view all the answers

    What is the primary reason that axonal regeneration does not occur in the CNS?

    <p>The absence of neurotrophic factors like Nerve Growth Factor (NGF) (D)</p> Signup and view all the answers

    Which of the following is NOT a principle of experience-dependent neuroplasticity?

    <p>Adaptation matters (C)</p> Signup and view all the answers

    Which brain structure is primarily responsible for receiving autonomic afferents?

    <p>Hypothalamus (B)</p> Signup and view all the answers

    What is the primary source of descending pathways from the CNS to target tissues for the somatic nervous system?

    <p>Cerebral Cortex (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the autonomic nervous system?

    <p>It is responsible for conscious perception (A)</p> Signup and view all the answers

    What is the primary function of the sympathetic nervous system?

    <p>Fight or flight (B)</p> Signup and view all the answers

    How do the sympathetic and parasympathetic nervous systems interact?

    <p>They can both innervate the same organs and work in concert or opposition. (B)</p> Signup and view all the answers

    Which of the following is an example of 'use it or lose it' principle of neuroplasticity?

    <p>Losing muscle mass due to inactivity (A)</p> Signup and view all the answers

    What aspect of the autonomic nervous system differentiates it from the somatic nervous system?

    <p>The presence of two neurons in the autonomic nervous system, with a synapse outside the CNS (B)</p> Signup and view all the answers

    How does the CNS respond to injury compared to the PNS?

    <p>The CNS has a limited capacity for regeneration while the PNS has a more robust capacity (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the sympathetic nervous system?

    <p>Stimulates digestive activity (D)</p> Signup and view all the answers

    The parasympathetic nervous system is primarily responsible for:

    <p>Promoting energy conservation and storage (B)</p> Signup and view all the answers

    Which of the following neurotransmitters is primarily released at postganglionic parasympathetic nerve terminals?

    <p>Acetylcholine (C)</p> Signup and view all the answers

    What is the primary function of the autonomic afferent system?

    <p>Receiving sensory information from the viscera (B)</p> Signup and view all the answers

    Which type of receptor is responsible for sensing changes in blood pressure?

    <p>Mechanoreceptors (B)</p> Signup and view all the answers

    What is the main role of the medulla in autonomic function?

    <p>Controlling heart rate, respiration, and blood vessel diameter (A)</p> Signup and view all the answers

    What is the most severe form of Spina Bifida?

    <p>Myeloschisis (A)</p> Signup and view all the answers

    What is the name of the developmental deformity of the hindbrain that can cause pressure on the brainstem?

    <p>Arnold-Chiari Malformation (C)</p> Signup and view all the answers

    During which stage of nervous system development does the neural tube form?

    <p>Embryonic (A)</p> Signup and view all the answers

    What is the primary function of the radial glia during nervous system development?

    <p>Guiding neurons to their correct positions (C)</p> Signup and view all the answers

    Which embryonic layer gives rise to the nervous system?

    <p>Ectoderm (A)</p> Signup and view all the answers

    What is the term for the group of muscles innervated by a single spinal nerve?

    <p>Myotome (C)</p> Signup and view all the answers

    Which of the following brain regions develops from the prosencephalon?

    <p>Cerebral hemispheres (D)</p> Signup and view all the answers

    What is a common characteristic of autism spectrum disorders?

    <p>Difficulty with social interactions and communication (C)</p> Signup and view all the answers

    Which of the following clinical conditions is NOT associated with autonomic nervous system dysfunction?

    <p>Multiple Sclerosis (D)</p> Signup and view all the answers

    What is the primary symptom associated with Horner's Syndrome?

    <p>Constricted pupil and drooping eyelid (D)</p> Signup and view all the answers

    What is the primary role of brain-derived neurotrophic factor (BDNF) in neural plasticity?

    <p>It directly promotes the growth and differentiation of new neurons and synapses. (C)</p> Signup and view all the answers

    How does experience-expectant plasticity relate to the development of ocular dominance columns?

    <p>Experience-expectant plasticity is the process responsible for the establishment of ocular dominance columns during early visual development. (C)</p> Signup and view all the answers

    What is the primary implication of the 'critical period' concept in relation to language acquisition?

    <p>If exposure to a second language occurs after puberty, it may result in limitations in vocabulary and grammar. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of normal (adaptive) cortical map plasticity?

    <p>The size and resolution of cortical maps are primarily dependent on genetics rather than sensory experience. (C)</p> Signup and view all the answers

    What is the primary mechanism observed in animal studies for recovery of hand function following stroke damage to the primary motor cortex?

    <p>A transfer of function occurs, utilizing alternative cortical areas for control. (C)</p> Signup and view all the answers

    What is the main principle behind Constraint-Induced Movement Therapy (CIMT) for stroke recovery?

    <p>CIMT forces the use of the affected limb for functional activities, promoting neural reorganization and plasticity. (A)</p> Signup and view all the answers

    What is the primary cellular mechanism involved in habituation, a decrease in response to a repetitive, benign stimulus?

    <p>Decreased release of excitatory neurotransmitters and potentially a decrease in free intracellular Ca2+. (C)</p> Signup and view all the answers

    What is the primary distinction between collateral sprouting and regenerative sprouting in the PNS response to axon damage?

    <p>Collateral sprouting involves branches of intact axons reinnervating the denervated axon. (C)</p> Signup and view all the answers

    What is Wallerian degeneration?

    <p>The degeneration of the distal segment of an axon following injury, including myelin sheath breakdown. (D)</p> Signup and view all the answers

    Which of the following is NOT a factor that influences recovery from CNS damage?

    <p>The ability of damaged axons to regenerate and form new synapses. (A)</p> Signup and view all the answers

    Which of the following statements about the effects of exercise on brain plasticity is TRUE?

    <p>Exercise induces increases in BDNF, mRNA, and proteins, impacting various brain regions. (D)</p> Signup and view all the answers

    How does the concept of plasticity relate to the resolution of cortical maps?

    <p>The resolution of cortical maps is influenced by the density of innervation and can be altered by changes in sensory input. (D)</p> Signup and view all the answers

    Which of the following is a key difference between how the CNS and PNS respond to axon damage?

    <p>The CNS has limited to no capacity for axon regeneration, unlike the PNS. (A)</p> Signup and view all the answers

    Which of the following is an example of a clinical implication of habituation?

    <p>Gradually exposing someone to a feared stimulus to reduce anxiety. (D)</p> Signup and view all the answers

    Which of the following are mechanisms associated with motor recovery after stroke damage to the primary motor cortex? (Select all that apply)

    <p>Activation of bilateral cortices. (A), Shifting activity to the ipsilateral hemisphere. (B), Dendritic growth and proliferation in alternative cortical areas. (D)</p> Signup and view all the answers

    Flashcards

    Neural Plasticity

    The ability of the nervous system to change functions, chemical profiles, or structures based on experience.

    Recovery vs. Compensation

    Recovery restores damaged brain functions; compensation involves unaffected systems taking over for the damaged ones.

    Experience-Dependent Plasticity

    Changes in cellular structure related to experiences; involves synapse strength and networks.

    Long-Term Potentiation (LTP)

    The process where repeated use of a synapse strengthens its connection.

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    Long-Term Depression (LTD)

    The process where lack of use leads to the weakening of a synapse.

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    Synaptic Changes

    Involves increasing/decreasing synapses and receptor density, affecting behavior and performance.

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    Glutamate in LTP

    Glutamate binds to NMDA receptors, allowing calcium to enter and activate AMPA receptors.

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    Maladaptive Plasticity

    Neural plasticity that does not result in positive recovery, often leads to dysfunctional changes.

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    CNS Response

    The CNS response is limited, showing Wallerian degeneration and chromatolysis, with no axonal regeneration.

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    Glial Scars

    Glial scars formed by astrocytes and microglia block regeneration in the CNS.

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    Plasticity

    Plasticity involves the ability of the CNS to adapt and reorganize, particularly in response to training or environmental changes.

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    Critical Period

    A critical period is a specific time during development when environmental stimuli profoundly impact brain development.

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    Experience-Dependent Neuroplasticity Principle 1

    Use it or lose it: Neural circuits are maintained through use; lack of use leads to loss.

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    Autonomic Nervous System (ANS)

    The ANS controls involuntary functions and maintains homeostasis in internal organs.

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    Sympathetic vs. Parasympathetic

    The ANS has two divisions: sympathetic (fight or flight) and parasympathetic (rest and digest).

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    Somatic vs. Autonomic Nervous System

    The somatic nervous system controls voluntary movements, while the autonomic nervous system manages involuntary functions.

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    Dual Innervation

    Most organs receive signals from both the sympathetic and parasympathetic divisions of the ANS.

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    Efferent Pathways

    Somatic efferent pathways involve one neuron to skeletal muscles; autonomic pathways usually involve two neurons with a synapse outside the CNS.

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    PSNS

    Parasympathetic Nervous System, most active at rest.

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    SNS

    Sympathetic Nervous System, active during stress or exercise.

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    ANS Efferent System

    Regulates visceral activities to maintain internal stability.

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    Sympathetic Division

    Thoracolumbar division with short preganglionic fibers and long postganglionic fibers.

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    Parasympathetic Division

    Craniosacral division with long preganglionic fibers and short postganglionic fibers.

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    Autonomic Afferents

    Sensory fibers that carry information from visceral organs to the CNS.

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    Visceral Receptors

    Receptors that detect internal stimuli like pressure and stretch.

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    Baroreceptor Reflex

    Regulates blood pressure by triggering heart rate changes as needed.

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    Micturition Reflex

    Reflex responsible for the urge to urinate.

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    Anencephaly

    Failure of the anterior neural tube to close, resulting in brain malformation.

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    Spina Bifida

    Failure of the posterior neural tube to close, leading to bony defects.

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    Cerebral Palsy

    Permanent movement and postural disorder due to brain damage.

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    Autism Spectrum Disorders

    Range of behavioral abnormalities including social skill deficits.

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    Diencephalon

    A secondary vesicle that develops into the thalamus and hypothalamus.

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    Neural Tube Formation Defects

    Conditions arising from failure of the neural tube to close during development.

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    LTP

    Long-Term Potentiation, a process enhancing synaptic strength due to increased activity.

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    LTD

    Long-Term Depression, a process that weakens synaptic strength.

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    BDNF

    Brain-Derived Neurotrophic Factor, a protein that supports neuronal survival and growth.

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    Experience-Expectant Plasticity

    Neuronal changes during development based on expected experiences.

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    Ocular Dominance Columns

    Regions in the visual cortex that respond preferentially to input from one eye.

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    Congenital Cataract

    A condition that can disrupt the development of ocular dominance columns.

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    Strabismus

    A condition where the eyes do not properly align, affecting visual development.

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    Reorganization of Cortical Maps

    Adjustment of functional areas in the brain after injury or experience.

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    Synaptogenesis

    The formation of new synapses in the brain following injury or experience.

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    Constraint-Induced Movement Therapy (CIMT)

    A rehabilitation strategy that encourages use of affected limbs by restricting unaffected ones.

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    Habituation

    Decreased response to a benign, repeated stimulus over time.

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    Wallerian Degeneration

    Process of degeneration occurring in the distal part of an injured axon.

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    PNS Response to Injury

    Peripheral Nervous System's ability to regenerate following damage.

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    Study Notes

    Neural Plasticity

    • Nervous system's ability to change functions, chemical profiles, or structures, shaped by experience.
    • Cannot change without experience.
    • Differences exist between Central Nervous System (CNS) and Peripheral Nervous System (PNS) in plasticity methods.
    • Reorganization of structure, function, and connections in response to intrinsic and extrinsic stimuli.
    • Can be observed as changes in individual neurons or entire systems.
    • Maladaptive recovery is possible, not always positive.

    Recovery vs. Compensation

    • Recovery: Restoration of damaged brain functions and neural tissues.
    • Compensation: Unaffected systems taking over damaged ones (undesirable).

    Experience-Dependent Plasticity

    • Changes in cellular structure (synapses, receptor density) are involved.
    • Leads to alterations in neural networks, behavior, and task performance.
    • Involves long-lasting changes in synaptic strength within neural networks.
    • Crucial for learning and memory; requires new protein synthesis, synapse growth, and existing synapse modifications.

    Long-Term Potentiation (LTP)

    • Repeated use of a synapse strengthens the connection.
    • Conversion of “silent” synapses (lacking certain receptors) to active ones over time.
    • Changes in postsynaptic membrane shape (increased surface area).
    • Generation of new dendritic spines and synapses.
    • Involves glutamate receptors (NMDA, AMPA).
    • Glutamate binding to NMDA triggers Ca2+ influx.
    • Ca2+ influx activates AMPA receptors, making the postsynaptic membrane more likely to depolarize upon glutamate release.

    Long-Term Depression (LTD)

    • Lack of synapse use leads to removal of AMPA receptors.
    • Can result in loss of dendritic spines.
    • Postsynaptic membrane is less likely to depolarize when glutamate is released.

    Brain-Derived Neurotrophic Factor (BDNF)

    • Neurotrophic protein influencing neural plasticity.
    • Supports existing neuron survival, new neuron and synapse growth/differentiation.
    • Supports axonal and dendritic sprouting.
    • Marker of plasticity, crucial for recovery processes.

    Experience-Expectant Plasticity (Developmental Neuronal Plasticity)

    • Changes in CNS organization during development.
    • Example: Ocular dominance columns critical for binocular vision and depth perception.
    • Early visual development can be disrupted by conditions like congenital cataracts and strabismus.

    Critical Periods

    • Limited time frames for optimal development of specific functions.
    • Vision's Critical Period: Visual cortex neuronal wiring is malleable during a critical time.
    • Language's Critical Period: Native fluency is more likely during early childhood language exposure.
    • Hearing's Critical Period: Cochlear implants are most effective when implanted early.

    Normal (Adaptive) Cortical Map Plasticity

    • Innervation density affects cortical map resolution (ex: Motor and somatosensory homunculi).
    • Homunculus maps vary in size, but the topographical order generally remains stable.

    Cortical Map Plasticity in Response to Injury

    • High innervation density in digit-related areas.
    • Animal studies show cortical redistribution following digit removal.

    Plasticity and CNS Damage Recovery

    • Recovery depends on age, injury extent/location, pathology, and rehabilitation implementation.
    • Reorganization is generally within the affected system.
    • Examples include motor recovery after stroke.

    Recovery from Stroke

    • Animal studies show increased synaptogenesis and dendritic remodeling after stroke.
    • Training can upregulate BDNF, linked to recovery.
    • Hand function recovery may involve activity shifts to alternative cortical areas (ipsilateral hemisphere, bilateral cortices).

    Exercise and Plasticity

    • Exercise increases BDNF, mRNA, and proteins in brain regions (cerebral cortex, cerebellum, spinal cord).

    Intervention Strategies

    • Constraint-induced movement therapy (CIMT) forces use of affected extremities.
    • High-intensity treadmill training

    Habituation

    • Decrease in response to repeated stimuli.
    • Potential cellular mechanisms: reduced excitatory neurotransmitter release, decreased intracellular Ca2+ release.
    • Prolonged repetition leads to more permanent structural changes, potentially decreasing synapse numbers.

    Cellular Recovery After Injury

    • CNS: Limited axonal regeneration due to lack of nerve growth factor (NGF) and glial scar formation.
    • PNS: More robust regeneration due to NGF within Schwann cells and greater collateral/regenerative sprouting potential.

    Principles to Enhance Experience-Dependent Neuroplasticity

    • Use it or lose it: Maintain relevant activity levels.
    • Use it and improve it: Optimize activity quality for desired changes.
    • Specificity: Focused tasks promote targeted improvements.
    • Repetition: Repeated engagement yields stronger results.
    • Intensity: Optimal intensity promotes optimal response.
    • Time: Consistent engagement over a period leads to greater change.

    Autonomic Nervous System

    • Maintains homeostasis through regulation of internal organs.
    • Influencing smooth muscle, cardiac muscle, secretory glands, and visceral targets.
    • Two main divisions: sympathetic ("fight or flight" ) & parasympathetic ("rest and digest").

    Similarities/Differences, Somatic & Autonomic

    • Similarities: Both have afferent and efferent fibers.
    • Differences:
      • Autonomic regulation typically nonconscious, hormonal.
      • Internal organs function independent of CNS input.
      • Somatic efferent: one neuron; autonomic: two neurons with a synapse outside CNS.

    General Physiological Differences, SNS/PSNS

    • SNS: Increases energy use, "fight or flight".
    • PSNS: Most active at rest, conserving energy for digestion/restoration.

    Autonomic Afferents

    • Originate from visceral receptors and blood vessels.
    • Enter spinal cord or brainstem via dorsal roots/cranial nerves.
    • Types of receptors: mechanoreceptors, chemoreceptors, nociceptors, thermoreceptors.

    Referred Pain

    • Visceral and somatic afferents converge; visceral pain may seem to emanate from a different somatic region.

    Control of Autonomic Function

    • Medulla, pons, hypothalamus, thalamus, and limbic systems regulate.

    Functions, SNS/PSNS

    • SNS: Increased HR, BP, blood glucose, respiration, digestion inhibition; vital for stressful situations.
    • PSNS: Increased digestion, B&B function, energy conservation; important for rest.

    ANS Dysfunction

    • Peripheral nerve injuries, spinal cord lesions, brainstem/cerebral involvement can cause ANS issues.
    • Disorders: hypertension, postural hypotension, syncope, etc.

    Horner's Syndrome

    • Caused by loss of sympathetic innervation.
    • Signs: miosis (pupil constriction), ptosis (drooping eyelid), anhidrosis (lack of sweat).

    Autonomic Dysreflexia

    • Life-threatening condition (spinal cord injury above T6).
    • Characterized by sudden high BP, headache, and sweating.
    • Treated by promptly sitting the affected person upright.

    Development of Nervous System

    • Stages: pre-embryonic, embryonic, fetal
    • Neurulation forms neural tube (CNS).
    • Cell proliferation, migration, differentiation, and synaptogenesis occur.
    • Myelination begins during fetal development.
    • Susceptibility to malformations between week 2 and 20 of gestation.

    Neural Tube Formation Defects

    • Anencephaly: Absence of brain structures, typically fatal.
    • Spina bifida (occulta, cystica, myelomeningocele): Varying degrees of spinal cord exposure.
    • Arnold-Chiari malformation: Hindbrain herniation.
    • Tethered spinal cord: Spinal cord attachment issues.

    Cerebral Palsy

    • Nonprogressive movement and postural disorder.
    • Caused by brain damage.
    • Various types: spastic, dyskinetic, ataxic, hypotonic, mixed.

    Autism Spectrum Disorders

    • Range of social and communication deficits, repetitive behaviors, limited interests.
    • Brain differences observed (reduced inter-cerebral communication, larger amygdala).

    Clinical Implications of Development

    • Crucial role of prenatal care (folate for neural tube defects).
    • Critical periods in the developing nervous system.
    • Variations between developing and matured nervous systems.

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    Description

    Explore the concepts of neural plasticity, recovery, and compensation in the nervous system. This quiz delves into how experiences shape brain function, structural changes, and the differences between compensation and recovery. Test your understanding of these critical processes in neuroscience.

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