Neurophysiology Lecture Quiz: Excitability and Ion Channels
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Questions and Answers

What determines if a channel is open or not?

Channel activation or gating mechanisms

Describe the different states of a sodium channel during an action potential.

Resting/deactivated, Activated, Inactivated

What ion movement underlies the membrane depolarization during an action potential?

Entry of Na+ ions

What process leads to the repolarization of the cell membrane after depolarization?

<p>Opening of K+ channels</p> Signup and view all the answers

What is the significance of Na+ channels in the initiation of an action potential?

<p>Na+ channels need to open to initiate an action potential</p> Signup and view all the answers

Explain the concept of equilibrium potential in relation to Na+ ions during an action potential.

<p>Na+ ions move towards equilibrium, changing the balance of charges across the membrane</p> Signup and view all the answers

What is the basis of nerve conduction?

<p>Ions flowing through ion channels in excitable membranes</p> Signup and view all the answers

Explain the ionic basis of action potential with reference to the ECG.

<p>Changes in Na+, K+, and Ca++ concentrations lead to depolarization and repolarization seen in the ECG.</p> Signup and view all the answers

What role do ion channels play in excitability?

<p>Ion channels allow current flow across the membrane, increasing flow when open.</p> Signup and view all the answers

Outline what makes a membrane excitable.

<p>The presence of ion channels and ionic gradients make a membrane excitable.</p> Signup and view all the answers

Explain the basis of the membrane potential.

<p>The membrane potential is the result of electrical and chemical gradients across the cell membrane, allowing for the movement of ions.</p> Signup and view all the answers

How do ion channels contribute to membrane excitability?

<p>Ion channels can activate, deactivate, and modulate, allowing for the controlled flow of ions and changes in membrane potential.</p> Signup and view all the answers

What is the resting membrane potential primarily determined by?

<p>Permeability to K+</p> Signup and view all the answers

During which phase of the myocyte action potential does activation of voltage-gated Na+ channels occur?

<p>Phase 0</p> Signup and view all the answers

What is the 'plateau' phase of the myocyte action potential characterized by?

<p>Inward current through slowly activating and inactivating voltage-gated Ca++ channels.</p> Signup and view all the answers

What is the primary cause of early repolarization during the myocyte action potential?

<p>Inactivation of Na+ channels</p> Signup and view all the answers

How is repolarization phase achieved in the myocyte action potential?

<p>Inactivation of Ca++ channels and increase in permeability to K+</p> Signup and view all the answers

Why might injection of a bolus of KCl lead to heart failure?

<p>Due to the disruption of the ionic balance and potential effects on action potentials in the heart.</p> Signup and view all the answers

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