Neurophysiology and Brain Metabolism
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Questions and Answers

What percentage of total body oxygen consumption is the adult brain responsible for?

  • 10%
  • 20% (correct)
  • 30%
  • 40%
  • What is the normal cerebral blood flow (CBF) in mL/100 g/min?

  • 50 (correct)
  • 30
  • 40
  • 60
  • How long of global ischemia can potentially cause irreversible injury to the brain?

  • 6-7 minutes
  • 4-5 minutes (correct)
  • 8-10 minutes
  • 2-3 minutes
  • What does CPP stand for in the context of neurophysiology?

    <p>Cerebral Perfusion Pressure</p> Signup and view all the answers

    What is the difference between mean arterial pressure (MAP) and either intracranial pressure (ICP) or central venous pressure (CVP) called?

    <p>Cerebrovascular Resistance (CVR)</p> Signup and view all the answers

    How does the brain regulate blood flow in response to moderate changes in mean arterial pressure (MAP) or cerebral perfusion pressure (CPP)?

    <p>It increases blood flow to maintain a consistent CBF</p> Signup and view all the answers

    What is the approximate range for the lower limit of autoregulation (LLA) of cerebral blood flow (CBF)?

    <p>60 to 100 mmHg</p> Signup and view all the answers

    Which phase of autoregulation responds to changes in systolic systemic blood pressure?

    <p>Rapid phase (dynamic autoregulation)</p> Signup and view all the answers

    What happens to cerebral blood flow (CBF) above the upper limit of autoregulation?

    <p>Becomes pressure-dependent</p> Signup and view all the answers

    What are the two types of autoregulation identified in the text?

    <p>Dynamic autoregulation and static autoregulation</p> Signup and view all the answers

    What physiological parameter besides mean arterial pressure (MAP) plays an important role in regulating cerebral blood flow (CBF)?

    <p>Arterial oxygen tension (PaO2)</p> Signup and view all the answers

    What effect does hypercapnia (elevated PaCO2) have on cerebral blood flow (CBF)?

    <p>Increases CBF</p> Signup and view all the answers

    How is regional cerebral blood flow (CBF) governed?

    <p>By a combination of humoral and neurogenic factors</p> Signup and view all the answers

    What effect do potent volatile anesthetics have on cerebral blood flow (CBF)?

    <p>Increase CBF</p> Signup and view all the answers

    What effect does nitrous oxide have on cerebral blood flow (CBF)?

    <p>Increase CBF</p> Signup and view all the answers

    What happens to spinal cord perfusion pressure (SCPP) when spinal subarachnoid space pressure (SSSP) increases?

    <p>SCPP decreases</p> Signup and view all the answers

    Which of the following substances has a cerebral vasoconstrictive effect?

    <p>Endothelin</p> Signup and view all the answers

    What effect do opioids have on cerebral blood flow (CBF)?

    <p>No effect on CBF</p> Signup and view all the answers

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