Neurophysiology and Brain Metabolism

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Questions and Answers

What percentage of total body oxygen consumption is the adult brain responsible for?

  • 10%
  • 20% (correct)
  • 30%
  • 40%

What is the normal cerebral blood flow (CBF) in mL/100 g/min?

  • 50 (correct)
  • 30
  • 40
  • 60

How long of global ischemia can potentially cause irreversible injury to the brain?

  • 6-7 minutes
  • 4-5 minutes (correct)
  • 8-10 minutes
  • 2-3 minutes

What does CPP stand for in the context of neurophysiology?

<p>Cerebral Perfusion Pressure (D)</p> Signup and view all the answers

What is the difference between mean arterial pressure (MAP) and either intracranial pressure (ICP) or central venous pressure (CVP) called?

<p>Cerebrovascular Resistance (CVR) (C)</p> Signup and view all the answers

How does the brain regulate blood flow in response to moderate changes in mean arterial pressure (MAP) or cerebral perfusion pressure (CPP)?

<p>It increases blood flow to maintain a consistent CBF (B)</p> Signup and view all the answers

What is the approximate range for the lower limit of autoregulation (LLA) of cerebral blood flow (CBF)?

<p>60 to 100 mmHg (D)</p> Signup and view all the answers

Which phase of autoregulation responds to changes in systolic systemic blood pressure?

<p>Rapid phase (dynamic autoregulation) (C)</p> Signup and view all the answers

What happens to cerebral blood flow (CBF) above the upper limit of autoregulation?

<p>Becomes pressure-dependent (A)</p> Signup and view all the answers

What are the two types of autoregulation identified in the text?

<p>Dynamic autoregulation and static autoregulation (B)</p> Signup and view all the answers

What physiological parameter besides mean arterial pressure (MAP) plays an important role in regulating cerebral blood flow (CBF)?

<p>Arterial oxygen tension (PaO2) (B)</p> Signup and view all the answers

What effect does hypercapnia (elevated PaCO2) have on cerebral blood flow (CBF)?

<p>Increases CBF (B)</p> Signup and view all the answers

How is regional cerebral blood flow (CBF) governed?

<p>By a combination of humoral and neurogenic factors (A)</p> Signup and view all the answers

What effect do potent volatile anesthetics have on cerebral blood flow (CBF)?

<p>Increase CBF (B)</p> Signup and view all the answers

What effect does nitrous oxide have on cerebral blood flow (CBF)?

<p>Increase CBF (B)</p> Signup and view all the answers

What happens to spinal cord perfusion pressure (SCPP) when spinal subarachnoid space pressure (SSSP) increases?

<p>SCPP decreases (D)</p> Signup and view all the answers

Which of the following substances has a cerebral vasoconstrictive effect?

<p>Endothelin (A)</p> Signup and view all the answers

What effect do opioids have on cerebral blood flow (CBF)?

<p>No effect on CBF (D)</p> Signup and view all the answers

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