Neurons and Neural Circuits

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Questions and Answers

Which of the following sequences accurately describes the direction of signal flow within a single neuron?

  • Dendrites → Cell body → Axon (correct)
  • Axon → Cell body → Dendrites
  • Cell body → Dendrites → Axon
  • Dendrites → Axon → Cell body

If a neurotoxin specifically targets and destroys oligodendrocytes, which function would be most directly affected?

  • Immune response within the brain.
  • Regulation of the chemical environment around neurons.
  • Speed of signal transmission along neuronal axons in the CNS. (correct)
  • Reception of signals from other neurons.

Which of the following best describes the primary function of neural circuits within the nervous system?

  • Supporting neurons structurally and metabolically.
  • Acting as the brain's immune cells by removing waste and pathogens.
  • Integrating information across different brain regions for complex functions.
  • Processing information and generating responses. (correct)

Astrocytes play a crucial role in maintaining the neural environment. What is their primary method of achieving this?

<p>By regulating chemical concentrations and blood flow around neurons. (B)</p> Signup and view all the answers

What is the critical role of microglia within the central nervous system?

<p>Acting as the primary immune cells to remove waste and pathogens. (B)</p> Signup and view all the answers

Which cellular component facilitates communication between different brain regions to perform complex functions like memory and decision-making?

<p>Neural networks. (C)</p> Signup and view all the answers

The reflex arc is a basic neural circuit. Which of the following represents the correct sequence of neuron activation in a typical reflex arc?

<p>Sensory neuron → Interneuron → Motor neuron (B)</p> Signup and view all the answers

Which of the following glial cells is primarily responsible for myelinating axons in the peripheral nervous system (PNS)?

<p>Schwann Cells (B)</p> Signup and view all the answers

Which of the following ions, when entering a neuron, would most likely cause an inhibitory postsynaptic potential (IPSP)?

<p>Chloride (Cl⁻) (A)</p> Signup and view all the answers

A drug that blocks acetylcholinesterase would have which of the following effects on synaptic transmission?

<p>Increased levels of acetylcholine in the synapse (A)</p> Signup and view all the answers

Which neurotransmitter is primarily involved in regulating mood, sleep, and appetite, and is often associated with depression when present at low levels?

<p>Serotonin (B)</p> Signup and view all the answers

What is the primary function of the sodium-potassium pump (Na⁺/K⁺ ATPase) in maintaining a neuron's resting membrane potential?

<p>To restore the resting potential by pumping 3 Na⁺ out and 2 K⁺ in (A)</p> Signup and view all the answers

In the context of neurotransmitter clearance, which process involves transporter proteins removing neurotransmitters from the synaptic cleft back into the presynaptic neuron?

<p>Reuptake (A)</p> Signup and view all the answers

Which of the following neurotransmitters is primarily associated with excitatory neurotransmission in the brain?

<p>Glutamate (D)</p> Signup and view all the answers

How do voltage-gated ion channels contribute to the generation and propagation of action potentials in neurons?

<p>By opening or closing in response to changes in membrane voltage (B)</p> Signup and view all the answers

A patient is diagnosed with a neurological disorder characterized by impaired motor control and a lack of motivation. Deficiency in which neurotransmitter is most likely contributing to these symptoms?

<p>Dopamine (D)</p> Signup and view all the answers

Which glial cell type in the CNS is characterized by its ability to differentiate into myelin-producing cells and receive synaptic inputs from neurons?

<p>Polydendrocytes (NG2 cells) (B)</p> Signup and view all the answers

What is the primary function of microglia within the central nervous system?

<p>Detecting and removing harmful substances, including pathogens and damaged cells (A)</p> Signup and view all the answers

Ependymal cells line the ventricles of the brain and central canal of the spinal cord. What specialized structure on these cells facilitates the movement of cerebrospinal fluid (CSF)?

<p>Cilia, which generate a current to circulate CSF (B)</p> Signup and view all the answers

Which of the following best describes the role of the choroid plexus?

<p>Secreting cerebrospinal fluid (CSF) (C)</p> Signup and view all the answers

Dysfunction of ependymal cells can lead to which of the following conditions?

<p>Hydrocephalus (C)</p> Signup and view all the answers

During an action potential, which ion primarily moves into the neuron, causing depolarization?

<p>Sodium (Na⁺) (C)</p> Signup and view all the answers

Which of the following accurately describes the role of potassium (K⁺) ions in neurophysiology?

<p>K⁺ ions move out of the neuron during repolarization, helping restore the resting membrane potential. (D)</p> Signup and view all the answers

Considering the functions of microglia, what potential consequence could result from their overactivation in neurodegenerative diseases, such as Alzheimer's?

<p>Chronic inflammation and neuronal death (B)</p> Signup and view all the answers

How do some viruses, such as rabies and herpes, utilize neuronal structures to invade the nervous system?

<p>By hijacking the retrograde axonal transport system powered by dynein. (A)</p> Signup and view all the answers

What is the most significant role of dendritic spines in neuronal function?

<p>To increase the surface area available for synapse formation, enhancing connectivity. (C)</p> Signup and view all the answers

Which of the following components are critical for the function of the Postsynaptic density (PSD)?

<p>Neurotransmitter receptors, signaling proteins, and scaffolding molecules. (B)</p> Signup and view all the answers

What is the primary functional distinction between the axon hillock and the initial segment in a neuron?

<p>The axon hillock integrates signals to determine whether to fire an action potential, while the initial segment is the site of action potential generation. (A)</p> Signup and view all the answers

If a neuron's axon is damaged, disrupting its ability to transmit signals effectively, which glial cells would be involved in the myelination of the regenerating axon segment, and where?

<p>Schwann cells in the peripheral nervous system. (C)</p> Signup and view all the answers

How does myelination affect the conduction velocity of action potentials, and what is the underlying mechanism?

<p>It increases conduction velocity by reducing ion leakage and allowing saltatory conduction. (B)</p> Signup and view all the answers

Which structural feature of a neuron is most directly responsible for integrating incoming signals and determining whether an action potential will be initiated?

<p>Axon hillock. (C)</p> Signup and view all the answers

What is the functional consequence of a neurological disorder that impairs the dynamics (growth and change) of dendritic spines?

<p>Impaired learning and memory due to reduced synaptic plasticity. (B)</p> Signup and view all the answers

What is the primary role of voltage-gated potassium (K⁺) channels during the repolarization phase of an action potential?

<p>To allow potassium ions to exit the neuron, making the inside more negative. (C)</p> Signup and view all the answers

During the absolute refractory period, why is it impossible for a neuron to fire another action potential, regardless of stimulus strength?

<p>All voltage-gated sodium channels are either open or inactivated. (D)</p> Signup and view all the answers

How do voltage-gated calcium (Ca²⁺) channels contribute to neurotransmitter release at synapses?

<p>By allowing calcium to enter the neuron, triggering neurotransmitter release. (C)</p> Signup and view all the answers

A neuron is currently in its relative refractory period. Which of the following conditions must be met for the neuron to fire another action potential?

<p>A stronger-than-usual stimulus is required to overcome the hyperpolarization and the remaining open potassium channels. (B)</p> Signup and view all the answers

What is the status of voltage-gated Na⁺ and K⁺ channels when a neuron is at its resting state (-70mV)?

<p>Both Na⁺ and K⁺ channels are closed. (B)</p> Signup and view all the answers

How does the inactivation of voltage-gated Na⁺ channels contribute to the action potential?

<p>It prevents further influx of Na⁺, leading to the end of the depolarization phase. (B)</p> Signup and view all the answers

What is the primary function of the refractory period in neurons?

<p>To ensure one-way signal transmission and regulate the frequency of nerve impulses. (B)</p> Signup and view all the answers

During hyperpolarization, the membrane potential becomes more negative than the resting potential. What causes this?

<p>Slow closing of $K^+$ channels. (C)</p> Signup and view all the answers

In continuous conduction, why is more energy required compared to saltatory conduction?

<p>Because ion channels must open and close at every point along the axon. (D)</p> Signup and view all the answers

Which of the following best describes the role of myelin in neuronal signal transmission?

<p>It provides insulation, allowing the action potential to jump between Nodes of Ranvier. (A)</p> Signup and view all the answers

What is the primary function of synaptic vesicles within a neuron?

<p>To store and release neurotransmitters into the synaptic cleft. (D)</p> Signup and view all the answers

In which type of neuron would you expect to find saltatory conduction?

<p>Myelinated motor neurons where rapid responses are necessary. (C)</p> Signup and view all the answers

Which of the following axons would likely have the fastest conduction velocity?

<p>A large-diameter, myelinated axon. (C)</p> Signup and view all the answers

What differentiates dense-core vesicles from synaptic vesicles in neurons?

<p>Dense-core vesicles are larger and store neuropeptides. (A)</p> Signup and view all the answers

How does the diameter of an axon affect the speed of action potential propagation?

<p>A larger diameter increases speed by reducing resistance to ion flow. (B)</p> Signup and view all the answers

Which of the following is the best example of where continuous conduction is typically found?

<p>Pain and autonomic neurons where speed is less critical. (A)</p> Signup and view all the answers

Flashcards

Neuron

The fundamental unit of the nervous system that transmits signals.

Parts of a Neuron

Neurons consist of dendrites, cell body, and axon.

Dendrites

Extensions of neurons that receive signals from other neurons.

Cell Body (Soma)

Processes the signals received by dendrites.

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Axon

A long projection that transmits signals to other neurons or muscles.

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Neural Circuit

A group of interconnected neurons that work together to process information.

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Glial Cells

Non-neuronal cells providing support to neurons in the nervous system.

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Types of Glial Cells

Include astrocytes, oligodendrocytes, Schwann cells, and microglia.

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Dynein

A motor protein that powers transport in neurons.

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Dendritic spines

Small protrusions on dendrites where synapses form, enhancing connections.

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Postsynaptic densities (PSD)

Protein-rich structures on the postsynaptic side of a synapse, crucial for synaptic strength.

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Axon hillock

Cone-shaped junction where a neuron decides to fire an action potential.

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Initial segment

The start of the axon where action potentials are generated, rich in Na⁺ channels.

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Myelin

Fatty sheath around axons that increases the speed of electrical signals.

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Polydendrocytes

Glial cells in the CNS, also known as NG2 cells, that can develop into oligodendrocytes.

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Microglia

Immune cells of the CNS that detect and remove harmful substances.

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Ependymal Cells

Glial cells lining the ventricles that produce and regulate cerebrospinal fluid (CSF).

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Cerebrospinal Fluid (CSF)

Fluid produced by ependymal cells that cushions the brain and spinal cord.

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Hydrocephalus

Condition caused by dysfunction in ependymal cells leading to excess CSF accumulation.

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Ion Movements

Flow of charged particles across a neuron's membrane, crucial for electrical signals.

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Action Potentials

Electrical signals generated by ion movements in neurons.

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Key Ions in Neurophysiology

Sodium (Na⁺) and Potassium (K⁺) are essential for generating electrical signals in neurons.

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Voltage-Activated Ion Channels

Channels that open or close based on membrane voltage, selective for ions like Na⁺, K⁺, Ca²⁺.

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Voltage-Gated Sodium Channels

Channels that open during depolarization, allowing Na⁺ to flow into the neuron.

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Depolarization

Stage where the neuron's membrane potential becomes less negative, reaching ~ -55mV.

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Action Potential Peak

When the neuron's membrane potential reaches around +30mV, Na⁺ channels inactivate and K⁺ channels open.

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Repolarization

Stage where the membrane potential becomes more negative again as K⁺ leaves the neuron.

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Hyperpolarization

Stage when the neuron's membrane potential drops to ~ -80mV, becoming more negative than resting state.

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Absolute Refractory Period

Time during which no new action potential can be triggered, regardless of stimulus strength.

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Relative Refractory Period

Period after the absolute refractory period when stronger stimuli can trigger an action potential due to hyperpolarization.

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Chloride Ion (Cl⁻)

Moves into the neuron, making it more negative.

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Calcium Ion (Ca²⁺)

Essential for neurotransmitter release at synapses.

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Voltage-gated Channels

Channels that open or close in response to voltage changes.

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Ligand-gated Channels

Channels that open when neurotransmitters bind.

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Sodium-Potassium Pump

Restores resting potential by pumping Na⁺ out and K⁺ in.

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Excitatory Neurotransmitters

Increase neuronal activity, like glutamate and acetylcholine.

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Inhibitory Neurotransmitters

Decrease neuronal activity, like GABA and glycine.

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Neurotransmitter Clearance

Processes that remove neurotransmitters from the synapse.

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Continuous Conduction

Transmission of action potentials along unmyelinated axons where every segment depolarizes sequentially.

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Saltatory Conduction

Fast transmission of action potentials in myelinated axons by jumping between Nodes of Ranvier.

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Factors Affecting Velocity

Elements that influence how fast action potentials travel, including axon diameter and myelination.

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Axon Diameter

Larger axons conduct signals faster due to lower resistance and easier ion flow.

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Myelination

Presence of a fatty layer around axons that enhances conduction speed by enabling saltatory conduction.

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Vesicles

Small membrane-bound sacs in cells that store and transport substances like neurotransmitters.

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Synaptic Vesicles

Vesicles located in axon terminals that store and release neurotransmitters during synaptic transmission.

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Dense-Core Vesicles

Larger vesicles that store neuropeptides, used for signaling in the nervous system.

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Study Notes

Introduction to Neurophysiology

  • Neurophysiology is the study of ion movements across a membrane.
  • These movements initiate signal transduction and action potentials.
  • The study also encompasses neurotransmitters.

Cellular Components of the Nervous System

  • Neurons: Fundamental units transmitting electrical and chemical signals.
    • Consist of dendrites, cell body, and axon.
    • Communicate via electrical impulses and neurotransmitters at synapses.
  • Neural Circuits: Functional groups of neurons processing information and generating responses.
    • Form the basis of neural activity, from reflexes to complex thoughts.
  • Neural Networks: Large-scale interconnected systems of neurons.
    • Integrate information across different brain regions.
    • Crucial for complex functions like memory, decision-making.
  • Glial Cells: Non-neuronal cells providing structural and functional support.
    • Types include astrocytes, oligodendrocytes/Schwann cells, microglia, ependymal cells.
    • Crucial for maintaining the neural environment, protecting neurons, and aiding signal transmission.

Structure and Mechanisms of a Neuron

  • Action Potential: Rapid temporary electrical signal travelling down the axon.
    • Steps: resting state, depolarization, repolarization, hyperpolarization, refractory period, return to resting potential.
    • All-or-nothing principle: Action potential happens if stimulus reaches threshold otherwise no signals are sent.
  • Synapses: Junctions between neurons where communication Occurs.
    • Types: Electrical (direct ion flow) and Chemical (neurotransmitters).
    • Synaptic cleft: gap (~20-40nm) between pre and postsynaptic neurons.
    • Synaptic transmission: Signal moves across cleft via neurotransmitters.

Functional Organization of a Neuron

  • Soma (cell body): Contains the nucleus and cytoplasm for cellular functions.
  • Perikaryon: Cytoplasm of the soma, excluding the nucleus, critical for protein synthesis.
  • Nissl substance: Rough endoplasmic reticulum (RER) and ribosomes, critical for protein synthesis.
  • Microtubules: Hollow protein filaments for transport of molecules along the axon.
  • Anterograde transport: Movement of molecules from the soma to axon terminals.
  • Retrograde transport: Movement of molecules from axon terminals to the soma.
  • Dendrites: Treelike extensions receiving signals from other neurons.
  • Dendritic spines: Increase surface area and allow for more connections with other neurons, important for learning and memory.
  • Axon: Long, cable-like extension transmitting action potentials.
  • Axon hillock: Cone-shaped junction where the neuron determines whether to fire an action potential.
  • Initial segment: Part of the axon where action potentials are generated.
  • Myelin: Fatty insulating sheath speeding up signal transmission by saltatory conduction.

Types of Neurons

  • Multipolar neurons: Most common type. Have one axon and multiple dendrites.
  • Pseudounipolar neurons: Sensory neurons with one axon that splits into two branches.
  • Bipolar neurons: Rare type with one axon and one dendrite.

Types of Synapses

  • Axodendritic synapses: Most common, axon synapsing with dendrite.
  • Axosomatic synapses: Axon synapsing with cell body of neuron, high influence.
  • Axoaxonic synapses: Axon synapsing with another axon, influence neurotransmitter release.
  • Temporospatial summation: Neurons summing up inputs from multiple synapses to initiate an action potential.

Types of Glia

  • Oligodendrocytes: Produce myelin in the central nervous system.
  • Schwann cells: Produce myelin in the peripheral nervous system.
  • Astrocytes: Provide structural support, regulate ion balance, control blood flow.
  • Microglia: Immune cells of CNS, remove harmful substances.
  • Ependymal cells: Produce and circulate cerebrospinal fluid (CSF).

Basic Neurophysiology

  • Ion channels and pumps: Crucial for action potential generation (voltage-gated).
  • Action potential steps: Resting state, depolarization, repolarization, hyperpolarization, refractory period, return to resting state.
  • Refractory periods: Prevent signal overlap.
  • Continuous conduction: Unmyelinated axons; slower transmission.
  • Saltatory conduction: Myelinated axons; faster transmission.
  • Factors influencing velocity: Axon diameter and myelination.

Synaptic Transmission

  • Synaptic vesicles: Store neurotransmitters.
  • Neurotransmitters: Chemical messengers transmitting signals between neurons.
    • Types include excitatory (e.g., glutamate) and inhibitory (e.g., GABA).
  • Ionotropic receptors: Fast-acting, directly open ion channels.
  • Metabotropic receptors: Slower-acting, activate intracellular signaling cascades.
  • Synaptic signal transduction: Excitation and inhibition in postsynaptic neuron.

Neurotransmitters

  • Glutamate: Primary excitatory neurotransmitter in the brain
  • GABA: Main inhibitory neurotransmitter in the brain.
  • Glycine: Primary inhibitory neurotransmitter in the spinal cord.
  • Acetylcholine: Used in neuromuscular junctions and brain.
  • Biogenic amines (dopamine, serotonin, norepinephrine, histamine): Involved in various functions like mood, movement, and alertness.
  • ATP: Plays a role in synaptic modulation.
  • Neuropeptides (substance P, endorphins, enkephalins, oxytocin, neuropeptide Y): Longer-lasting effects influencing various functions.

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