Neurons and Neural Circuits
48 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following sequences accurately describes the direction of signal flow within a single neuron?

  • Dendrites → Cell body → Axon (correct)
  • Axon → Cell body → Dendrites
  • Cell body → Dendrites → Axon
  • Dendrites → Axon → Cell body
  • If a neurotoxin specifically targets and destroys oligodendrocytes, which function would be most directly affected?

  • Immune response within the brain.
  • Regulation of the chemical environment around neurons.
  • Speed of signal transmission along neuronal axons in the CNS. (correct)
  • Reception of signals from other neurons.
  • Which of the following best describes the primary function of neural circuits within the nervous system?

  • Supporting neurons structurally and metabolically.
  • Acting as the brain's immune cells by removing waste and pathogens.
  • Integrating information across different brain regions for complex functions.
  • Processing information and generating responses. (correct)
  • Astrocytes play a crucial role in maintaining the neural environment. What is their primary method of achieving this?

    <p>By regulating chemical concentrations and blood flow around neurons. (B)</p> Signup and view all the answers

    What is the critical role of microglia within the central nervous system?

    <p>Acting as the primary immune cells to remove waste and pathogens. (B)</p> Signup and view all the answers

    Which cellular component facilitates communication between different brain regions to perform complex functions like memory and decision-making?

    <p>Neural networks. (C)</p> Signup and view all the answers

    The reflex arc is a basic neural circuit. Which of the following represents the correct sequence of neuron activation in a typical reflex arc?

    <p>Sensory neuron → Interneuron → Motor neuron (B)</p> Signup and view all the answers

    Which of the following glial cells is primarily responsible for myelinating axons in the peripheral nervous system (PNS)?

    <p>Schwann Cells (B)</p> Signup and view all the answers

    Which of the following ions, when entering a neuron, would most likely cause an inhibitory postsynaptic potential (IPSP)?

    <p>Chloride (Cl⁻) (A)</p> Signup and view all the answers

    A drug that blocks acetylcholinesterase would have which of the following effects on synaptic transmission?

    <p>Increased levels of acetylcholine in the synapse (A)</p> Signup and view all the answers

    Which neurotransmitter is primarily involved in regulating mood, sleep, and appetite, and is often associated with depression when present at low levels?

    <p>Serotonin (B)</p> Signup and view all the answers

    What is the primary function of the sodium-potassium pump (Na⁺/K⁺ ATPase) in maintaining a neuron's resting membrane potential?

    <p>To restore the resting potential by pumping 3 Na⁺ out and 2 K⁺ in (A)</p> Signup and view all the answers

    In the context of neurotransmitter clearance, which process involves transporter proteins removing neurotransmitters from the synaptic cleft back into the presynaptic neuron?

    <p>Reuptake (A)</p> Signup and view all the answers

    Which of the following neurotransmitters is primarily associated with excitatory neurotransmission in the brain?

    <p>Glutamate (D)</p> Signup and view all the answers

    How do voltage-gated ion channels contribute to the generation and propagation of action potentials in neurons?

    <p>By opening or closing in response to changes in membrane voltage (B)</p> Signup and view all the answers

    A patient is diagnosed with a neurological disorder characterized by impaired motor control and a lack of motivation. Deficiency in which neurotransmitter is most likely contributing to these symptoms?

    <p>Dopamine (D)</p> Signup and view all the answers

    Which glial cell type in the CNS is characterized by its ability to differentiate into myelin-producing cells and receive synaptic inputs from neurons?

    <p>Polydendrocytes (NG2 cells) (B)</p> Signup and view all the answers

    What is the primary function of microglia within the central nervous system?

    <p>Detecting and removing harmful substances, including pathogens and damaged cells (A)</p> Signup and view all the answers

    Ependymal cells line the ventricles of the brain and central canal of the spinal cord. What specialized structure on these cells facilitates the movement of cerebrospinal fluid (CSF)?

    <p>Cilia, which generate a current to circulate CSF (B)</p> Signup and view all the answers

    Which of the following best describes the role of the choroid plexus?

    <p>Secreting cerebrospinal fluid (CSF) (C)</p> Signup and view all the answers

    Dysfunction of ependymal cells can lead to which of the following conditions?

    <p>Hydrocephalus (C)</p> Signup and view all the answers

    During an action potential, which ion primarily moves into the neuron, causing depolarization?

    <p>Sodium (Na⁺) (C)</p> Signup and view all the answers

    Which of the following accurately describes the role of potassium (K⁺) ions in neurophysiology?

    <p>K⁺ ions move out of the neuron during repolarization, helping restore the resting membrane potential. (D)</p> Signup and view all the answers

    Considering the functions of microglia, what potential consequence could result from their overactivation in neurodegenerative diseases, such as Alzheimer's?

    <p>Chronic inflammation and neuronal death (B)</p> Signup and view all the answers

    How do some viruses, such as rabies and herpes, utilize neuronal structures to invade the nervous system?

    <p>By hijacking the retrograde axonal transport system powered by dynein. (A)</p> Signup and view all the answers

    What is the most significant role of dendritic spines in neuronal function?

    <p>To increase the surface area available for synapse formation, enhancing connectivity. (C)</p> Signup and view all the answers

    Which of the following components are critical for the function of the Postsynaptic density (PSD)?

    <p>Neurotransmitter receptors, signaling proteins, and scaffolding molecules. (B)</p> Signup and view all the answers

    What is the primary functional distinction between the axon hillock and the initial segment in a neuron?

    <p>The axon hillock integrates signals to determine whether to fire an action potential, while the initial segment is the site of action potential generation. (A)</p> Signup and view all the answers

    If a neuron's axon is damaged, disrupting its ability to transmit signals effectively, which glial cells would be involved in the myelination of the regenerating axon segment, and where?

    <p>Schwann cells in the peripheral nervous system. (C)</p> Signup and view all the answers

    How does myelination affect the conduction velocity of action potentials, and what is the underlying mechanism?

    <p>It increases conduction velocity by reducing ion leakage and allowing saltatory conduction. (B)</p> Signup and view all the answers

    Which structural feature of a neuron is most directly responsible for integrating incoming signals and determining whether an action potential will be initiated?

    <p>Axon hillock. (C)</p> Signup and view all the answers

    What is the functional consequence of a neurological disorder that impairs the dynamics (growth and change) of dendritic spines?

    <p>Impaired learning and memory due to reduced synaptic plasticity. (B)</p> Signup and view all the answers

    What is the primary role of voltage-gated potassium (K⁺) channels during the repolarization phase of an action potential?

    <p>To allow potassium ions to exit the neuron, making the inside more negative. (C)</p> Signup and view all the answers

    During the absolute refractory period, why is it impossible for a neuron to fire another action potential, regardless of stimulus strength?

    <p>All voltage-gated sodium channels are either open or inactivated. (D)</p> Signup and view all the answers

    How do voltage-gated calcium (Ca²⁺) channels contribute to neurotransmitter release at synapses?

    <p>By allowing calcium to enter the neuron, triggering neurotransmitter release. (C)</p> Signup and view all the answers

    A neuron is currently in its relative refractory period. Which of the following conditions must be met for the neuron to fire another action potential?

    <p>A stronger-than-usual stimulus is required to overcome the hyperpolarization and the remaining open potassium channels. (B)</p> Signup and view all the answers

    What is the status of voltage-gated Na⁺ and K⁺ channels when a neuron is at its resting state (-70mV)?

    <p>Both Na⁺ and K⁺ channels are closed. (B)</p> Signup and view all the answers

    How does the inactivation of voltage-gated Na⁺ channels contribute to the action potential?

    <p>It prevents further influx of Na⁺, leading to the end of the depolarization phase. (B)</p> Signup and view all the answers

    What is the primary function of the refractory period in neurons?

    <p>To ensure one-way signal transmission and regulate the frequency of nerve impulses. (B)</p> Signup and view all the answers

    During hyperpolarization, the membrane potential becomes more negative than the resting potential. What causes this?

    <p>Slow closing of $K^+$ channels. (C)</p> Signup and view all the answers

    In continuous conduction, why is more energy required compared to saltatory conduction?

    <p>Because ion channels must open and close at every point along the axon. (D)</p> Signup and view all the answers

    Which of the following best describes the role of myelin in neuronal signal transmission?

    <p>It provides insulation, allowing the action potential to jump between Nodes of Ranvier. (A)</p> Signup and view all the answers

    What is the primary function of synaptic vesicles within a neuron?

    <p>To store and release neurotransmitters into the synaptic cleft. (D)</p> Signup and view all the answers

    In which type of neuron would you expect to find saltatory conduction?

    <p>Myelinated motor neurons where rapid responses are necessary. (C)</p> Signup and view all the answers

    Which of the following axons would likely have the fastest conduction velocity?

    <p>A large-diameter, myelinated axon. (C)</p> Signup and view all the answers

    What differentiates dense-core vesicles from synaptic vesicles in neurons?

    <p>Dense-core vesicles are larger and store neuropeptides. (A)</p> Signup and view all the answers

    How does the diameter of an axon affect the speed of action potential propagation?

    <p>A larger diameter increases speed by reducing resistance to ion flow. (B)</p> Signup and view all the answers

    Which of the following is the best example of where continuous conduction is typically found?

    <p>Pain and autonomic neurons where speed is less critical. (A)</p> Signup and view all the answers

    Flashcards

    Neuron

    The fundamental unit of the nervous system that transmits signals.

    Parts of a Neuron

    Neurons consist of dendrites, cell body, and axon.

    Dendrites

    Extensions of neurons that receive signals from other neurons.

    Cell Body (Soma)

    Processes the signals received by dendrites.

    Signup and view all the flashcards

    Axon

    A long projection that transmits signals to other neurons or muscles.

    Signup and view all the flashcards

    Neural Circuit

    A group of interconnected neurons that work together to process information.

    Signup and view all the flashcards

    Glial Cells

    Non-neuronal cells providing support to neurons in the nervous system.

    Signup and view all the flashcards

    Types of Glial Cells

    Include astrocytes, oligodendrocytes, Schwann cells, and microglia.

    Signup and view all the flashcards

    Dynein

    A motor protein that powers transport in neurons.

    Signup and view all the flashcards

    Dendritic spines

    Small protrusions on dendrites where synapses form, enhancing connections.

    Signup and view all the flashcards

    Postsynaptic densities (PSD)

    Protein-rich structures on the postsynaptic side of a synapse, crucial for synaptic strength.

    Signup and view all the flashcards

    Axon hillock

    Cone-shaped junction where a neuron decides to fire an action potential.

    Signup and view all the flashcards

    Initial segment

    The start of the axon where action potentials are generated, rich in Na⁺ channels.

    Signup and view all the flashcards

    Myelin

    Fatty sheath around axons that increases the speed of electrical signals.

    Signup and view all the flashcards

    Polydendrocytes

    Glial cells in the CNS, also known as NG2 cells, that can develop into oligodendrocytes.

    Signup and view all the flashcards

    Microglia

    Immune cells of the CNS that detect and remove harmful substances.

    Signup and view all the flashcards

    Ependymal Cells

    Glial cells lining the ventricles that produce and regulate cerebrospinal fluid (CSF).

    Signup and view all the flashcards

    Cerebrospinal Fluid (CSF)

    Fluid produced by ependymal cells that cushions the brain and spinal cord.

    Signup and view all the flashcards

    Hydrocephalus

    Condition caused by dysfunction in ependymal cells leading to excess CSF accumulation.

    Signup and view all the flashcards

    Ion Movements

    Flow of charged particles across a neuron's membrane, crucial for electrical signals.

    Signup and view all the flashcards

    Action Potentials

    Electrical signals generated by ion movements in neurons.

    Signup and view all the flashcards

    Key Ions in Neurophysiology

    Sodium (Na⁺) and Potassium (K⁺) are essential for generating electrical signals in neurons.

    Signup and view all the flashcards

    Voltage-Activated Ion Channels

    Channels that open or close based on membrane voltage, selective for ions like Na⁺, K⁺, Ca²⁺.

    Signup and view all the flashcards

    Voltage-Gated Sodium Channels

    Channels that open during depolarization, allowing Na⁺ to flow into the neuron.

    Signup and view all the flashcards

    Depolarization

    Stage where the neuron's membrane potential becomes less negative, reaching ~ -55mV.

    Signup and view all the flashcards

    Action Potential Peak

    When the neuron's membrane potential reaches around +30mV, Na⁺ channels inactivate and K⁺ channels open.

    Signup and view all the flashcards

    Repolarization

    Stage where the membrane potential becomes more negative again as K⁺ leaves the neuron.

    Signup and view all the flashcards

    Hyperpolarization

    Stage when the neuron's membrane potential drops to ~ -80mV, becoming more negative than resting state.

    Signup and view all the flashcards

    Absolute Refractory Period

    Time during which no new action potential can be triggered, regardless of stimulus strength.

    Signup and view all the flashcards

    Relative Refractory Period

    Period after the absolute refractory period when stronger stimuli can trigger an action potential due to hyperpolarization.

    Signup and view all the flashcards

    Chloride Ion (Cl⁻)

    Moves into the neuron, making it more negative.

    Signup and view all the flashcards

    Calcium Ion (Ca²⁺)

    Essential for neurotransmitter release at synapses.

    Signup and view all the flashcards

    Voltage-gated Channels

    Channels that open or close in response to voltage changes.

    Signup and view all the flashcards

    Ligand-gated Channels

    Channels that open when neurotransmitters bind.

    Signup and view all the flashcards

    Sodium-Potassium Pump

    Restores resting potential by pumping Na⁺ out and K⁺ in.

    Signup and view all the flashcards

    Excitatory Neurotransmitters

    Increase neuronal activity, like glutamate and acetylcholine.

    Signup and view all the flashcards

    Inhibitory Neurotransmitters

    Decrease neuronal activity, like GABA and glycine.

    Signup and view all the flashcards

    Neurotransmitter Clearance

    Processes that remove neurotransmitters from the synapse.

    Signup and view all the flashcards

    Continuous Conduction

    Transmission of action potentials along unmyelinated axons where every segment depolarizes sequentially.

    Signup and view all the flashcards

    Saltatory Conduction

    Fast transmission of action potentials in myelinated axons by jumping between Nodes of Ranvier.

    Signup and view all the flashcards

    Factors Affecting Velocity

    Elements that influence how fast action potentials travel, including axon diameter and myelination.

    Signup and view all the flashcards

    Axon Diameter

    Larger axons conduct signals faster due to lower resistance and easier ion flow.

    Signup and view all the flashcards

    Myelination

    Presence of a fatty layer around axons that enhances conduction speed by enabling saltatory conduction.

    Signup and view all the flashcards

    Vesicles

    Small membrane-bound sacs in cells that store and transport substances like neurotransmitters.

    Signup and view all the flashcards

    Synaptic Vesicles

    Vesicles located in axon terminals that store and release neurotransmitters during synaptic transmission.

    Signup and view all the flashcards

    Dense-Core Vesicles

    Larger vesicles that store neuropeptides, used for signaling in the nervous system.

    Signup and view all the flashcards

    Study Notes

    Introduction to Neurophysiology

    • Neurophysiology is the study of ion movements across a membrane.
    • These movements initiate signal transduction and action potentials.
    • The study also encompasses neurotransmitters.

    Cellular Components of the Nervous System

    • Neurons: Fundamental units transmitting electrical and chemical signals.
      • Consist of dendrites, cell body, and axon.
      • Communicate via electrical impulses and neurotransmitters at synapses.
    • Neural Circuits: Functional groups of neurons processing information and generating responses.
      • Form the basis of neural activity, from reflexes to complex thoughts.
    • Neural Networks: Large-scale interconnected systems of neurons.
      • Integrate information across different brain regions.
      • Crucial for complex functions like memory, decision-making.
    • Glial Cells: Non-neuronal cells providing structural and functional support.
      • Types include astrocytes, oligodendrocytes/Schwann cells, microglia, ependymal cells.
      • Crucial for maintaining the neural environment, protecting neurons, and aiding signal transmission.

    Structure and Mechanisms of a Neuron

    • Action Potential: Rapid temporary electrical signal travelling down the axon.
      • Steps: resting state, depolarization, repolarization, hyperpolarization, refractory period, return to resting potential.
      • All-or-nothing principle: Action potential happens if stimulus reaches threshold otherwise no signals are sent.
    • Synapses: Junctions between neurons where communication Occurs.
      • Types: Electrical (direct ion flow) and Chemical (neurotransmitters).
      • Synaptic cleft: gap (~20-40nm) between pre and postsynaptic neurons.
      • Synaptic transmission: Signal moves across cleft via neurotransmitters.

    Functional Organization of a Neuron

    • Soma (cell body): Contains the nucleus and cytoplasm for cellular functions.
    • Perikaryon: Cytoplasm of the soma, excluding the nucleus, critical for protein synthesis.
    • Nissl substance: Rough endoplasmic reticulum (RER) and ribosomes, critical for protein synthesis.
    • Microtubules: Hollow protein filaments for transport of molecules along the axon.
    • Anterograde transport: Movement of molecules from the soma to axon terminals.
    • Retrograde transport: Movement of molecules from axon terminals to the soma.
    • Dendrites: Treelike extensions receiving signals from other neurons.
    • Dendritic spines: Increase surface area and allow for more connections with other neurons, important for learning and memory.
    • Axon: Long, cable-like extension transmitting action potentials.
    • Axon hillock: Cone-shaped junction where the neuron determines whether to fire an action potential.
    • Initial segment: Part of the axon where action potentials are generated.
    • Myelin: Fatty insulating sheath speeding up signal transmission by saltatory conduction.

    Types of Neurons

    • Multipolar neurons: Most common type. Have one axon and multiple dendrites.
    • Pseudounipolar neurons: Sensory neurons with one axon that splits into two branches.
    • Bipolar neurons: Rare type with one axon and one dendrite.

    Types of Synapses

    • Axodendritic synapses: Most common, axon synapsing with dendrite.
    • Axosomatic synapses: Axon synapsing with cell body of neuron, high influence.
    • Axoaxonic synapses: Axon synapsing with another axon, influence neurotransmitter release.
    • Temporospatial summation: Neurons summing up inputs from multiple synapses to initiate an action potential.

    Types of Glia

    • Oligodendrocytes: Produce myelin in the central nervous system.
    • Schwann cells: Produce myelin in the peripheral nervous system.
    • Astrocytes: Provide structural support, regulate ion balance, control blood flow.
    • Microglia: Immune cells of CNS, remove harmful substances.
    • Ependymal cells: Produce and circulate cerebrospinal fluid (CSF).

    Basic Neurophysiology

    • Ion channels and pumps: Crucial for action potential generation (voltage-gated).
    • Action potential steps: Resting state, depolarization, repolarization, hyperpolarization, refractory period, return to resting state.
    • Refractory periods: Prevent signal overlap.
    • Continuous conduction: Unmyelinated axons; slower transmission.
    • Saltatory conduction: Myelinated axons; faster transmission.
    • Factors influencing velocity: Axon diameter and myelination.

    Synaptic Transmission

    • Synaptic vesicles: Store neurotransmitters.
    • Neurotransmitters: Chemical messengers transmitting signals between neurons.
      • Types include excitatory (e.g., glutamate) and inhibitory (e.g., GABA).
    • Ionotropic receptors: Fast-acting, directly open ion channels.
    • Metabotropic receptors: Slower-acting, activate intracellular signaling cascades.
    • Synaptic signal transduction: Excitation and inhibition in postsynaptic neuron.

    Neurotransmitters

    • Glutamate: Primary excitatory neurotransmitter in the brain
    • GABA: Main inhibitory neurotransmitter in the brain.
    • Glycine: Primary inhibitory neurotransmitter in the spinal cord.
    • Acetylcholine: Used in neuromuscular junctions and brain.
    • Biogenic amines (dopamine, serotonin, norepinephrine, histamine): Involved in various functions like mood, movement, and alertness.
    • ATP: Plays a role in synaptic modulation.
    • Neuropeptides (substance P, endorphins, enkephalins, oxytocin, neuropeptide Y): Longer-lasting effects influencing various functions.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    Test your knowledge of neuron structure, function, and neural circuits. Questions cover signal flow, glial cell functions, and the role of neurons in reflexes and brain communication. Assess your understanding now!

    More Like This

    Use Quizgecko on...
    Browser
    Browser