Neuromuscular Blocking Drugs Overview
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Questions and Answers

Which drug is a competitive nicotinic ganglion blocker with a duration of up to 10 hours?

  • Succinylcholine
  • Curare
  • Dantrolene
  • Mecamylamine (correct)

What is the primary mechanism of action of non-depolarizing neuromuscular blockers?

  • Blocking sodium ion channels
  • Promoting muscle contraction
  • Inhibiting acetylcholine binding (correct)
  • Enhancing acetylcholine release

Which type of neuromuscular blocking drug competes with acetylcholine for receptors?

  • Non-depolarizing blockers (correct)
  • Succinylcholine
  • Depolarizing blockers
  • Dantrolene

What is the main therapeutic use of Curare (d-Tubocurarine)?

<p>Producing muscle relaxation during surgery (D)</p> Signup and view all the answers

Which neuromuscular blocker blocks sodium ion channels of the end-plate at high doses?

<p>Curare (D)</p> Signup and view all the answers

What is the pharmacokinetic route of administration for Succinylcholine?

<p>Intravenous (IV) (A)</p> Signup and view all the answers

Which drug directly inhibits the release of calcium ions from the sarcoplasmic reticulum?

<p>Dantrolene (A)</p> Signup and view all the answers

Which of the following statements about ganglionic blockers is FALSE?

<p>Can be effectively used as a neuromuscular antagonist (D)</p> Signup and view all the answers

What is the primary neurochemical effect of nicotine on ganglia and striated muscle?

<p>Depolarizes ganglia inducing muscular paralysis (C)</p> Signup and view all the answers

Which of the following drugs is a short-acting competitive nicotinic ganglion blocker used for emergency lowering of blood pressure?

<p>Trimethaphan (A)</p> Signup and view all the answers

In comparison to ganglionic blockers, how do cholinergic antagonists primarily act on the nervous system?

<p>By blocking acetylcholine receptors in autonomic ganglia (C)</p> Signup and view all the answers

Which of the following is a FALSE statement about muscle paralysis induced by non-depolarizing blockers?

<p>They lead to depolarization of the muscle membrane (B)</p> Signup and view all the answers

Which drug is a non-selective nicotinic antagonist that acts on autonomic ganglia and was historically used as an antihypertensive agent?

<p>Mecamylamine (B)</p> Signup and view all the answers

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