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Questions and Answers
During neurogenesis, proliferating neural precursor cells undergo apoptosis.
During neurogenesis, proliferating neural precursor cells undergo apoptosis.
False (B)
Mcl-1 and Bcl-xL are pro-apoptotic proteins.
Mcl-1 and Bcl-xL are pro-apoptotic proteins.
False (B)
Nestin-mediated, nervous system-specific conditional deletion of mcl-1 and bcl-x was used to examine their distinct roles in neurogenesis.
Nestin-mediated, nervous system-specific conditional deletion of mcl-1 and bcl-x was used to examine their distinct roles in neurogenesis.
True (A)
In the MKO embryo, apoptosis begins at embryonic day 11.
In the MKO embryo, apoptosis begins at embryonic day 11.
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In the BKO embryo, apoptosis begins at embryonic day 10.
In the BKO embryo, apoptosis begins at embryonic day 10.
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The double conditional knockout (DKO) results in embryonic lethality at E15.
The double conditional knockout (DKO) results in embryonic lethality at E15.
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Only Mcl-1 is necessary for cell survival during developmental neurogenesis.
Only Mcl-1 is necessary for cell survival during developmental neurogenesis.
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The DKO embryo shows no signs of apoptosis in the central nervous system.
The DKO embryo shows no signs of apoptosis in the central nervous system.
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The roles of Mcl-1 and Bcl-xL in promoting survival are redundant.
The roles of Mcl-1 and Bcl-xL in promoting survival are redundant.
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Neurogenesis occurs in the peripheral nervous system.
Neurogenesis occurs in the peripheral nervous system.
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