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Questions and Answers
During neurogenesis, proliferating neural precursor cells undergo apoptosis.
False
Mcl-1 and Bcl-xL are pro-apoptotic proteins.
False
Nestin-mediated, nervous system-specific conditional deletion of mcl-1 and bcl-x was used to examine their distinct roles in neurogenesis.
True
In the MKO embryo, apoptosis begins at embryonic day 11.
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In the BKO embryo, apoptosis begins at embryonic day 10.
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The double conditional knockout (DKO) results in embryonic lethality at E15.
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Only Mcl-1 is necessary for cell survival during developmental neurogenesis.
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The DKO embryo shows no signs of apoptosis in the central nervous system.
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The roles of Mcl-1 and Bcl-xL in promoting survival are redundant.
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Neurogenesis occurs in the peripheral nervous system.
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