Neuroblast Numb and Notch Signaling Quiz
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Questions and Answers

What is the role of Hox genes in specifying rostral-caudal axis formation?

  • Determining the differentiation of ventral motor neurons
  • Inducing floorplate formation by the notochord
  • Regulating sensory input in the spinal cord
  • Overlapping expression in segments of the hindbrain and spinal cord (correct)

    • Which Hox gene is expressed at the most posterior part of the neural tube and has low responsiveness to retinoic acid?

  • Hox9
  • Hox5
  • Hox1
  • Hox13 (correct)

    • What is the function of Sonic Hedgehog (Shh) in the ventral spinal cord?

  • Differentiating ventral motor neurons (correct)
  • Regulating Hox gene expression
  • Creating a gradient dictating cell identity
  • Inducing sensory neuron formation

    • How does SHH signaling affect the inhibition of Smoothened (SMO)?

    <p>SHH binding to PTC stops the inhibition of SMO</p> Signup and view all the answers

    What factor secreted by the notochord induces floorplate formation in the neural tube?

    <p>SHH</p> Signup and view all the answers

    Which cells express Sonic Hedgehog (Shh) in the ventral spinal cord?

    <p>Specialized glial cells</p> Signup and view all the answers

    In dissociated cell culture experiments, what type of neurons are induced by high concentrations of Shh?

    <p>Motor neurons</p> Signup and view all the answers

    What is the role of BMPs in neural tube development?

    <p>Inducing differentiation of roofplate cells</p> Signup and view all the answers

    What is the function of Dorsalin in neural crest cell development?

    <p>Promoting differentiation of neural crest cells</p> Signup and view all the answers

    What happens when there is a mutation in the transmembrane proteins Notch or Delta in Drosophila?

    <p>Production of a fly embryo with a big brain but no skin</p> Signup and view all the answers

    What is the implication of laser ablating a neuroblast cell in a grasshopper?

    <p>Suggests lateral inhibition mechanism for neuroblast selection</p> Signup and view all the answers

    How does Notch signaling affect neural cell identity?

    <p>Maintains proneural identity and inhibits neuroblast identity</p> Signup and view all the answers

    What is the outcome of an imbalance in Delta and Notch molecules at the cell surface?

    <p>Activation of support cell differentiation</p> Signup and view all the answers

    What prevents Notch signaling by binding to the cytoplasmic tail of Notch?

    <p>Numb</p> Signup and view all the answers

    How does the interaction between Delta and Notch influence downstream gene transcription?

    <p>Promotion of transcription factors to activate downstream genes</p> Signup and view all the answers

    In Drosophila, which cells arise from a single Sensory Organ Precursor (SOP)?

    <p>Bristle, socket, sheath, and sensory neuron cells</p> Signup and view all the answers

    What is critical for the asymmetric distribution in dividing progenitor cells?

    <p>Numb</p> Signup and view all the answers

    Which factor determines the fate of cells produced during oblique divisions of radial glial cells?

    <p>Par3 levels</p> Signup and view all the answers

    What do BMPs impose on neural crest cells migrating in the environment?

    <p>Neuronal identity</p> Signup and view all the answers

    Which transcription factors are required for induction of neuronal identity in newly differentiated sympathetic neurons?

    <p>bHLH</p> Signup and view all the answers

    'Oblique divisions allow asymmetric distribution of apically localized proteins and detachment from apical surface' - which protein is mentioned as being localized in the apical part of RGC?

    <p>Par3</p> Signup and view all the answers

    What is the main difference between the migration of neural crest cells in the PNS and CNS?

    <p>In the PNS, neural crest cells undergo differentiation in the periphery, whereas in the CNS they divide and differentiate in the ventricular zone.</p> Signup and view all the answers

    Which protein is responsible for regulating adhesion to glia and migration in migrating neurons?

    <p>Astrotactin (Astn1)</p> Signup and view all the answers

    What did experiments with cortical neurons using 3H-thymidine injections reveal about neuron positioning in the cortex?

    <p>Early born neurons were closest to the cortical surface.</p> Signup and view all the answers

    Which cortical defect is characterized by a migration arrest of cortical neurons before reaching their destination?

    <p>Lissencephaly</p> Signup and view all the answers

    What is the function of Reelin in cortical development?

    <p>Acts as a secreted protein that regulates layer formation</p> Signup and view all the answers

    Which two members of the lipoprotein receptor family are identified as Reelin receptors?

    <p>VLDLR and ApoER2</p> Signup and view all the answers

    What is the primary characteristic of tangential migration in the CNS?

    <p>Cells disperse individually without following a specific substrate.</p> Signup and view all the answers

    True or False: In lissencephaly, there is a disruption in laminar structure in the brain.

    <p><strong>True</strong></p> Signup and view all the answers

    True or False: Neurons generated at later stages in cortical development tend to form deeper layers of the cortex.

    <p><strong>False</strong></p> Signup and view all the answers

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