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Questions and Answers
What is the role of Hox genes in specifying rostral-caudal axis formation?
What is the role of Hox genes in specifying rostral-caudal axis formation?
- Determining the differentiation of ventral motor neurons
- Inducing floorplate formation by the notochord
- Regulating sensory input in the spinal cord
- Overlapping expression in segments of the hindbrain and spinal cord (correct)
Which Hox gene is expressed at the most posterior part of the neural tube and has low responsiveness to retinoic acid?
Which Hox gene is expressed at the most posterior part of the neural tube and has low responsiveness to retinoic acid?
- Hox9
- Hox5
- Hox1
- Hox13 (correct)
What is the function of Sonic Hedgehog (Shh) in the ventral spinal cord?
What is the function of Sonic Hedgehog (Shh) in the ventral spinal cord?
- Differentiating ventral motor neurons (correct)
- Regulating Hox gene expression
- Creating a gradient dictating cell identity
- Inducing sensory neuron formation
How does SHH signaling affect the inhibition of Smoothened (SMO)?
How does SHH signaling affect the inhibition of Smoothened (SMO)?
What factor secreted by the notochord induces floorplate formation in the neural tube?
What factor secreted by the notochord induces floorplate formation in the neural tube?
Which cells express Sonic Hedgehog (Shh) in the ventral spinal cord?
Which cells express Sonic Hedgehog (Shh) in the ventral spinal cord?
In dissociated cell culture experiments, what type of neurons are induced by high concentrations of Shh?
In dissociated cell culture experiments, what type of neurons are induced by high concentrations of Shh?
What is the role of BMPs in neural tube development?
What is the role of BMPs in neural tube development?
What is the function of Dorsalin in neural crest cell development?
What is the function of Dorsalin in neural crest cell development?
What happens when there is a mutation in the transmembrane proteins Notch or Delta in Drosophila?
What happens when there is a mutation in the transmembrane proteins Notch or Delta in Drosophila?
What is the implication of laser ablating a neuroblast cell in a grasshopper?
What is the implication of laser ablating a neuroblast cell in a grasshopper?
How does Notch signaling affect neural cell identity?
How does Notch signaling affect neural cell identity?
What is the outcome of an imbalance in Delta and Notch molecules at the cell surface?
What is the outcome of an imbalance in Delta and Notch molecules at the cell surface?
What prevents Notch signaling by binding to the cytoplasmic tail of Notch?
What prevents Notch signaling by binding to the cytoplasmic tail of Notch?
How does the interaction between Delta and Notch influence downstream gene transcription?
How does the interaction between Delta and Notch influence downstream gene transcription?
In Drosophila, which cells arise from a single Sensory Organ Precursor (SOP)?
In Drosophila, which cells arise from a single Sensory Organ Precursor (SOP)?
What is critical for the asymmetric distribution in dividing progenitor cells?
What is critical for the asymmetric distribution in dividing progenitor cells?
Which factor determines the fate of cells produced during oblique divisions of radial glial cells?
Which factor determines the fate of cells produced during oblique divisions of radial glial cells?
What do BMPs impose on neural crest cells migrating in the environment?
What do BMPs impose on neural crest cells migrating in the environment?
Which transcription factors are required for induction of neuronal identity in newly differentiated sympathetic neurons?
Which transcription factors are required for induction of neuronal identity in newly differentiated sympathetic neurons?
'Oblique divisions allow asymmetric distribution of apically localized proteins and detachment from apical surface' - which protein is mentioned as being localized in the apical part of RGC?
'Oblique divisions allow asymmetric distribution of apically localized proteins and detachment from apical surface' - which protein is mentioned as being localized in the apical part of RGC?
What is the main difference between the migration of neural crest cells in the PNS and CNS?
What is the main difference between the migration of neural crest cells in the PNS and CNS?
Which protein is responsible for regulating adhesion to glia and migration in migrating neurons?
Which protein is responsible for regulating adhesion to glia and migration in migrating neurons?
What did experiments with cortical neurons using 3H-thymidine injections reveal about neuron positioning in the cortex?
What did experiments with cortical neurons using 3H-thymidine injections reveal about neuron positioning in the cortex?
Which cortical defect is characterized by a migration arrest of cortical neurons before reaching their destination?
Which cortical defect is characterized by a migration arrest of cortical neurons before reaching their destination?
What is the function of Reelin in cortical development?
What is the function of Reelin in cortical development?
Which two members of the lipoprotein receptor family are identified as Reelin receptors?
Which two members of the lipoprotein receptor family are identified as Reelin receptors?
What is the primary characteristic of tangential migration in the CNS?
What is the primary characteristic of tangential migration in the CNS?
True or False: In lissencephaly, there is a disruption in laminar structure in the brain.
True or False: In lissencephaly, there is a disruption in laminar structure in the brain.
True or False: Neurons generated at later stages in cortical development tend to form deeper layers of the cortex.
True or False: Neurons generated at later stages in cortical development tend to form deeper layers of the cortex.
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