Neuroblast Numb and Notch Signaling Quiz

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What is the role of Hox genes in specifying rostral-caudal axis formation?

Determining the differentiation of ventral motor neurons

Inducing floorplate formation by the notochord

Regulating sensory input in the spinal cord

Overlapping expression in segments of the hindbrain and spinal cord (correct)

Which Hox gene is expressed at the most posterior part of the neural tube and has low responsiveness to retinoic acid?

Hox9

Hox5

Hox1

Hox13 (correct)

What is the function of Sonic Hedgehog (Shh) in the ventral spinal cord?

Differentiating ventral motor neurons (correct)

Regulating Hox gene expression

Creating a gradient dictating cell identity

Inducing sensory neuron formation

How does SHH signaling affect the inhibition of Smoothened (SMO)?

SHH binding to PTC stops the inhibition of SMO Signup and view all the answers

What factor secreted by the notochord induces floorplate formation in the neural tube?

SHH Signup and view all the answers

Which cells express Sonic Hedgehog (Shh) in the ventral spinal cord?

Specialized glial cells Signup and view all the answers

In dissociated cell culture experiments, what type of neurons are induced by high concentrations of Shh?

Motor neurons Signup and view all the answers

What is the role of BMPs in neural tube development?

Inducing differentiation of roofplate cells Signup and view all the answers

What is the function of Dorsalin in neural crest cell development?

Promoting differentiation of neural crest cells Signup and view all the answers

What happens when there is a mutation in the transmembrane proteins Notch or Delta in Drosophila?

Production of a fly embryo with a big brain but no skin Signup and view all the answers

What is the implication of laser ablating a neuroblast cell in a grasshopper?

Suggests lateral inhibition mechanism for neuroblast selection Signup and view all the answers

How does Notch signaling affect neural cell identity?

Maintains proneural identity and inhibits neuroblast identity Signup and view all the answers

What is the outcome of an imbalance in Delta and Notch molecules at the cell surface?

Activation of support cell differentiation Signup and view all the answers

What prevents Notch signaling by binding to the cytoplasmic tail of Notch?

Numb Signup and view all the answers

How does the interaction between Delta and Notch influence downstream gene transcription?

Promotion of transcription factors to activate downstream genes Signup and view all the answers

In Drosophila, which cells arise from a single Sensory Organ Precursor (SOP)?

Bristle, socket, sheath, and sensory neuron cells Signup and view all the answers

What is critical for the asymmetric distribution in dividing progenitor cells?

Numb Signup and view all the answers

Which factor determines the fate of cells produced during oblique divisions of radial glial cells?

Par3 levels Signup and view all the answers

What do BMPs impose on neural crest cells migrating in the environment?

Neuronal identity Signup and view all the answers

Which transcription factors are required for induction of neuronal identity in newly differentiated sympathetic neurons?

bHLH Signup and view all the answers

'Oblique divisions allow asymmetric distribution of apically localized proteins and detachment from apical surface' - which protein is mentioned as being localized in the apical part of RGC?

Par3 Signup and view all the answers

What is the main difference between the migration of neural crest cells in the PNS and CNS?

In the PNS, neural crest cells undergo differentiation in the periphery, whereas in the CNS they divide and differentiate in the ventricular zone. Signup and view all the answers

Which protein is responsible for regulating adhesion to glia and migration in migrating neurons?

Astrotactin (Astn1) Signup and view all the answers

What did experiments with cortical neurons using 3H-thymidine injections reveal about neuron positioning in the cortex?

Early born neurons were closest to the cortical surface. Signup and view all the answers

Which cortical defect is characterized by a migration arrest of cortical neurons before reaching their destination?

Lissencephaly Signup and view all the answers

What is the function of Reelin in cortical development?

Acts as a secreted protein that regulates layer formation Signup and view all the answers

Which two members of the lipoprotein receptor family are identified as Reelin receptors?

VLDLR and ApoER2 Signup and view all the answers

What is the primary characteristic of tangential migration in the CNS?

Cells disperse individually without following a specific substrate. Signup and view all the answers

True or False: In lissencephaly, there is a disruption in laminar structure in the brain.

True Signup and view all the answers

True or False: Neurons generated at later stages in cortical development tend to form deeper layers of the cortex.

False Signup and view all the answers