Podcast
Questions and Answers
Which of the following is NOT a correct pairing of a term and its definition?
Which of the following is NOT a correct pairing of a term and its definition?
Which combination correctly describes the function and pathways of the Somatic Nervous System?
Which combination correctly describes the function and pathways of the Somatic Nervous System?
If a neuroanatomist is describing a structure as being ‘medial’, what is the most accurate interpretation?
If a neuroanatomist is describing a structure as being ‘medial’, what is the most accurate interpretation?
Which plane of section divides the brain into anterior and posterior portions?
Which plane of section divides the brain into anterior and posterior portions?
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What is the correct term used to describe the direction of movement along the spinal cord from the brainstem towards the tail end?
What is the correct term used to describe the direction of movement along the spinal cord from the brainstem towards the tail end?
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Which of the following structures is primarily composed of myelinated nerve fibers?
Which of the following structures is primarily composed of myelinated nerve fibers?
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Which of the following terms is NOT synonymous with the other three?
Which of the following terms is NOT synonymous with the other three?
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A group of axons traveling together within the CNS is known as a:
A group of axons traveling together within the CNS is known as a:
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During the early stages of development, which layer of the embryo eventually gives rise to the neural plate that forms the basis of the central nervous system?
During the early stages of development, which layer of the embryo eventually gives rise to the neural plate that forms the basis of the central nervous system?
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What is the primary signaling mechanism employed by the notochord during embryonic development?
What is the primary signaling mechanism employed by the notochord during embryonic development?
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What is the primary developmental structure that gives rise to the ganglia of the peripheral nervous system?
What is the primary developmental structure that gives rise to the ganglia of the peripheral nervous system?
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Which of the following structures is responsible for forming the ventral nerve roots that carry motor signals to the muscles?
Which of the following structures is responsible for forming the ventral nerve roots that carry motor signals to the muscles?
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During the development of the brain, which primary vesicle eventually differentiates into the thalamus and hypothalamus?
During the development of the brain, which primary vesicle eventually differentiates into the thalamus and hypothalamus?
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What is the name of the structure that connects the third and fourth ventricles of the brain?
What is the name of the structure that connects the third and fourth ventricles of the brain?
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Which of the following structures is NOT derived from the rhombencephalon (hindbrain)?
Which of the following structures is NOT derived from the rhombencephalon (hindbrain)?
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What is the clinical consequence of a failure of the neural tube to close properly during embryonic development?
What is the clinical consequence of a failure of the neural tube to close properly during embryonic development?
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Which subtype of Arnold Chiari malformation is typically asymptomatic?
Which subtype of Arnold Chiari malformation is typically asymptomatic?
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What is the primary underlying cause of hydrocephalus in individuals with Arnold Chiari malformation?
What is the primary underlying cause of hydrocephalus in individuals with Arnold Chiari malformation?
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The development of the brain and spinal cord occurs at different rates, leading to a significant difference in the length of the neural tube in adults. Which of the following structures marks the final ending point of the neural tube in adults?
The development of the brain and spinal cord occurs at different rates, leading to a significant difference in the length of the neural tube in adults. Which of the following structures marks the final ending point of the neural tube in adults?
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Which of the following structures is responsible for forming the dorsal nerve roots, which carry sensory information to the spinal cord?
Which of the following structures is responsible for forming the dorsal nerve roots, which carry sensory information to the spinal cord?
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What is the name of the small tunnel that links the ventricular system of the forebrain to the hindbrain?
What is the name of the small tunnel that links the ventricular system of the forebrain to the hindbrain?
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Which of the following is a potential consequence of exposure of the neural tube in individuals with spina bifida?
Which of the following is a potential consequence of exposure of the neural tube in individuals with spina bifida?
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What is the most caudal aspect of the rhombencephalon, which eventually differentiates into the medulla oblongata and the pons?
What is the most caudal aspect of the rhombencephalon, which eventually differentiates into the medulla oblongata and the pons?
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The optic outgrowth from the prosencephalon eventually develops into what structure?
The optic outgrowth from the prosencephalon eventually develops into what structure?
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Which one of the following is NOT a component of the 'conducting area' of a neuron?
Which one of the following is NOT a component of the 'conducting area' of a neuron?
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What is the primary role of the "presynaptic terminal" in neuronal communication?
What is the primary role of the "presynaptic terminal" in neuronal communication?
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Which type of neuron possesses a single axon and multiple dendrites, making it the most common type in the nervous system?
Which type of neuron possesses a single axon and multiple dendrites, making it the most common type in the nervous system?
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In the context of a neuron, what is the primary function of microtubules?
In the context of a neuron, what is the primary function of microtubules?
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Which of the following is TRUE regarding the 'resting membrane potential' of a neuron?
Which of the following is TRUE regarding the 'resting membrane potential' of a neuron?
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What is the fundamental difference between 'passive' and 'active' ion channels?
What is the fundamental difference between 'passive' and 'active' ion channels?
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Which of the following accurately describes the significance of 'nodes of Ranvier' in nerve conduction?
Which of the following accurately describes the significance of 'nodes of Ranvier' in nerve conduction?
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Why is it essential for the electrical signal to travel 'all-or-nothing' down the axon?
Why is it essential for the electrical signal to travel 'all-or-nothing' down the axon?
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Which of the following correctly states the 'temporal sequence of nerve conduction'?
Which of the following correctly states the 'temporal sequence of nerve conduction'?
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Which of the following accurately describes the role of 'neurotransmitter vesicles' in neuronal communication?
Which of the following accurately describes the role of 'neurotransmitter vesicles' in neuronal communication?
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What is the purpose of the 'synaptic cleft' in neuronal communication?
What is the purpose of the 'synaptic cleft' in neuronal communication?
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What is the primary function of the 'sodium-potassium pump' in maintaining the resting membrane potential of a neuron?
What is the primary function of the 'sodium-potassium pump' in maintaining the resting membrane potential of a neuron?
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Which of the following is NOT a major ion involved in the process of nerve action potential?
Which of the following is NOT a major ion involved in the process of nerve action potential?
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Which of the following is TRUE regarding the 'depolarization phase' of an action potential?
Which of the following is TRUE regarding the 'depolarization phase' of an action potential?
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What is the primary function of 'myelin' in nerve conduction?
What is the primary function of 'myelin' in nerve conduction?
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Which of the following is NOT an example of a 'non-surgical treatment' that capitalizes on the principles of neuronal communication?
Which of the following is NOT an example of a 'non-surgical treatment' that capitalizes on the principles of neuronal communication?
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Which of the following is NOT a characteristic of Guillain-Barré Syndrome?
Which of the following is NOT a characteristic of Guillain-Barré Syndrome?
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Which of these glial cells is responsible for producing myelin in the peripheral nervous system?
Which of these glial cells is responsible for producing myelin in the peripheral nervous system?
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What is the function of the nodes of Ranvier?
What is the function of the nodes of Ranvier?
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Which of these is NOT a function of astrocytes?
Which of these is NOT a function of astrocytes?
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How does the process of myelin formation differ between the CNS and PNS?
How does the process of myelin formation differ between the CNS and PNS?
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Which of the following statements about multiple sclerosis is TRUE?
Which of the following statements about multiple sclerosis is TRUE?
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Which of the following describes the role of calcium ions in neurotransmitter release at the presynaptic terminal?
Which of the following describes the role of calcium ions in neurotransmitter release at the presynaptic terminal?
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Which phase of the action potential is characterized by the opening of voltage-gated sodium channels and the influx of sodium ions into the axon?
Which phase of the action potential is characterized by the opening of voltage-gated sodium channels and the influx of sodium ions into the axon?
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What is the primary function of neuroglia in the nervous system?
What is the primary function of neuroglia in the nervous system?
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Which of these is NOT a characteristic of action potentials?
Which of these is NOT a characteristic of action potentials?
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What is the role of the blood-brain barrier?
What is the role of the blood-brain barrier?
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Which of the following is a key difference between astrocytomas and glioblastomas?
Which of the following is a key difference between astrocytomas and glioblastomas?
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What is the primary function of microglial cells?
What is the primary function of microglial cells?
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Why is the hyperpolarization phase important in the action potential cycle?
Why is the hyperpolarization phase important in the action potential cycle?
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Which of these is a key characteristic of a local potential?
Which of these is a key characteristic of a local potential?
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What is the role of cholinesterase inhibitors in the treatment of myasthenia gravis?
What is the role of cholinesterase inhibitors in the treatment of myasthenia gravis?
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Which of the following is the correct order of events for the transmission of a nerve impulse?
Which of the following is the correct order of events for the transmission of a nerve impulse?
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Which of these options is the MOST CORRECT about the function of voltage-gated sodium channels opening in the action potential?
Which of these options is the MOST CORRECT about the function of voltage-gated sodium channels opening in the action potential?
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What is the primary function of Ion pumps in the process of generating nerve impulses?
What is the primary function of Ion pumps in the process of generating nerve impulses?
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What is the primary role of calcium ions in facilitating the release of neurotransmitters at the synapse?
What is the primary role of calcium ions in facilitating the release of neurotransmitters at the synapse?
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Which of these is NOT a characteristic of electrical synapses?
Which of these is NOT a characteristic of electrical synapses?
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Which type of neurotransmitter receptor is directly involved in opening ion channels, allowing rapid transmission of signals?
Which type of neurotransmitter receptor is directly involved in opening ion channels, allowing rapid transmission of signals?
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What is the primary function of acetylcholine as a neurotransmitter?
What is the primary function of acetylcholine as a neurotransmitter?
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Which of the following neurotransmitters is considered inhibitory and plays a role in regulating anxiety and seizures?
Which of the following neurotransmitters is considered inhibitory and plays a role in regulating anxiety and seizures?
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The process of hyperpolarization in a neuron refers to:
The process of hyperpolarization in a neuron refers to:
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Which of the following is a key characteristic of the refractory period in a neuron?
Which of the following is a key characteristic of the refractory period in a neuron?
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What is the primary role of the presynaptic terminal in chemical neurotransmission?
What is the primary role of the presynaptic terminal in chemical neurotransmission?
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Which of the following is NOT considered a characteristic of chemical synapses?
Which of the following is NOT considered a characteristic of chemical synapses?
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Which of the following is a primary difference between ionotropic and metabotropic receptors?
Which of the following is a primary difference between ionotropic and metabotropic receptors?
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What is the primary mechanism by which Botox (Botulinum toxin) exerts its effects?
What is the primary mechanism by which Botox (Botulinum toxin) exerts its effects?
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Which of the following is an accurate description of Myasthenia Gravis?
Which of the following is an accurate description of Myasthenia Gravis?
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What are the primary functions of the neurotransmitters dopamine, norepinephrine, and epinephrine?
What are the primary functions of the neurotransmitters dopamine, norepinephrine, and epinephrine?
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Flashcards
Nucleus
Nucleus
Groups of neurons within the CNS with similar function.
Ganglia
Ganglia
Groups of neuronal cell bodies outside the CNS sharing functions.
Afferent
Afferent
Incoming information that arrives at the CNS.
Efferent
Efferent
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Grey matter
Grey matter
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White matter
White matter
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Somatic nervous system
Somatic nervous system
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Autonomic nervous system
Autonomic nervous system
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Peripheral Nervous System
Peripheral Nervous System
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Central Nervous System
Central Nervous System
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Neurulation
Neurulation
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Three Germ Layers
Three Germ Layers
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Ectoderm
Ectoderm
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Mesoderm
Mesoderm
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Neural Tube
Neural Tube
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Somite
Somite
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Prosencephalon
Prosencephalon
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Rhombencephalon
Rhombencephalon
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Arnold Chiari Malformation
Arnold Chiari Malformation
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Spina Bifida
Spina Bifida
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Cranial Nerves
Cranial Nerves
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Inductive Signaling
Inductive Signaling
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Neural Crest
Neural Crest
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Oculomotor nerve (III)
Oculomotor nerve (III)
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Trochlear nerve (IV)
Trochlear nerve (IV)
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Abducens nerve (VI)
Abducens nerve (VI)
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Trigeminal nerve (V)
Trigeminal nerve (V)
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Facial nerve (VII)
Facial nerve (VII)
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Vestibulocochlear nerve (VIII)
Vestibulocochlear nerve (VIII)
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Glossopharyngeal nerve (IX)
Glossopharyngeal nerve (IX)
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Vagus nerve (X)
Vagus nerve (X)
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Hypoglossal nerve (XII)
Hypoglossal nerve (XII)
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Neuron Structure
Neuron Structure
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Action potential
Action potential
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Myelin sheath
Myelin sheath
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Node of Ranvier
Node of Ranvier
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Neurotransmitter
Neurotransmitter
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Resting membrane potential
Resting membrane potential
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Ligand-gated channels
Ligand-gated channels
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Voltage-gated channels
Voltage-gated channels
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Modality-gated channels
Modality-gated channels
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Ion pumps
Ion pumps
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Resting potential
Resting potential
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Repolarization
Repolarization
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Hyperpolarization
Hyperpolarization
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Chemically gated channels
Chemically gated channels
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Excitatory neurotransmitters
Excitatory neurotransmitters
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Inhibitory neurotransmitters
Inhibitory neurotransmitters
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Ionotropic receptors
Ionotropic receptors
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Metabotropic receptors
Metabotropic receptors
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Botox mechanism
Botox mechanism
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Myasthenia Gravis
Myasthenia Gravis
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Neuromuscular Junction
Neuromuscular Junction
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Cholinesterase Inhibitors
Cholinesterase Inhibitors
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Astrocytes
Astrocytes
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Microglial Cells
Microglial Cells
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Oligodendrocytes
Oligodendrocytes
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Schwann Cells
Schwann Cells
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Myelination
Myelination
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Saltatory Conduction
Saltatory Conduction
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Multiple Sclerosis
Multiple Sclerosis
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Guillain Barre Syndrome
Guillain Barre Syndrome
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Study Notes
Neuroanatomy Basics
- Common Terms:
- Nucleus: Groups of neurons in CNS with similar function.
- Ganglia: Groups of neuron cell bodies outside CNS with similar function.
- Tract: Bundle of axons in CNS (e.g., corticospinal tract).
- Nerve: Bundle of axons outside CNS.
- Afferent: Incoming information.
- Efferent: Outgoing information.
- Gray matter: Brain/spinal cord tissue with neuron cell bodies and dendrites.
- White matter: Brain/spinal cord tissue with nerve fibers and myelin sheaths.
- Somatic nervous system: Afferent/efferent via skeletal muscle (external environment).
- Autonomic nervous system: Afferent/efferent via smooth muscle and glands (internal environment).
- Sulci: Grooves.
- Fissure: Larger sulcus.
- Gyrus: Folds/ridges.
Organization of Central Nervous System
-
Brain Orientation:
- Dorsal: Superior aspect of brain.
- Ventral: Inferior aspect of brain.
- Anterior/Rostral: Forward part of brain.
- Posterior/Caudal: Back part of brain.
-
Spinal Cord Orientation:
- Caudal: Toward the tail end.
- Rostral: Toward the brainstem.
- Dorsal: Posterior aspect of spinal cord.
- Ventral: Anterior aspect of spinal cord.
-
Other Descriptions:
- Medial: Midline of the brain.
- Lateral: Further from the core of the brain.
-
Planes of the CNS:
- Horizontal: Upper and lower halves.
- Sagittal: Left and right halves.
- Coronal: Anterior/posterior halves.
Central vs. Peripheral Nervous System
-
Central Nervous System (CNS):
- Brain and spinal cord.
- Enclosed by bone.
- Upper motor neurons.
-
Peripheral Nervous System (PNS):
- Cranial nerves (arising from brainstem).
- Spinal nerves (anterior horn, cauda equina).
- Lower motor neurons.
- Peripheral nerves (e.g., axillary, sciatic).
Embryological Development
-
CNS Development:
- Creation of brain and spinal cord.
- Formation process (Gastrulation, Neurulation).
-
Gastrulation (~18 days):
- Three germ layers develop (ectoderm, mesoderm, endoderm).
- Ectoderm: Forms skin;
- Mesoderm: Contains notochord (structure influencing tissue formation).
- Endoderm: Forms respiratory and GI tracts.
-
Neurulation (3-4 weeks gestation):
- Neural plate: Thickening of ectoderm.
- Neural fold: Folds to form neural tube;
- Neural tube: Inner layer is gray matter, outer layer is white matter,
- Neural crest: Forms CNS ganglia (sensory/visceral).
- Cranial/rostral aspect: Forms brain.
- Posterior aspect: Forms spinal cord.
- Somite: Forms bone, muscle, and skin dermis.
-
Inductive signaling: Influences cell fate during development using chemical signals.
- Spinal Nerves (3-6 weeks):
- Somites divide, forming alar (dorsal, sensory) and basal (ventral, motor) plates
- Neurulation occurs slower than vertebral column development (stops near L1-L2 for adults).
- Spinal Nerves (3-6 weeks):
-
Brain Development (4-6 weeks):
- Prosencephalon (forebrain): Thalamus, hypothalamus, cerebral hemispheres.
- Mesencephalon (midbrain): Midbrain structures.
- Rhombencephalon (hindbrain): Medulla, pons, cerebellum.
- Develops components of the ventricular system
-
Spina Bifida: Neural tube doesn't close completely.
- Can happen anywhere but usually in the lumbar region.
- Exposure of spinal cord/tissues with potential CNS damage.
-
Arnold-Chiari Malformation: Hindbrain deformity (rhombencephalon); cerebellar tonsils protruding through foramen magnum.
- Type 1 (asymptomatic); Type 2 (symptomatic)
- Compression leading to CSF buildup (hydrocephalus).
- Requires surgery.
Cranial Nerves
- Specific nerve origins and functions described.
Cell Properties and Transmission
-
Neuron Structure:
- Dendrite: Input area.
- Soma: Cell body, protein synthesis.
- Axon: Conducts signals to presynaptic terminals.
- Presynaptic terminal: releases neurotransmitters.
-
Neuron Types:
- Multipolar: Multiple dendrites, one axon.
- Bipolar: Axon and dendrite extending from soma in opposite directions..
- Unipolar: Transmits periphery to CNS, (Single branch).
-
Special Feature in Axon:
- Nodes of Ranvier: Exposed axon areas where ion channels are concentrated.
- Myelin: Insulates axon, increases signal speed.
-
Synapse:
- Synaptic cleft: Space between neurons.
- Neurotransmitter vesicle: Holds neurotransmitters.
-
Propagation of Information:
- Passive current in soma.
- Action potential in axon (all-or-nothing).
- Neurotransmitter release at presynaptic terminal; activation of neighboring neuron/muscle fiber.
-
Nerve Propagation (Details):
- Ions (Na+, K+, Cl-, Ca2+).
- Passive channels.
- Ligand-gated channels.
- Voltage-gated channels.
- Ion pumps.
- Resting potential (-70 mV).
- Action potential: Rapid change in membrane potential.
- Depolarization, repolarization, refractory period, hyperpolarization.
-
Chemical vs Electrical synapses
- Electrical synapses are rapid through gap junctions, chemical are slower via neurotransmitters across synaptic cleft.
-
Neurotransmitters:
- Excitatory: Acetylcholine, glutamate, catecholamines (dopamine, norepinephrine, epinephrine).
- Inhibitory: GABA, endocannabinoids.
-
Post-synaptic NT Receptors:
- Ionotropic: Fast, ligand-gated ion channels.
- Metabotropic: Slower, G-protein-coupled receptors (e.g., glutamate, acetylcholine, GABA).
-
Clinical Applications (Toxins, Diseases):
- Botox: Paralyzes muscles; blocks neurotransmitter release (acetylcholine).
- Myasthenia Gravis: Autoimmune disease affecting neuromuscular junction.
- Treatment: Cholinesterase inhibitors to improve nerve-muscle communication.
Non-neural Cells in the Nervous System
-
Neuroglia (Glial Cells):
- Astrocytes (CNS): Maintain ionic balance, waste management;
- Microglia (CNS): Phagocytic;
- Oligodendrocytes (CNS): Produce myelin layers;
- Schwann cells (PNS): Produce myelin sheath.
-
Myelination: Insulates axons, allowing faster signal transmission.
-
Differences between CNS and PNS myelination: type of glial cell.
-
Saltatory Conduction: Action potentials "jump" between nodes of Ranvier.
-
Clinical application of Demyelination:
- Multiple Sclerosis (CNS)
- Guillain-Barré Syndrome (PNS)
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Description
Test your knowledge on the basic terms and concepts of neuroanatomy. This quiz covers essential vocabulary such as nuclei, ganglia, tracts, and the organization of the central nervous system. Perfect for students looking to reinforce their understanding of neural structure and function.