Clinical Neuroscience Week 1 – Embryological Development and Cell Pro (Hard)
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Questions and Answers

Which of the following is NOT a correct pairing of a term and its definition?

  • Nucleus: Groups of neurons located within the CNS that share similar function
  • Tract: A bundle of axons traveling together in the CNS
  • Nerve: A bundle of axons located outside the CNS
  • Ganglia: Groups of neuronal cell bodies within the CNS that share similar function (correct)
  • Which combination correctly describes the function and pathways of the Somatic Nervous System?

  • Afferent only, providing sensory information from the external environment
  • Efferent only, controlling skeletal muscle for voluntary movement
  • Afferent/Efferent via skeletal muscle from the external environment (correct)
  • Afferent/Efferent via smooth muscle and glands from the internal environment
  • If a neuroanatomist is describing a structure as being ‘medial’, what is the most accurate interpretation?

  • The structure is located furthest away from the midline of the brain
  • The structure is located on the ventral side of the brain
  • The structure is located on the dorsal side of the brain
  • The structure is located towards the midline of the brain (correct)
  • Which plane of section divides the brain into anterior and posterior portions?

    <p>Coronal plane (C)</p> Signup and view all the answers

    What is the correct term used to describe the direction of movement along the spinal cord from the brainstem towards the tail end?

    <p>Caudal (C)</p> Signup and view all the answers

    Which of the following structures is primarily composed of myelinated nerve fibers?

    <p>White matter (A)</p> Signup and view all the answers

    Which of the following terms is NOT synonymous with the other three?

    <p>Caudal (D)</p> Signup and view all the answers

    A group of axons traveling together within the CNS is known as a:

    <p>Tract (C)</p> Signup and view all the answers

    During the early stages of development, which layer of the embryo eventually gives rise to the neural plate that forms the basis of the central nervous system?

    <p>Ectoderm (D)</p> Signup and view all the answers

    What is the primary signaling mechanism employed by the notochord during embryonic development?

    <p>Secretion of chemical signaling molecules (A)</p> Signup and view all the answers

    What is the primary developmental structure that gives rise to the ganglia of the peripheral nervous system?

    <p>Neural crest (D)</p> Signup and view all the answers

    Which of the following structures is responsible for forming the ventral nerve roots that carry motor signals to the muscles?

    <p>Basal plate (C)</p> Signup and view all the answers

    During the development of the brain, which primary vesicle eventually differentiates into the thalamus and hypothalamus?

    <p>Prosencephalon (D)</p> Signup and view all the answers

    What is the name of the structure that connects the third and fourth ventricles of the brain?

    <p>Cerebral aqueduct (C)</p> Signup and view all the answers

    Which of the following structures is NOT derived from the rhombencephalon (hindbrain)?

    <p>Thalamus (C)</p> Signup and view all the answers

    What is the clinical consequence of a failure of the neural tube to close properly during embryonic development?

    <p>Spina Bifida (D)</p> Signup and view all the answers

    Which subtype of Arnold Chiari malformation is typically asymptomatic?

    <p>Type I (A)</p> Signup and view all the answers

    What is the primary underlying cause of hydrocephalus in individuals with Arnold Chiari malformation?

    <p>Blockage of the flow of cerebrospinal fluid (D)</p> Signup and view all the answers

    The development of the brain and spinal cord occurs at different rates, leading to a significant difference in the length of the neural tube in adults. Which of the following structures marks the final ending point of the neural tube in adults?

    <p>The level of L1-L2 (B)</p> Signup and view all the answers

    Which of the following structures is responsible for forming the dorsal nerve roots, which carry sensory information to the spinal cord?

    <p>Alar Plate (C)</p> Signup and view all the answers

    What is the name of the small tunnel that links the ventricular system of the forebrain to the hindbrain?

    <p>Cerebral aqueduct (B)</p> Signup and view all the answers

    Which of the following is a potential consequence of exposure of the neural tube in individuals with spina bifida?

    <p>Damage to the central nervous system (D)</p> Signup and view all the answers

    What is the most caudal aspect of the rhombencephalon, which eventually differentiates into the medulla oblongata and the pons?

    <p>Myelencephalon (A)</p> Signup and view all the answers

    The optic outgrowth from the prosencephalon eventually develops into what structure?

    <p>The eyes (B)</p> Signup and view all the answers

    Which one of the following is NOT a component of the 'conducting area' of a neuron?

    <p>Dendrite (B)</p> Signup and view all the answers

    What is the primary role of the "presynaptic terminal" in neuronal communication?

    <p>Releasing neurotransmitters into the synaptic cleft (B)</p> Signup and view all the answers

    Which type of neuron possesses a single axon and multiple dendrites, making it the most common type in the nervous system?

    <p>Multipolar neuron (B)</p> Signup and view all the answers

    In the context of a neuron, what is the primary function of microtubules?

    <p>Providing structural support and scaffolding for the neuron (A)</p> Signup and view all the answers

    Which of the following is TRUE regarding the 'resting membrane potential' of a neuron?

    <p>It is primarily established by the passive movement of potassium out of the neuron (C)</p> Signup and view all the answers

    What is the fundamental difference between 'passive' and 'active' ion channels?

    <p>Passive channels allow ions to move across the membrane based on their concentration gradient, while active channels require energy to open and close. (B)</p> Signup and view all the answers

    Which of the following accurately describes the significance of 'nodes of Ranvier' in nerve conduction?

    <p>They are specialized regions where sodium channels are concentrated, allowing for efficient saltatory conduction. (C)</p> Signup and view all the answers

    Why is it essential for the electrical signal to travel 'all-or-nothing' down the axon?

    <p>To ensure that the signal remains consistent in strength despite the distance traveled. (A)</p> Signup and view all the answers

    Which of the following correctly states the 'temporal sequence of nerve conduction'?

    <p>Synaptic input --&gt; local potential --&gt; action potential --&gt; neurotransmitter release (D)</p> Signup and view all the answers

    Which of the following accurately describes the role of 'neurotransmitter vesicles' in neuronal communication?

    <p>They store and release neurotransmitters into the synaptic cleft. (C)</p> Signup and view all the answers

    What is the purpose of the 'synaptic cleft' in neuronal communication?

    <p>To house the receptors that bind neurotransmitters and initiate a response in the postsynaptic neuron. (D)</p> Signup and view all the answers

    What is the primary function of the 'sodium-potassium pump' in maintaining the resting membrane potential of a neuron?

    <p>To transport sodium ions into the neuron and potassium ions out of the neuron. (C)</p> Signup and view all the answers

    Which of the following is NOT a major ion involved in the process of nerve action potential?

    <p>Iron (B)</p> Signup and view all the answers

    Which of the following is TRUE regarding the 'depolarization phase' of an action potential?

    <p>It is triggered by the opening of sodium channels, allowing sodium to flow into the neuron. (D)</p> Signup and view all the answers

    What is the primary function of 'myelin' in nerve conduction?

    <p>To insulate the axon and speed up the conduction of action potentials. (A)</p> Signup and view all the answers

    Which of the following is NOT an example of a 'non-surgical treatment' that capitalizes on the principles of neuronal communication?

    <p>Craniotomy (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Guillain-Barré Syndrome?

    <p>It is a demyelinating disorder of the CNS. (A)</p> Signup and view all the answers

    Which of these glial cells is responsible for producing myelin in the peripheral nervous system?

    <p>Schwann cells (D)</p> Signup and view all the answers

    What is the function of the nodes of Ranvier?

    <p>To facilitate the rapid conduction of action potentials along the axon. (D)</p> Signup and view all the answers

    Which of these is NOT a function of astrocytes?

    <p>Production of myelin in the CNS. (C)</p> Signup and view all the answers

    How does the process of myelin formation differ between the CNS and PNS?

    <p>The glial cells responsible for myelin production are different in the CNS and PNS. (A)</p> Signup and view all the answers

    Which of the following statements about multiple sclerosis is TRUE?

    <p>It can lead to increased muscle tone and hyperreflexia. (C)</p> Signup and view all the answers

    Which of the following describes the role of calcium ions in neurotransmitter release at the presynaptic terminal?

    <p>Calcium ions bind to proteins associated with vesicles, facilitating their fusion with the presynaptic membrane. (B)</p> Signup and view all the answers

    Which phase of the action potential is characterized by the opening of voltage-gated sodium channels and the influx of sodium ions into the axon?

    <p>Depolarization (D)</p> Signup and view all the answers

    What is the primary function of neuroglia in the nervous system?

    <p>To support the metabolic processes and signaling of neurons. (C)</p> Signup and view all the answers

    Which of these is NOT a characteristic of action potentials?

    <p>Their amplitude is proportional to the intensity of the stimulus. (C)</p> Signup and view all the answers

    What is the role of the blood-brain barrier?

    <p>To prevent the entry of harmful substances into the brain. (C)</p> Signup and view all the answers

    Which of the following is a key difference between astrocytomas and glioblastomas?

    <p>Astrocytomas are benign tumors while glioblastomas are malignant. (C)</p> Signup and view all the answers

    What is the primary function of microglial cells?

    <p>To remove cellular debris and pathogens in the CNS. (A)</p> Signup and view all the answers

    Why is the hyperpolarization phase important in the action potential cycle?

    <p>It prevents the neuron from firing uncontrollably. (D)</p> Signup and view all the answers

    Which of these is a key characteristic of a local potential?

    <p>It can be either excitatory or inhibitory. (B)</p> Signup and view all the answers

    What is the role of cholinesterase inhibitors in the treatment of myasthenia gravis?

    <p>To inhibit the breakdown of acetylcholine. (B)</p> Signup and view all the answers

    Which of the following is the correct order of events for the transmission of a nerve impulse?

    <p>Synaptic input - local potential - action potential - neurotransmitter release. (D)</p> Signup and view all the answers

    Which of these options is the MOST CORRECT about the function of voltage-gated sodium channels opening in the action potential?

    <p>Voltage-gated sodium channels open to allow sodium to enter the neuron in order to create a positive charge (B)</p> Signup and view all the answers

    What is the primary function of Ion pumps in the process of generating nerve impulses?

    <p>They actively transport ions across the membrane, establishing and maintaining the concentration gradients that drive the electrical signals. (A)</p> Signup and view all the answers

    What is the primary role of calcium ions in facilitating the release of neurotransmitters at the synapse?

    <p>Calcium ions bind to proteins associated with synaptic vesicles, leading to their fusion with the presynaptic membrane and exocytosis of neurotransmitters. (C)</p> Signup and view all the answers

    Which of these is NOT a characteristic of electrical synapses?

    <p>They require a neurotransmitter to facilitate communication between neurons. (C)</p> Signup and view all the answers

    Which type of neurotransmitter receptor is directly involved in opening ion channels, allowing rapid transmission of signals?

    <p>Ionotropic receptors (C)</p> Signup and view all the answers

    What is the primary function of acetylcholine as a neurotransmitter?

    <p>It is involved in muscle contraction and other bodily functions, including memory and learning. (B)</p> Signup and view all the answers

    Which of the following neurotransmitters is considered inhibitory and plays a role in regulating anxiety and seizures?

    <p>GABA (B)</p> Signup and view all the answers

    The process of hyperpolarization in a neuron refers to:

    <p>The neuron becoming more negatively charged, making it less likely to fire an action potential. (D)</p> Signup and view all the answers

    Which of the following is a key characteristic of the refractory period in a neuron?

    <p>It is a period when the neuron requires a stronger-than-usual stimulus to fire an action potential. (D)</p> Signup and view all the answers

    What is the primary role of the presynaptic terminal in chemical neurotransmission?

    <p>It synthesizes and packages neurotransmitters into vesicles for release. (D)</p> Signup and view all the answers

    Which of the following is NOT considered a characteristic of chemical synapses?

    <p>They allow for more rapid communication compared to electrical synapses. (D)</p> Signup and view all the answers

    Which of the following is a primary difference between ionotropic and metabotropic receptors?

    <p>Ionotropic receptors directly open ion channels, while metabotropic receptors use a secondary messenger system. (D)</p> Signup and view all the answers

    What is the primary mechanism by which Botox (Botulinum toxin) exerts its effects?

    <p>Botox interferes with calcium ion influx into the presynaptic terminal, inhibiting the fusion of synaptic vesicles with the presynaptic membrane. (B)</p> Signup and view all the answers

    Which of the following is an accurate description of Myasthenia Gravis?

    <p>It is an autoimmune disease that destroys the postsynaptic acetylcholine receptors, leading to muscle weakness. (A)</p> Signup and view all the answers

    What are the primary functions of the neurotransmitters dopamine, norepinephrine, and epinephrine?

    <p>They are involved in the regulation of mood, arousal, and attention. (D)</p> Signup and view all the answers

    Flashcards

    Nucleus

    Groups of neurons within the CNS with similar function.

    Ganglia

    Groups of neuronal cell bodies outside the CNS sharing functions.

    Afferent

    Incoming information that arrives at the CNS.

    Efferent

    Outgoing information that exits the CNS.

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    Grey matter

    Darker brain tissue, mostly nerve cell bodies and dendrites.

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    White matter

    Paler tissue in the CNS, mainly nerve fibers with myelin.

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    Somatic nervous system

    Controls afferent/efferent actions via skeletal muscles.

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    Autonomic nervous system

    Afferent/efferent system for smooth muscles and glands.

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    Peripheral Nervous System

    Nervous system outside the brain and spinal cord.

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    Central Nervous System

    Consists of the brain and spinal cord.

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    Neurulation

    Process of forming the neural tube during CNS development.

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    Three Germ Layers

    Ectoderm, mesoderm, and endoderm formed during gastrulation.

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    Ectoderm

    Outer layer that forms skin and nervous system.

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    Mesoderm

    Middle layer responsible for muscle and bone formation.

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    Neural Tube

    Structure formed from neural plate, becomes CNS.

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    Somite

    Ball-like structures that become muscle and bone.

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    Prosencephalon

    Forebrain, forms important structures like thalamus and hypothalamus.

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    Rhombencephalon

    Hindbrain that forms the medulla oblongata and pons.

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    Arnold Chiari Malformation

    Deformity causing cerebellar tonsils to herniate.

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    Spina Bifida

    Failure of the neural tube to close properly.

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    Cranial Nerves

    Nerves that arise directly from the brain.

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    Inductive Signaling

    Process by which one cell influences the fate of nearby cells.

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    Neural Crest

    Cells that lead to ganglia of the peripheral nervous system.

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    Oculomotor nerve (III)

    Controls most eye movements and pupil constriction.

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    Trochlear nerve (IV)

    Innervates the superior oblique muscle, enabling downward eye movement.

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    Abducens nerve (VI)

    Controls lateral movement of the eye.

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    Trigeminal nerve (V)

    Provides sensation to the face and controls mastication.

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    Facial nerve (VII)

    Controls muscles of facial expression.

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    Vestibulocochlear nerve (VIII)

    Involved in hearing and balance.

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    Glossopharyngeal nerve (IX)

    Mixed nerve for taste and oropharyngeal sensation.

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    Vagus nerve (X)

    Supplies organs in the thorax and abdomen; key in parasympathetic functions.

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    Hypoglossal nerve (XII)

    Controls tongue movements except for one muscle.

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    Neuron Structure

    Fundamental cell of the nervous system with key components like dendrites and axons.

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    Action potential

    Rapid electrical signal that travels along the axon.

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    Myelin sheath

    Insulating layer that speeds up neural signals.

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    Node of Ranvier

    Gaps in myelin sheath where action potentials are generated.

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    Neurotransmitter

    Chemicals that transmit signals across synapses between neurons.

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    Resting membrane potential

    The difference in charge across the neuronal membrane at rest.

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    Ligand-gated channels

    Channels that respond to specific neurotransmitters binding to them.

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    Voltage-gated channels

    Channels that open in response to changes in electrical potential across the membrane.

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    Modality-gated channels

    Channels that open in response to specific mechanical forces like stretch or temperature changes.

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    Ion pumps

    Proteins that help establish ion concentration gradients across the cell membrane.

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    Resting potential

    The state when a neuron has no net ion flow, typically around -70 mV.

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    Repolarization

    The process during which a neuron returns to its resting potential after an action potential.

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    Hyperpolarization

    A state where the neuron cannot fire regardless of stimulus intensity.

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    Chemically gated channels

    Channels altered by neurotransmitters that change membrane potential.

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    Excitatory neurotransmitters

    Substances like acetylcholine and glutamate that increase neuron activity.

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    Inhibitory neurotransmitters

    Neurotransmitters like GABA that decrease neuron activity and prevent firing.

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    Ionotropic receptors

    Fast-acting receptors that allow ions to flow across the membrane in response to neurotransmitters.

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    Metabotropic receptors

    Slower receptors that use transduction mechanisms to create longer-lasting effects.

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    Botox mechanism

    Paralyzes muscles by inhibiting calcium in presynaptic terminals, blocking neurotransmitter release.

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    Myasthenia Gravis

    An autoimmune disease causing severe muscle weakness by destroying postsynaptic receptors.

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    Neuromuscular Junction

    The synapse where a motor neuron communicates with a muscle fiber.

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    Cholinesterase Inhibitors

    Medications that enhance communication between nerves and muscles.

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    Astrocytes

    Star-shaped glial cells that support neurons and maintain ionic balance.

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    Microglial Cells

    Immune cells in the CNS responsible for cleaning debris.

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    Oligodendrocytes

    CNS cells that produce myelin for several axons at once.

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    Schwann Cells

    PNS cells that produce myelin for individual axons in stages.

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    Myelination

    The formation of a myelin sheath around an axon for faster signal transmission.

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    Saltatory Conduction

    The process where action potentials jump from node to node.

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    Multiple Sclerosis

    An autoimmune disease causing demyelination in the CNS.

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    Guillain Barre Syndrome

    An autoimmune disorder where myelin is stripped from peripheral nerves.

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    Study Notes

    Neuroanatomy Basics

    • Common Terms:
      • Nucleus: Groups of neurons in CNS with similar function.
      • Ganglia: Groups of neuron cell bodies outside CNS with similar function.
      • Tract: Bundle of axons in CNS (e.g., corticospinal tract).
      • Nerve: Bundle of axons outside CNS.
      • Afferent: Incoming information.
      • Efferent: Outgoing information.
      • Gray matter: Brain/spinal cord tissue with neuron cell bodies and dendrites.
      • White matter: Brain/spinal cord tissue with nerve fibers and myelin sheaths.
      • Somatic nervous system: Afferent/efferent via skeletal muscle (external environment).
      • Autonomic nervous system: Afferent/efferent via smooth muscle and glands (internal environment).
      • Sulci: Grooves.
      • Fissure: Larger sulcus.
      • Gyrus: Folds/ridges.

    Organization of Central Nervous System

    • Brain Orientation:

      • Dorsal: Superior aspect of brain.
      • Ventral: Inferior aspect of brain.
      • Anterior/Rostral: Forward part of brain.
      • Posterior/Caudal: Back part of brain.
    • Spinal Cord Orientation:

      • Caudal: Toward the tail end.
      • Rostral: Toward the brainstem.
      • Dorsal: Posterior aspect of spinal cord.
      • Ventral: Anterior aspect of spinal cord.
    • Other Descriptions:

      • Medial: Midline of the brain.
      • Lateral: Further from the core of the brain.
    • Planes of the CNS:

      • Horizontal: Upper and lower halves.
      • Sagittal: Left and right halves.
      • Coronal: Anterior/posterior halves.

    Central vs. Peripheral Nervous System

    • Central Nervous System (CNS):

      • Brain and spinal cord.
      • Enclosed by bone.
      • Upper motor neurons.
    • Peripheral Nervous System (PNS):

      • Cranial nerves (arising from brainstem).
      • Spinal nerves (anterior horn, cauda equina).
      • Lower motor neurons.
      • Peripheral nerves (e.g., axillary, sciatic).

    Embryological Development

    • CNS Development:

      • Creation of brain and spinal cord.
      • Formation process (Gastrulation, Neurulation).
    • Gastrulation (~18 days):

      • Three germ layers develop (ectoderm, mesoderm, endoderm).
      • Ectoderm: Forms skin;
      • Mesoderm: Contains notochord (structure influencing tissue formation).
      • Endoderm: Forms respiratory and GI tracts.
    • Neurulation (3-4 weeks gestation):

      • Neural plate: Thickening of ectoderm.
      • Neural fold: Folds to form neural tube;
      • Neural tube: Inner layer is gray matter, outer layer is white matter,
      • Neural crest: Forms CNS ganglia (sensory/visceral).
      • Cranial/rostral aspect: Forms brain.
      • Posterior aspect: Forms spinal cord.
      • Somite: Forms bone, muscle, and skin dermis.
    • Inductive signaling: Influences cell fate during development using chemical signals.

      • Spinal Nerves (3-6 weeks):
        • Somites divide, forming alar (dorsal, sensory) and basal (ventral, motor) plates
        • Neurulation occurs slower than vertebral column development (stops near L1-L2 for adults).
    • Brain Development (4-6 weeks):

      • Prosencephalon (forebrain): Thalamus, hypothalamus, cerebral hemispheres.
      • Mesencephalon (midbrain): Midbrain structures.
      • Rhombencephalon (hindbrain): Medulla, pons, cerebellum.
      • Develops components of the ventricular system
    • Spina Bifida: Neural tube doesn't close completely.

      • Can happen anywhere but usually in the lumbar region.
      • Exposure of spinal cord/tissues with potential CNS damage.
    • Arnold-Chiari Malformation: Hindbrain deformity (rhombencephalon); cerebellar tonsils protruding through foramen magnum.

      • Type 1 (asymptomatic); Type 2 (symptomatic)
      • Compression leading to CSF buildup (hydrocephalus).
      • Requires surgery.

    Cranial Nerves

    • Specific nerve origins and functions described.

    Cell Properties and Transmission

    • Neuron Structure:

      • Dendrite: Input area.
      • Soma: Cell body, protein synthesis.
      • Axon: Conducts signals to presynaptic terminals.
      • Presynaptic terminal: releases neurotransmitters.
    • Neuron Types:

      • Multipolar: Multiple dendrites, one axon.
      • Bipolar: Axon and dendrite extending from soma in opposite directions..
      • Unipolar: Transmits periphery to CNS, (Single branch).
    • Special Feature in Axon:

      • Nodes of Ranvier: Exposed axon areas where ion channels are concentrated.
      • Myelin: Insulates axon, increases signal speed.
    • Synapse:

      • Synaptic cleft: Space between neurons.
      • Neurotransmitter vesicle: Holds neurotransmitters.
    • Propagation of Information:

      • Passive current in soma.
      • Action potential in axon (all-or-nothing).
      • Neurotransmitter release at presynaptic terminal; activation of neighboring neuron/muscle fiber.
    • Nerve Propagation (Details):

      • Ions (Na+, K+, Cl-, Ca2+).
      • Passive channels.
      • Ligand-gated channels.
      • Voltage-gated channels.
      • Ion pumps.
      • Resting potential (-70 mV).
      • Action potential: Rapid change in membrane potential.
        • Depolarization, repolarization, refractory period, hyperpolarization.
    • Chemical vs Electrical synapses

      • Electrical synapses are rapid through gap junctions, chemical are slower via neurotransmitters across synaptic cleft.
    • Neurotransmitters:

      • Excitatory: Acetylcholine, glutamate, catecholamines (dopamine, norepinephrine, epinephrine).
      • Inhibitory: GABA, endocannabinoids.
    • Post-synaptic NT Receptors:

      • Ionotropic: Fast, ligand-gated ion channels.
      • Metabotropic: Slower, G-protein-coupled receptors (e.g., glutamate, acetylcholine, GABA).
    • Clinical Applications (Toxins, Diseases):

      • Botox: Paralyzes muscles; blocks neurotransmitter release (acetylcholine).
      • Myasthenia Gravis: Autoimmune disease affecting neuromuscular junction.
      • Treatment: Cholinesterase inhibitors to improve nerve-muscle communication.

    Non-neural Cells in the Nervous System

    • Neuroglia (Glial Cells):

      • Astrocytes (CNS): Maintain ionic balance, waste management;
      • Microglia (CNS): Phagocytic;
      • Oligodendrocytes (CNS): Produce myelin layers;
      • Schwann cells (PNS): Produce myelin sheath.
    • Myelination: Insulates axons, allowing faster signal transmission.

    • Differences between CNS and PNS myelination: type of glial cell.

    • Saltatory Conduction: Action potentials "jump" between nodes of Ranvier.

    • Clinical application of Demyelination:

      • Multiple Sclerosis (CNS)
      • Guillain-Barré Syndrome (PNS)

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    Test your knowledge on the basic terms and concepts of neuroanatomy. This quiz covers essential vocabulary such as nuclei, ganglia, tracts, and the organization of the central nervous system. Perfect for students looking to reinforce their understanding of neural structure and function.

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