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Questions and Answers
What structure forms the central nervous system?
What structure forms the central nervous system?
- Spinal fluid
- Neural tube (correct)
- Neural ectoderm
- Embryonic mesoderm
What is the recommended daily intake of folic acid for women of childbearing age to help prevent neural tube defects?
What is the recommended daily intake of folic acid for women of childbearing age to help prevent neural tube defects?
- 200 micrograms
- 600 micrograms
- 400 micrograms (correct)
- 800 micrograms
Which of the following neural tube defects is NOT compatible with life?
Which of the following neural tube defects is NOT compatible with life?
- Anencephaly (correct)
- Neural tumors
- Encephalocele
- Spina bifida
When does the neural tube typically close during embryonic development?
When does the neural tube typically close during embryonic development?
Which vitamin is critical for neural tube closure?
Which vitamin is critical for neural tube closure?
Flashcards
Neural Tube
Neural Tube
The straw-shaped structure that forms the central nervous system, including the brain and spinal cord.
Neural Tube Defect
Neural Tube Defect
A birth defect that occurs when the neural tube fails to close completely during fetal development. It can lead to various disabilities.
Anencephaly
Anencephaly
A severe neural tube defect where the brain fails to develop properly. This defect is incompatible with life.
Spina Bifida
Spina Bifida
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Folate
Folate
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Study Notes
Neural Tube Formation
- The central nervous system (brain and spinal cord) develops from the neural tube.
- The neural tube is a straw-shaped structure arising from the neural ectoderm.
- Neural tube formation occurs 20-27 days after conception.
- Initially, the neural tube is open at both ends; closure is complete by day 28.
Neural Tube Defects
- Neural tube defects (NTDs) occur when the neural tube fails to close.
- NTDs occur in approximately 1 in 1000 births.
- Anencephaly is a type of NTD resulting from failure of closure at the head end. It is incompatible with life.
- Spina bifida is a type of NTD resulting from incomplete closure at the tail end. It is associated with disability.
- Genetic and epigenetic mechanisms influence neural tube closure.
Preventing Neural Tube Defects
- Folate is crucial for proper neural tube closure.
- Adequate folate intake during pregnancy can significantly reduce the risk of NTDs.
- Prenatal folate supplementation is a key preventive measure.
- The recommended daily intake of folic acid for women of childbearing age is 400 micrograms (mcg) in addition to folate intake from food.
- Adequate folate intake during pregnancy can help prevent up to approximately 75% of NTDs.
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