Neural Tube Formation and Defects

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Questions and Answers

What structure forms the central nervous system?

  • Spinal fluid
  • Neural tube (correct)
  • Neural ectoderm
  • Embryonic mesoderm

What is the recommended daily intake of folic acid for women of childbearing age to help prevent neural tube defects?

  • 200 micrograms
  • 600 micrograms
  • 400 micrograms (correct)
  • 800 micrograms

Which of the following neural tube defects is NOT compatible with life?

  • Anencephaly (correct)
  • Neural tumors
  • Encephalocele
  • Spina bifida

When does the neural tube typically close during embryonic development?

<p>By day 28 after conception (D)</p> Signup and view all the answers

Which vitamin is critical for neural tube closure?

<p>Folate (C)</p> Signup and view all the answers

Flashcards

Neural Tube

The straw-shaped structure that forms the central nervous system, including the brain and spinal cord.

Neural Tube Defect

A birth defect that occurs when the neural tube fails to close completely during fetal development. It can lead to various disabilities.

Anencephaly

A severe neural tube defect where the brain fails to develop properly. This defect is incompatible with life.

Spina Bifida

A neural tube defect where the spinal cord doesn't close completely, leading to varying levels of disability.

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Folate

A crucial vitamin for neural tube closure during fetal development. Taking folate before and during pregnancy helps prevent many neural tube defects.

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Study Notes

Neural Tube Formation

  • The central nervous system (brain and spinal cord) develops from the neural tube.
  • The neural tube is a straw-shaped structure arising from the neural ectoderm.
  • Neural tube formation occurs 20-27 days after conception.
  • Initially, the neural tube is open at both ends; closure is complete by day 28.

Neural Tube Defects

  • Neural tube defects (NTDs) occur when the neural tube fails to close.
  • NTDs occur in approximately 1 in 1000 births.
  • Anencephaly is a type of NTD resulting from failure of closure at the head end. It is incompatible with life.
  • Spina bifida is a type of NTD resulting from incomplete closure at the tail end. It is associated with disability.
  • Genetic and epigenetic mechanisms influence neural tube closure.

Preventing Neural Tube Defects

  • Folate is crucial for proper neural tube closure.
  • Adequate folate intake during pregnancy can significantly reduce the risk of NTDs.
  • Prenatal folate supplementation is a key preventive measure.
  • The recommended daily intake of folic acid for women of childbearing age is 400 micrograms (mcg) in addition to folate intake from food.
  • Adequate folate intake during pregnancy can help prevent up to approximately 75% of NTDs.

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