Nervous Tissue: Histology MT120225

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

During the development of the nervous system, which layer gives rise to the nervous tissue?

  • Mesoderm layer
  • Endoderm layer
  • Ectoderm layer (correct)
  • Yolk sac

If a developing embryo's neural crest cells failed to properly migrate, which of the following structures would most likely be affected?

  • The development of the spinal cord
  • The development of the peripheral nervous system (correct)
  • The formation of the neural tube
  • The formation of the tooth enamel

Which of the following describes the correct order of development of the nervous system?

  • Neural tube → neural plate → neural crest
  • Neural plate → neural tube → neural crest (correct)
  • Neural crest → neural plate → neural tube
  • Neural plate → neural crest → neural tube

Which secondary vesicle of the developing brain gives rise to the thalamus and hypothalamus?

<p>Diencephalon (B)</p> Signup and view all the answers

Which part of the brain is responsible for coordinating complex muscular movements?

<p>Cerebellum (C)</p> Signup and view all the answers

Which of the brain's adult derivatives is primarily responsible for memory storage?

<p>Hippocampus (A)</p> Signup and view all the answers

The somatic sensory division of the nervous system is responsible for:

<p>Consciously perceived sensations (D)</p> Signup and view all the answers

What distinguishes visceral sensory input from somatic sensory input?

<p>Visceral input comes from blood vessels and internal organs. (B)</p> Signup and view all the answers

Which type of neuron is primarily responsible for conveying action potentials from the CNS to effectors in the PNS?

<p>Motor neurons (D)</p> Signup and view all the answers

What structural adaptation of dendrites increases the surface area available for signal reception?

<p>Dendritic spines (D)</p> Signup and view all the answers

Which of the following best describes the function of the axon hillock?

<p>It is the attachment site of the axon to the cell body and where the action potential is initiated. (C)</p> Signup and view all the answers

Lipofuscin is a hallmark of cellular aging. Where would lipofuscin be found in the neuron?

<p>Cell Body (C)</p> Signup and view all the answers

How do axodendritic synapses differ structurally and functionally from axosomatic synapses?

<p>Axodendritic synapse is where a signal is sent from the axon to a dendrite of another neuron while the axosomatic synapse is where the inhibitory signal is sent to the cell body. (C)</p> Signup and view all the answers

Which glial cell is responsible for myelinating axons in the central nervous system?

<p>Oligodendrocytes (B)</p> Signup and view all the answers

What is the function of ependymal cells?

<p>Lining brain ventricles and assisting in CSF production (A)</p> Signup and view all the answers

Astrocytes contribute to the blood-brain barrier by:

<p>Regulating interstitial fluid composition and providing structural support (B)</p> Signup and view all the answers

Which glial cells are the primary immune defense in the central nervous system?

<p>Microglia (C)</p> Signup and view all the answers

What role do satellite cells play in the peripheral nervous system?

<p>Insulating neuronal cell bodies in ganglia (A)</p> Signup and view all the answers

Which of the following is a key function of Schwann cells in the peripheral nervous system?

<p>Myelinating axons (A)</p> Signup and view all the answers

Unlike neurons in the central nervous system, neurons in the peripheral nervous system have more ability to repair themselves . What allows them this ability?

<p>The presence of Schwann cells (B)</p> Signup and view all the answers

Which of the following describes the structure and function of the myelin sheath?

<p>A multi-layered lipid rich insulation that speeds up nerve impulses (A)</p> Signup and view all the answers

What is the primary function of the nodes of Ranvier?

<p>Facilitating saltatory conduction (C)</p> Signup and view all the answers

How does saltatory conduction increase the speed of nerve impulse transmission?

<p>By allowing action potentials to jump between nodes of Ranvier (A)</p> Signup and view all the answers

What structural features allow unmyelinated nerve fibers to conduct impulses?

<p>Voltage-gated ion channels along the entire length (A)</p> Signup and view all the answers

What are the key structural components of a synapse?

<p>Presynaptic axon terminal, synaptic cleft, and post-synaptic cell membrane (A)</p> Signup and view all the answers

Excitatory neurotransmitters cause what change in the postsynaptic neuron, making it more likely to fire an impulse?

<p>Depolarization (A)</p> Signup and view all the answers

How do inhibitory neurotransmitters affect the postsynaptic membrane's potential?

<p>Cause hyperpolarization (B)</p> Signup and view all the answers

Which neurotransmitter is primarily involved in stimulating muscle contraction?

<p>Acetylcholine (A)</p> Signup and view all the answers

What is the role of glutamate in the nervous system?

<p>It promotes cognitive function in the brain, especially in learning and memory. (A)</p> Signup and view all the answers

Which neurotransmitter is primarily involved in inhibiting neuron activity within the CNS, including the retina?

<p>Glycine (A)</p> Signup and view all the answers

What is the function of the choroid plexus in the central nervous system?

<p>To produce cerebrospinal fluid (CSF) (D)</p> Signup and view all the answers

The blood-brain barrier protects the brain by:

<p>Regulating the substances from blood into the brain (D)</p> Signup and view all the answers

If the arachnoid villi were blocked, what would be the immediate likely health consequence?

<p>Accumulation of CSF (Cerebrospinal Fluid) (B)</p> Signup and view all the answers

Which type of tissue primarily comprises the dura mater?

<p>Dense irregular connective tissue (A)</p> Signup and view all the answers

Relative to white matter, grey matter has:

<p>More neuroglial cells and neuron cell bodes but fewer myelinated axons compared to white matter (C)</p> Signup and view all the answers

Which feature distinguishes sensory ganglia from autonomic ganglia?

<p>Types of neurons present. (D)</p> Signup and view all the answers

What connective tissue layer immediately surrounds individual nerve fibers in the PNS?

<p>Endoneurium (A)</p> Signup and view all the answers

What characteristic distinguishes mixed nerves from sensory or motor nerves?

<p>The presence of both afferent and efferent fibers. (D)</p> Signup and view all the answers

Which of the following best describes the sprouts penetrating bands of Büngner, seen in neuronal regeneration?

<p>Regenerating axons following the path created by Schwann cells after injury. (A)</p> Signup and view all the answers

Which property of nervous tissue allows it to respond to various stimuli?

<p>Irritability (B)</p> Signup and view all the answers

Which of the following best describes the role of conductivity in nervous tissue?

<p>Transmitting impulses (D)</p> Signup and view all the answers

During nervous system development, the neural folds elevate and approach one another, ultimately forming what structure?

<p>Neural tube (B)</p> Signup and view all the answers

Which of the following adult brain structures arises directly from the mesencephalon during development?

<p>Midbrain (B)</p> Signup and view all the answers

Which division of the nervous system is responsible for consciously perceived sensory input from receptors?

<p>Somatic sensory (C)</p> Signup and view all the answers

Which type of neuron is responsible for conveying action potentials away from the CNS to effectors in the periphery?

<p>Motor neurons (C)</p> Signup and view all the answers

What is the primary function of dendritic arborization in neurons?

<p>Increasing the receptor surface area (D)</p> Signup and view all the answers

Within the neuron cell body, what is the functional significance of a highly developed rough endoplasmic reticulum (RER)?

<p>Protein synthesis (A)</p> Signup and view all the answers

Which of the following describes the primary effect of inhibitory neurotransmitters on the postsynaptic neuron?

<p>Hyperpolarization and decreased likelihood of firing an action potential (B)</p> Signup and view all the answers

What is the role of the plasmalemma in the dendrites of a neuron?

<p>Containing receptor sites for binding chemical signals (B)</p> Signup and view all the answers

Which glial cell type is responsible for electrically insulating PNS cell bodies and regulating neuron/waste exchange?

<p>Satellite cells (C)</p> Signup and view all the answers

What is the functional importance of the junctions formed by flat epithelioid cells within the perineurium of a nerve?

<p>Sealing the fascicle for protection (D)</p> Signup and view all the answers

Which of the following glial cells is most directly involved in assisting with neuronal development in the CNS?

<p>Astrocytes (A)</p> Signup and view all the answers

What is the primary role of ependymal cells in the central nervous system?

<p>Production and circulation of cerebrospinal fluid (B)</p> Signup and view all the answers

How do microglia contribute to the overall health and function of the central nervous system?

<p>By providing immune defense through phagocytosis (D)</p> Signup and view all the answers

Damage to which structure would most directly affect the structural integrity and organization of the CNS?

<p>Astrocytes (C)</p> Signup and view all the answers

Which of the following statements accurately compares and contrasts grey matter and white matter?

<p>White matter is mostly myelinated, while grey matter consists primarily of cell bodies and dendrites. (A)</p> Signup and view all the answers

What structural component is unique to the dura mater, distinguishing it from other meningeal layers?

<p>A dual periosteal and meningeal layer (A)</p> Signup and view all the answers

What is the function of the arachnoid villi?

<p>Absorbing cerebrospinal fluid into venous sinuses (A)</p> Signup and view all the answers

How does the blood-brain barrier (BBB) primarily safeguard the brain?

<p>By regulating the movement of substances from the blood into the brain (A)</p> Signup and view all the answers

Which structural feature of the choroid plexus facilitates its function of producing cerebrospinal fluid?

<p>Highly specialized tissue with elaborate folds (B)</p> Signup and view all the answers

What potential effect would damage to the ventral horns of the spinal cord have on the body?

<p>Impaired motor function (D)</p> Signup and view all the answers

What is the defining structural characteristic of peripheral nerves?

<p>They are enclosed by the epineurium. (C)</p> Signup and view all the answers

Which statement best describes the structure and function of myelinated nerve fibers?

<p>Enclosed by myelin sheath and prevent loss of nerve impulse. (C)</p> Signup and view all the answers

What feature distinguishes unmyelinated nerve fibers?

<p>Envelopment by Schwann cells with no multiple wrappings (B)</p> Signup and view all the answers

How do sensory and autonomic ganglia differ in their functional roles within the peripheral nervous system?

<p>Sensory ganglia contain afferent information, autonomic ganglia are involved in autonomic functions (C)</p> Signup and view all the answers

Efferent Fibers contain ______.

<p>Fibers from the CNS (D)</p> Signup and view all the answers

The ______ is a site of communication between 2 neurons or between a neuron and an effector cell.

<p>Synapse (D)</p> Signup and view all the answers

Which of the following describes the location of Axodendritic synaptic contact?

<p>Synapse that occurs with a dendrite. (A)</p> Signup and view all the answers

What effect do excitatory neurotransmitters trigger at the postsynaptic membrane?

<p>Excitation to encourage the post synaptic neuron from firing. (A)</p> Signup and view all the answers

Which statement describes where acetylcholine commonly occurs in the nervous tissue?

<p>Stimulates muscle contraction (B)</p> Signup and view all the answers

Which of the following describes the primary function of Glutamine?

<p>Promote cognitive function in the brain (B)</p> Signup and view all the answers

Which neurotransmitter is essential for sleep, appetite, cognition and mood?

<p>Serotonin (D)</p> Signup and view all the answers

Which of the following describes the function of the neurotransmitter GABA?

<p>Enhances inhibitory brain function in the brain. (A)</p> Signup and view all the answers

Which of the following helps regulate response to noxious and potentially harmful stimuli?

<p>Enkephalin (D)</p> Signup and view all the answers

Damage to the cerebellum will cause issues with what bodily function?

<p>Coordination of complex muscle movements. (B)</p> Signup and view all the answers

If damage occurred to the Corpus Callosum, what is the primary function that may become defective?

<p>Fiber tracts between Cerebrum and Cerebellum(mammalian only). (D)</p> Signup and view all the answers

If a patients Spinal Cord has damaged Dorsal Horns, what symptoms may be present?

<p>Difficulty perceiving sensory information. (B)</p> Signup and view all the answers

What type of neuron is responsible for stimulating a motor movement?

<p>2 Ventral Horns- Contain Multipolar Neurons. (C)</p> Signup and view all the answers

Spinal Cord dorsal horns: ______

<p>Contain interneurons. (A)</p> Signup and view all the answers

Ovoid structures primarily surrounded by glial satellite cells are best described as?

<p>Ganglia (C)</p> Signup and view all the answers

How does the arrangement of neuronal cell bodies, dendrites, and axons differ between gray matter and white matter?

<p>Gray matter consists primarily of neuronal cell bodies and dendrites, while white matter consists largely of myelinated axons. (C)</p> Signup and view all the answers

If a researcher is studying the rate of action potential propagation in different types of nerve fibers, which characteristic would most likely lead to faster conduction?

<p>Larger axon diameter and the presence of nodes of Ranvier (D)</p> Signup and view all the answers

Why is the Blood Brain Barrier essential for proper neuronal function?

<p>It prevents the entry of harmful substance, toxins and pathogens from the blood into the brain tissue. (D)</p> Signup and view all the answers

How do the structural and functional characteristics of neurons support their ability to conduct electrical impulses over long distances?

<p>Long axons, myelin sheaths, and nodes of Ranvier (C)</p> Signup and view all the answers

Which of the following accurately compares the dura mater, arachnoid mater, and pia mater, in terms of function?

<p>The dura mater provides protection, the arachnoid mater cushions and facilitates CSF flow, and the pia mater supports the brain's structure and vasculature. (D)</p> Signup and view all the answers

Which glial cell type is responsible for myelinating axons in the PNS?

<p>Schwann cells (D)</p> Signup and view all the answers

How do the functions of sensory neurons, motor neurons, and interneurons collectively contribute to a coordinated response to an external stimulus?

<p>Sensory neurons detect the stimulus and relay the signal to interneurons, which process the information and transmit instructions to motor neurons. (C)</p> Signup and view all the answers

How does the organization of the peripheral nervous system (PNS) facilitate sensory input and motor output?

<p>The PNS includes sensory neurons for input and motor neurons for output, connected via spinal and cranial nerves. (C)</p> Signup and view all the answers

How does the presence or absence of a myelin sheath impact the conduction of nerve impulses in the peripheral nervous system (PNS)?

<p>Unmyelinated fibers conduct impulses slower because they rely on continuous regeneration of the action potential along the axon. (D)</p> Signup and view all the answers

How do excitatory and inhibitory neurotransmitters interact to regulate neuronal activity and maintain balanced signaling in the central nervous system (CNS)?

<p>Excitatory neurotransmitters shift the postsynaptic membrane potential toward depolarization, while inhibitory neurotransmitters shift it toward hyperpolarization. (B)</p> Signup and view all the answers

If a patient experiences a traumatic injury that severs a peripheral nerve, which of the following factors would be most crucial for the successful regeneration of the nerve fibers?

<p>Severance of the axon but with the cell body and myelin sheath intact. (C)</p> Signup and view all the answers

Which of the following correctly pairs a specific glial cell with its primary function in the central nervous system (CNS)?

<p>Ependymal cells: Producing cerebrospinal fluid (CSF) (D)</p> Signup and view all the answers

After a stroke, a patient exhibits difficulty coordinating movements and maintaining balance. Damage to which part of the brain is most likely responsible for these symptoms?

<p>Cerebellum (A)</p> Signup and view all the answers

What is the role of glutamate in neurotransmission?

<p>Promotes cognitive function in the brain (learning and memory) (A)</p> Signup and view all the answers

What is the primary function of GABA in the nervous system?

<p>The primary inhibitory neurotransmitter (B)</p> Signup and view all the answers

Enkephalins are neurotransmitters known to help regulate response to noxious stimuli. According to the text, which classification do enkephalins belong?

<p>Neuropeptide (C)</p> Signup and view all the answers

A patient suffers from a spinal cord injury that selectively damages the dorsal horns. What primary sensory deficits might the patient experience as a direct result of this injury?

<p>Loss of touch sensation (C)</p> Signup and view all the answers

Which of the following lists the layers of the meninges in order, from superficial to deep?

<p>Dura mater, arachnoid mater, pia mater (D)</p> Signup and view all the answers

Flashcards

Nervous tissue?

A network of billion nerve cells assisted by glial cells.

Central Nervous System

Receives information and sends information to the body.

Peripheral Nervous System

Detects stimuli and sends information to the CNS, communicates messages from CNS to the body.

Irritability (Nervous Tissue)

The ability to react to various stimuli.

Signup and view all the flashcards

Conductivity (Nervous Tissue)

The ability to transmit impulses.

Signup and view all the flashcards

Neurons

Cells that receive stimuli and conduct electrical impulses to effector cells; structural and functional unit of the nervous system.

Signup and view all the flashcards

Parts of a neuron?

Cell body, dendrites, and axons.

Signup and view all the flashcards

Cell Body (Neuron)

Trophic center of the neuron; contains nucleus and nucleolus, cytoplasmic organelles, and cytoskeletal filaments.

Signup and view all the flashcards

Dendrites:

Principal signal reception and processing sites on neurons. They contain receptor sites for binding chemical signals

Signup and view all the flashcards

Axon

Long projection that propagates nerve impulses toward another neuron, muscle fiber, or glandular cell.

Signup and view all the flashcards

Functional classes of neurons?

Sensory/afferent, Motor/efferent and Interneurons/association

Signup and view all the flashcards

Neuroglia/ Glial cells

Support, nourish, and protecting cells of the nervous system. They maintain interstitial fluid and continuously divide throughout lifetime.

Signup and view all the flashcards

Types of Neuroglia

Astrocytes, Oligodendrocytes, Microglia, Ependymal Cells, Schwann Cells and Satellite Cells.

Signup and view all the flashcards

Astrocytes

Forms part of the blood-brain barrier, regulates interstitial fluid composition and provides structural support.

Signup and view all the flashcards

Oligodendrocytes

Myelinates and insulates CNS axons, provides faster action potential propagation.

Signup and view all the flashcards

Microglia

Phagocytic cells that move throughout the CNS, protects the CNS by engulfing infectious agents and other potential harmful substances.

Signup and view all the flashcards

Ependymal cells

Lines ventricles of brain and central canal of spinal cord, assists in production and circulation of cerebrospinal fluid (CSF).

Signup and view all the flashcards

Schwann Cells

Surround and insulate PNS axons and myelinate those having large diameters. Allows for faster action potential propagation along PNS axons .

Signup and view all the flashcards

Satellite cells

Insulates PNS cell bodies and regulates nutrient/waste exchange.

Signup and view all the flashcards

Myelin Sheath

Multi-layered lipid rich covering around some axons and formed by plasma membrane of oligodendrocyte or schwann cells

Signup and view all the flashcards

Synapse

Site of communication between two neurons or neuron and a effector cell

Signup and view all the flashcards

Classification as to site of Synaptic contact

Involves Axodendritic, Axosomatic and Axoaxonic

Signup and view all the flashcards

Postsynaptic responses

Release of neurotransmitters causes either inhibition or excitation at the postsynaptic membrane

Signup and view all the flashcards

Excitatory neurotransmitters

Stimulates muscle contraction, promote cognitive function and related to sleep, appetite, cognition, and mood

Signup and view all the flashcards

Inhibitory neurotransmitters

A primary inhibitory neurotransmitter that inhibits activity between neurons in the CNS.

Signup and view all the flashcards

Major structures of the Central Nervous System

Includes Cerebrum, Cerebellum, Brain Stem, Spinal cord, and Meninges.

Signup and view all the flashcards

White Matter

Consists of tissues mainly with myelinated nerve fibers, oligodendrocytes, some astrocytes, and microglia.

Signup and view all the flashcards

Gray Matter

Consists of tissues mainly of neuronal cell bodies, dendrites, astrocytes, and microglial cells

Signup and view all the flashcards

Meningeal Layers

It has three layers: Dura Mater with thick, external dense irregular connective tissue, Arachnoid Mater with absorption of CSF, and Pia Mater with flattened mesenchymal derived cells

Signup and view all the flashcards

Blood Brain Barrier

Regulates substances from blood and consists of capillary endothelial cells, tight junctions, endothelial basement membrane, and end-foot processes of astrocytes.

Signup and view all the flashcards

Choroid plexuses

Made up of specialized tissue with elaborate folds.

Signup and view all the flashcards

Cerebellum Cortex

Is organized into 3 layers.

Signup and view all the flashcards

Sensory nerves

Contain afferent fibers (to the CNS)

Signup and view all the flashcards

Motor nerves

Contain efferent fibers (from the CNS)

Signup and view all the flashcards

Mixed nerves

Contain both afferent and efferent fibers.

Signup and view all the flashcards

Ganglia

Composed of neuronal cell bodies and surrounded by glial satellite cells. Types include sensory and autonomic.

Signup and view all the flashcards

Study Notes

Prayer before study

  • Asking for understanding, memory, accuracy, skill, thoroughness, clarity, guidance and completion

Nervous Tissue (Unit 4)

  • This lecture is for Human Histology MT120225
  • Department of Medical Technology - Second Semester A.Î¥. 2024-2025

Course Content

  • Overview of the Nervous Tissue
  • Central Nervous System
  • Peripheral Nervous System
  • Neural Plasticity and Regeneration

Unit Intended Learning Outcome

  • Students must identify the different types of nervous tissue and their respective functions

What is nervous tissue?

  • It comprises a network of billions of nerve cells
  • These are assisted by glial cells

Properties and Function

  • The Central Nervous System (CNS) receives and sends information to the body
  • The Peripheral Nervous System (PNS) detects stimuli, sends information to the CNS, and communicates messages from the CNS to the body

Properties of Nervous Tissues

  • Irritability - Reacts to various stimuli
  • Conductivity - Transmits impulses

Development of Nervous Tissue

  • Nervous tissue derives from the ectoderm

Anatomical Division of the Nervous System

  • Divided into the Central Nervous System (CNS) and Peripheral Nervous System (PNS)

Functional Division of the Nervous System

  • Sensory nervous system detects stimuli and transmits information from receptors to the CNS
  • Motor nervous system initiates and transmits information from the CNS to effectors
  • Somatic Sensory input is consciously perceived from receptors(eyes, ears and skin)
  • Visceral Sensory input is not consciously perceived from blood vessels and internal organs(heart)
  • Somatic Motor output is consciously or voluntarily controlled by skeletal muscle effectors
  • Autonomic Motor output is involuntarily controlled by cardiac muscle, smooth muscle, and glands effectors

Cells of the Nervous Tissue: Neurons

  • Neurons are the structural and functional units that receive stimuli and conduct electrical impulses to effector cells
  • Neurons lose the ability to undergo mitotic division, leading to long-term effects from damage
  • Neurons can maintain and renew their subcellular components and undergo neural plasticity
  • Neurons have three main parts: Cell body, Dendrites and Axons

Neuron Parts: Cell Body

  • It is the trophic center of the cell and contains cytoplamic organells, a nucleus and nucleolus
  • Cytoplamic organelles consist of free ribosomes, highly developed RER, golgi apparatus, mitochondria, lysosomes and lipofuscin
  • Cytoskeletal Filaments include Microtubules, actin filaments and intermediate filaments

Neuron Parts: Dendrites

  • Dendrites are the principal sites for signal reception and processing
  • The plasmalemma contains receptor sites for binding chemical signals
  • Dendrites are short, tapering, and highly branched.
  • Dendritic arborization increases the receptor area
  • Dendritic spines support synaptic plasticity, learning, and memory formation.

Neuron Parts: Axons

  • Axons propagate nerve impulses toward another neuron, muscle fiber, or glandular cell and comprise several key structues:
  • Axon hillock = attachment site
  • Axon collateral = branches along the length of an axon
  • Terminal boutons = the end of the axon
  • Collaterals = coordinate complex neural circuits
  • Axon initial segment = region between the apex of the axon hillock and the beginning of myelin sheath

Functional Classification of Neurons

  • Sensory/Afferent Neurons: Action potential conveyed into the CNS, mostly unipolar in structure
  • Motor/Efferent Neurons: Action potential conveyed away from the CNS to effectors in the PNS. They are mostly multipolar in structure
  • Interneurons/Association Neurons: They form a communicating and integrative network between sensory and motor neurons. Most are multipolar in structure

Cells of the Nervous System: Glial Cells

  • Neuroglia/Glial Cells play a support role for the nervous system
  • Glial cells support, nourish, and protects neurons
  • Glial cells maintain the interstitial fluid of the NS and can divide constantly
  • The types of neuroglia are: Astrocytes, Oligodendrocytes, Microglia, Ependymal cells, Schwann cells and Satellite cells

Glial Cells: Astrocytes

  • Protoplasmic Astrocytes: many short branching processes found in gray matter
  • Fibrous Astrocytes: many long unbranched processes located mainly in white matter

Myelin Sheath

  • Multi-layered lipid rich covering around some axons
  • Formed by concentric layers of the plasma membrane of oligodendrocyte/schwann cells
  • Functions include insulation, speeding up nerve impulses and reducing the total amount of ion exchange during action potential

Synapses

  • Synapses are sites of communication between two neurons or between a neuron and an effector cell. Includes:
  • Presynaptic Axon Terminal
  • Synaptic Cleft
  • Post-synaptic Cell Membrane

Synapses: Classification by Site of Synaptic Contact

  • Axodendritic
  • Axosomatic
  • Axoaxonic

Postsynaptic Responses

  • Neurotransmitter release can cause excitation or inhibition at the postsynaptic membrane

Neurotransmitters

  • Can be excitatory or inhibitory

Excitatory Neurotransmitters

  • Acetylcholine stimulates muscle contraction
  • Glutamine promotes cognitive function in the brain
  • Serotonin affects sleep, appetite, cognition, and mood
  • Excitatory neurotransmitters cause depolarization, making the postsynaptic neuron more likely to fire impulses

Inhibitory Neurotransmitters

  • GABA is the primary inhibitory neurotransmitter
  • Glycine inhibits activity between neurons in the CNS, including the retina
  • Inhibitory neurotransmitters cause hyperpolarization, making the postsynaptic neuron less likely to fire impulses

Central Nervous System (CNS) Structures

  • Cerebrum
  • Cerebellum
  • Brainstem
  • Spinal cord
  • Meninges

CNS Tissues

  • White Matter largely contains myelinated nerve fibers, oligodendrocytes, and some astrocytes and microglia
  • Gray Matter largely contains neuronal cell bodies, dendrites, astrocytes, and microglial cells

Connective Tissue of the CNS: Meningeal Layers

  • Protects the CNS and are comprised of 3 layers
  • Dura Mater (outermost): thick external dense irregular connective tissue continuous with the periosteum of the skull
  • Arachnoid mater (middle): Sheet of connective tissue in contact with the dura mater and a system of loosely arranged trabeculae continuous with pia mater
  • Arachnoid villi: sites for absorption of CSF into the venous sinuses.
  • Pia Mater (innermost): consists of flattened mesenchymal derived cells attached to the glial limiting membrane

Blood Brain Barrier

  • Regulates the passage of substances from the blood into the brain
  • Composed of capillary endothelial cells, tight junctions, endothelial basement membrane, and end-foot processes of astrocytes.

Choroid Plexuses

  • Consist of highly specialized tissue with elaborate folds located in the ventricles

Cerebrum

  • Contains the cerebral cortex which is gray matter
  • Deep to the cerebral cortex lies the subcortical white matter
  • Major neuronal cell types are the pyramidal cells, stellate cells, and other cells

Cerebellum

  • The cerebellar cortex is organized into 3 layers.

Spinal Cord

  • The gray matter in the spinal cord is H shaped and contains 2 dorsal horns and 2 ventral horns
  • Dorsal horns contain interneurons and receive sensory fibers from neurons in the spinal cord
  • Ventral horns contain multipolar motor neurons
  • White matter is peripherally located and consists of ascending and descending fibers, mostly myelinated

Peripheral Nervous System (PNS) Components

  • Nerves and Ganglia
  • Nerve endings

Structures of the Peripheral Nervous System: Connective Tissue Coverings of Nerves

  • Epineurium: external coat of the nerve
  • Perineurium: surrounds each bundle of the nerve
  • Endoneurium: surrounds individual nerve fiber

Peripheral Nerves

  • Groups of axons sheathed by schwann cells that can be myelinated or unmyelinated

Myelinated Nerve Fibers

  • Enclosed by a myelin sheath derived from the plasma membrane of Schwann cells to prevent nerve impulse loss
  • Circular constrictions (nodes of Ranvier)
    • Internodal segments or Schwann segments
    • Gaps between myelin segment where axon is partially covered by Schwann cells
    • Impulse conductions are saltatory

Unmyelinated Nerve Fibers

  • Smallest diameter axons
  • Wrapped with a simple fold of Schwann cells but no multiple wrapping to form a myelin sheath
  • Contain voltage-gated ion channels along the entire length but there are no Nodes of Ranvier
  • Impulse conduction is not saltatory and slower

Peripheral Nerves: Classification by Function

  • Sensory: contain afferent fibers (to the CNS)
  • Motor: contain efferent fibers (from the CNS)
  • Mixed: contain both afferent and efferent fibers

Ganglia

  • Ovoid structures composed of neuronal cell bodies surrounded by glial satellite cells closely associated with cranial and spinal nerves
  • Two types: sensory (cranial ganglia, dorsal root ganglia) and autonomic (sympathetic ganglion, parasympathetic ganglion)

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Use Quizgecko on...
Browser
Browser