Podcast
Questions and Answers
During the development of the nervous system, which layer gives rise to the nervous tissue?
During the development of the nervous system, which layer gives rise to the nervous tissue?
- Mesoderm layer
- Endoderm layer
- Ectoderm layer (correct)
- Yolk sac
If a developing embryo's neural crest cells failed to properly migrate, which of the following structures would most likely be affected?
If a developing embryo's neural crest cells failed to properly migrate, which of the following structures would most likely be affected?
- The development of the spinal cord
- The development of the peripheral nervous system (correct)
- The formation of the neural tube
- The formation of the tooth enamel
Which of the following describes the correct order of development of the nervous system?
Which of the following describes the correct order of development of the nervous system?
- Neural tube → neural plate → neural crest
- Neural plate → neural tube → neural crest (correct)
- Neural crest → neural plate → neural tube
- Neural plate → neural crest → neural tube
Which secondary vesicle of the developing brain gives rise to the thalamus and hypothalamus?
Which secondary vesicle of the developing brain gives rise to the thalamus and hypothalamus?
Which part of the brain is responsible for coordinating complex muscular movements?
Which part of the brain is responsible for coordinating complex muscular movements?
Which of the brain's adult derivatives is primarily responsible for memory storage?
Which of the brain's adult derivatives is primarily responsible for memory storage?
The somatic sensory division of the nervous system is responsible for:
The somatic sensory division of the nervous system is responsible for:
What distinguishes visceral sensory input from somatic sensory input?
What distinguishes visceral sensory input from somatic sensory input?
Which type of neuron is primarily responsible for conveying action potentials from the CNS to effectors in the PNS?
Which type of neuron is primarily responsible for conveying action potentials from the CNS to effectors in the PNS?
What structural adaptation of dendrites increases the surface area available for signal reception?
What structural adaptation of dendrites increases the surface area available for signal reception?
Which of the following best describes the function of the axon hillock?
Which of the following best describes the function of the axon hillock?
Lipofuscin is a hallmark of cellular aging. Where would lipofuscin be found in the neuron?
Lipofuscin is a hallmark of cellular aging. Where would lipofuscin be found in the neuron?
How do axodendritic synapses differ structurally and functionally from axosomatic synapses?
How do axodendritic synapses differ structurally and functionally from axosomatic synapses?
Which glial cell is responsible for myelinating axons in the central nervous system?
Which glial cell is responsible for myelinating axons in the central nervous system?
What is the function of ependymal cells?
What is the function of ependymal cells?
Astrocytes contribute to the blood-brain barrier by:
Astrocytes contribute to the blood-brain barrier by:
Which glial cells are the primary immune defense in the central nervous system?
Which glial cells are the primary immune defense in the central nervous system?
What role do satellite cells play in the peripheral nervous system?
What role do satellite cells play in the peripheral nervous system?
Which of the following is a key function of Schwann cells in the peripheral nervous system?
Which of the following is a key function of Schwann cells in the peripheral nervous system?
Unlike neurons in the central nervous system, neurons in the peripheral nervous system have more ability to repair themselves . What allows them this ability?
Unlike neurons in the central nervous system, neurons in the peripheral nervous system have more ability to repair themselves . What allows them this ability?
Which of the following describes the structure and function of the myelin sheath?
Which of the following describes the structure and function of the myelin sheath?
What is the primary function of the nodes of Ranvier?
What is the primary function of the nodes of Ranvier?
How does saltatory conduction increase the speed of nerve impulse transmission?
How does saltatory conduction increase the speed of nerve impulse transmission?
What structural features allow unmyelinated nerve fibers to conduct impulses?
What structural features allow unmyelinated nerve fibers to conduct impulses?
What are the key structural components of a synapse?
What are the key structural components of a synapse?
Excitatory neurotransmitters cause what change in the postsynaptic neuron, making it more likely to fire an impulse?
Excitatory neurotransmitters cause what change in the postsynaptic neuron, making it more likely to fire an impulse?
How do inhibitory neurotransmitters affect the postsynaptic membrane's potential?
How do inhibitory neurotransmitters affect the postsynaptic membrane's potential?
Which neurotransmitter is primarily involved in stimulating muscle contraction?
Which neurotransmitter is primarily involved in stimulating muscle contraction?
What is the role of glutamate in the nervous system?
What is the role of glutamate in the nervous system?
Which neurotransmitter is primarily involved in inhibiting neuron activity within the CNS, including the retina?
Which neurotransmitter is primarily involved in inhibiting neuron activity within the CNS, including the retina?
What is the function of the choroid plexus in the central nervous system?
What is the function of the choroid plexus in the central nervous system?
The blood-brain barrier protects the brain by:
The blood-brain barrier protects the brain by:
If the arachnoid villi were blocked, what would be the immediate likely health consequence?
If the arachnoid villi were blocked, what would be the immediate likely health consequence?
Which type of tissue primarily comprises the dura mater?
Which type of tissue primarily comprises the dura mater?
Relative to white matter, grey matter has:
Relative to white matter, grey matter has:
Which feature distinguishes sensory ganglia from autonomic ganglia?
Which feature distinguishes sensory ganglia from autonomic ganglia?
What connective tissue layer immediately surrounds individual nerve fibers in the PNS?
What connective tissue layer immediately surrounds individual nerve fibers in the PNS?
What characteristic distinguishes mixed nerves from sensory or motor nerves?
What characteristic distinguishes mixed nerves from sensory or motor nerves?
Which of the following best describes the sprouts penetrating bands of Büngner, seen in neuronal regeneration?
Which of the following best describes the sprouts penetrating bands of Büngner, seen in neuronal regeneration?
Which property of nervous tissue allows it to respond to various stimuli?
Which property of nervous tissue allows it to respond to various stimuli?
Which of the following best describes the role of conductivity in nervous tissue?
Which of the following best describes the role of conductivity in nervous tissue?
During nervous system development, the neural folds elevate and approach one another, ultimately forming what structure?
During nervous system development, the neural folds elevate and approach one another, ultimately forming what structure?
Which of the following adult brain structures arises directly from the mesencephalon during development?
Which of the following adult brain structures arises directly from the mesencephalon during development?
Which division of the nervous system is responsible for consciously perceived sensory input from receptors?
Which division of the nervous system is responsible for consciously perceived sensory input from receptors?
Which type of neuron is responsible for conveying action potentials away from the CNS to effectors in the periphery?
Which type of neuron is responsible for conveying action potentials away from the CNS to effectors in the periphery?
What is the primary function of dendritic arborization in neurons?
What is the primary function of dendritic arborization in neurons?
Within the neuron cell body, what is the functional significance of a highly developed rough endoplasmic reticulum (RER)?
Within the neuron cell body, what is the functional significance of a highly developed rough endoplasmic reticulum (RER)?
Which of the following describes the primary effect of inhibitory neurotransmitters on the postsynaptic neuron?
Which of the following describes the primary effect of inhibitory neurotransmitters on the postsynaptic neuron?
What is the role of the plasmalemma in the dendrites of a neuron?
What is the role of the plasmalemma in the dendrites of a neuron?
Which glial cell type is responsible for electrically insulating PNS cell bodies and regulating neuron/waste exchange?
Which glial cell type is responsible for electrically insulating PNS cell bodies and regulating neuron/waste exchange?
What is the functional importance of the junctions formed by flat epithelioid cells within the perineurium of a nerve?
What is the functional importance of the junctions formed by flat epithelioid cells within the perineurium of a nerve?
Which of the following glial cells is most directly involved in assisting with neuronal development in the CNS?
Which of the following glial cells is most directly involved in assisting with neuronal development in the CNS?
What is the primary role of ependymal cells in the central nervous system?
What is the primary role of ependymal cells in the central nervous system?
How do microglia contribute to the overall health and function of the central nervous system?
How do microglia contribute to the overall health and function of the central nervous system?
Damage to which structure would most directly affect the structural integrity and organization of the CNS?
Damage to which structure would most directly affect the structural integrity and organization of the CNS?
Which of the following statements accurately compares and contrasts grey matter and white matter?
Which of the following statements accurately compares and contrasts grey matter and white matter?
What structural component is unique to the dura mater, distinguishing it from other meningeal layers?
What structural component is unique to the dura mater, distinguishing it from other meningeal layers?
What is the function of the arachnoid villi?
What is the function of the arachnoid villi?
How does the blood-brain barrier (BBB) primarily safeguard the brain?
How does the blood-brain barrier (BBB) primarily safeguard the brain?
Which structural feature of the choroid plexus facilitates its function of producing cerebrospinal fluid?
Which structural feature of the choroid plexus facilitates its function of producing cerebrospinal fluid?
What potential effect would damage to the ventral horns of the spinal cord have on the body?
What potential effect would damage to the ventral horns of the spinal cord have on the body?
What is the defining structural characteristic of peripheral nerves?
What is the defining structural characteristic of peripheral nerves?
Which statement best describes the structure and function of myelinated nerve fibers?
Which statement best describes the structure and function of myelinated nerve fibers?
What feature distinguishes unmyelinated nerve fibers?
What feature distinguishes unmyelinated nerve fibers?
How do sensory and autonomic ganglia differ in their functional roles within the peripheral nervous system?
How do sensory and autonomic ganglia differ in their functional roles within the peripheral nervous system?
Efferent Fibers contain ______.
Efferent Fibers contain ______.
The ______ is a site of communication between 2 neurons or between a neuron and an effector cell.
The ______ is a site of communication between 2 neurons or between a neuron and an effector cell.
Which of the following describes the location of Axodendritic synaptic contact?
Which of the following describes the location of Axodendritic synaptic contact?
What effect do excitatory neurotransmitters trigger at the postsynaptic membrane?
What effect do excitatory neurotransmitters trigger at the postsynaptic membrane?
Which statement describes where acetylcholine commonly occurs in the nervous tissue?
Which statement describes where acetylcholine commonly occurs in the nervous tissue?
Which of the following describes the primary function of Glutamine?
Which of the following describes the primary function of Glutamine?
Which neurotransmitter is essential for sleep, appetite, cognition and mood?
Which neurotransmitter is essential for sleep, appetite, cognition and mood?
Which of the following describes the function of the neurotransmitter GABA?
Which of the following describes the function of the neurotransmitter GABA?
Which of the following helps regulate response to noxious and potentially harmful stimuli?
Which of the following helps regulate response to noxious and potentially harmful stimuli?
Damage to the cerebellum will cause issues with what bodily function?
Damage to the cerebellum will cause issues with what bodily function?
If damage occurred to the Corpus Callosum, what is the primary function that may become defective?
If damage occurred to the Corpus Callosum, what is the primary function that may become defective?
If a patients Spinal Cord has damaged Dorsal Horns, what symptoms may be present?
If a patients Spinal Cord has damaged Dorsal Horns, what symptoms may be present?
What type of neuron is responsible for stimulating a motor movement?
What type of neuron is responsible for stimulating a motor movement?
Spinal Cord dorsal horns: ______
Spinal Cord dorsal horns: ______
Ovoid structures primarily surrounded by glial satellite cells are best described as?
Ovoid structures primarily surrounded by glial satellite cells are best described as?
How does the arrangement of neuronal cell bodies, dendrites, and axons differ between gray matter and white matter?
How does the arrangement of neuronal cell bodies, dendrites, and axons differ between gray matter and white matter?
If a researcher is studying the rate of action potential propagation in different types of nerve fibers, which characteristic would most likely lead to faster conduction?
If a researcher is studying the rate of action potential propagation in different types of nerve fibers, which characteristic would most likely lead to faster conduction?
Why is the Blood Brain Barrier essential for proper neuronal function?
Why is the Blood Brain Barrier essential for proper neuronal function?
How do the structural and functional characteristics of neurons support their ability to conduct electrical impulses over long distances?
How do the structural and functional characteristics of neurons support their ability to conduct electrical impulses over long distances?
Which of the following accurately compares the dura mater, arachnoid mater, and pia mater, in terms of function?
Which of the following accurately compares the dura mater, arachnoid mater, and pia mater, in terms of function?
Which glial cell type is responsible for myelinating axons in the PNS?
Which glial cell type is responsible for myelinating axons in the PNS?
How do the functions of sensory neurons, motor neurons, and interneurons collectively contribute to a coordinated response to an external stimulus?
How do the functions of sensory neurons, motor neurons, and interneurons collectively contribute to a coordinated response to an external stimulus?
How does the organization of the peripheral nervous system (PNS) facilitate sensory input and motor output?
How does the organization of the peripheral nervous system (PNS) facilitate sensory input and motor output?
How does the presence or absence of a myelin sheath impact the conduction of nerve impulses in the peripheral nervous system (PNS)?
How does the presence or absence of a myelin sheath impact the conduction of nerve impulses in the peripheral nervous system (PNS)?
How do excitatory and inhibitory neurotransmitters interact to regulate neuronal activity and maintain balanced signaling in the central nervous system (CNS)?
How do excitatory and inhibitory neurotransmitters interact to regulate neuronal activity and maintain balanced signaling in the central nervous system (CNS)?
If a patient experiences a traumatic injury that severs a peripheral nerve, which of the following factors would be most crucial for the successful regeneration of the nerve fibers?
If a patient experiences a traumatic injury that severs a peripheral nerve, which of the following factors would be most crucial for the successful regeneration of the nerve fibers?
Which of the following correctly pairs a specific glial cell with its primary function in the central nervous system (CNS)?
Which of the following correctly pairs a specific glial cell with its primary function in the central nervous system (CNS)?
After a stroke, a patient exhibits difficulty coordinating movements and maintaining balance. Damage to which part of the brain is most likely responsible for these symptoms?
After a stroke, a patient exhibits difficulty coordinating movements and maintaining balance. Damage to which part of the brain is most likely responsible for these symptoms?
What is the role of glutamate in neurotransmission?
What is the role of glutamate in neurotransmission?
What is the primary function of GABA in the nervous system?
What is the primary function of GABA in the nervous system?
Enkephalins are neurotransmitters known to help regulate response to noxious stimuli. According to the text, which classification do enkephalins belong?
Enkephalins are neurotransmitters known to help regulate response to noxious stimuli. According to the text, which classification do enkephalins belong?
A patient suffers from a spinal cord injury that selectively damages the dorsal horns. What primary sensory deficits might the patient experience as a direct result of this injury?
A patient suffers from a spinal cord injury that selectively damages the dorsal horns. What primary sensory deficits might the patient experience as a direct result of this injury?
Which of the following lists the layers of the meninges in order, from superficial to deep?
Which of the following lists the layers of the meninges in order, from superficial to deep?
Flashcards
Nervous tissue?
Nervous tissue?
A network of billion nerve cells assisted by glial cells.
Central Nervous System
Central Nervous System
Receives information and sends information to the body.
Peripheral Nervous System
Peripheral Nervous System
Detects stimuli and sends information to the CNS, communicates messages from CNS to the body.
Irritability (Nervous Tissue)
Irritability (Nervous Tissue)
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Conductivity (Nervous Tissue)
Conductivity (Nervous Tissue)
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Neurons
Neurons
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Parts of a neuron?
Parts of a neuron?
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Cell Body (Neuron)
Cell Body (Neuron)
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Dendrites:
Dendrites:
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Axon
Axon
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Functional classes of neurons?
Functional classes of neurons?
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Neuroglia/ Glial cells
Neuroglia/ Glial cells
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Types of Neuroglia
Types of Neuroglia
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Astrocytes
Astrocytes
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Oligodendrocytes
Oligodendrocytes
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Microglia
Microglia
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Ependymal cells
Ependymal cells
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Schwann Cells
Schwann Cells
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Satellite cells
Satellite cells
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Myelin Sheath
Myelin Sheath
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Synapse
Synapse
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Classification as to site of Synaptic contact
Classification as to site of Synaptic contact
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Postsynaptic responses
Postsynaptic responses
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Excitatory neurotransmitters
Excitatory neurotransmitters
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Inhibitory neurotransmitters
Inhibitory neurotransmitters
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Major structures of the Central Nervous System
Major structures of the Central Nervous System
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White Matter
White Matter
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Gray Matter
Gray Matter
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Meningeal Layers
Meningeal Layers
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Blood Brain Barrier
Blood Brain Barrier
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Choroid plexuses
Choroid plexuses
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Cerebellum Cortex
Cerebellum Cortex
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Sensory nerves
Sensory nerves
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Motor nerves
Motor nerves
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Mixed nerves
Mixed nerves
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Ganglia
Ganglia
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Study Notes
Prayer before study
- Asking for understanding, memory, accuracy, skill, thoroughness, clarity, guidance and completion
Nervous Tissue (Unit 4)
- This lecture is for Human Histology MT120225
- Department of Medical Technology - Second Semester A.Î¥. 2024-2025
Course Content
- Overview of the Nervous Tissue
- Central Nervous System
- Peripheral Nervous System
- Neural Plasticity and Regeneration
Unit Intended Learning Outcome
- Students must identify the different types of nervous tissue and their respective functions
What is nervous tissue?
- It comprises a network of billions of nerve cells
- These are assisted by glial cells
Properties and Function
- The Central Nervous System (CNS) receives and sends information to the body
- The Peripheral Nervous System (PNS) detects stimuli, sends information to the CNS, and communicates messages from the CNS to the body
Properties of Nervous Tissues
- Irritability - Reacts to various stimuli
- Conductivity - Transmits impulses
Development of Nervous Tissue
- Nervous tissue derives from the ectoderm
Anatomical Division of the Nervous System
- Divided into the Central Nervous System (CNS) and Peripheral Nervous System (PNS)
Functional Division of the Nervous System
- Sensory nervous system detects stimuli and transmits information from receptors to the CNS
- Motor nervous system initiates and transmits information from the CNS to effectors
- Somatic Sensory input is consciously perceived from receptors(eyes, ears and skin)
- Visceral Sensory input is not consciously perceived from blood vessels and internal organs(heart)
- Somatic Motor output is consciously or voluntarily controlled by skeletal muscle effectors
- Autonomic Motor output is involuntarily controlled by cardiac muscle, smooth muscle, and glands effectors
Cells of the Nervous Tissue: Neurons
- Neurons are the structural and functional units that receive stimuli and conduct electrical impulses to effector cells
- Neurons lose the ability to undergo mitotic division, leading to long-term effects from damage
- Neurons can maintain and renew their subcellular components and undergo neural plasticity
- Neurons have three main parts: Cell body, Dendrites and Axons
Neuron Parts: Cell Body
- It is the trophic center of the cell and contains cytoplamic organells, a nucleus and nucleolus
- Cytoplamic organelles consist of free ribosomes, highly developed RER, golgi apparatus, mitochondria, lysosomes and lipofuscin
- Cytoskeletal Filaments include Microtubules, actin filaments and intermediate filaments
Neuron Parts: Dendrites
- Dendrites are the principal sites for signal reception and processing
- The plasmalemma contains receptor sites for binding chemical signals
- Dendrites are short, tapering, and highly branched.
- Dendritic arborization increases the receptor area
- Dendritic spines support synaptic plasticity, learning, and memory formation.
Neuron Parts: Axons
- Axons propagate nerve impulses toward another neuron, muscle fiber, or glandular cell and comprise several key structues:
- Axon hillock = attachment site
- Axon collateral = branches along the length of an axon
- Terminal boutons = the end of the axon
- Collaterals = coordinate complex neural circuits
- Axon initial segment = region between the apex of the axon hillock and the beginning of myelin sheath
Functional Classification of Neurons
- Sensory/Afferent Neurons: Action potential conveyed into the CNS, mostly unipolar in structure
- Motor/Efferent Neurons: Action potential conveyed away from the CNS to effectors in the PNS. They are mostly multipolar in structure
- Interneurons/Association Neurons: They form a communicating and integrative network between sensory and motor neurons. Most are multipolar in structure
Cells of the Nervous System: Glial Cells
- Neuroglia/Glial Cells play a support role for the nervous system
- Glial cells support, nourish, and protects neurons
- Glial cells maintain the interstitial fluid of the NS and can divide constantly
- The types of neuroglia are: Astrocytes, Oligodendrocytes, Microglia, Ependymal cells, Schwann cells and Satellite cells
Glial Cells: Astrocytes
- Protoplasmic Astrocytes: many short branching processes found in gray matter
- Fibrous Astrocytes: many long unbranched processes located mainly in white matter
Myelin Sheath
- Multi-layered lipid rich covering around some axons
- Formed by concentric layers of the plasma membrane of oligodendrocyte/schwann cells
- Functions include insulation, speeding up nerve impulses and reducing the total amount of ion exchange during action potential
Synapses
- Synapses are sites of communication between two neurons or between a neuron and an effector cell. Includes:
- Presynaptic Axon Terminal
- Synaptic Cleft
- Post-synaptic Cell Membrane
Synapses: Classification by Site of Synaptic Contact
- Axodendritic
- Axosomatic
- Axoaxonic
Postsynaptic Responses
- Neurotransmitter release can cause excitation or inhibition at the postsynaptic membrane
Neurotransmitters
- Can be excitatory or inhibitory
Excitatory Neurotransmitters
- Acetylcholine stimulates muscle contraction
- Glutamine promotes cognitive function in the brain
- Serotonin affects sleep, appetite, cognition, and mood
- Excitatory neurotransmitters cause depolarization, making the postsynaptic neuron more likely to fire impulses
Inhibitory Neurotransmitters
- GABA is the primary inhibitory neurotransmitter
- Glycine inhibits activity between neurons in the CNS, including the retina
- Inhibitory neurotransmitters cause hyperpolarization, making the postsynaptic neuron less likely to fire impulses
Central Nervous System (CNS) Structures
- Cerebrum
- Cerebellum
- Brainstem
- Spinal cord
- Meninges
CNS Tissues
- White Matter largely contains myelinated nerve fibers, oligodendrocytes, and some astrocytes and microglia
- Gray Matter largely contains neuronal cell bodies, dendrites, astrocytes, and microglial cells
Connective Tissue of the CNS: Meningeal Layers
- Protects the CNS and are comprised of 3 layers
- Dura Mater (outermost): thick external dense irregular connective tissue continuous with the periosteum of the skull
- Arachnoid mater (middle): Sheet of connective tissue in contact with the dura mater and a system of loosely arranged trabeculae continuous with pia mater
- Arachnoid villi: sites for absorption of CSF into the venous sinuses.
- Pia Mater (innermost): consists of flattened mesenchymal derived cells attached to the glial limiting membrane
Blood Brain Barrier
- Regulates the passage of substances from the blood into the brain
- Composed of capillary endothelial cells, tight junctions, endothelial basement membrane, and end-foot processes of astrocytes.
Choroid Plexuses
- Consist of highly specialized tissue with elaborate folds located in the ventricles
Cerebrum
- Contains the cerebral cortex which is gray matter
- Deep to the cerebral cortex lies the subcortical white matter
- Major neuronal cell types are the pyramidal cells, stellate cells, and other cells
Cerebellum
- The cerebellar cortex is organized into 3 layers.
Spinal Cord
- The gray matter in the spinal cord is H shaped and contains 2 dorsal horns and 2 ventral horns
- Dorsal horns contain interneurons and receive sensory fibers from neurons in the spinal cord
- Ventral horns contain multipolar motor neurons
- White matter is peripherally located and consists of ascending and descending fibers, mostly myelinated
Peripheral Nervous System (PNS) Components
- Nerves and Ganglia
- Nerve endings
Structures of the Peripheral Nervous System: Connective Tissue Coverings of Nerves
- Epineurium: external coat of the nerve
- Perineurium: surrounds each bundle of the nerve
- Endoneurium: surrounds individual nerve fiber
Peripheral Nerves
- Groups of axons sheathed by schwann cells that can be myelinated or unmyelinated
Myelinated Nerve Fibers
- Enclosed by a myelin sheath derived from the plasma membrane of Schwann cells to prevent nerve impulse loss
- Circular constrictions (nodes of Ranvier)
- Internodal segments or Schwann segments
- Gaps between myelin segment where axon is partially covered by Schwann cells
- Impulse conductions are saltatory
Unmyelinated Nerve Fibers
- Smallest diameter axons
- Wrapped with a simple fold of Schwann cells but no multiple wrapping to form a myelin sheath
- Contain voltage-gated ion channels along the entire length but there are no Nodes of Ranvier
- Impulse conduction is not saltatory and slower
Peripheral Nerves: Classification by Function
- Sensory: contain afferent fibers (to the CNS)
- Motor: contain efferent fibers (from the CNS)
- Mixed: contain both afferent and efferent fibers
Ganglia
- Ovoid structures composed of neuronal cell bodies surrounded by glial satellite cells closely associated with cranial and spinal nerves
- Two types: sensory (cranial ganglia, dorsal root ganglia) and autonomic (sympathetic ganglion, parasympathetic ganglion)
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