Compendium 8
86 Questions
6 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is a neuron and its role in the nervous system?

A neuron is the basic structural and functional unit of the nervous system, responsible for transmitting electrical signals throughout the body.

Define neuroglia and their function in relation to neurons.

Neuroglia are supporting cells that maintain homeostasis, provide support and protection for neurons.

What constitutes an action potential in the nervous system?

An action potential is an electronic signal that propagates along the axon of a neuron, transmitting information through the nervous system.

Describe the role of sensory receptors in the nervous system.

<p>Sensory receptors are specialized cells that detect various stimuli such as temperature, pain, and light, converting them into sensory input for the nervous system.</p> Signup and view all the answers

What is the function of the synapse in neuronal communication?

<p>A synapse is the junction between a neuron and another cell, facilitating the transmission of signals through neurotransmitters.</p> Signup and view all the answers

Explain how the central nervous system integrates information.

<p>The central nervous system processes sensory input to interpret and decide on appropriate responses, which may be immediate or delayed.</p> Signup and view all the answers

What are the primary components of the central nervous system?

<p>The central nervous system consists primarily of the brain and spinal cord.</p> Signup and view all the answers

How does the nervous system help maintain homeostasis?

<p>The nervous system maintains homeostasis by regulating bodily functions through sensory input, integration of information, and motor output.</p> Signup and view all the answers

What is a reflex arc and what are its components?

<p>A reflex arc is the anatomical pathway of a reflex. Its components include a sensory receptor, sensory neuron, interneuron, motor neuron, and effector organ.</p> Signup and view all the answers

Differentiate between somatic and autonomic reflexes with examples.

<p>Somatic reflexes involve skeletal muscles, such as the patellar reflex, while autonomic reflexes involve smooth muscles or glands, like the pupillary reflex.</p> Signup and view all the answers

Explain the difference between monosynaptic and polysynaptic reflexes.

<p>Monosynaptic reflexes involve a simple pathway with one synapse between sensory and motor neurons, whereas polysynaptic reflexes have multiple synapses with interneurons.</p> Signup and view all the answers

What role does the brain play after a reflex has occurred?

<p>After a reflex response, the brain receives a signal informing it of the reflex action that has taken place.</p> Signup and view all the answers

Describe the roles of sensory and motor neurons in the nervous system.

<p>Sensory neurons carry messages toward the CNS, while motor neurons send messages away from the CNS toward muscles or glands.</p> Signup and view all the answers

What are the main functions of the parasympathetic nervous system?

<p>The parasympathetic nervous system promotes rest and digestion, stimulating processes like digestion and urine production while relaxing the body.</p> Signup and view all the answers

How do neuroglial cells differ from neurons in the nervous system?

<p>Neuroglial cells support and protect neurons, while neurons are the primary cells responsible for transmitting electrical impulses.</p> Signup and view all the answers

Describe the structure and function of dendrites in a neuron.

<p>Dendrites are highly branched extensions of the neuron that collect stimuli and generate electrical currents to transmit information to the cell body.</p> Signup and view all the answers

What is the role of the myelin sheath in neuronal function?

<p>The myelin sheath insulates axons, speeding up the transmission of electrical impulses along the neuron.</p> Signup and view all the answers

Identify and describe the three structural types of neurons.

<p>The three structural types are multipolar (many processes), bipolar (two processes), and unipolar (one process) neurons.</p> Signup and view all the answers

What are the functions of astrocytes in the central nervous system?

<p>Astrocytes provide structural support, maintain blood-brain barrier integrity, regulate ion balance, and contribute to the repair of nervous tissue.</p> Signup and view all the answers

Explain the function of oligodendrocytes and Schwann cells.

<p>Oligodendrocytes insulate axons in the CNS, while Schwann cells form myelin sheaths around axons in the PNS.</p> Signup and view all the answers

What is the significance of the node of Ranvier in neuronal signaling?

<p>The node of Ranvier allows for the rapid transmission of electrical impulses by facilitating saltatory conduction.</p> Signup and view all the answers

How do sensory neurons differ functionally from motor neurons?

<p>Sensory neurons conduct impulses toward the CNS from sensory receptors, whereas motor neurons transmit impulses away from the CNS to muscles or glands.</p> Signup and view all the answers

What role do microglial cells have in the central nervous system?

<p>Microglial cells act as the immune cells of the CNS, patrolling for injury or pathogens and phagocytosing debris.</p> Signup and view all the answers

What is the primary function of the sodium potassium pump in neurons?

<p>It maintains the differential levels of Na+ and K+ by pumping three Na+ out of the cell in exchange for two K+ into the cell.</p> Signup and view all the answers

Describe the condition of gated Na+ and K+ channels during resting membrane potential.

<p>All gated Na+ and K+ channels are closed, while K+ leak channels are open, allowing K+ to move out of the cell.</p> Signup and view all the answers

What initiates depolarization in a neuron?

<p>Depolarization is initiated by a stimulus strong enough to meet the threshold of around -55mV, causing Na+ voltage-gated channels to open.</p> Signup and view all the answers

What happens to K+ channels during the depolarization phase of action potential?

<p>K+ voltage-gated channels are closed during the initial depolarization phase.</p> Signup and view all the answers

Explain the process of repolarization in a neuron.

<p>During repolarization, Na+ voltage-gated channels close and K+ voltage-gated channels open, allowing K+ to exit the cell and making the intracellular environment more negative.</p> Signup and view all the answers

What is the afterpotential, and why does it occur?

<p>The afterpotential is a phase where the membrane potential becomes very negative (around -75mV) due to the slow closure of K+ channels that continue to allow K+ to leave the cell.</p> Signup and view all the answers

How does the sodium potassium pump contribute to re-establishing resting membrane potential?

<p>The sodium potassium pump actively redistributes ions by pumping three Na+ out of the cell in exchange for two K+ entering, re-establishing the resting membrane potential of -70mV.</p> Signup and view all the answers

What is the significance of the negative intracellular change created during resting membrane potential?

<p>The negative intracellular change is essential for generating action potentials and maintaining the electrical excitability of the neuron.</p> Signup and view all the answers

What role do gated channels play during the action potential process?

<p>Gated channels regulate the flow of Na+ and K+ ions, opening and closing at specific phases to produce the changes in membrane potential that characterize action potentials.</p> Signup and view all the answers

In what state is the Na+ and K+ concentration during resting membrane potential compared to the action potential phases?

<p>During resting membrane potential, Na+ concentration is higher outside the cell while K+ concentration is higher inside the cell; this is reversed during depolarization.</p> Signup and view all the answers

What are the two main types of synapses and how do they differ?

<p>The two main types are electrical synapses and chemical synapses. Electrical synapses transmit signals via gap junctions, while chemical synapses use neurotransmitters to convey signals across a synaptic cleft.</p> Signup and view all the answers

Describe the role of neurotransmitters in a chemical synapse.

<p>Neurotransmitters are chemical messengers that transmit action potentials across the synapse by binding to receptors on the postsynaptic membrane.</p> Signup and view all the answers

What happens to calcium ions when an action potential reaches the presynaptic terminal?

<p>Voltage gated Ca2+ channels open, allowing Ca2+ to diffuse into the cell, triggering the exocytosis of synaptic vesicles.</p> Signup and view all the answers

Identify the components of a synapse.

<p>The components of a synapse include the presynaptic terminal, presynaptic membrane, postsynaptic membrane, synaptic cleft, neurotransmitters, and synaptic vesicles.</p> Signup and view all the answers

What is the function of acetylcholinesterase at a synapse?

<p>Acetylcholinesterase breaks down acetylcholine into choline and acetic acid, preventing continuous stimulation of receptors.</p> Signup and view all the answers

How does the spinal cord relate to the central nervous system (CNS)?

<p>The spinal cord is a crucial part of the CNS, extending from the brain to the lower back and facilitating communication between the brain and the body.</p> Signup and view all the answers

Explain how depolarization occurs in the postsynaptic cell.

<p>Depolarization occurs when neurotransmitters bind to receptors, causing ligand gated Na+ channels to open and Na+ to diffuse into the cell.</p> Signup and view all the answers

What structural elements protect the spinal cord?

<p>The spinal cord is protected by the vertebral column and the meninges, which comprise several layers of connective tissue.</p> Signup and view all the answers

What processes occur for neurotransmitter removal at a synapse?

<p>Neurotransmitters unbind from their receptors, are broken down by enzymes like acetylcholinesterase, and can be reabsorbed or diffuse away from the synaptic cleft.</p> Signup and view all the answers

What significance do dendrites hold for neurons?

<p>Dendrites are important for neurons as they collect sensory information and synapse with many other cells, enhancing communication.</p> Signup and view all the answers

What are the two primary types of neurons in the peripheral nervous system and their functions?

<p>Sensory neurons collect input from sensory receptors and transmit it to the CNS, while motor neurons transmit signals from the CNS to effectors like muscles and glands.</p> Signup and view all the answers

How does the somatic nervous system differ from the autonomic nervous system?

<p>The somatic nervous system is voluntary and controls skeletal muscles, while the autonomic nervous system is involuntary and regulates smooth and cardiac muscles as well as glands.</p> Signup and view all the answers

Describe the role of the ganglia in the peripheral nervous system.

<p>Ganglia are collections of neuron cell bodies outside the CNS that play a crucial role in relaying signals between neurons.</p> Signup and view all the answers

Explain the difference in neuron structure between the sympathetic and parasympathetic divisions of the autonomic nervous system.

<p>The sympathetic division has a shorter preganglionic neuron and a longer postganglionic neuron, while the parasympathetic division has longer preganglionic and shorter postganglionic neurons.</p> Signup and view all the answers

What is the enteric nervous system and its main function?

<p>The enteric nervous system is a complex network of neurons located in the walls of the digestive tract that controls digestive processes including muscle contraction and gland secretion.</p> Signup and view all the answers

What initiates the release of neurotransmitters from the presynaptic terminal?

<p>An action potential arriving at the presynaptic terminal causes voltage-gated Ca2+ channels to open, allowing Ca2+ to diffuse into the cell.</p> Signup and view all the answers

Identify the two functional divisions of the PNS and their main roles.

<p>The sensory (afferent) division detects stimuli and transmits information to the CNS, while the motor (efferent) division transmits signals from the CNS to effectors.</p> Signup and view all the answers

How is acetylcholine removed from the synaptic cleft after it has bound to its receptors?

<p>Acetylcholine unbinds from its receptors and is broken down by acetylcholinesterase into choline and acetic acid.</p> Signup and view all the answers

How do the neuron pathways in the sympathetic nervous system contribute to its 'fight or flight' response?

<p>The shorter neuron pathways lead to faster responses, allowing the body to quickly prepare for physical activity in threatening situations.</p> Signup and view all the answers

Describe the difference between electrical and chemical synapses.

<p>Electrical synapses use gap junctions for direct electrical communication, while chemical synapses use neurotransmitters to transmit signals across a synaptic cleft.</p> Signup and view all the answers

What roles do the pre-synaptic and post-synaptic membranes play in neurotransmission?

<p>The pre-synaptic membrane releases neurotransmitters, while the post-synaptic membrane contains receptors that bind these neurotransmitters.</p> Signup and view all the answers

Describe how the PNS interacts with the CNS in response to environmental stimuli.

<p>The PNS detects stimuli through sensory receptors, sends this information to the CNS, which processes it and sends a motor response back via the PNS.</p> Signup and view all the answers

What protective structures surround the spinal cord?

<p>The spinal cord is protected by the vertebral column and meninges, which consist of multiple layers of connective tissue.</p> Signup and view all the answers

What is the primary difference in conduction speed between myelinated and unmyelinated axons?

<p>Myelinated axons conduct impulses faster due to saltatory conduction, while unmyelinated axons conduct impulses more slowly as a continuous wave.</p> Signup and view all the answers

How do the locations of grey matter and white matter differ in the brain and spinal cord?

<p>Grey matter is located on the periphery of the brain and in the center of the spinal cord, while white matter lies deeper in the brain and on the outer part of the spinal cord.</p> Signup and view all the answers

What role does the Na+/K+ pump play in maintaining resting membrane potential?

<p>The Na+/K+ pump actively transports Na+ out of the cell and K+ into the cell, helping to establish and maintain the differences in ionic concentration across the membrane.</p> Signup and view all the answers

Define depolarization in the context of action potential.

<p>Depolarization is the process where the membrane potential becomes less negative, leading to the opening of voltage-gated Na+ channels and the rapid influx of Na+ into the cell.</p> Signup and view all the answers

What is the significance of the Nodes of Ranvier in myelinated axons?

<p>The Nodes of Ranvier are important for facilitating saltatory conduction, allowing electrical impulses to jump between nodes, which increases the speed of conduction.</p> Signup and view all the answers

In what manner does the ionic concentration differ between the intracellular and extracellular environments?

<p>The extracellular environment has higher concentrations of Na+ and Cl-, while the intracellular environment has higher concentrations of K+ and proteins.</p> Signup and view all the answers

What defines the selectivity of ion channels in a cell membrane?

<p>Ion channels are selectively permeable based on factors such as size, solubility, polarity, and the specific needs of the cell.</p> Signup and view all the answers

Describe the changes in ion movement during the phase of repolarization.

<p>During repolarization, K+ channels open allowing K+ to flow out of the cell, while Na+ channels close, returning the membrane potential back toward resting levels.</p> Signup and view all the answers

Explain the composition of grey matter and where it is primarily located.

<p>Grey matter is composed of neuronal cell bodies, dendrites, unmyelinated axons, and glial cells, and is mainly found in the outer cortex of the brain and the 'H' shaped area in the spinal cord.</p> Signup and view all the answers

How does the structure of unmyelinated axons differ from that of myelinated axons?

<p>Unmyelinated axons are thinner and rest within the invaginations of Schwann cells or oligodendrocytes, lacking a myelin sheath.</p> Signup and view all the answers

How does the sodium potassium pump contribute to the maintenance of resting membrane potential?

<p>The sodium potassium pump maintains resting membrane potential by pumping three Na+ ions out of the cell and two K+ ions into the cell, creating a negative charge inside the cell.</p> Signup and view all the answers

What must happen for an action potential to occur in a neuron?

<p>An action potential occurs when a stimulus depolarizes the neuron to reach a threshold of about -55mV.</p> Signup and view all the answers

Describe the changes in membrane potential during the depolarization phase.

<p>During depolarization, the membrane potential becomes more positive as Na+ ions rush into the cell, exceeding 0mV.</p> Signup and view all the answers

What occurs during the repolarization phase of an action potential?

<p>During repolarization, Na+ voltage-gated channels close and K+ voltage-gated channels open, causing K+ to exit the cell and membrane potential to become more negative.</p> Signup and view all the answers

What causes the afterpotential following an action potential?

<p>The afterpotential occurs due to the slow closure of K+ channels, allowing K+ to continue exiting the cell, leading to a more negative membrane potential.</p> Signup and view all the answers

What role does the sodium-potassium pump play after an action potential has occurred?

<p>After an action potential, the sodium-potassium pump re-establishes the resting membrane potential by restoring the original distribution of Na+ and K+ ions.</p> Signup and view all the answers

Explain the significance of K+ leak channels during the resting membrane potential.

<p>K+ leak channels contribute to resting membrane potential by allowing K+ to move out of the cell, which creates a negative charge inside.</p> Signup and view all the answers

How does the concentration gradient affect the movement of Na+ during depolarization?

<p>The concentration gradient drives Na+ to move into the cell during depolarization, making the intracellular environment more positive.</p> Signup and view all the answers

What happens to the extracellular and intracellular charge during the depolarization phase of an action potential?

<p>During depolarization, the inside of the neuron becomes positive while the outside becomes more negative.</p> Signup and view all the answers

Describe what occurs at the end of the repolarization phase.

<p>At the end of repolarization, Na+ channels are closed and K+ channels eventually close, stabilizing the membrane potential back to resting levels.</p> Signup and view all the answers

What is the primary difference between non-gated and gated ion channels?

<p>Non-gated ion channels are always open, while gated channels require specific signals to open.</p> Signup and view all the answers

How does the concentration gradient affect the movement of K+ and Na+ ions in a resting neuron?

<p>In a resting neuron, K+ ions diffuse out due to a higher concentration inside, while Na+ ions diffuse in due to a higher concentration outside.</p> Signup and view all the answers

What role do negatively charged proteins play in the resting membrane potential?

<p>Negatively charged proteins, which remain inside the cell, contribute to the overall negative charge of the intracellular environment.</p> Signup and view all the answers

Why is the resting membrane potential typically around -70mV in neurons?

<p>The resting membrane potential is around -70mV because of the unequal distribution of Na+ and K+ ions across the membrane and the permeability of the membrane to K+.</p> Signup and view all the answers

What is the significance of having more K+ leak channels than Na+ leak channels?

<p>More K+ leak channels facilitate greater diffusion of K+ out of the cell, which is vital for maintaining the negative resting membrane potential.</p> Signup and view all the answers

What initiates the opening of ligand-gated ion channels?

<p>Ligand-gated ion channels open when a specific chemical, or ligand, attaches to the channel.</p> Signup and view all the answers

Explain the importance of voltage-gated ion channels in neuronal function.

<p>Voltage-gated ion channels are crucial as they open in response to changes in membrane potential, allowing for rapid depolarization during action potentials.</p> Signup and view all the answers

What role does the Na+/K+ pump play in establishing resting membrane potential?

<p>The Na+/K+ pump maintains resting membrane potential by actively transporting 3 Na+ ions out and 2 K+ ions into the cell.</p> Signup and view all the answers

How do other gated ion channels respond to stimuli like temperature or pressure?

<p>Other gated ion channels open in response to specific physical stimuli, such as temperature changes or mechanical pressure.</p> Signup and view all the answers

Describe how the resting membrane potential can vary between different cell types.

<p>The resting membrane potential can vary in different cell types due to differences in ion channel composition and ion concentrations.</p> Signup and view all the answers

Study Notes

Nervous System Terminology

  • Neuron is the fundamental building block of the nervous system, responsible for transmitting information.
  • Neuroglia are supporting cells that provide structural and functional support for neurons.
  • Axon is the long, slender projection of a neuron that carries nerve impulses away from the cell body.
  • Nerve is a bundle of axons (nerve fibers) and their sheaths.
  • Sensory receptors are specialized cells that detect stimuli like temperature, pain, touch, light, sound, and odor.
  • Action potential is the electrical signal that transmits information throughout the nervous system.
  • Effector organ or effector cell is the target organ, tissue, or cell that carries out the response to a stimulus.
  • Synapse is the junction between a neuron and another cell, enabling communication between them.

Functions of the Nervous System

  • Receive sensory input: Processes information from both the internal and external environment using specialized cells.
  • Integrate information: The central nervous system interprets sensory input and decides on an appropriate response.
  • Motor output: The nervous system sends signals to effectors to carry out the response.
  • Maintain homeostasis: The nervous system regulates various bodily functions to maintain a stable internal environment.
  • Higher-level functions: The nervous system enables complex functions like thinking, memory, emotion, consciousness, and decision-making.

Divisions of the Nervous System

  • Central Nervous System (CNS): The brain and spinal cord, responsible for integrating and coordinating information.
  • Peripheral Nervous System (PNS): All nerves outside the CNS, responsible for relaying information to and from the CNS.
  • Autonomic Nervous System (ANS): Part of the PNS that controls involuntary functions of the body, further divided into sympathetic and parasympathetic nervous systems.
  • Sympathetic Nervous System: "Fight-or-flight" response, preparing the body for stressful situations.
  • Parasympathetic Nervous System: "Rest-and-digest" response, promoting relaxation and digestion.

Cells of the Nervous System

  • Neuron: Highly specialized, electrically excitable cell that transmits information via electrical impulses.
    • Cell body (soma): Contains the nucleus and other organelles.
    • Dendrites: Branching extensions that receive stimuli.
    • Axon: Carries nerve impulses away from the cell body.
    • Myelin sheath: A fatty covering that insulates axons, increasing the speed of nerve impulse transmission.
    • Node of Ranvier: Gaps in the myelin sheath where the axon is exposed.
  • Neuroglia: Supporting cells that provide structural and functional support for neurons.
    • Astrocytes: Star-shaped cells that provide structural support, regulate the blood-brain barrier, and contribute to neurotransmitter recycling.
    • Ependymal cells: Line the ventricles of the brain and the central canal of the spinal cord, producing and regulating cerebrospinal fluid.
    • Microglial cells: Small, phagocytic cells that remove cellular debris and pathogens.
    • Oligodendrocytes (CNS) & Schwann cells (PNS): Form myelin sheaths around axons, enhancing nerve impulse conduction.
    • Satellite cells: Surrounding cell bodies of sensory and autonomic ganglia, providing support and nutrition.

Neuron Structural Classification

  • Multipolar: Has multiple dendrites and a single axon.
  • Bipolar: Has one dendrite and one axon.
  • Unipolar/Pseudounipolar: Has a single process that functions as both a dendrite and an axon.

Neuron Functional Classification

  • Sensory neuron (Afferent): Transmits sensory information from receptors towards the CNS.
  • Motor neuron (Efferent): Transmits motor commands from the CNS to effectors.
  • Interneuron: Connects neurons within the CNS, integrating and processing information.

Action Potential

  • Resting Membrane Potential: The electrical difference across the neuron's membrane when it is not transmitting a nerve impulse.
  • Depolarisation: The membrane potential becomes more positive, due to an influx of sodium ions (Na+).
  • Repolarisation: The membrane potential returns to negative values, due to an efflux of potassium ions (K+).
  • Afterpotential: A brief period following repolarization where the membrane potential becomes even more negative than the resting potential.
  • Sodium-Potassium Pump: An active transport mechanism that actively pumps Na+ out of the cell and K+ into the cell, helping to maintain the resting membrane potential and restore ion gradients after an action potential.

Chemical Synapse

  • Pre-synaptic terminal: The end of the axon terminal where neurotransmitters are released.
  • Post-synaptic membrane: The membrane of the target cell that receives the neurotransmitter.
  • Synaptic cleft: The narrow gap between the pre-synaptic and post-synaptic membranes.
  • Neurotransmitters: Chemical messengers that transmit signals across the synapse.
  • Synaptic vesicles: Small sacs in the pre-synaptic terminal containing neurotransmitters.
  • Neurotransmitter release: An action potential arriving at the presynaptic terminal triggers the release of neurotransmitters into the synaptic cleft.
  • Neurotransmitter removal: Neurotransmitters are removed from the synaptic cleft by reuptake into the presynaptic terminal, enzymatic degradation, or diffusion away from the synapse.

Spinal Cord

  • The spinal cord is a major part of the CNS, extending from the brain to the second lumbar vertebra.
  • It is encased in the vertebral column and meninges for protection.
  • It serves as a pathway for nerve impulses traveling between the brain and the body.
  • The spinal cord is also responsible for reflex actions.

Reflex Arc

  • Reflex Arc is the neural pathway responsible for a reflex action.
    • Sensory receptor: Detects the stimulus.
    • Sensory neuron: Transmits the signal to the spinal cord.
    • Interneuron: Connects the sensory neuron to the motor neuron.
    • Motor neuron: Transmits the signal to the effector organ.
    • Effector organ: Carries out the response.
  • Somatic reflexes: Involve skeletal muscles.
  • Autonomic reflexes: Involve smooth muscles, cardiac muscles, or viscera.
  • Monosynaptic reflexes: Simple reflexes with one synapse between the sensory and motor neurons.
  • Polysynaptic reflexes: Complex reflexes with multiple synapses, involving interneurons.

Reaction

  • A voluntary response to a stimulus involving the brain and spinal cord.
  • Reactions are typically slower than reflexes.
  • Reaction time can be improved through repetition.

Peripheral Nervous System

  • The PNS is responsible for relaying information between the CNS and the body, and includes sensory receptors, cranial nerves, spinal nerves, ganglia, and plexuses.
  • The PNS is divided into the somatic nervous system, autonomic nervous system, and the enteric nervous system.

Functional Divisions of the Nervous System

  • The CNS interacts with the PNS: the PNS senses, sends the signal to the CNS, the CNS produces the motor output and sends it back to the body via the PNS.

Somatic Nervous System

  • The SNS controls voluntary muscle movements, receives input from the environment through sensory receptors, and sends motor signals to skeletal muscles.
  • The SNS is largely under conscious control and uses a single neuron system that originates in the CNS.
  • Axons are myelinated.

Autonomic Nervous System (ANS)

  • The ANS controls involuntary functions like heart rate, digestion, and breathing and functions without conscious control.
  • It is composed of the sympathetic and parasympathetic nervous systems, which work together.
  • The ANS uses a two-neuron system with preganglionic axons, which are myelinated and originate in the CNS, synapsing with postganglionic axons, which are unmyelinated and run to the target tissue.
  • Axons can either stimulate or inhibit target tissues.

Enteric Nervous System

  • The ENS is a specialized nervous system located within the walls of the digestive tract, controlling digestive functions.
  • It consists of sensory neurons that connect the digestive tract to the CNS, motor neurons that connect the CNS to the digestive tract, and enteric neurons, which are confined to the digestive tract.
  • The ENS is responsible for regulating smooth muscle contraction, gland secretion, and detecting content changes in the digestive tract.

Sensory vs Motor Division

  • The sensory division, or afferent division, receives sensory input from the internal and external environment via specialized sensory receptors.
  • Signals are sent to the CNS via sensory neurons, whose cell bodies are located outside the CNS.
  • The motor division, or efferent division, sends signals from the CNS to muscles and glands via motor neurons, whose cell bodies are located in the CNS.

Sympathetic Nervous System

  • The sympathetic nervous system is responsible for the "fight-or-flight" response, preparing the body for physical activity or stressful situations.
  • It originates in the thoracolumbar region of the spinal cord.
  • The sympathetic nervous system has a shorter neuron pathway than the parasympathetic nervous system resulting in faster response times.

Myelinated vs Unmyelinated Axons

  • Myelinated axons are wrapped in myelin sheaths formed by Schwann cells (PNS) or oligodendrocytes (CNS), creating nodes of Ranvier.
  • This structure allows for saltatory conduction of electrical impulses, leading to faster signal transmission.
  • Unmyelinated axons are not wrapped in myelin, resulting in continuous wave conduction and slower transmission speeds.

Grey Matter vs White Matter

  • Grey matter is composed of neuron cell bodies, dendrites, axons, glial cells, and synapses.
  • It is found on the periphery of the brain (cortex) and the inner part of the spinal cord, forming an 'H' shape.
  • White matter primarily consists of long-range myelinated axons and is found on the inner side of the brain and the outer part of the spinal cord.

Electrical Signals in Neurons

  • Signals are transmitted as electrical impulses, forming the basis for communication and function of neurons.
  • Key terms associated with electrical signals include resting membrane potential, action potential, graded potential, after potential, depolarization, repolarization, and hyperpolarization.

Membrane Potential

  • Membrane potential refers to the electrical charge difference across the cell membrane and is determined by ionic concentration differences and the permeability of the membrane.

Cell Membrane -- Ion Concentration

  • The cell membrane is selectively permeable, allowing the passage of ions through specialized channels.
  • Differences in ion concentration across the membrane create electrical potential.
  • The Na+/K+ pump actively transport ions across the membrane, maintaining concentration gradients.
  • Extracellular fluid has a higher concentration of Na+ and Cl- ions, while the intracellular environment has a higher concentration of K+, proteins, and PO4-3 ions.

Cell Membrane -- Ion Channels

  • Ion channels provide specific pathways for ions to cross the membrane.
  • Non-gated ion channels, or leak channels, are always open and allow the passage of ions based on concentration gradients.
  • Gated ion channels open in response to specific stimuli, such as ligands, voltage changes, or other factors.

Resting Membrane Potential

  • Resting membrane potential is the charge difference across the cell membrane in a resting state, typically around -70mV in neurons.
  • The inside of the cell is more negative than the outside, creating a polarized state.
  • The resting membrane potential is established by the activity of leak channels and the Na+/K+ pump.

Establishing Resting Membrane Potential

  • The concentration gradients of Na+ and K+ across the membrane.
  • The presence of more K+ leak channels than Na+ leak channels allow for more K+ to diffuse out of the cell than Na+ diffusing in.
  • The action of the Na+/K+ pump actively pumps 3 Na+ ions out of the cell for every 2 K+ ions pumped in, maintaining the concentration gradients.
  • Resting membrane potential is achieved when the movement of K+ out of the cell is equal to the movement of K+ into the cell.

Action Potential

  • An action potential is a rapid depolarization and repolarization of the cell membrane, transmitting information down the axon of a neuron.
  • It consists of several stages, including resting membrane potential, depolarization, repolarization, and afterpotential.

Depolarization

  • Depolarization occurs when a stimulus triggers the opening of Na+ voltage-gated channels, allowing Na+ to flow into the cell and making the inside more positive.
  • K+ voltage-gated channels remain closed during this phase.
  • The membrane potential becomes more positive, exceeding 0mV.
  • Depolarization can only occur if the stimulus reaches the threshold potential, typically around -55mV.

Repolarization

  • Repolarization occurs when Na+ voltage-gated channels close, and K+ voltage-gated channels open, allowing K+ to flow out of the cell.
  • This movement of K+ makes the inside of the cell more negative again.
  • The membrane potential returns to its resting state.

Afterpotential

  • Afterpotential occurs after repolarization when K+ voltage-gated channels close slowly, and K+ continues to leave the cell, making the membrane potential more negative than the resting potential.

Re-establishing Resting Membrane Potential

  • The resting membrane potential is re-established by the Na+/K+ pump actively pumping Na+ out of the cell and K+ into the cell, while all Na+ and K+ gated channels are closed.

Relevant Concepts

  • Depolarization: a change in membrane potential that makes it more positive.
  • Presynaptic cell: the cell that is sending the signal.
  • Postsynaptic cell: the cell that is receiving the signal.

Electrical vs Chemical Synapses

  • Electrical synapses are less common, with electrical signals passing through gap junctions.
  • Chemical synapses are more common, using chemical messengers called neurotransmitters to transmit electrical signals across the synaptic cleft.

Chemical Synapse

  • Chemical synapses consist of a presynaptic terminal, presynaptic membrane, postsynaptic membrane, synaptic cleft, neurotransmitters, and synaptic vesicles.

Neurotransmitter Release

  • An action potential arriving at the presynaptic terminal opens Ca2+ voltage-gated channels, allowing Ca2+ to enter the cell.
  • Ca2+ stimulates exocytosis of synaptic vesicles, releasing neurotransmitter molecules into the synaptic cleft.
  • Neurotransmitters bind to their receptors on the postsynaptic membrane.

Neurotransmitter Removal

  • Acetylcholine is a neurotransmitter that binds to its receptors, triggering a response in the postsynaptic cell.
  • Acetylcholine unbinds from its receptors, and acetylcholinesterase hydrolyzes it into choline and acetic acid, preventing further activation.
  • Choline is taken up by the presynaptic terminal for resynthesis of acetylcholine.
  • Excess acetylcholine diffuses away from the synaptic cleft.

Spinal Cord Introduction

  • The spinal cord is a vital part of the CNS, extending from the brain to the second lumbar vertebra.
  • It is protected by the vertebral column and the meninges.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

Compendium 8 Notes PDF

Description

Test your knowledge of essential nervous system terminology. This quiz covers key concepts such as neurons, neuroglia, axons, and more. Understand the structure and functions of the nervous system as you explore its fundamental components.

More Like This

Use Quizgecko on...
Browser
Browser