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Questions and Answers
What is a neuron and its role in the nervous system?
What is a neuron and its role in the nervous system?
A neuron is the basic structural and functional unit of the nervous system, responsible for transmitting electrical signals throughout the body.
Define neuroglia and their function in relation to neurons.
Define neuroglia and their function in relation to neurons.
Neuroglia are supporting cells that maintain homeostasis, provide support and protection for neurons.
What constitutes an action potential in the nervous system?
What constitutes an action potential in the nervous system?
An action potential is an electronic signal that propagates along the axon of a neuron, transmitting information through the nervous system.
Describe the role of sensory receptors in the nervous system.
Describe the role of sensory receptors in the nervous system.
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What is the function of the synapse in neuronal communication?
What is the function of the synapse in neuronal communication?
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Explain how the central nervous system integrates information.
Explain how the central nervous system integrates information.
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What are the primary components of the central nervous system?
What are the primary components of the central nervous system?
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How does the nervous system help maintain homeostasis?
How does the nervous system help maintain homeostasis?
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What is a reflex arc and what are its components?
What is a reflex arc and what are its components?
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Differentiate between somatic and autonomic reflexes with examples.
Differentiate between somatic and autonomic reflexes with examples.
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Explain the difference between monosynaptic and polysynaptic reflexes.
Explain the difference between monosynaptic and polysynaptic reflexes.
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What role does the brain play after a reflex has occurred?
What role does the brain play after a reflex has occurred?
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Describe the roles of sensory and motor neurons in the nervous system.
Describe the roles of sensory and motor neurons in the nervous system.
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What are the main functions of the parasympathetic nervous system?
What are the main functions of the parasympathetic nervous system?
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How do neuroglial cells differ from neurons in the nervous system?
How do neuroglial cells differ from neurons in the nervous system?
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Describe the structure and function of dendrites in a neuron.
Describe the structure and function of dendrites in a neuron.
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What is the role of the myelin sheath in neuronal function?
What is the role of the myelin sheath in neuronal function?
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Identify and describe the three structural types of neurons.
Identify and describe the three structural types of neurons.
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What are the functions of astrocytes in the central nervous system?
What are the functions of astrocytes in the central nervous system?
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Explain the function of oligodendrocytes and Schwann cells.
Explain the function of oligodendrocytes and Schwann cells.
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What is the significance of the node of Ranvier in neuronal signaling?
What is the significance of the node of Ranvier in neuronal signaling?
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How do sensory neurons differ functionally from motor neurons?
How do sensory neurons differ functionally from motor neurons?
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What role do microglial cells have in the central nervous system?
What role do microglial cells have in the central nervous system?
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What is the primary function of the sodium potassium pump in neurons?
What is the primary function of the sodium potassium pump in neurons?
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Describe the condition of gated Na+ and K+ channels during resting membrane potential.
Describe the condition of gated Na+ and K+ channels during resting membrane potential.
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What initiates depolarization in a neuron?
What initiates depolarization in a neuron?
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What happens to K+ channels during the depolarization phase of action potential?
What happens to K+ channels during the depolarization phase of action potential?
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Explain the process of repolarization in a neuron.
Explain the process of repolarization in a neuron.
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What is the afterpotential, and why does it occur?
What is the afterpotential, and why does it occur?
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How does the sodium potassium pump contribute to re-establishing resting membrane potential?
How does the sodium potassium pump contribute to re-establishing resting membrane potential?
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What is the significance of the negative intracellular change created during resting membrane potential?
What is the significance of the negative intracellular change created during resting membrane potential?
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What role do gated channels play during the action potential process?
What role do gated channels play during the action potential process?
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In what state is the Na+ and K+ concentration during resting membrane potential compared to the action potential phases?
In what state is the Na+ and K+ concentration during resting membrane potential compared to the action potential phases?
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What are the two main types of synapses and how do they differ?
What are the two main types of synapses and how do they differ?
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Describe the role of neurotransmitters in a chemical synapse.
Describe the role of neurotransmitters in a chemical synapse.
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What happens to calcium ions when an action potential reaches the presynaptic terminal?
What happens to calcium ions when an action potential reaches the presynaptic terminal?
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Identify the components of a synapse.
Identify the components of a synapse.
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What is the function of acetylcholinesterase at a synapse?
What is the function of acetylcholinesterase at a synapse?
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How does the spinal cord relate to the central nervous system (CNS)?
How does the spinal cord relate to the central nervous system (CNS)?
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Explain how depolarization occurs in the postsynaptic cell.
Explain how depolarization occurs in the postsynaptic cell.
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What structural elements protect the spinal cord?
What structural elements protect the spinal cord?
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What processes occur for neurotransmitter removal at a synapse?
What processes occur for neurotransmitter removal at a synapse?
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What significance do dendrites hold for neurons?
What significance do dendrites hold for neurons?
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What are the two primary types of neurons in the peripheral nervous system and their functions?
What are the two primary types of neurons in the peripheral nervous system and their functions?
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How does the somatic nervous system differ from the autonomic nervous system?
How does the somatic nervous system differ from the autonomic nervous system?
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Describe the role of the ganglia in the peripheral nervous system.
Describe the role of the ganglia in the peripheral nervous system.
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Explain the difference in neuron structure between the sympathetic and parasympathetic divisions of the autonomic nervous system.
Explain the difference in neuron structure between the sympathetic and parasympathetic divisions of the autonomic nervous system.
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What is the enteric nervous system and its main function?
What is the enteric nervous system and its main function?
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What initiates the release of neurotransmitters from the presynaptic terminal?
What initiates the release of neurotransmitters from the presynaptic terminal?
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Identify the two functional divisions of the PNS and their main roles.
Identify the two functional divisions of the PNS and their main roles.
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How is acetylcholine removed from the synaptic cleft after it has bound to its receptors?
How is acetylcholine removed from the synaptic cleft after it has bound to its receptors?
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How do the neuron pathways in the sympathetic nervous system contribute to its 'fight or flight' response?
How do the neuron pathways in the sympathetic nervous system contribute to its 'fight or flight' response?
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Describe the difference between electrical and chemical synapses.
Describe the difference between electrical and chemical synapses.
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What roles do the pre-synaptic and post-synaptic membranes play in neurotransmission?
What roles do the pre-synaptic and post-synaptic membranes play in neurotransmission?
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Describe how the PNS interacts with the CNS in response to environmental stimuli.
Describe how the PNS interacts with the CNS in response to environmental stimuli.
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What protective structures surround the spinal cord?
What protective structures surround the spinal cord?
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What is the primary difference in conduction speed between myelinated and unmyelinated axons?
What is the primary difference in conduction speed between myelinated and unmyelinated axons?
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How do the locations of grey matter and white matter differ in the brain and spinal cord?
How do the locations of grey matter and white matter differ in the brain and spinal cord?
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What role does the Na+/K+ pump play in maintaining resting membrane potential?
What role does the Na+/K+ pump play in maintaining resting membrane potential?
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Define depolarization in the context of action potential.
Define depolarization in the context of action potential.
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What is the significance of the Nodes of Ranvier in myelinated axons?
What is the significance of the Nodes of Ranvier in myelinated axons?
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In what manner does the ionic concentration differ between the intracellular and extracellular environments?
In what manner does the ionic concentration differ between the intracellular and extracellular environments?
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What defines the selectivity of ion channels in a cell membrane?
What defines the selectivity of ion channels in a cell membrane?
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Describe the changes in ion movement during the phase of repolarization.
Describe the changes in ion movement during the phase of repolarization.
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Explain the composition of grey matter and where it is primarily located.
Explain the composition of grey matter and where it is primarily located.
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How does the structure of unmyelinated axons differ from that of myelinated axons?
How does the structure of unmyelinated axons differ from that of myelinated axons?
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How does the sodium potassium pump contribute to the maintenance of resting membrane potential?
How does the sodium potassium pump contribute to the maintenance of resting membrane potential?
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What must happen for an action potential to occur in a neuron?
What must happen for an action potential to occur in a neuron?
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Describe the changes in membrane potential during the depolarization phase.
Describe the changes in membrane potential during the depolarization phase.
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What occurs during the repolarization phase of an action potential?
What occurs during the repolarization phase of an action potential?
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What causes the afterpotential following an action potential?
What causes the afterpotential following an action potential?
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What role does the sodium-potassium pump play after an action potential has occurred?
What role does the sodium-potassium pump play after an action potential has occurred?
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Explain the significance of K+ leak channels during the resting membrane potential.
Explain the significance of K+ leak channels during the resting membrane potential.
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How does the concentration gradient affect the movement of Na+ during depolarization?
How does the concentration gradient affect the movement of Na+ during depolarization?
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What happens to the extracellular and intracellular charge during the depolarization phase of an action potential?
What happens to the extracellular and intracellular charge during the depolarization phase of an action potential?
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Describe what occurs at the end of the repolarization phase.
Describe what occurs at the end of the repolarization phase.
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What is the primary difference between non-gated and gated ion channels?
What is the primary difference between non-gated and gated ion channels?
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How does the concentration gradient affect the movement of K+ and Na+ ions in a resting neuron?
How does the concentration gradient affect the movement of K+ and Na+ ions in a resting neuron?
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What role do negatively charged proteins play in the resting membrane potential?
What role do negatively charged proteins play in the resting membrane potential?
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Why is the resting membrane potential typically around -70mV in neurons?
Why is the resting membrane potential typically around -70mV in neurons?
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What is the significance of having more K+ leak channels than Na+ leak channels?
What is the significance of having more K+ leak channels than Na+ leak channels?
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What initiates the opening of ligand-gated ion channels?
What initiates the opening of ligand-gated ion channels?
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Explain the importance of voltage-gated ion channels in neuronal function.
Explain the importance of voltage-gated ion channels in neuronal function.
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What role does the Na+/K+ pump play in establishing resting membrane potential?
What role does the Na+/K+ pump play in establishing resting membrane potential?
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How do other gated ion channels respond to stimuli like temperature or pressure?
How do other gated ion channels respond to stimuli like temperature or pressure?
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Describe how the resting membrane potential can vary between different cell types.
Describe how the resting membrane potential can vary between different cell types.
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Study Notes
Nervous System Terminology
- Neuron is the fundamental building block of the nervous system, responsible for transmitting information.
- Neuroglia are supporting cells that provide structural and functional support for neurons.
- Axon is the long, slender projection of a neuron that carries nerve impulses away from the cell body.
- Nerve is a bundle of axons (nerve fibers) and their sheaths.
- Sensory receptors are specialized cells that detect stimuli like temperature, pain, touch, light, sound, and odor.
- Action potential is the electrical signal that transmits information throughout the nervous system.
- Effector organ or effector cell is the target organ, tissue, or cell that carries out the response to a stimulus.
- Synapse is the junction between a neuron and another cell, enabling communication between them.
Functions of the Nervous System
- Receive sensory input: Processes information from both the internal and external environment using specialized cells.
- Integrate information: The central nervous system interprets sensory input and decides on an appropriate response.
- Motor output: The nervous system sends signals to effectors to carry out the response.
- Maintain homeostasis: The nervous system regulates various bodily functions to maintain a stable internal environment.
- Higher-level functions: The nervous system enables complex functions like thinking, memory, emotion, consciousness, and decision-making.
Divisions of the Nervous System
- Central Nervous System (CNS): The brain and spinal cord, responsible for integrating and coordinating information.
- Peripheral Nervous System (PNS): All nerves outside the CNS, responsible for relaying information to and from the CNS.
- Autonomic Nervous System (ANS): Part of the PNS that controls involuntary functions of the body, further divided into sympathetic and parasympathetic nervous systems.
- Sympathetic Nervous System: "Fight-or-flight" response, preparing the body for stressful situations.
- Parasympathetic Nervous System: "Rest-and-digest" response, promoting relaxation and digestion.
Cells of the Nervous System
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Neuron: Highly specialized, electrically excitable cell that transmits information via electrical impulses.
- Cell body (soma): Contains the nucleus and other organelles.
- Dendrites: Branching extensions that receive stimuli.
- Axon: Carries nerve impulses away from the cell body.
- Myelin sheath: A fatty covering that insulates axons, increasing the speed of nerve impulse transmission.
- Node of Ranvier: Gaps in the myelin sheath where the axon is exposed.
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Neuroglia: Supporting cells that provide structural and functional support for neurons.
- Astrocytes: Star-shaped cells that provide structural support, regulate the blood-brain barrier, and contribute to neurotransmitter recycling.
- Ependymal cells: Line the ventricles of the brain and the central canal of the spinal cord, producing and regulating cerebrospinal fluid.
- Microglial cells: Small, phagocytic cells that remove cellular debris and pathogens.
- Oligodendrocytes (CNS) & Schwann cells (PNS): Form myelin sheaths around axons, enhancing nerve impulse conduction.
- Satellite cells: Surrounding cell bodies of sensory and autonomic ganglia, providing support and nutrition.
Neuron Structural Classification
- Multipolar: Has multiple dendrites and a single axon.
- Bipolar: Has one dendrite and one axon.
- Unipolar/Pseudounipolar: Has a single process that functions as both a dendrite and an axon.
Neuron Functional Classification
- Sensory neuron (Afferent): Transmits sensory information from receptors towards the CNS.
- Motor neuron (Efferent): Transmits motor commands from the CNS to effectors.
- Interneuron: Connects neurons within the CNS, integrating and processing information.
Action Potential
- Resting Membrane Potential: The electrical difference across the neuron's membrane when it is not transmitting a nerve impulse.
- Depolarisation: The membrane potential becomes more positive, due to an influx of sodium ions (Na+).
- Repolarisation: The membrane potential returns to negative values, due to an efflux of potassium ions (K+).
- Afterpotential: A brief period following repolarization where the membrane potential becomes even more negative than the resting potential.
- Sodium-Potassium Pump: An active transport mechanism that actively pumps Na+ out of the cell and K+ into the cell, helping to maintain the resting membrane potential and restore ion gradients after an action potential.
Chemical Synapse
- Pre-synaptic terminal: The end of the axon terminal where neurotransmitters are released.
- Post-synaptic membrane: The membrane of the target cell that receives the neurotransmitter.
- Synaptic cleft: The narrow gap between the pre-synaptic and post-synaptic membranes.
- Neurotransmitters: Chemical messengers that transmit signals across the synapse.
- Synaptic vesicles: Small sacs in the pre-synaptic terminal containing neurotransmitters.
- Neurotransmitter release: An action potential arriving at the presynaptic terminal triggers the release of neurotransmitters into the synaptic cleft.
- Neurotransmitter removal: Neurotransmitters are removed from the synaptic cleft by reuptake into the presynaptic terminal, enzymatic degradation, or diffusion away from the synapse.
Spinal Cord
- The spinal cord is a major part of the CNS, extending from the brain to the second lumbar vertebra.
- It is encased in the vertebral column and meninges for protection.
- It serves as a pathway for nerve impulses traveling between the brain and the body.
- The spinal cord is also responsible for reflex actions.
Reflex Arc
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Reflex Arc is the neural pathway responsible for a reflex action.
- Sensory receptor: Detects the stimulus.
- Sensory neuron: Transmits the signal to the spinal cord.
- Interneuron: Connects the sensory neuron to the motor neuron.
- Motor neuron: Transmits the signal to the effector organ.
- Effector organ: Carries out the response.
- Somatic reflexes: Involve skeletal muscles.
- Autonomic reflexes: Involve smooth muscles, cardiac muscles, or viscera.
- Monosynaptic reflexes: Simple reflexes with one synapse between the sensory and motor neurons.
- Polysynaptic reflexes: Complex reflexes with multiple synapses, involving interneurons.
Reaction
- A voluntary response to a stimulus involving the brain and spinal cord.
- Reactions are typically slower than reflexes.
- Reaction time can be improved through repetition.
Peripheral Nervous System
- The PNS is responsible for relaying information between the CNS and the body, and includes sensory receptors, cranial nerves, spinal nerves, ganglia, and plexuses.
- The PNS is divided into the somatic nervous system, autonomic nervous system, and the enteric nervous system.
Functional Divisions of the Nervous System
- The CNS interacts with the PNS: the PNS senses, sends the signal to the CNS, the CNS produces the motor output and sends it back to the body via the PNS.
Somatic Nervous System
- The SNS controls voluntary muscle movements, receives input from the environment through sensory receptors, and sends motor signals to skeletal muscles.
- The SNS is largely under conscious control and uses a single neuron system that originates in the CNS.
- Axons are myelinated.
Autonomic Nervous System (ANS)
- The ANS controls involuntary functions like heart rate, digestion, and breathing and functions without conscious control.
- It is composed of the sympathetic and parasympathetic nervous systems, which work together.
- The ANS uses a two-neuron system with preganglionic axons, which are myelinated and originate in the CNS, synapsing with postganglionic axons, which are unmyelinated and run to the target tissue.
- Axons can either stimulate or inhibit target tissues.
Enteric Nervous System
- The ENS is a specialized nervous system located within the walls of the digestive tract, controlling digestive functions.
- It consists of sensory neurons that connect the digestive tract to the CNS, motor neurons that connect the CNS to the digestive tract, and enteric neurons, which are confined to the digestive tract.
- The ENS is responsible for regulating smooth muscle contraction, gland secretion, and detecting content changes in the digestive tract.
Sensory vs Motor Division
- The sensory division, or afferent division, receives sensory input from the internal and external environment via specialized sensory receptors.
- Signals are sent to the CNS via sensory neurons, whose cell bodies are located outside the CNS.
- The motor division, or efferent division, sends signals from the CNS to muscles and glands via motor neurons, whose cell bodies are located in the CNS.
Sympathetic Nervous System
- The sympathetic nervous system is responsible for the "fight-or-flight" response, preparing the body for physical activity or stressful situations.
- It originates in the thoracolumbar region of the spinal cord.
- The sympathetic nervous system has a shorter neuron pathway than the parasympathetic nervous system resulting in faster response times.
Myelinated vs Unmyelinated Axons
- Myelinated axons are wrapped in myelin sheaths formed by Schwann cells (PNS) or oligodendrocytes (CNS), creating nodes of Ranvier.
- This structure allows for saltatory conduction of electrical impulses, leading to faster signal transmission.
- Unmyelinated axons are not wrapped in myelin, resulting in continuous wave conduction and slower transmission speeds.
Grey Matter vs White Matter
- Grey matter is composed of neuron cell bodies, dendrites, axons, glial cells, and synapses.
- It is found on the periphery of the brain (cortex) and the inner part of the spinal cord, forming an 'H' shape.
- White matter primarily consists of long-range myelinated axons and is found on the inner side of the brain and the outer part of the spinal cord.
Electrical Signals in Neurons
- Signals are transmitted as electrical impulses, forming the basis for communication and function of neurons.
- Key terms associated with electrical signals include resting membrane potential, action potential, graded potential, after potential, depolarization, repolarization, and hyperpolarization.
Membrane Potential
- Membrane potential refers to the electrical charge difference across the cell membrane and is determined by ionic concentration differences and the permeability of the membrane.
Cell Membrane -- Ion Concentration
- The cell membrane is selectively permeable, allowing the passage of ions through specialized channels.
- Differences in ion concentration across the membrane create electrical potential.
- The Na+/K+ pump actively transport ions across the membrane, maintaining concentration gradients.
- Extracellular fluid has a higher concentration of Na+ and Cl- ions, while the intracellular environment has a higher concentration of K+, proteins, and PO4-3 ions.
Cell Membrane -- Ion Channels
- Ion channels provide specific pathways for ions to cross the membrane.
- Non-gated ion channels, or leak channels, are always open and allow the passage of ions based on concentration gradients.
- Gated ion channels open in response to specific stimuli, such as ligands, voltage changes, or other factors.
Resting Membrane Potential
- Resting membrane potential is the charge difference across the cell membrane in a resting state, typically around -70mV in neurons.
- The inside of the cell is more negative than the outside, creating a polarized state.
- The resting membrane potential is established by the activity of leak channels and the Na+/K+ pump.
Establishing Resting Membrane Potential
- The concentration gradients of Na+ and K+ across the membrane.
- The presence of more K+ leak channels than Na+ leak channels allow for more K+ to diffuse out of the cell than Na+ diffusing in.
- The action of the Na+/K+ pump actively pumps 3 Na+ ions out of the cell for every 2 K+ ions pumped in, maintaining the concentration gradients.
- Resting membrane potential is achieved when the movement of K+ out of the cell is equal to the movement of K+ into the cell.
Action Potential
- An action potential is a rapid depolarization and repolarization of the cell membrane, transmitting information down the axon of a neuron.
- It consists of several stages, including resting membrane potential, depolarization, repolarization, and afterpotential.
Depolarization
- Depolarization occurs when a stimulus triggers the opening of Na+ voltage-gated channels, allowing Na+ to flow into the cell and making the inside more positive.
- K+ voltage-gated channels remain closed during this phase.
- The membrane potential becomes more positive, exceeding 0mV.
- Depolarization can only occur if the stimulus reaches the threshold potential, typically around -55mV.
Repolarization
- Repolarization occurs when Na+ voltage-gated channels close, and K+ voltage-gated channels open, allowing K+ to flow out of the cell.
- This movement of K+ makes the inside of the cell more negative again.
- The membrane potential returns to its resting state.
Afterpotential
- Afterpotential occurs after repolarization when K+ voltage-gated channels close slowly, and K+ continues to leave the cell, making the membrane potential more negative than the resting potential.
Re-establishing Resting Membrane Potential
- The resting membrane potential is re-established by the Na+/K+ pump actively pumping Na+ out of the cell and K+ into the cell, while all Na+ and K+ gated channels are closed.
Relevant Concepts
- Depolarization: a change in membrane potential that makes it more positive.
- Presynaptic cell: the cell that is sending the signal.
- Postsynaptic cell: the cell that is receiving the signal.
Electrical vs Chemical Synapses
- Electrical synapses are less common, with electrical signals passing through gap junctions.
- Chemical synapses are more common, using chemical messengers called neurotransmitters to transmit electrical signals across the synaptic cleft.
Chemical Synapse
- Chemical synapses consist of a presynaptic terminal, presynaptic membrane, postsynaptic membrane, synaptic cleft, neurotransmitters, and synaptic vesicles.
Neurotransmitter Release
- An action potential arriving at the presynaptic terminal opens Ca2+ voltage-gated channels, allowing Ca2+ to enter the cell.
- Ca2+ stimulates exocytosis of synaptic vesicles, releasing neurotransmitter molecules into the synaptic cleft.
- Neurotransmitters bind to their receptors on the postsynaptic membrane.
Neurotransmitter Removal
- Acetylcholine is a neurotransmitter that binds to its receptors, triggering a response in the postsynaptic cell.
- Acetylcholine unbinds from its receptors, and acetylcholinesterase hydrolyzes it into choline and acetic acid, preventing further activation.
- Choline is taken up by the presynaptic terminal for resynthesis of acetylcholine.
- Excess acetylcholine diffuses away from the synaptic cleft.
Spinal Cord Introduction
- The spinal cord is a vital part of the CNS, extending from the brain to the second lumbar vertebra.
- It is protected by the vertebral column and the meninges.
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Test your knowledge of essential nervous system terminology. This quiz covers key concepts such as neurons, neuroglia, axons, and more. Understand the structure and functions of the nervous system as you explore its fundamental components.