Nervous System Overview and Divisions
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Questions and Answers

Which of the following is NOT a function of the myelin sheath?

  • Electrical insulation of the axon
  • Protection of the axon
  • Production of neurotransmitters (correct)
  • Increases the speed of nerve impulse transmission
  • Myelinated fibers conduct nerve impulses more slowly than non-myelinated fibers.

    False (B)

    What type of glial cell is responsible for forming the myelin sheath in the peripheral nervous system (PNS)?

    Schwann cells

    In the CNS, the myelin sheath is formed by ______, while in the PNS, it is formed by ______.

    <p>oligodendrocytes, Schwann cells</p> Signup and view all the answers

    Match the following terms related to the myelin sheath with their corresponding descriptions:

    <p>Myelin sheath = A fatty, insulating substance surrounding axons Oligodendrocytes = Glial cells that form myelin in the CNS Schwann cells = Glial cells that form myelin in the PNS Neurilemma = The outer collar of perinuclear cytoplasm in Schwann cells Node of Ranvier = Gaps between segments of myelin where the axon is exposed</p> Signup and view all the answers

    Which of the following is NOT a function of astrocytes?

    <p>Form myelin sheaths around axons (B)</p> Signup and view all the answers

    Neuroglia are the main cells responsible for transmitting electrical signals in the nervous system.

    <p>False (B)</p> Signup and view all the answers

    What are the three functional zones of a neuron and their roles?

    <p>The three functional zones of a neuron are the receptive zone, the integrating zone, and the transmitting zone. The receptive zone receives input from other neurons, the integrating zone sums up the input and decides whether to send a signal, and the transmitting zone sends a signal to other cells.</p> Signup and view all the answers

    The ____ are the most abundant type of neuroglia in the CNS.

    <p>astrocytes</p> Signup and view all the answers

    Match the following neuroglia with their primary function:

    <p>Astrocytes = Support and brace neurons Microglial cells = Phagocytize microorganisms and debris Ependymal cells = Form myelin sheaths around axons Oligodendrocytes = Line central cavities of the brain and spinal cord Satellite cells = Surround neuron cell bodies in the PNS Schwann cells = Surround peripheral nerve fibers and form myelin sheaths</p> Signup and view all the answers

    Which of the following statements accurately describes the differences between a nerve and a tract?

    <p>A nerve is a bundle of axons in the PNS, while a tract is a bundle of axons in the CNS. (A)</p> Signup and view all the answers

    Ependymal cells are responsible for forming the blood-brain barrier.

    <p>False (B)</p> Signup and view all the answers

    What is the difference between a nucleus and a ganglion?

    <p>A nucleus is a cluster of neuron cell bodies located in the CNS, while a ganglion is a cluster of neuron cell bodies located in the PNS.</p> Signup and view all the answers

    What is the primary function of excitatory neurotransmitters at the synapse?

    <p>Cause depolarization of the postsynaptic membrane (C)</p> Signup and view all the answers

    The same neurotransmitter is always released at a specific synapse.

    <p>True (A)</p> Signup and view all the answers

    What are the two main inhibitory neurotransmitters, and what effect do they have on the postsynaptic membrane?

    <p>The two main inhibitory neurotransmitters are GABA (gamma-aminobutyric acid) and glycine. They cause hyperpolarization of the postsynaptic membrane, making it less likely to generate an action potential.</p> Signup and view all the answers

    The most common neurotransmitter in the peripheral nervous system (PNS) is ______.

    <p>acetylcholine</p> Signup and view all the answers

    Match the neurotransmitter with its primary effect at the synapse:

    <p>Acetylcholine = Excitatory Glutamate = Excitatory GABA = Inhibitory Glycine = Inhibitory</p> Signup and view all the answers

    The resting membrane potential (RMP) is always positive on the inside of the cell.

    <p>False (B)</p> Signup and view all the answers

    The sodium-potassium pump actively transports ______ sodium ions out of the cell for every ______ potassium ions pumped into the cell.

    <p>three, two</p> Signup and view all the answers

    Which of the following is NOT a characteristic of graded potentials?

    <p>They propagate over long distances without decrement. (E)</p> Signup and view all the answers

    Match each type of potential with its correct description:

    <p>Graded potential = A localized change in membrane potential that can vary in magnitude and duration. Action potential = A rapid, all-or-none electrical signal that travels down the axon of a neuron. Resting membrane potential = The difference in electrical charge across the plasma membrane of a cell at rest.</p> Signup and view all the answers

    What are the four steps involved in the generation of an action potential? Briefly describe each step.

    <p>The four steps involved in generating an action potential are: 1) <strong>Resting State:</strong> The neuron is at its resting membrane potential. 2) <strong>Depolarization:</strong> The neuron is stimulated, causing sodium channels to open, allowing sodium ions to flow into the cell, making it more positive. 3) <strong>Repolarization:</strong> Sodium channels close, while potassium channels open, allowing potassium ions to flow out of the cell, making it more negative. 4) <strong>Hyperpolarization:</strong> Potassium channels remain open for a brief period, leading to a more negative charge than the resting potential. The membrane then returns to its resting state.</p> Signup and view all the answers

    What is the threshold of an action potential?

    <p>The minimum stimulus required to trigger an action potential. (D)</p> Signup and view all the answers

    Explain how action potentials are propagated along neurons.

    <p>Action potentials are propagated along neurons by a process called saltatory conduction. The signal jumps from one node of Ranvier to the next, skipping over the myelin-covered sections of the axon. This process ensures that the signal is transmitted quickly and efficiently, without losing strength.</p> Signup and view all the answers

    EPSPs are depolarizing events that make it more likely for a neuron to fire an action potential.

    <p>True (A)</p> Signup and view all the answers

    What is the function of an excitatory postsynaptic potential (EPSP)?

    <p>Causes a graded depolarization of the postsynaptic membrane. (C)</p> Signup and view all the answers

    The combined effect of multiple simultaneous inputs from different synapses is called ______.

    <p>spatial summation</p> Signup and view all the answers

    A single EPSP is always sufficient to trigger an action potential in the postsynaptic neuron.

    <p>False (B)</p> Signup and view all the answers

    Explain the difference between excitatory and inhibitory postsynaptic potentials.

    <p>Excitatory postsynaptic potentials (EPSPs) cause depolarization of the postsynaptic membrane, making it more likely for an action potential to occur. Inhibitory postsynaptic potentials (IPSPs) cause hyperpolarization of the postsynaptic membrane, making it less likely for an action potential to occur.</p> Signup and view all the answers

    Match the following terms with their corresponding descriptions:

    <p>Synapse = A junction between two neurons where information is transmitted. Chemical synapse = A synapse where a chemical messenger is transmitted across the junction. Excitatory postsynaptic potential (EPSP) = A graded depolarization of the postsynaptic membrane. Inhibitory postsynaptic potential (IPSP) = A graded hyperpolarization of the postsynaptic membrane.</p> Signup and view all the answers

    What does it mean for behavior to occur when neurons are released from inhibition?

    <p>When the EPSPs are stronger than the IPSPs, allowing the neuron to fire an action potential. (A)</p> Signup and view all the answers

    IPSPs make the postsynaptic membrane more permeable to potassium (K+) and chloride (Cl-) ions.

    <p>True (A)</p> Signup and view all the answers

    The combined effect of repeated inputs from the same synapse is called ______.

    <p>temporal summation</p> Signup and view all the answers

    What triggers the release of acetylcholine (ACh) in the excitatory cholinergic effect?

    <p>Calcium influx through voltage-gated channels (B)</p> Signup and view all the answers

    The excitatory adrenergic effect involves direct action through voltage-gated channels.

    <p>False (B)</p> Signup and view all the answers

    What is the result of GABA binding to its receptors in the postsynaptic neuron?

    <p>Hyperpolarization</p> Signup and view all the answers

    In the excitatory adrenergic effect, cAMP is produced by the conversion of ATP to _____ by adenylate cyclase.

    <p>cAMP</p> Signup and view all the answers

    Match the neurotransmitter with its effect:

    <p>Norepinephrine (NE) = Excitatory Adrenergic effect GABA = Inhibitory effect Acetylcholine (ACh) = Excitatory Cholinergic effect</p> Signup and view all the answers

    Flashcards

    Neuroglia

    Support cells in the nervous system that surround neurons.

    Astrocytes

    Most abundant neuroglia that supports and braces neurons.

    Microglial cells

    Small cells that monitor neurons and clean up debris.

    Ependymal Cells

    Line brain cavities and help circulate cerebrospinal fluid (CSF).

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    Oligodendrocytes

    Neuroglia that wrap nerve fibers in the CNS with myelin.

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    Schwann cells

    Cells that form myelin sheaths in the PNS and help in nerve regeneration.

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    Neuron

    Excitable cell that transmits electrical signals in the nervous system.

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    Nerve vs Tract

    A nerve is a bundle of nerve fibers in the PNS, while a tract is in the CNS.

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    Neurotransmitter

    Chemical substances that enable communication between cells.

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    Excitatory neurotransmitters

    Neurotransmitters that cause depolarization and promote action potentials (AP).

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    Inhibitory neurotransmitters

    Neurotransmitters that cause hyperpolarization and suppress action potentials (AP).

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    Direct action of neurotransmitter

    Neurotransmitter binds to a receptor, directly opening ion channels.

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    Indirect action of neurotransmitter

    Neurotransmitter triggers second messengers which eventually open channels.

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    Excitatory Cholinergic Effect

    Action potential is initiated through direct signaling via acetylcholine (ACh) release.

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    Calcium Channels Role

    Voltage-gated calcium channels open in the synaptic knob, triggering neurotransmitter release.

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    Excitatory Adrenergic Effect

    Norepinephrine (NE) activates second messenger cAMP for indirect signaling.

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    GABA-ergic Effect

    GABA neurotransmitter causes hyperpolarization, making it harder for the postsynaptic neuron to reach threshold.

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    Neuronal Integration Basics

    Patterns of neuronal organization and processing are key to understanding neural integration.

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    Synapse

    A junction between two presynaptic and postsynaptic neurons.

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    Chemical Synapse

    A synapse where neurotransmitters are transmitted across the gap between neurons.

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    Excitatory Postsynaptic Potential (EPSP)

    Graded depolarization that helps generate an action potential in the postsynaptic neuron.

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    Inhibitory Postsynaptic Potential (IPSP)

    Graded hyperpolarization that makes the postsynaptic membrane less likely to generate an action potential.

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    Summation

    The process of combining multiple EPSPs and/or IPSPs to trigger an action potential.

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    Spatial Summation

    The combined effect of simultaneous inputs from different synapses on a single neuron.

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    Temporal Summation

    The combined effect of repeated inputs from the same synapse on a single neuron.

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    Behavior and Neuron Interaction

    Behavior occurs when EPSP overcomes IPSP, leading to action potential generation.

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    Resting Membrane Potential (RMP)

    Voltage across a cell's membrane when not sending signals, typically -50 to -90 mV.

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    Ion flow

    Movement of ions through specific channels to maintain RMP.

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    K+/Na+ permeability

    The cell membrane is more permeable to K+ than Na+.

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    Na/K pump

    Transport mechanism that moves 3 Na+ out and 2 K+ in, maintaining RMP.

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    Graded Potential

    Short-lived signals that can be depolarizing or hyperpolarizing, varying in strength.

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    EPSP

    Excitatory postsynaptic potential, a type of graded potential that depolarizes the membrane.

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    IPSP

    Inhibitory postsynaptic potential, a type of graded potential that hyperpolarizes the membrane.

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    Action Potential (AP)

    A rapid change in membrane potential that propagates along neurons.

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    Myelin Sheath

    A protective layer around axons that speeds up nerve impulses.

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    CNS Myelin Formation

    Oligodendrocytes form myelin in the CNS, coiling around multiple axons.

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    PNS Myelin Formation

    Schwann cells wrap around axons in a jelly-roll manner to form myelin in the PNS.

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    Resting Membrane Potential

    The electric charge difference across the cell membrane when a neuron is not transmitting signals.

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    Myelinated vs Nonmyelinated Fibers

    Myelinated fibers transmit impulses faster than nonmyelinated fibers.

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    Study Notes

    Nervous System Overview

    • The nervous system is the master controlling and communicating system of the body
    • Its cells communicate via electrical and chemical signals, enabling rapid and specific responses
    • Sensory receptors detect stimuli, transmitting sensory input along afferent pathways
    • Integration—processing and interpreting sensory input and deciding on an appropriate response—happens in a control center.
    • Motor output, via efferent pathways, triggers a reaction in effectors (muscles or glands)

    Nervous System Divisions

    • Central Nervous System (CNS): consisting of the brain and spinal cord
    • Peripheral Nervous System (PNS): consisting of cranial nerves and spinal nerves

    Nervous Tissue

    • Highly cellular, with little extracellular space
    • Two major cell types:
      • Neuroglia: Supporting cells that surround and wrap delicate neurons
      • Neurons: Excitable nerve cells that transmit electrical signals (structural and functional units of the nervous system)

    Neuron Anatomy

    • Has a cell body (soma) and processes (dendrites and axons)
    • Three Functional Zones
      • Receptive (dendritic zone): Receives input
      • Conduct excitation (axon): Conducts the excitation. Initiates in initial segment
        • Secretory/Transmission zone (telodendritic zone): Transmits output

    Myelin Sheath

    • Composed of Schwann cells in the PNS and oligodendrocytes in the CNS
    • Insulates axons, increasing speed of nerve impulse transmission

    Nerve and Tract Difference

    • Nerve: A bundle of axons in the PNS
    • Tract: Bundle of axons in the CNS

    Membrane Potentials

    • Resting Membrane Potential (RMP): The voltage across the plasma membrane of a resting neuron, typically ranging from -50 to -90 mV
    • RMP is generated by differences in ion concentrations (inside vs. outside) and membrane permeability.

    Graded Potentials

    • Short-lived, local changes in membrane potential
    • Strength decreases with distance
    • Can be depolarizing (EPSP) or hyperpolarizing (IPSP)
    • They can summate (add together) to reach a threshold

    Action Potentials (AP)

    • Brief, large depolarization events
    • "All-or-none" phenomenon
    • Generated by voltage-gated ion channels, resulting in rapid and specific movement of ions
    • They propagate along axons and are essential for long-distance communication.
    • Contain 4 phases, and steps to an Action Potential (depolarization, repolarization, hyperpolarization)
      • Threshold: membrane depolarization must reach a certain voltage to initiate an AP
      • Activation Gate: voltage-gated Na+ channels open (depolarization)
      • Inactivation Gate: voltage-gated Na+ channels close, K+ channels open. (Repolarization)

    Refractory Periods

    • Absolute Refractory Period: A period after an AP where no new AP can be elicited, no matter the size of the stimulus
    • Relative Refractory Period: A period after the absolute refractory period where a new AP can be elicited, but it will require a larger stimulus than normal

    Conduction Velocity Factors

    • Larger diameter axons
    • Presence of myelin

    Saltatory Conduction

    • APs jump between myelinated sections (nodes of Ranvier) along the axon, increasing the speed of conduction

    Synapses

    • Junctions between neurons or between a neuron and another cell type (e.g., muscle)
    • Chemical Synapse: Neurotransmitters transmit the signal across the synaptic cleft; most common

    Synaptic Transmission Steps

    • Action potential arrives at the axon terminal
    • Voltage-gated Ca2+ channels open, Ca2+ enters
    • Neurotransmitter is released via exocytosis
    • Neurotransmitter binds to receptors on the postsynaptic membrane
    • Response in the postsynaptic cell (either excitation or Inhibition)
    • Neurotransmitter removal

    Synaptic Potentials

    • EPSPs (Excitatory): Graded depolarizations that increase the likelihood of an AP
    • IPSPs (Inhibitory): Graded hyperpolarizations that decrease the likelihood of an AP

    Synaptic Summation

    • Spatial Summation: Combined effect of multiple simultaneous inputs from different synapses
    • Temporal Summation: Combined effect of repeated inputs from the same synapse

    Neuron Classification

    • Grouped by number of processes (multipolar, bipolar, unipolar).
    • Classified by functions (sensory, motor, interneurons)

    Neurotransmitters and Receptors

    • Chemical messengers that transmit signals across synapses
    • Classes include excitatory (e.g., acetylcholine, glutamate) and inhibitory (e.g., GABA, glycine)
    • Action at Specific receptors

    Neural Integration

    • Common patterns of neuronal organization, including diverging, converging, reverberating, and parallel after-discharge circuits.

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    Description

    Explore the intricate functioning of the nervous system in this quiz. Learn about its divisions, including the Central and Peripheral Nervous Systems, and the essential role of nervous tissue. Test your knowledge on how neurons and neuroglia contribute to the communication within the body.

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