Nervous System Development Quiz

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

What two parts does the pontine flexure divide the hindbrain into?

  • Anterior and posterior
  • Dorsal and ventral
  • Rostral and caudal (correct)
  • Superior and inferior

Which structure develops from the myelencephalon?

  • Thalamus
  • Pons
  • Cerebellum
  • Medulla oblongata (correct)

During the development of the myelencephalon, what major structures form from neuroblasts in the alar plates?

  • Dorsal horns of the spinal cord
  • Motor nuclei
  • Gracile and cuneate nuclei (correct)
  • Corticospinal fibers

What is the shape of the cavity in the myelencephalon as a result of the pontine flexure?

<p>Diamond-shaped (C)</p> Signup and view all the answers

What is the role of the metencephalon in hindbrain development?

<p>It develops into the pons and cerebellum. (D)</p> Signup and view all the answers

Which part of the cerebellum is the oldest phylogenetically?

<p>Archicerebellum (A)</p> Signup and view all the answers

Which part of the cerebellum is primarily associated with sensory data from the limbs?

<p>Anterior lobe (C)</p> Signup and view all the answers

What happens to the gray matter in the pons due to the pontine flexure?

<p>It disperses and spreads. (D)</p> Signup and view all the answers

What developmental feature allows for an increase in the surface area of the cerebral cortex?

<p>Formation of gyri and sulci (D)</p> Signup and view all the answers

What common abnormal development can result from defective closure of the rostral neuropore?

<p>Meroencephaly (B)</p> Signup and view all the answers

Which condition is characterized by the protrusion of both nerve tissue and the meninges?

<p>Meningoencephalocele (B)</p> Signup and view all the answers

What is the primary cause of most cases of cerebral palsy?

<p>Maternal infections or thyroid disorders (D)</p> Signup and view all the answers

Which embryonic structures are primarily involved in alterations leading to brain birth defects?

<p>Notochord, somites, and cranium (D)</p> Signup and view all the answers

What prenatal factor can contribute to the risk of abnormal brain development?

<p>Certain genetic conditions (B)</p> Signup and view all the answers

Which structure primarily covers the protrusion in meningoencephalocele?

<p>Meninges and skin (B)</p> Signup and view all the answers

Which brain region is most commonly associated with posterior fonticle openings?

<p>Occipital region (D)</p> Signup and view all the answers

What is the primary role of the pons in the brainstem?

<p>Connects the cerebral and cerebellar cortices with the spinal cord (B)</p> Signup and view all the answers

Which structure is primarily responsible for processing visual and auditory information in the midbrain?

<p>Colliculus superior and inferior (B)</p> Signup and view all the answers

What is the significance of the cerebellum within the brain?

<p>It comprises a significant number of neurons but only a small volume (C)</p> Signup and view all the answers

How do the telencephalon and diencephalon differ?

<p>Telencephalon consists of cerebral hemispheres, while diencephalon contains the third ventricle (C)</p> Signup and view all the answers

What connects the cerebral vesicles to the third ventricular cavity?

<p>Foramen interventriculare (B)</p> Signup and view all the answers

Which layer provides a significant number of dopaminergic neurons associated with Parkinson's disease?

<p>Substantia nigra (D)</p> Signup and view all the answers

What is the main function of the cerebral aqueduct in the midbrain?

<p>Connects the third and fourth ventricles (D)</p> Signup and view all the answers

What type of developmental changes does the midbrain undergo compared to other brain regions?

<p>Minimal changes (C)</p> Signup and view all the answers

What is the primary role of oligodendrocytes in the central nervous system?

<p>Myelination of axons (B)</p> Signup and view all the answers

At what level does the spinal cord typically terminate in adults?

<p>Inferior border of the first lumbar vertebra (C)</p> Signup and view all the answers

Which layer of the meninges is derived from neural crest cells?

<p>Arachnoid mater (D)</p> Signup and view all the answers

What happens to the pia mater distal to the caudal end of the spinal cord?

<p>It forms the filum terminale (C)</p> Signup and view all the answers

Which process occurs first during the development of spinal ganglion cells?

<p>Fusion of processes in a T-shape (A)</p> Signup and view all the answers

What is the primary reason for the spinal cord's position in relation to the vertebral canal during development?

<p>The vertebral canal lengthens more than the spinal cord (D)</p> Signup and view all the answers

Which component forms the outermost layer of the meninges?

<p>Dura mater (D)</p> Signup and view all the answers

Which type of myelination occurs first according to the given developmental process?

<p>Motor roots (D)</p> Signup and view all the answers

From which embryonic layer is the nervous system primarily derived?

<p>Ectoderm (D)</p> Signup and view all the answers

What is the initial structure formed during the third week of embryonic development that precedes the neural tube?

<p>Neural plate (C)</p> Signup and view all the answers

During which week does the neurulation process begin?

<p>Fourth week (D)</p> Signup and view all the answers

What structure induces the formation of the neural plate?

<p>Notochord (C)</p> Signup and view all the answers

What does the lumen of the neural tube become?

<p>Neural canal (D)</p> Signup and view all the answers

What part of the neural structure represents the future spinal cord?

<p>Caudal one-third of the neural plate (A)</p> Signup and view all the answers

What are the openings at either end of the neural tube called?

<p>Neuropores (C)</p> Signup and view all the answers

What develops from the caudal part of the neural plate?

<p>Primordial spinal cord (B)</p> Signup and view all the answers

What is the role of the ventricular zone in the developing spinal cord?

<p>It is responsible for the proliferation of neuroepithelial cells that form neurons and macroglial cells. (D)</p> Signup and view all the answers

What structures develop from the intermediate zone of the spinal cord?

<p>Neurons and neuroblasts (A)</p> Signup and view all the answers

Which zone of the spinal cord contains cell bodies that form the dorsal gray horns?

<p>Alar plate (B)</p> Signup and view all the answers

What initiates the separation of the dorsal part from the ventral part of the spinal cord?

<p>Differential thickening of lateral walls (A)</p> Signup and view all the answers

What type of cells are derived from neural crest cells in the development of spinal ganglia?

<p>Unipolar neurons (C)</p> Signup and view all the answers

What becomes of neuroepithelial cells once they stop producing neuroblasts and glioblasts?

<p>They differentiate into ependymal cells. (A)</p> Signup and view all the answers

Which structure forms from the bulging of the basal plates?

<p>Ventral median fissure (A)</p> Signup and view all the answers

What is the primary function of glioblasts in the early development of the CNS?

<p>They provide structural support and insulation to neurons. (B)</p> Signup and view all the answers

What is the main function of the cerebellum beyond motor coordination?

<p>Processing social and emotional behaviors (C)</p> Signup and view all the answers

Which structure forms the connection between the third and fourth ventricles in the midbrain?

<p>Cerebral aqueduct (C)</p> Signup and view all the answers

Which part of the forebrain comprises the primordia of the cerebral hemispheres?

<p>Telencephalon (D)</p> Signup and view all the answers

What do the optic vesicles in the forebrain eventually develop into?

<p>Retinae and optic nerves (C)</p> Signup and view all the answers

What is the primary role of the Crus cerebri in the midbrain?

<p>Carrying fibers from the cerebrum (B)</p> Signup and view all the answers

How does the volume of the cerebellum compare to that of the entire brain?

<p>It constitutes 10% of the brain's volume (D)</p> Signup and view all the answers

What forms the lateral ventricles in the developing brain?

<p>Telencephalic vesicles (B)</p> Signup and view all the answers

Which layer in the midbrain is associated with the production of dopaminergic neurons?

<p>Substantia nigra (A)</p> Signup and view all the answers

What major structures develop from the metencephalon during hindbrain development?

<p>Pons and cerebellum (D)</p> Signup and view all the answers

Which part of the cerebellum is primarily responsible for the selective control of limb movements?

<p>Posterior lobe (D)</p> Signup and view all the answers

What determines the diamond shape of the cavity in the myelencephalon?

<p>Stretching of the roof plate (A)</p> Signup and view all the answers

What is the result of neuroblast development in the basal plate of the myelencephalon?

<p>Development of motor nuclei (C)</p> Signup and view all the answers

How do the lateral walls of the pons change as a result of the pontine flexure?

<p>They diverge, spreading the gray matter in the floor of the fourth ventricle (D)</p> Signup and view all the answers

Which nuclei are formed by neuroblasts migrating from the alar plates in the myelencephalon?

<p>Gracile and cuneate nuclei (B)</p> Signup and view all the answers

What role does the archicerebellum play in the cerebellum's structure?

<p>It processes sensory data from the ears. (D)</p> Signup and view all the answers

What happens to the gray matter in the pons as a consequence of the developmental changes during the pontine flexure?

<p>It becomes less organized due to lateral movement. (C)</p> Signup and view all the answers

What is the primary component formed by the elongation of the thalamus that bulges into the lateral ventricle?

<p>Corpus striatum (D)</p> Signup and view all the answers

Which region remains thin due to a low increase in neuroblasts adjacent to the diencephalon?

<p>Choroid plexus (C)</p> Signup and view all the answers

The largest cerebral commissure, which connects neocortical areas, is known as what?

<p>Corpus callosum (C)</p> Signup and view all the answers

What separates the thalamus from the hypothalamus?

<p>Hypothalamic sulcus (B)</p> Signup and view all the answers

Which layer of the neural tube gives rise to the cortical layers and is located peripherally?

<p>Intermediate zone (B)</p> Signup and view all the answers

Which commissure connects the olfactory bulbs and related areas of the hemispheres?

<p>Anterior commissure (B)</p> Signup and view all the answers

Which structure develops as a median diverticulum from the caudal part of the diencephalon?

<p>Pineal gland (C)</p> Signup and view all the answers

Which of the following zones of the neural tube is innermost?

<p>Ventricular zone (A)</p> Signup and view all the answers

Flashcards

Pontine Flexure

A bend in the brainstem that divides the hindbrain into myelencephalon and metencephalon.

Myelencephalon

The caudal part of the hindbrain, developing into the medulla oblongata.

Medulla Oblongata

The part of the brain stem that is formed from the myelencephalon.

Metencephalon

The rostral part of the hindbrain, developing into the pons and cerebellum.

Signup and view all the flashcards

Fourth Ventricle

The cavity of the hindbrain, formed from the hindbrain's cavity.

Signup and view all the flashcards

Gracile Nuclei

Isolated areas of gray matter in the medulla, mediating sensory information.

Signup and view all the flashcards

Cuneate Nuclei

Isolated areas of gray matter in the medulla, mediating sensory information.

Signup and view all the flashcards

Corticospinal Fibers

Motor fibers descending from the cerebral cortex, passing through the medulla.

Signup and view all the flashcards

Archicerebellum

Oldest part of the cerebellum, connecting with the vestibular apparatus.

Signup and view all the flashcards

Paleocerebellum

Older part of cerebellum linked to limb sensory information.

Signup and view all the flashcards

Neocerebellum

Most recent part of the cerebellum; controls limb movement.

Signup and view all the flashcards

Cerebral Hemisphere Growth

Initially grow in anterior, dorsal, and inferior directions, forming the frontal, temporal, and occipital lobes. The neopallidum arches over the diencephalon.

Signup and view all the flashcards

Insula Location

The area between the frontal and temporal lobes, initially sunken, and later covered as other parts grow.

Signup and view all the flashcards

Gyri

Rounded surface elevations on the cerebral hemispheres.

Signup and view all the flashcards

Sulci

Grooves or furrows between the gyri on the cerebral hemispheres.

Signup and view all the flashcards

Brain Surface Area Increase

Gyri and sulci increase surface area of the cerebral cortex without needing a larger cranium.

Signup and view all the flashcards

Birth Defects: Cause

Abnormal brain development is common, approximately 3 out of 1000 births, and is due to factors like genetic, nutritional, and environmental issues.

Signup and view all the flashcards

Birth Defects: Rostral Neuropore

Most major birth defects result from defective closure of the rostral neuropore (an NTD) during the fourth week of development.

Signup and view all the flashcards

Meningocele

Meninges and CSF protrude from an opening, often in the occipital region, of the skull.

Signup and view all the flashcards

Meningoencephalocele

Protrusion of nerve tissue along with meninges and CSF.

Signup and view all the flashcards

Meningo-hydroencephalocele

Protrusion of ventricular cavity (fluid-filled space) along with meninges and CSF.

Signup and view all the flashcards

Pons

Part of the brainstem, named for the robust nerve fiber band crossing the median plane.

Signup and view all the flashcards

Cerebellum

Small brain, the part of the brain that is involved in motor coordination, balance, and aspects of social/cognitive functions.

Signup and view all the flashcards

Midbrain (mesencephalon)

Part of the brainstem that undergoes less change during development

Signup and view all the flashcards

Cerebral Aqueduct

Channel connecting the third and fourth ventricles in the midbrain

Signup and view all the flashcards

Colliculi (superior and inferior)

Structures in the midbrain formed from migrating neuroblasts, involved in vision and hearing respectively

Signup and view all the flashcards

Substantia Nigra

Dark-colored brain structure involved in movement, part of the midbrain; associated with Parkinson's disease

Signup and view all the flashcards

Crus Cerebri

The ventral part of the midbrain; where fibers from the cerebrum pass

Signup and view all the flashcards

Telencephalon

The rostral (front) part of the forebrain; including the primordia of the cerebral hemispheres.

Signup and view all the flashcards

Diencephalon

The caudal (rear) part of the forebrain.

Signup and view all the flashcards

Lateral Ventricles

Cavities that form part of the telencephalon and contribute to the formation of the third ventricle

Signup and view all the flashcards

Optic Vesicles

Outgrowths that develop on either side of the forebrain, become the retinas and optic nerves, a part of the forebrain.

Signup and view all the flashcards

Telencephalic Vesicles

Diverticula posterior to optic vesicles; the beginnings of the cerebral hemispheres and lateral ventricles

Signup and view all the flashcards

Neural Tube Formation

The process where the neural plate folds to form a hollow tube, the precursor to the central nervous system (CNS).

Signup and view all the flashcards

Neural Crest Cells

Cells that detach during neural tube formation and give rise to components of the peripheral nervous system (PNS), including nerves and ganglia.

Signup and view all the flashcards

Neuroectoderm

The specialized embryonic tissue that develops into the nervous system.

Signup and view all the flashcards

Neural Plate

A thickened area of ectoderm that gives rise to the neural tube during nervous system development.

Signup and view all the flashcards

Neurulation

The process of forming the neural tube from the neural plate.

Signup and view all the flashcards

CNS Development

The development of the central nervous system from the neural tube.

Signup and view all the flashcards

PNS Development

The development of the peripheral nervous system from the neural crest.

Signup and view all the flashcards

Notochord Role

The notochord induces the formation of the neural plate, initiating CNS development.

Signup and view all the flashcards

Rostral Neuropore

The cranial opening in the neural tube that closes to complete the formation of the brain.

Signup and view all the flashcards

Caudal Neuropore

The caudal opening of the neural tube, that closes to complete the spinal cord formation.

Signup and view all the flashcards

Neuroepithelial cells

Cells forming the initial wall of the neural tube; precursors to neurons and macroglial cells.

Signup and view all the flashcards

Ventricular zone

Innermost layer of the neural tube, containing neuroepithelial cells.

Signup and view all the flashcards

Marginal zone

Outer layer of the neural tube, eventually becoming the white matter.

Signup and view all the flashcards

Mantle layer

Intermediate layer of the neural tube; differentiates into gray matter.

Signup and view all the flashcards

Neuroblasts

Precursors to neurons that develop cytoplasmic processes.

Signup and view all the flashcards

Glioblasts

Precursors to glial cells, supporting cells of the CNS.

Signup and view all the flashcards

Ependymal cells

Cells derived from neuroepithelial cells, lining the central canal.

Signup and view all the flashcards

Alar plate

Dorsal part of the spinal cord; forms dorsal gray horns.

Signup and view all the flashcards

Basal plate

Ventral part of the spinal cord; forms ventral gray horns.

Signup and view all the flashcards

Spinal ganglia (dorsal root ganglia)

Clusters of nerve cell bodies outside the spinal cord; contain unipolar neurons.

Signup and view all the flashcards

Sulcus limitans

Shallow groove separating alar and basal plates.

Signup and view all the flashcards

Spinal Ganglion Axons

Initially bipolar, the processes soon unite in a T-shape.

Signup and view all the flashcards

Peripheral Process Function

Acts as a dendrite, conducting signals toward the cell body.

Signup and view all the flashcards

Central Process Role

Forms the dorsal roots of spinal nerves, entering the spinal cord.

Signup and view all the flashcards

Meninges Development

Derived from neural crest and mesenchyme cells, forming the protective membranes.

Signup and view all the flashcards

Dura Mater

Tough, outer meninx derived from surrounding mesenchyme.

Signup and view all the flashcards

Pia Arachnoid

Inner layer of meninges, composed of pia and arachnoid mater (leptomeninges).

Signup and view all the flashcards

Myelination in CNS

Oligodendrocytes myelinate the central nervous system.

Signup and view all the flashcards

Myelination in PNS

Schwann cells myelinate the peripheral nervous system.

Signup and view all the flashcards

Spinal Cord Length (Embryonic)

Initially, the spinal cord spans the entire vertebral canal.

Signup and view all the flashcards

Spinal Cord Descent

Vertebrae and dura grow faster than the spinal cord, pulling it lower.

Signup and view all the flashcards

Conus Medullaris

Lower end of the spinal cord's adult position.

Signup and view all the flashcards

Filum Terminale

Thin strand extending from medullary cone, attaching to coccyx.

Signup and view all the flashcards

Pontine Flexure

A bend in the brainstem dividing the hindbrain into myelencephalon & metencephalon, influencing medulla & pons formation.

Signup and view all the flashcards

Myelencephalon

The caudal (tail end) portion of the hindbrain; becomes the medulla oblongata.

Signup and view all the flashcards

Medulla Oblongata

The lower part of the brainstem; crucial for vital functions like breathing & heart rate.

Signup and view all the flashcards

Metencephalon

The rostral (front) part of the hindbrain; leads to pons & cerebellum.

Signup and view all the flashcards

Fourth Ventricle

The hindbrain's central cavity, formed by hindbrain's cavity; continuous with the central canal.

Signup and view all the flashcards

Gracile Nuclei

Medial gray matter clusters in the medulla; sensory information processing.

Signup and view all the flashcards

Cuneate Nuclei

Lateral gray matter clusters in the medulla; sensory information processing.

Signup and view all the flashcards

Corticospinal Fibers

Motor fibers from cerebral cortex to spinal cord, passing through medulla, vital for movements.

Signup and view all the flashcards

Cerebellum

The small brain, crucial for motor coordination, balance, and aspects of social cognition.

Signup and view all the flashcards

Archicerebellum

Oldest part of the cerebellum; vestibular apparatus connection.

Signup and view all the flashcards

Paleocerebellum

Older part of cerebellum; receives sensory data from limbs and trunk.

Signup and view all the flashcards

Neocerebellum

Newest part of cerebellum; limb movement control.

Signup and view all the flashcards

Corpus Striatum Formation

The basal parts of the cerebral hemispheres, growing and bulging into the lateral ventricle, forming a striated structure.

Signup and view all the flashcards

Hippocampus Location

Located in the cerebral hemisphere wall above the choroidal fissure, linked to smell, memory, and stem cells.

Signup and view all the flashcards

Cerebral Hemisphere Zones

Developing cerebral hemispheres initially have three zones: ventricular, intermediate, and marginal.

Signup and view all the flashcards

Gray Matter Location

Gray matter is found peripherally in the cerebral hemispheres, formed by migrating intermediate zone cells into the marginal zone.

Signup and view all the flashcards

White Matter Formation

Axons from the gray matter cells pass centrally, forming the large volume of white matter.

Signup and view all the flashcards

Diencephalon Swellings

Three swellings develop in the lateral walls of the third ventricle, becoming the thalamus, hypothalamus, and epithalamus.

Signup and view all the flashcards

Cerebral Commissures

Groups of nerve fibers (commissures) connecting corresponding areas of the cerebral hemispheres.

Signup and view all the flashcards

Lamina Terminalis

Rostral (anterior) end of forebrain, a path for cerebral commissures.

Signup and view all the flashcards

Anterior Commissure

Connects olfactory bulbs and related areas between cerebral hemispheres.

Signup and view all the flashcards

Corpus Callosum

Largest cerebral commissure, connecting neocortical areas.

Signup and view all the flashcards

Pons Function

The pons is a part of the brainstem that acts as a bridge, connecting the cerebral and cerebellar cortices with the spinal cord; its robust nerve fibers form a ridge on its anterior and lateral aspects.

Signup and view all the flashcards

Cerebellum Structure

The cerebellum is a part of the brain that's only 10% of the brain's volume but contains over 50% of its neurons; associated in motor coordination, balance, proprioception and social/cognitive /emotional behaviors.

Signup and view all the flashcards

Midbrain (Mesencephalon) Change

The midbrain, or mesencephalon, is a part of the brainstem that undergoes less developmental change than other brain areas.

Signup and view all the flashcards

Cerebral Aqueduct Function

The cerebral aqueduct is a narrow channel in the midbrain that connects the third and fourth ventricles.

Signup and view all the flashcards

Colliculi Formation

Colliculi (superior and inferior) are structures in the midbrain formed from migrating neuroblasts, involved in vision and hearing, respectively.

Signup and view all the flashcards

Substantia Nigra Function

The substantia nigra is a dark-colored midbrain structure that plays a role in movement and is associated with Parkinson's disease.

Signup and view all the flashcards

Crus Cerebri Function

Crus cerebri is the ventral region of the midbrain through which fibers from the cerebrum pass.

Signup and view all the flashcards

Telencephalon Definition

The rostral (front) part of the forebrain, containing the beginnings of the cerebral hemispheres.

Signup and view all the flashcards

Diencephalon Definition

The caudal (rear) part of the forebrain.

Signup and view all the flashcards

Lateral Ventricles' Position

The lateral ventricles are interconnected cavities within the telencephalon that are connected to the third ventricle.

Signup and view all the flashcards

Optic Vesicles Origin

Two outgrowths appearing on either side of the forebrain, developing into retinas and optic nerves.

Signup and view all the flashcards

Telencephalic Vesicles

Arise more dorsally and rostrally from the forebrain, forming the beginnings of the cerebral hemispheres and lateral ventricles

Signup and view all the flashcards

Study Notes

Nervous System Development

  • The nervous system develops from the ectoderm, the outermost layer of the embryonic disc.
  • Cells differentiate at the primitive streak and form the mesodermal and endodermal layers.
  • The ectoderm originates from the epiblast.

Neural Plate and CNS Development

  • The developing nervous system appears in the third week of embryonic development.
  • The neural plate, a thickening of the ectoderm, forms on the posterior aspect of the trilaminar embryo.
  • The notochord induces the formation of the neural plate.
  • The neural plate differentiates to form neural folds with a neural groove in between.
  • Neurulation occurs, forming the neural tube.
  • The neural tube gives rise to the central nervous system (CNS).
  • The neural crest gives rise to the peripheral nervous system (PNS) and autonomic nervous system (ANS).
  • Neural tube formation starts during the fourth week (22-23 days) in the region of the fourth to sixth pairs of somites.
  • The cranial two-thirds of the neural plate and tube form the future brain, and the caudal one-third forms the future spinal cord.
  • The neural folds fuse to form the neural tube, occurring from the fifth somite cranially and caudally.
  • The neural tube's lumen becomes the neural canal, communicating with the amniotic cavity.
  • Cranial (rostral) neuropore closure occurs around day 25; caudal (caudal) neuropore closure occurs around day 27.

Spinal Cord Development

  • The primordial spinal cord develops from the caudal part of the neural plate and caudal eminence.
  • The neural tube develops into the spinal cord caudally of the fourth pair of somites.
  • Initially, the wall of the neural tube is composed of a thick, pseudostratified columnar neuroepithelium.
  • Neuroepithelial cells form the ventricular zone (ependymal layer), giving rise to neurons and macroglial cells.
  • The outer parts of the neuroepithelial cells form the marginal zone, which becomes the white matter of the spinal cord.
  • The middle layer (mantle) becomes the gray matter.
  • Nerve fibers (axons) grow into the marginal zone from the spinal cord, spinal ganglia, and brain.

Spinal Ganglia Development

  • Unipolar neurons in the spinal ganglia develop from neural crest cells.
  • Initial bipolar neurons' axons unite to form a T-shaped structure.
  • Peripheral processes act as dendrites, while central processes form the dorsal roots of spinal nerves.

Meninges Development

  • Meninges (spinal cord membranes) develop from neural crest cells and mesenchyme between days 20 and 35.
  • These cells surround the neural tube.
  • The external layer thickens into the dura mater.
  • The internal layer comprises pia mater and arachnoid mater (leptomeninges).
  • The dura mater is a tough and durable membrane.
  • Arachnoid mater and pia mater are a single layer.
  • Pia mater intimately covers the CNS.

Myelination

  • Myelination begins at the end of the fetal period and continues postnatally.
  • Oligodendrocytes are responsible for myelination in the CNS.
  • Schwann cells are responsible for myelination in the periphery.
  • Myelin is observed in peripheral nerves by the 20th week.
  • Motor roots myelinate before sensory roots.

Spinal Cord Positional Changes

  • The spinal cord initially extends the entire length of the vertebral canal.
  • The cord's inferior end (conus medullaris) remains elevated in the embryo.
  • At birth, the spinal cord terminates at the first lumbar vertebra.
  • In adults, the spinal cord typically terminates at the lower border of the first lumbar vertebra.
  • Dura mater and arachnoid mater typically end at S2, but pia mater extends into filum terminale.
  • The filum terminale attaches to the first coccygeal vertebra.
  • Spinal nerves exit intervertebral foramina opposite their points of origin.

Brain Development Overview

  • The neural tube cranial to the fourth somite forms the brain.
  • Neuroprogenitor cells differentiate to form specific brain areas.
  • Neural folds close, forming three primary brain vesicles (forebrain, midbrain, hindbrain).
  • The forebrain divides into telencephalon and diencephalon; the midbrain does not divide; the hindbrain divides into metencephalon and myelencephalon, forming five secondary brain vesicles.

Midbrain Development

  • The midbrain (mesencephalon) undergoes minimal change.
  • The neural canal narrows into the cerebral aqueduct, connecting the third and fourth ventricles.

Forebrain Development

  • The rostral (anterior) part of the forebrain forms the telencephalon.
  • The caudal (posterior) part of the forebrain forms the diencephalon.
  • The cavities of the telencephalon and diencephalon contribute to the formation of the third ventricle.
  • The optic vesicles originate from the forebrain.
  • The telencephalic vesicles form the cerebral hemispheres.
  • The lateral ventricles originate from these vesicles.

Hindbrain Development

  • The cervical flexure separates the hindbrain from the spinal cord.
  • The pontine flexure divides the hindbrain into the rostral (metencephalon) and caudal (myelencephalon) portions.
  • The myelencephalon becomes the medulla oblongata.
  • The metencephalon becomes the pons and the cerebellum.
  • The cavity of the hindbrain becomes the fourth ventricle and central canal of the medulla.

Metencephalon Development

  • The metencephalon forms the pons and cerebellum.
  • The pontine flexure causes lateral expansion of pons.
  • Three columns of motor nuclei are present on the basal plates.
  • The cerebellum forms from the dorsal parts of the alar plates.

Myelencephalon Development

  • Neuroblasts in the alar plates migrate to the marginal zone.
  • The medulla forms the gracile and cuneate nuclei.
  • The pyramids consist of corticospinal fibers.
  • The roof plate thins during pontine flexure.
  • The cavity of the myelencephalon becomes diamond-shaped.

Cerebellum Development

  • The cerebellum structure reflects its evolutionary development.
  • The archicerebellum (flocculonodular lobe) is the oldest part, with connections to the vestibular apparatus.
  • The paleocerebellum (vermis and anterior lobe) is newer, involved in sensory data from the limbs.
  • The neocerebellum (posterior lobe) is the newest, involved in selective limb movements.

Cerebral Commissures

  • Groups of nerve fibers (commissures) connect corresponding areas of cerebral hemispheres as the cortex develops.
  • The lamina terminalis is the natural pathway between the hemispheres.
  • The first commissures to form are the anterior commissure and hippocampal commissure.
  • The corpus callosum is a large commissure connecting neocortical areas.
  • The corpus callosum initially develops within the lamina terminalis, then arches over the diencephalon.

Cerebral Hemisphere Development

  • Hemispheres grow in anterior, dorsal, and inferior directions.
  • Frontal, temporal, and occipital lobes develop.
  • The insula is the area between the frontal and temporal lobes.
  • Surface gyri and sulci create increased surface area in the cortex.

Birth Defects of the Brain

  • Abnormal brain development is relatively common (approximately 3 per 1,000 births).
  • Birth defects can stem from:
    • Embryologic history complexity
    • Defective closure of the rostral neuropore.
    • Involvement of overlying tissues (meninges and calvaria)
    • Genetic, nutritional, and environmental factors

Other Brain Development Note

  • Prenatal risk factors (maternal infection/thyroid disorder, Rh incompatibility, genetic conditions) contribute to cerebral palsy.
  • Central motor deficits sometimes result from birth events.
  • Holoprosencephaly (incomplete cerebral hemisphere separation) often includes facial abnormalities. Genetic and environmental factors are implicated and may arise from destruction of embryonic midline cells.
  • Hydranencephaly (absence of cerebral hemispheres) is rare with little to no cognitive development.
  • Microcephaly is a neurodevelopmental disorder characterized by a small calvaria and brain, but normal-sized face. Factors such as genetic origin, exposure to ionizing radiation, infectious agents, certain drugs, and premature synostosis can contribute to this disorder.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Development of the Central Nervous System
5 questions
Central Nervous System Development
7 questions
Central Nervous System Overview
79 questions
Use Quizgecko on...
Browser
Browser