Nervous System - Chapter Review
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Questions and Answers

Which of the following events is NOT directly associated with the generation of an inhibitory postsynaptic potential (IPSP)?

  • Hyperpolarization of the postsynaptic membrane
  • Decreased likelihood of an action potential being fired
  • Influx of sodium ions (correct)
  • Opening of chloride channels
  • What is the primary function of the axon hillock in the process of synaptic transmission?

  • Release of neurotransmitters into the synaptic cleft
  • Integration of incoming signals to determine if an action potential will be fired (correct)
  • Reception of neurotransmitters from presynaptic neurons
  • Conduction of action potentials along the axon
  • Which of the following scenarios would MOST likely result in a postsynaptic neuron being less likely to fire an action potential?

  • Activation of multiple excitatory synapses simultaneously
  • An influx of sodium ions into the postsynaptic neuron
  • Activation of a metabotropic receptor that opens potassium channels
  • Binding of a neurotransmitter to an ionotropic receptor that opens chloride channels (correct)
  • How do metabotropic receptors differ from ionotropic receptors in their mechanisms of action?

    <p>Metabotropic receptors involve a series of intracellular events, while ionotropic receptors directly open ion channels (C)</p> Signup and view all the answers

    What is the PRIMARY role of the synaptic cleft in neuronal communication?

    <p>To provide a space for the diffusion and binding of neurotransmitters, facilitating chemical communication between neurons (A)</p> Signup and view all the answers

    Which of the following statements about the Action Potential is NOT true?

    <p>A stronger stimulus will cause a larger amplitude of the Action Potential. (B)</p> Signup and view all the answers

    What is the role of the axon hillock in the generation of an action potential?

    <p>It is the point where the decision to fire an action potential is made. (A)</p> Signup and view all the answers

    What is the primary function of the myelin sheath in saltatory conduction?

    <p>To isolate the axon, increasing the speed of action potential conduction by allowing it to jump between nodes of Ranvier. (A)</p> Signup and view all the answers

    If a neuron is at its resting potential, and a stimulus causes an influx of chloride ions (Cl-) into the neuron, how will this affect the neuron's membrane potential?

    <p>It will cause the membrane potential to become more negative, decreasing the likelihood of an action potential. (D)</p> Signup and view all the answers

    How do excitatory postsynaptic potentials (EPSPs) influence the likelihood of an action potential?

    <p>They increase the likelihood of an action potential by making the neuron more positive. (C)</p> Signup and view all the answers

    What is the primary role of inhibitory postsynaptic potentials (IPSPs) in neuronal communication?

    <p>To reduce the likelihood of an action potential being fired by the postsynaptic neuron. (D)</p> Signup and view all the answers

    What is the correct sequence of events leading to an action potential at the synapse?

    <p>Action potential propagates down the axon, presynaptic neuron releases neurotransmitters, neurotransmitters bind to receptors on the postsynaptic neuron. (D)</p> Signup and view all the answers

    How does the concentration gradient contribute to the movement of ions during an action potential?

    <p>The concentration gradient pushes ions from areas of high concentration to areas of low concentration, but only if the electrical gradient is also favorable. (D)</p> Signup and view all the answers

    What is the primary function of the axon hillock in neural communication?

    <p>To generate action potentials by integrating incoming signals from dendrites and cell body (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the relationship between excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs) at the synapse?

    <p>EPSPs and IPSPs are both generated when a neurotransmitter binds to a postsynaptic receptor, but EPSPs cause depolarization while IPSPs cause hyperpolarization. (D)</p> Signup and view all the answers

    How does the location of synaptic input on a neuron affect the strength of the signal at the axon hillock?

    <p>Synaptic inputs closer to the axon hillock have a greater influence on the generation of action potentials than those farther away, due to the passive decay of electrical signals. (C)</p> Signup and view all the answers

    Why are graded potentials, such as EPSPs and IPSPs, considered 'graded'?

    <p>Because their amplitude is proportional to the strength of the stimulus that triggered them, allowing for coding of signal intensity. (A)</p> Signup and view all the answers

    Which of the following processes directly underlies the ability of neurons to integrate multiple incoming signals at the same time?

    <p>Spatial summation, where multiple synaptic inputs occurring simultaneously at different locations on the neuron are combined. (C)</p> Signup and view all the answers

    Flashcards

    Synapse

    A junction where neurons communicate with each other.

    Presynaptic Events

    Processes occurring before neurotransmitter release at the synapse.

    Neurotransmitter Binding

    Attachment of neurotransmitters to receptor sites on the postsynaptic cell.

    Ionotropic Receptors

    Receptors that open ion channels directly when binding with neurotransmitters.

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    Metabotropic Receptors

    Receptors that initiate a chain of reactions leading to indirect ion channel opening.

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    Saltatory Conduction

    The process where action potentials jump between nodes of Ranvier on myelinated axons, increasing conduction speed.

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    EPSP (Excitatory PostSynaptic Potential)

    A graded potential that makes a neuron more likely to fire an action potential.

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    IPSP (Inhibitory PostSynaptic Potential)

    A graded potential that makes a neuron less likely to fire an action potential.

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    Temporal Summation

    The process where multiple inputs from the same source over time combine to affect the neuron's potential.

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    Spatial Summation

    The process where inputs from multiple sources at the same time combine to affect the neuron's potential.

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    Action Potential

    A rapid rise and fall in membrane potential due to Na+ and K+ ion movements.

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    Depolarization

    The phase where Na+ ions enter the neuron and reduce the negative charge inside.

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    Repolarization

    The phase where K+ ions exit the neuron, restoring membrane potential towards resting level.

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    Hyperpolarization

    The state where the membrane potential becomes more negative than the resting potential after K+ exits.

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    Refractory Period

    The time after an action potential when it is difficult to trigger another one.

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    Threshold Potential

    The minimum membrane potential required to initiate an action potential.

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    All-or-None Principle

    The action potential either occurs fully or not at all, regardless of stimulus strength.

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    Study Notes

    Nervous System - Continued

    • The nervous system is responsible for taking in information, making decisions, and passing that information along.

    Review

    • Diffusion Force = Electrostatic Pressure Force.
    • Equilibrium is reached when the forces are balanced between two sides of a membrane.

    The Nernst Equation

    • E = membrane potential (voltage difference across the membrane)
    • z = valence (charge) of the ion.
    • F = Faraday constant (related to electrical force)
    • T = absolute temperature (in Kelvin).
    • R = universal gas constant.
    • [Ion]out = concentration of the ion outside the cell.
    • [Ion]in = concentration of the ion inside the cell.

    Establishing the Membrane Potential

    • Extracellular environment is typically positive.
    • Intracellular environment is typically negative.
    • Leaking channels: ion channels that are always open, allowing ions to leak across the membrane.
    • Gated channels: ion channels that open and close in response to stimuli, and play an important role in establishing the resting potential.
    • Na/K Pump: moves 3 Na ions out of the cell and 2 K ions into the cell for each ATP it uses, important to maintain ion concentrations and resting potential.

    Resting Potential

    • ENa = 62 mV
    • Ek= -80 mV
    • Resting potential: –70 mV

    Action Potential

    • Caused by the brief opening of voltage-gated Na+ channels and then the brief opening of voltage-gated K+ channels.
    • Five stages: Resting Potential, Sufficient Depolarization, Overshoot Phase, Undershoot Phase, Return to Resting Potential

    The Action Potential - To Review...

    • K+ moves in and out freely.
    • Na+ is trapped inside the cell.
    • Cl- is mostly outside the cell

    Apply a depolarizing current...

    • Begin with more Na+ outside the cell.
    • Depolarizing current opens Na+ channels.
    • Positive Na+ ions rush into the cell.
    • If the depolarizing current reaches threshold (-40 mV), an action potential (AP) will occur.

    Overshoot Phase

    • Voltage drops to 0 mV, then continues to become more positive.
    • Na+ channels open rapidly; Na+ enters the cell, depolarizing the neuron.
    • After the opening of Na+ channels, K+ channels open, and K+ leaves the cell.
    • At the peak, Na+ channels close, and no more Na+ enters the neuron.

    Undershoot Phase

    • Repolarization: K+ continues to leave the cell, causing the membrane potential to return to the resting level.
    • K+ channels close slowly, causing hyperpolarization (Undershoot).
    • Refractory period: hard to "fire" again.

    Return to Resting Potential

    • K+ channels close.
    • Na+ channels reset, causing membrane potential to return to the resting level.
    • Re-establishes equilibrium between concentration and voltage gradient.

    Action Potential is All or None

    • Increasing the current beyond threshold does not increase the AP amplitude. The amplitude remains constant.

    The Rate Law

    • The strength of a stimulus is represented by the rate of firing of an axon.
    • The magnitude (size) of each action potential is always constant.
    • Stronger stimuli = more APs.

    Conduction of the Action Potential

    • When an action potential is triggered, its size remains the same as it travels down the axon.

    Neural Communication

    • Neural computation = decision-making.
    • Synapse = passing information.
    • Neurons take in information, make decisions, and pass information.

    Synaptic Connections Between Neurons

    • The arrows represent the direction information is traveling.
    • Synapse on soma, synapse on dendrite, axon, terminal button, myelin sheath.

    Communication Between Neurons

    • Excitatory or inhibitory.

    Postsynaptic Potentials

    • Excitatory Postsynaptic Potential (EPSP): reduces the charge away from threshold, increasing probability of AP.
    • Inhibitory Postsynaptic Potential (IPSP): increases the charge away from threshold, decreasing probability of AP.
    • Lasts only a few milliseconds, then decays, and resting potential is restored.

    Again, It's All About Ions

    • EPSP & IPSP are graded potentials.
    • Size is proportional to the stimulation.
    • Even at high stimulation, AP is not always produced.
    • No voltage-sensitive channels on the cell body (dendrites and axon hillock).
    • Spread passively over the dendrite/cell body.

    AP vs Graded Potentials

    • Action Potentials: all-or-nothing, digital, axon, transport information without loss of change, maintenance of information.
    • Graded Potentials: graded, analog, cell body & dendrites, allows information processing.

    What Happens Next

    • IPSPs & EPSPs spread passively over cell body & dendrites (no voltage-sensitive channels).
    • Axon hillock (voltage-sensitive channels), think of as a point of summary.
    • If threshold is reached, an AP is generated.

    Temporal Summation

    • EPSPs or IPSPs over a short time frame may sum to create a stronger signal.

    Spatial Summation

    • EPSPs or IPSPs from different synapses sum at the axon hillock.

    What is Critical

    • Whether the sum of depolarization reaches a critical threshold..
    • Both positive and negative addends (EPSPs & IPSPs).

    Summation

    • EPSPs & IPSPs spread passively over the cell body, decaying with distance.
    • Point of origin matters: inputs farther out on the dendrite contribute less.
    • Summation is like a weighted sum.

    The Computation Can Be Complex ... examples shown

    • Different neuron signals (excitatory or inhibitory) can lead to more complex responses.

    Basal Ganglia

    • Indirect and direct pathways.
    • The structures include the cortex, substantia nigra, striatum, globus pallidus, thalamus, etc.

    How are they Communicating? ... diagrams showing

    • The relationship between the parts and how they work.

    Details of a Synapse

    • Structure and parts of a synapse are shown. (Synaptic vesicle, synaptic cleft, presynaptic membrane, postsynaptic membrane, etc.)

    Presynaptic Events

    • Nerve impulse propagates down the axon to the axon terminal.
    • Calcium channels open, leading to synaptic vesicle fusion, and transmitter release.

    Postsynaptic Events

    • Neurotransmitters bind receptors.
    • Conveys neural message to the postsynaptic cell..

    Ionotropic Receptors

    • The ion channel opens when a neurotransmitter attaches to the binding site.

    Ionic Movements During Postsynaptic Potentials

    • Influx of Na+, efflux of K+, and influx of Cl−.

    Metabotropic Receptors

    • Neurotransmitter binds to a receptor.
    • initiates a chain of chemical events (indirectly).
    • Indirect signaling of ion channels.

    Saltatory Conduction

    • Myelin sheath provides insulation, leading to more efficient nerve impulse propagation.
    • Action potential jumps between nodes of Ranvier.

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    Description

    This quiz covers essential concepts related to the nervous system, including the Nernst Equation and membrane potential. Understand the roles of diffusion and electrostatic forces in cellular environments. Test your knowledge on the functions of ion channels and the effects of extracellular and intracellular conditions.

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