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Questions and Answers
Which of the following events is NOT directly associated with the generation of an inhibitory postsynaptic potential (IPSP)?
Which of the following events is NOT directly associated with the generation of an inhibitory postsynaptic potential (IPSP)?
What is the primary function of the axon hillock in the process of synaptic transmission?
What is the primary function of the axon hillock in the process of synaptic transmission?
Which of the following scenarios would MOST likely result in a postsynaptic neuron being less likely to fire an action potential?
Which of the following scenarios would MOST likely result in a postsynaptic neuron being less likely to fire an action potential?
How do metabotropic receptors differ from ionotropic receptors in their mechanisms of action?
How do metabotropic receptors differ from ionotropic receptors in their mechanisms of action?
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What is the PRIMARY role of the synaptic cleft in neuronal communication?
What is the PRIMARY role of the synaptic cleft in neuronal communication?
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Which of the following statements about the Action Potential is NOT true?
Which of the following statements about the Action Potential is NOT true?
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What is the role of the axon hillock in the generation of an action potential?
What is the role of the axon hillock in the generation of an action potential?
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What is the primary function of the myelin sheath in saltatory conduction?
What is the primary function of the myelin sheath in saltatory conduction?
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If a neuron is at its resting potential, and a stimulus causes an influx of chloride ions (Cl-) into the neuron, how will this affect the neuron's membrane potential?
If a neuron is at its resting potential, and a stimulus causes an influx of chloride ions (Cl-) into the neuron, how will this affect the neuron's membrane potential?
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How do excitatory postsynaptic potentials (EPSPs) influence the likelihood of an action potential?
How do excitatory postsynaptic potentials (EPSPs) influence the likelihood of an action potential?
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What is the primary role of inhibitory postsynaptic potentials (IPSPs) in neuronal communication?
What is the primary role of inhibitory postsynaptic potentials (IPSPs) in neuronal communication?
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What is the correct sequence of events leading to an action potential at the synapse?
What is the correct sequence of events leading to an action potential at the synapse?
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How does the concentration gradient contribute to the movement of ions during an action potential?
How does the concentration gradient contribute to the movement of ions during an action potential?
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What is the primary function of the axon hillock in neural communication?
What is the primary function of the axon hillock in neural communication?
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Which of the following statements accurately describes the relationship between excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs) at the synapse?
Which of the following statements accurately describes the relationship between excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs) at the synapse?
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How does the location of synaptic input on a neuron affect the strength of the signal at the axon hillock?
How does the location of synaptic input on a neuron affect the strength of the signal at the axon hillock?
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Why are graded potentials, such as EPSPs and IPSPs, considered 'graded'?
Why are graded potentials, such as EPSPs and IPSPs, considered 'graded'?
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Which of the following processes directly underlies the ability of neurons to integrate multiple incoming signals at the same time?
Which of the following processes directly underlies the ability of neurons to integrate multiple incoming signals at the same time?
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Flashcards
Synapse
Synapse
A junction where neurons communicate with each other.
Presynaptic Events
Presynaptic Events
Processes occurring before neurotransmitter release at the synapse.
Neurotransmitter Binding
Neurotransmitter Binding
Attachment of neurotransmitters to receptor sites on the postsynaptic cell.
Ionotropic Receptors
Ionotropic Receptors
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Metabotropic Receptors
Metabotropic Receptors
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Saltatory Conduction
Saltatory Conduction
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EPSP (Excitatory PostSynaptic Potential)
EPSP (Excitatory PostSynaptic Potential)
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IPSP (Inhibitory PostSynaptic Potential)
IPSP (Inhibitory PostSynaptic Potential)
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Temporal Summation
Temporal Summation
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Spatial Summation
Spatial Summation
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Action Potential
Action Potential
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Depolarization
Depolarization
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Repolarization
Repolarization
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Hyperpolarization
Hyperpolarization
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Refractory Period
Refractory Period
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Threshold Potential
Threshold Potential
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All-or-None Principle
All-or-None Principle
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Study Notes
Nervous System - Continued
- The nervous system is responsible for taking in information, making decisions, and passing that information along.
Review
- Diffusion Force = Electrostatic Pressure Force.
- Equilibrium is reached when the forces are balanced between two sides of a membrane.
The Nernst Equation
- E = membrane potential (voltage difference across the membrane)
- z = valence (charge) of the ion.
- F = Faraday constant (related to electrical force)
- T = absolute temperature (in Kelvin).
- R = universal gas constant.
- [Ion]out = concentration of the ion outside the cell.
- [Ion]in = concentration of the ion inside the cell.
Establishing the Membrane Potential
- Extracellular environment is typically positive.
- Intracellular environment is typically negative.
- Leaking channels: ion channels that are always open, allowing ions to leak across the membrane.
- Gated channels: ion channels that open and close in response to stimuli, and play an important role in establishing the resting potential.
- Na/K Pump: moves 3 Na ions out of the cell and 2 K ions into the cell for each ATP it uses, important to maintain ion concentrations and resting potential.
Resting Potential
- ENa = 62 mV
- Ek= -80 mV
- Resting potential: –70 mV
Action Potential
- Caused by the brief opening of voltage-gated Na+ channels and then the brief opening of voltage-gated K+ channels.
- Five stages: Resting Potential, Sufficient Depolarization, Overshoot Phase, Undershoot Phase, Return to Resting Potential
The Action Potential - To Review...
- K+ moves in and out freely.
- Na+ is trapped inside the cell.
- Cl- is mostly outside the cell
Apply a depolarizing current...
- Begin with more Na+ outside the cell.
- Depolarizing current opens Na+ channels.
- Positive Na+ ions rush into the cell.
- If the depolarizing current reaches threshold (-40 mV), an action potential (AP) will occur.
Overshoot Phase
- Voltage drops to 0 mV, then continues to become more positive.
- Na+ channels open rapidly; Na+ enters the cell, depolarizing the neuron.
- After the opening of Na+ channels, K+ channels open, and K+ leaves the cell.
- At the peak, Na+ channels close, and no more Na+ enters the neuron.
Undershoot Phase
- Repolarization: K+ continues to leave the cell, causing the membrane potential to return to the resting level.
- K+ channels close slowly, causing hyperpolarization (Undershoot).
- Refractory period: hard to "fire" again.
Return to Resting Potential
- K+ channels close.
- Na+ channels reset, causing membrane potential to return to the resting level.
- Re-establishes equilibrium between concentration and voltage gradient.
Action Potential is All or None
- Increasing the current beyond threshold does not increase the AP amplitude. The amplitude remains constant.
The Rate Law
- The strength of a stimulus is represented by the rate of firing of an axon.
- The magnitude (size) of each action potential is always constant.
- Stronger stimuli = more APs.
Conduction of the Action Potential
- When an action potential is triggered, its size remains the same as it travels down the axon.
Neural Communication
- Neural computation = decision-making.
- Synapse = passing information.
- Neurons take in information, make decisions, and pass information.
Synaptic Connections Between Neurons
- The arrows represent the direction information is traveling.
- Synapse on soma, synapse on dendrite, axon, terminal button, myelin sheath.
Communication Between Neurons
- Excitatory or inhibitory.
Postsynaptic Potentials
- Excitatory Postsynaptic Potential (EPSP): reduces the charge away from threshold, increasing probability of AP.
- Inhibitory Postsynaptic Potential (IPSP): increases the charge away from threshold, decreasing probability of AP.
- Lasts only a few milliseconds, then decays, and resting potential is restored.
Again, It's All About Ions
- EPSP & IPSP are graded potentials.
- Size is proportional to the stimulation.
- Even at high stimulation, AP is not always produced.
- No voltage-sensitive channels on the cell body (dendrites and axon hillock).
- Spread passively over the dendrite/cell body.
AP vs Graded Potentials
- Action Potentials: all-or-nothing, digital, axon, transport information without loss of change, maintenance of information.
- Graded Potentials: graded, analog, cell body & dendrites, allows information processing.
What Happens Next
- IPSPs & EPSPs spread passively over cell body & dendrites (no voltage-sensitive channels).
- Axon hillock (voltage-sensitive channels), think of as a point of summary.
- If threshold is reached, an AP is generated.
Temporal Summation
- EPSPs or IPSPs over a short time frame may sum to create a stronger signal.
Spatial Summation
- EPSPs or IPSPs from different synapses sum at the axon hillock.
What is Critical
- Whether the sum of depolarization reaches a critical threshold..
- Both positive and negative addends (EPSPs & IPSPs).
Summation
- EPSPs & IPSPs spread passively over the cell body, decaying with distance.
- Point of origin matters: inputs farther out on the dendrite contribute less.
- Summation is like a weighted sum.
The Computation Can Be Complex ... examples shown
- Different neuron signals (excitatory or inhibitory) can lead to more complex responses.
Basal Ganglia
- Indirect and direct pathways.
- The structures include the cortex, substantia nigra, striatum, globus pallidus, thalamus, etc.
How are they Communicating? ... diagrams showing
- The relationship between the parts and how they work.
Details of a Synapse
- Structure and parts of a synapse are shown. (Synaptic vesicle, synaptic cleft, presynaptic membrane, postsynaptic membrane, etc.)
Presynaptic Events
- Nerve impulse propagates down the axon to the axon terminal.
- Calcium channels open, leading to synaptic vesicle fusion, and transmitter release.
Postsynaptic Events
- Neurotransmitters bind receptors.
- Conveys neural message to the postsynaptic cell..
Ionotropic Receptors
- The ion channel opens when a neurotransmitter attaches to the binding site.
Ionic Movements During Postsynaptic Potentials
- Influx of Na+, efflux of K+, and influx of Cl−.
Metabotropic Receptors
- Neurotransmitter binds to a receptor.
- initiates a chain of chemical events (indirectly).
- Indirect signaling of ion channels.
Saltatory Conduction
- Myelin sheath provides insulation, leading to more efficient nerve impulse propagation.
- Action potential jumps between nodes of Ranvier.
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Description
This quiz covers essential concepts related to the nervous system, including the Nernst Equation and membrane potential. Understand the roles of diffusion and electrostatic forces in cellular environments. Test your knowledge on the functions of ion channels and the effects of extracellular and intracellular conditions.