Nerve Tissue Histology Overview

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Questions and Answers

Which connective tissue layer directly encloses individual nerve axons?

  • Myelin sheath
  • Perineurium
  • Epineurium
  • Endoneurium (correct)

What is the primary function of motor nerves?

  • Carry motor commands from the CNS to muscles or glands. (correct)
  • To connect sensory and motor neurons
  • Transmit sensory data from the periphery to the CNS.
  • Facilitate the initial response to stimuli by neurons

A nerve containing both sensory and motor fibers is classified as a:

  • Motor nerve
  • Sensory nerve
  • Mixed nerve (correct)
  • Peripheral nerve

The ability of neurons to respond to stimuli is best described as:

<p>Excitability (A)</p> Signup and view all the answers

What is the role of the perineurium in nerve structure?

<p>Encloses fascicles. (B)</p> Signup and view all the answers

Which term describes the propagation of electrical impulses along a neuron's membrane?

<p>Conductivity (C)</p> Signup and view all the answers

Which layer of connective tissue provides the outermost encasement for an entire nerve?

<p>Epineurium (C)</p> Signup and view all the answers

What is the defining characteristic of sensory nerves?

<p>They transmit sensory information to the CNS. (C)</p> Signup and view all the answers

Neurons are specialized for transmitting information rapidly and accurately. This is an example of:

<p>Specialization (C)</p> Signup and view all the answers

Which of these are key components of nerve structure?

<p>Bundles of nerve fibers (fascicles) and connective tissue layers. (D)</p> Signup and view all the answers

Which layer of the cerebral cortex is characterized by the presence of lipofuscin inclusions, indicating cellular aging?

<p>Layer IV (A)</p> Signup and view all the answers

Direct current flow through gap junctions is a characteristic of which type of synapse?

<p>Electrical synapse (B)</p> Signup and view all the answers

In the context of synaptic transmission, which type relies on the release of neurotransmitters?

<p>Chemical synapse (A)</p> Signup and view all the answers

Which layer of the cerebral cortex directly precedes the multiform layer?

<p>Ganglion Layer (V) (C)</p> Signup and view all the answers

What distinguishes the function of an electrical synapse in reflex pathways?

<p>Rapid signal transmission (A)</p> Signup and view all the answers

Which of the following is a characteristic inclusion associated with cellular aging?

<p>Lipofuscin accumulation (C)</p> Signup and view all the answers

Amyloid plaques and neurofibrillary tangles are most closely associated with which condition?

<p>Alzheimer's disease (C)</p> Signup and view all the answers

Which layer is most likely to show signs of lipofuscin accumulation?

<p>Inner Granular Layer (IV) (C)</p> Signup and view all the answers

What is the primary function of the Nodes of Ranvier in neuron physiology?

<p>To act as the site of action potential regeneration enabling saltatory conduction. (A)</p> Signup and view all the answers

Which glial cells are responsible for the production of myelin in the peripheral nervous system (PNS)?

<p>Schwann cells (C)</p> Signup and view all the answers

Which of the following is a key function of ependymal cells?

<p>Producing cerebrospinal fluid (CSF). (B)</p> Signup and view all the answers

What is the role of satellite cells within the peripheral nervous system (PNS)?

<p>To provide structural and metabolic support to neurons in ganglia. (A)</p> Signup and view all the answers

What is a unique characteristic of Schwann cells regarding myelination?

<p>They myelinate single axons. (C)</p> Signup and view all the answers

What is the primary role of oligodendrocytes within the central nervous system?

<p>Forming the myelin sheath around multiple axons to enhance signal speed. (A)</p> Signup and view all the answers

Which glial cells primarily contribute to the inhibitory environment that hinders nerve regeneration after CNS damage?

<p>Astrocytes. (C)</p> Signup and view all the answers

Which of the following best describes the function of a myelin sheath?

<p>To accelerate signal conduction along axons. (C)</p> Signup and view all the answers

What is the primary functional difference between oligodendrocytes and Schwann cells?

<p>Oligodendrocytes form myelin sheaths in the CNS, while Schwann cells form them in the PNS. (C)</p> Signup and view all the answers

What role do astrocytes play within the central nervous system?

<p>Regulating the blood-brain barrier, maintaining ion balance, and aiding in tissue repair. (C)</p> Signup and view all the answers

What is the consequence of glial scar formation in the context of CNS damage?

<p>A permanent loss of function due to an inhibitory environment. (C)</p> Signup and view all the answers

Which glial cells are responsible for the phagocytic removal of cellular debris in the CNS?

<p>Microglia. (A)</p> Signup and view all the answers

Which of the following is an example of an inhibitory neurotransmitter within the CNS?

<p>GABA. (C)</p> Signup and view all the answers

In Parkinson's disease, which specific neuronal population experiences significant loss?

<p>Dopaminergic neurons in the substantia nigra (C)</p> Signup and view all the answers

What is the primary pathological process observed in Multiple Sclerosis (MS)?

<p>Autoimmune destruction of central nervous system myelin (B)</p> Signup and view all the answers

What structure is primarily affected in Guillain-Barré Syndrome?

<p>Myelin in the peripheral nervous system (A)</p> Signup and view all the answers

Which factor primarily contributes to the more effective axonal regeneration observed in the peripheral nervous system (PNS) compared to the central nervous system (CNS)?

<p>Schwann cell activity (A)</p> Signup and view all the answers

Which of the following is a key component of the synapse where neurotransmitters are released?

<p>Presynaptic terminal (C)</p> Signup and view all the answers

What is the space between the presynaptic and postsynaptic membranes called?

<p>Synaptic cleft (D)</p> Signup and view all the answers

Which structure is primarily responsible for coordinating movement and maintaining balance?

<p>Cerebellum (C)</p> Signup and view all the answers

Which of the following neurotransmitters is considered excitatory?

<p>Glutamate (D)</p> Signup and view all the answers

What is the main function of the tissue categorized as periosteum?

<p>To cover the bone with dense irregular connective tissue. (B)</p> Signup and view all the answers

Where are neurotransmitter receptors primarily located?

<p>Postsynaptic membrane (B)</p> Signup and view all the answers

Which part of the central nervous system is mainly involved in higher cognitive functions and sensory interpretation?

<p>Cerebrum (B)</p> Signup and view all the answers

The brainstem plays a crucial role in which of the following involuntary functions?

<p>Regulation of heart rate and respiration (A)</p> Signup and view all the answers

What is the anatomical relationship between the scalp and the skull?

<p>The scalp is an outer protective layer of the head, exterior to the skull. (B)</p> Signup and view all the answers

What is the primary function of satellite cell nuclei?

<p>To provide metabolic and structural support to neuron cell bodies. (C)</p> Signup and view all the answers

Which of the following sequences accurately represents the flow of structural layers from exterior to interior?

<p>Scalp, periosteum, skull (D)</p> Signup and view all the answers

What is the correct arrangement of white and grey matter in the cerebrum?

<p>Center = white matter, periphery = grey matter (B)</p> Signup and view all the answers

What is the correct arrangement of white and grey matter in the brainstem?

<p>Center = grey matter, periphery = white matter (D)</p> Signup and view all the answers

Flashcards

Endoneurium

Connective tissue layer surrounding each individual axon within a nerve.

Fascicles

Bundles of nerve fibers (axons) within a nerve.

Perineurium

Connective tissue layer that encloses fascicles (bundles of nerve fibers) within a nerve.

Epineurium

Outermost layer of connective tissue that encases the entire nerve.

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Sensory Nerves

Nerves that transmit sensory information from the body to the central nervous system (CNS).

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Motor Nerves

Nerves that carry motor commands from the CNS to muscles and glands.

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Mixed Nerves

Nerves that contain both sensory and motor fibers.

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Excitability

The ability of neurons to respond to stimuli.

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Conductivity

The transmission of electrical impulses (action potentials) along the neuron's membrane.

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Neurons

Specialized cells in the nervous system that transmit information via electrical signals.

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Scalp

The outer protective layer of the head, consisting of skin, connective tissue, and muscle.

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Brain

The control center of the nervous system, responsible for processing information, coordinating actions, and thoughts.

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Cerebrum

The outermost layer of the brain responsible for higher cognitive functions like planning, memory, and language.

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Cerebellum

The part of the brain responsible for coordinating movement and balance.

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Brainstem

The structure connecting the cerebrum and cerebellum to the spinal cord, controlling vital functions like breathing and heart rate.

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White matter

The inner layer of the brain, primarily composed of white matter, responsible for transmitting signals between different areas of the brain.

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Gray matter

The outer layer of the brain, primarily composed of gray matter, responsible for processing information and controlling movement.

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Satellite cells

Cells located around neuron cell bodies, providing structural and metabolic support.

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Periosteum

Dense irregular connective tissue covering the bone, providing structural protection for the brain.

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Central Nervous System (CNS)

The part of the nervous system consisting of the brain and spinal cord.

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Inner Granular Layer (IV)

The innermost layer of the retina, responsible for processing visual information before it is sent to the brain.

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Lipofuscin

A pigment that accumulates in cells as they age. It is found in the Inner Granular Layer of the retina.

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Ganglion Layer (V)

A layer of the retina containing neurons that receive input from the Inner Granular Layer and project to the brain.

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Multiform Layer (VI)

The outermost layer of the retina, responsible for integrating information from different parts of the retina.

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Electrical Synapse

A type of synapse where electrical signals flow directly from one neuron to another through gap junctions, allowing for rapid communication.

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Chemical Synapse

A type of synapse where chemical messengers called neurotransmitters are released from one neuron to another, allowing for more complex communication.

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Alzheimer's Disease

A neurodegenerative disease characterized by the build-up of amyloid plaques and neurofibrillary tangles in the brain. These affect neurons in the Multiform Layer.

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Multiform Layer ( VI )

A layer of the retina where neurons receive input from the Inner Granular Layer and project to other retinal layers. It shows differences in neurons based on their size and functionality.

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Parkinson's Disease

A neurodegenerative disease characterized by the loss of dopamine-producing neurons in the substantia nigra, leading to motor control problems.

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Multiple Sclerosis (MS)

A neurodegenerative disease that results from the destruction of myelin in the central nervous system (CNS) by autoimmune attacks. This disrupts nerve impulse conduction.

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Guillain-Barré Syndrome (GBS)

A neurodegenerative disease that involves demyelination of the peripheral nervous system (PNS). This often affects the limbs causing weakness and numbness.

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Synapse

The site where a nerve impulse transmits from one neuron to another cell. Consists of the presynaptic terminal, synaptic cleft, and postsynaptic membrane.

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Presynaptic Terminal

The part of the neuron that releases neurotransmitters into the synaptic cleft.

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Synaptic Cleft

The space between the presynaptic terminal and the postsynaptic membrane.

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Postsynaptic Membrane

The part of the neuron that receives neurotransmitters and responds to the signal.

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Excitatory Neurotransmitters

Neurotransmitters that increase the likelihood of a postsynaptic neuron firing an action potential. Examples include glutamate and acetylcholine.

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Neuroglia (Glial Cells)

Specialized cells in the nervous system that support and protect neurons. They provide structural support, insulation, and nutrient supply.

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Nodes of Ranvier

Gaps in the myelin sheath that allow for faster nerve signal transmission by enabling 'jumping' of the signal from node to node.

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Schwann Cells

Type of glial cell found in the PNS, responsible for forming myelin sheaths around individual axons.

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Ependymal Cells

Type of glial cell located in the CNS, responsible for producing cerebrospinal fluid (CSF).

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Myelin Sheath

Insulates axons to speed up signal transmission. This layer is formed by specialized cells called Schwann cells in the PNS and oligodendrocytes in the CNS.

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Oligodendrocytes

Specialized cells found in the central nervous system (CNS) that form the myelin sheath for multiple axons. This greatly enhances the speed of signal conduction.

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Astrocytes

A type of glial cell in the CNS that plays a crucial role in regulating the blood-brain barrier, maintaining ion balance, and repairing damaged tissue.

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Microglia

Immune cells in the CNS that act as 'scavengers' to engulf and destroy harmful pathogens and cellular debris.

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GABA

A type of neurotransmitter that inhibits nerve impulses, meaning it slows down or stops signals from traveling along nerve cells.

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CNS Damage and Recovery

Damage to the central nervous system (CNS) can lead to permanent loss of function due to the creation of a glial scar, which forms a barrier that prevents nerve regeneration.

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Myelination

The process of wrapping axons with a myelin sheath, which increases the speed of nerve impulses. This is vital for optimal communication in the nervous system.

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Study Notes

Nerve Tissue Histology Mind Map

  • Nerve Tissue Overview: The nervous system is composed of nerve tissue, which includes neurons and neuroglia. Neurons are the functional units, transmitting signals. Neuroglia support and protect neurons.

  • Neuron Structure: Neurons consist of a cell body (soma), dendrites (receiving signals), and an axon (sending signals). The axon may be myelinated (for faster signal transmission) or unmyelinated. Myelin is produced by Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS). Nodes of Ranvier are gaps in the myelin sheath where action potentials regenerate.

  • Neuroglia: Neuroglia (glial cells) support neurons and maintain homeostasis. Types include astrocytes (regulate blood-brain barrier), oligodendrocytes (produce myelin in CNS), microglia (immune cells), and ependymal cells (produce cerebrospinal fluid). Schwann cells in the PNS myelinate single axons, while satellite cells support neurons in ganglia.

  • Nerve Types: Nerves can be sensory (transmit sensory data), motor (carry motor commands), or mixed (contain both). Nerves are bundles of axons and connective tissues. Layers include epineurium (outermost), perineurium (surrounds fascicles), and endoneurium (surrounds individual axons).

  • Synapses: Neurons communicate via synapses, where a neurotransmitter is released from one neuron to stimulate an adjacent neuron. Synapses can be chemical (mediated by neurotransmitters) or electrical (direct current, gap junctions).

  • CNS (Central Nervous System): Includes the brain and spinal cord. Grey matter contains neuronal cell bodies and numerous synapses. White matter is primarily composed of myelinated axons. Distinct layers of the cerebral cortex like molecular (1), outer granular (II), outer pyramidal (III), inner granular (IV), ganglion (V), and multiform (VI).

  • PNS (Peripheral Nervous System): Includes nerves and ganglia. Nerves connect the CNS to the body. Ganglia are clusters of neuronal cell bodies outside the CNS. Somatic nervous system (voluntary control of skeletal muscles) and autonomic nervous system (involuntary control of smooth muscles, glands, internal organs) is a part of the PNS. The sympathetic and parasympathetic divisions compose the autonomic nervous system.

  • Meninges: Dura mater, arachnoid mater, and pia mater are protective membranes covering the brain and spinal cord. Dura mater is the outermost tough membrane. Arachnoid mater is a web-like middle layer that contains arachnoid villi for CSF reabsorption. Pia mater is a thin inner layer that closely adheres to the brain's surface.

  • Neurodegenerative and Demyelinating Diseases: Diseases like Alzheimer's (amyloid plaques and neurofibrillary tangles), Parkinson's (loss of dopaminergic neurons), Multiple Sclerosis (CNS myelin damage), and Guillain-Barré syndrome (PNS myelin damage).

  • Axonal Regeneration: Regeneration is more effective in the PNS than in the CNS. Schwann cells in the PNS help for regeneration while CNS has an inhibitory environment created by glial scar formation inhibiting regeneration.

  • Functional Divisions of the Nervous System: Sensory Input - Detects environmental changes. Integration - Processes and interprets sensory information. Motor Output - Transmits signals to effectors. Higher Functions - Cognition, emotion, memory, learning.

Cell Body (Soma)

  • Contains the nucleus and organelles, synthesizes neurotransmitters.

  • Dendrites: Branching processes that receive input signals from other neurons or sensory stimuli.

  • Axon: Long projection that transmits electrical impulses away from the soma.

  • Axon Hillock: Region where action potentials are initiated in the axon.

  • Axon Terminals: Release neurotransmitters to target cells.

  • Cytoskeleton: Neurofilaments, microtubules (transport), microfilaments support the structure and function.

  • Organelles: Nissl bodies (rough ER for protein synthesis), mitochondria (high energy demands). Inclusions include melanin or lipofuscin (cellular aging).

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