Nerve Physiology Quiz
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Questions and Answers

What structure of a neuron is primarily responsible for receiving impulses?

  • Axon
  • Myelin sheath
  • Dendrites (correct)
  • Soma
  • What is a key characteristic that distinguishes myelinated nerves from unmyelinated nerves?

  • They conduct impulses more slowly.
  • They have a thicker axon diameter.
  • They lack a resting membrane potential.
  • They are wrapped in a protein-lipid complex. (correct)
  • Which property of nerves allows them to respond to various stimuli?

  • In fatiguability
  • Adaptation
  • Conductivity
  • Excitability (correct)
  • Which statement accurately represents the 'All or none law' in nerve physiology?

    <p>Only maximal stimuli produce a nerve impulse. (C)</p> Signup and view all the answers

    What term describes the potential difference across the membranes of excitable tissues during rest?

    <p>Resting membrane potential (A)</p> Signup and view all the answers

    Which factor does NOT affect nerve impulse conduction?

    <p>Fatigue from repeated stimulation (A)</p> Signup and view all the answers

    Adaptation in nerve physiology refers to which of the following?

    <p>Nerves eventually stop responding to a continuous stimulus. (A)</p> Signup and view all the answers

    What is meant by 'potential difference' in the context of nerve physiology?

    <p>The difference in charge between two points. (D)</p> Signup and view all the answers

    What is the typical resting membrane potential (RMP) value for nerve fibers?

    <p>-70 mV (C)</p> Signup and view all the answers

    Which ion has a higher permeability across the membrane at rest?

    <p>Potassium ions (K+) (A)</p> Signup and view all the answers

    Which of the following processes primarily contributes to maintaining the resting membrane potential?

    <p>Na+/K+-ATPase pump (B)</p> Signup and view all the answers

    What is the effect of depolarization on membrane potential?

    <p>It reduces negativity toward zero (-60 mV) (B)</p> Signup and view all the answers

    During hyperpolarization, what happens to the membrane potential?

    <p>It increases in negativity (-90 to -110 mV) (C)</p> Signup and view all the answers

    Which ion distribution is characteristic of a typical nerve cell at rest?

    <p>Higher concentrations of K+ inside the cell (C)</p> Signup and view all the answers

    What causes the inside of a nerve cell to be relatively negative compared to the outside at rest?

    <p>Presence of negatively charged proteins inside (D)</p> Signup and view all the answers

    How does the Na+/K+-ATPase pump function in maintaining resting membrane potential?

    <p>It pumps 3 Na+ ions out and 2 K+ ions into the cell (B)</p> Signup and view all the answers

    What is the threshold stimulus in the context of action potentials?

    <p>The minimum stimulus required to achieve an action potential. (C)</p> Signup and view all the answers

    During depolarization, which ions primarily rush into the cell?

    <p>Sodium ions (Na+) (D)</p> Signup and view all the answers

    What occurs during the repolarization phase of an action potential?

    <p>Potassium ions (K+) exit the cell, returning the membrane potential to a negative value. (C)</p> Signup and view all the answers

    What is hyperpolarization in the context of action potential?

    <p>An overshoot beyond the resting membrane potential due to prolonged K⁺ channel opening. (A)</p> Signup and view all the answers

    Which of the following describes the absolute refractory period?

    <p>A period of complete unresponsiveness to any stimulus, regardless of intensity. (C)</p> Signup and view all the answers

    Which mechanism helps return the membrane potential to the resting state after action potential?

    <p>Na⁺-K⁺ pump adjusts excess Na⁺ and K⁺ levels. (A)</p> Signup and view all the answers

    In which phase does the membrane potential change dramatically from -70mV to +35mV?

    <p>Depolarization phase. (A)</p> Signup and view all the answers

    What effect does the delayed opening of voltage-gated potassium channels have during hyperpolarization?

    <p>It results in an overshoot in the hyperpolarizing direction. (B)</p> Signup and view all the answers

    What is one primary mechanism for the removal of acetylcholine from the synaptic space?

    <p>Destruction by acetylcholinesterase (B)</p> Signup and view all the answers

    What characteristic of neuromuscular transmission is described as involving a 0.5 msec delay?

    <p>Impulse propagation time (A)</p> Signup and view all the answers

    What effect does calcium influx have on neuromuscular transmission?

    <p>It promotes the rupture of acetylcholine vesicles (A)</p> Signup and view all the answers

    Which drug is specifically known to antagonize the action of acetylcholine at the neuromuscular junction?

    <p>Curare (B)</p> Signup and view all the answers

    How does myasthenia gravis primarily affect the neuromuscular junction?

    <p>Produces antibodies that block acetylcholine receptors (B)</p> Signup and view all the answers

    What is an irreversible outcome of organophosphate exposure?

    <p>Irreversible inhibition of acetylcholinesterase (A)</p> Signup and view all the answers

    What condition can result in paralysis of respiratory muscles in its severe form?

    <p>Myasthenia gravis (B)</p> Signup and view all the answers

    What does the depletion of acetylcholine vesicles result in during neuromuscular transmission?

    <p>Neuromuscular transmission fatigue (B)</p> Signup and view all the answers

    What is the primary characteristic of local potentials in terms of their signaling function?

    <p>They are important for short distance signaling. (A)</p> Signup and view all the answers

    What happens to the magnitude of a local potential when a stronger stimulus is applied?

    <p>It increases proportionately to the stimulus strength. (D)</p> Signup and view all the answers

    Which type of conduction occurs in myelinated nerves?

    <p>Saltatory conduction. (D)</p> Signup and view all the answers

    How are local potentials characterized in terms of spatial propagation?

    <p>They are non-propagated and localized. (C)</p> Signup and view all the answers

    What is the nature of the response of local potentials to repeated stimuli?

    <p>They can be summated. (B)</p> Signup and view all the answers

    What describes the conduction speed in unmyelinated nerves compared to myelinated nerves?

    <p>Unmyelinated conduction is slower. (A)</p> Signup and view all the answers

    What directly affects the duration of acetylcholine's action in the synaptic space?

    <p>Destruction by acetylcholinesterase. (D)</p> Signup and view all the answers

    Which statement about non-voltage gated channels is true in relation to local potentials?

    <p>They are responsible for the occurrence of local potentials. (D)</p> Signup and view all the answers

    Flashcards

    Soma

    The main cell body of a neuron, containing the nucleus and other organelles.

    Axon

    A long, slender projection that extends from the soma, transmitting nerve impulses away from the cell body.

    Dendrites

    Branching projections that receive nerve impulses and conduct them toward the cell body.

    Myelin

    A fatty substance that wraps around axons, increasing the speed and efficiency of nerve impulse conduction.

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    Nodes of Ranvier

    Gaps in the myelin sheath on axons, where nerve impulses jump from one node to another.

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    Excitability

    The ability of a nerve or muscle to respond to stimuli.

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    Conductivity

    The ability of a nerve to conduct a nerve impulse along its length.

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    All or none law

    The principle stating that a nerve fiber will either produce a maximal action potential or no action potential at all, regardless of the strength of the stimulus.

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    Resting membrane potential (RMP)

    The difference in electrical charge between the inside and outside of a nerve cell membrane when it's not transmitting signals.

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    Selective membrane permeability (RMP)

    The cell membrane is more permeable (allows things through) to potassium ions (K+) than sodium ions (Na+). This is because there are more K+ leakage channels than Na+ leakage channels.

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    Na+/K+-ATPase pump (RMP)

    A pump that moves 3 sodium ions (Na+) out of the cell and 2 potassium ions (K+) into the cell, requiring energy (ATP). This contributes to the negative charge inside the cell.

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    Polarized state

    The state of the membrane potential when it's at rest, typically around -70mV. The inside of the cell is negatively charged compared to the outside.

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    Depolarized state

    A reduction in the membrane potential's negativity, becoming less negative. It could reach zero or even become positive.

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    Hyperpolarized state

    An increase in the membrane potential's negativity, becoming more negative.

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    Depolarization

    The state of the membrane potential during an action potential when the inside of the cell becomes momentarily positive compared to the outside.

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    Repolarization

    The state of the membrane potential during an action potential when the inside of the cell returns to its negative resting potential.

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    What is threshold stimulus?

    The minimum stimulus required to generate an action potential in a nerve or muscle cell.

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    Hyperpolarization

    A brief overshoot in the negative direction of the membrane potential, after repolarization is completed.

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    Back to RMP

    The resting membrane potential (RMP) is restored by closing voltage-gated potassium channels and the Na⁺-K⁺ pump re-establishes the ion gradients.

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    Absolute Refractory Period

    A period during which the nerve is absolutely unexcitable to any stimulus, regardless of its strength.

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    Relative Refractory Period

    A period where the nerve is partially responsive to stimuli, but requires a stronger than normal stimulus to trigger an action potential.

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    Excitability Changes during Action Potential

    These changes in excitability during an action potential ensure that the nerve impulse travels in one direction and prevent back propagation.

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    What is a local potential?

    A local potential is a temporary change in the membrane potential that occurs only at the site of stimulation. It is graded, meaning its amplitude is proportional to the strength of the stimulus.

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    What are the types of local potentials?

    Local potentials can be either excitatory or inhibitory, depending on the type of stimulus and the receptors involved. An excitatory potential increases the likelihood of an action potential occurring, while an inhibitory potential decreases the likelihood.

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    What is a subthreshold stimulus?

    A subthreshold stimulus is a stimulus that is not strong enough to trigger an action potential. However, it can still create a local potential.

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    What is saltatory conduction?

    Saltatory conduction is the rapid conduction of nerve impulses along myelinated axons, where the impulses jump from one node of Ranvier to the next.

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    What is point-to-point conduction?

    Point-to-point conduction is the slower conduction of nerve impulses along unmyelinated axons, where the impulses travel continuously along the entire length of the axon.

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    What is myelin?

    Myelin is a fatty substance that surrounds axons, increasing the speed and efficiency of nerve impulse conduction. It acts as an insulator, preventing leakage of the electrical signal.

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    What are the nodes of Ranvier?

    The nodes of Ranvier are gaps in the myelin sheath on axons. Nerve impulses jump from one node to the next, allowing for faster conduction.

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    What is acetylcholine?

    Acetylcholine is a neurotransmitter that is released at the neuromuscular junction, causing muscle contraction.

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    Acetylcholine removal

    The rapid removal of acetylcholine from the synaptic cleft prevents continued muscle excitation.

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    Acetylcholinesterase

    An enzyme that breaks down acetylcholine in the synaptic cleft.

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    Unidirectional NMT

    Neuromuscular transmission only goes in one direction: from nerve to muscle.

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    Delay in NMT

    There's a slight delay between the nerve impulse arriving at the junction and the muscle responding.

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    NMT Fatigue

    Repetitive nerve stimulation can lead to a decrease in signal strength.

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    Ion Effects on NMT

    Calcium ions enhance neuromuscular transmission by stimulating acetylcholine release. Magnesium inhibits it by stabilizing the vesicles.

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    Drugs that enhance NMT

    Certain drugs mimic acetylcholine and activate its receptors.

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    Curare and NMT

    Curare blocks acetylcholine receptors, preventing muscle contraction.

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    Botulinum toxin and NMT

    Botulinum toxin blocks the release of acetylcholine from nerve terminals.

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    Myasthenia Gravis

    A condition characterized by muscle weakness due to insufficient acetylcholine transmission.

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    Myasthenia Gravis and Autoimmunity

    In Myasthenia Gravis, the body's immune system attacks acetylcholine receptors.

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    Consequences of Myasthenia Gravis

    Severe Myasthenia Gravis can lead to paralysis, particularly of the respiratory muscles.

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    Study Notes

    Nerve Physiology

    • Nerve physiology is the study of how nerves function.

    Structure of the Neuron

    • Neurons consist of three main parts:
      • Soma: The main cell body.
      • Axon: A single, long projection extending from the soma. It transmits nerve impulses away from the soma.
      • Dendrites: Branching projections from the soma. They receive impulses and conduct them toward the cell body.

    Types of Nerve Axons

    • Axons can be myelinated or unmyelinated:
      • Myelinated axons: The axon is wrapped with myelin, a protein-lipid complex. Myelin sheaths interrupt at the Nodes of Ranvier. This type of nerve conduction is Faster and More Economical in energy consumption.
      • Unmyelinated axons: The axon lacks myelin sheaths, and conduction is Slower and requires High energy consumption.

    Properties of Nerves

    • Excitability: The nerve's ability to respond to various stimuli.
      • A stimulus is any change in the internal or external environment that causes a reaction. (Chemical, Electrical, Mechanical, and Thermal).
    • Conductivity: The nerve impulse's rapid transmission along the nerve fiber.
    • All or None Law: A minimal stimulus (threshold) is needed to excite a nerve. This stimulus produces a maximal action potential.
    • Adaptability: The nerve quickly adapts to the stimulating current.
    • Fatigue Resistance: Nerves resist fatigue due to repeated stimulations.

    Basic Principles of Electricity

    • Potential Difference: The difference in charge between two points.
    • Membrane Potential: The difference in charge on both sides of the nerve membrane.
    • Resting Membrane Potential (RMP): The potential difference across excitable membranes (nerve/muscle) at rest. Nerve fibers: -70mV; Skeletal and cardiac muscle fibers: -90mV.

    Distribution of Major Mobile Ions Across the Plasma Membrane

    • Differences exist in the composition of extracellular and intracellular fluids.
    • The inside of the cell membrane is relatively negative compared to the outside during rest.

    Resting Membrane Potential (RMP)

    • RMP is the potential difference between the inner and outer surfaces of excitable tissue membranes at rest.
      • Nerve Fibers: ~-70 mV
      • Skeletal and cardiac muscle fibers: ~-90 mV

    Causes of Unequal Ion Distribution

    • Selective membrane permeability: Potassium (K+) ions pass through the membrane more easily than Sodium (Na+) ions; this is vital to maintain the negative internal environment of the cell.
    • Active transport via the Na+/K+ pump: This pump actively transports 3 Sodium ions out of the cell and 2 Potassium ions into the cell, contributing to the maintenance of the resting membrane potential.

    Action Potentials

    • Transient changes in membrane potential that occur in response to a threshold stimulus.
    • Phases of Action Potential:
      • Depolarization: The membrane potential becomes less negative, and eventually positive. This results from the opening of voltage-gated sodium channels and rapid influx of sodium ions.
      • Repolarization: The membrane potential returns to a more negative value. This results from the closing of voltage-gated sodium channels and the opening of voltage-gated potassium channels, allowing potassium ions to move out of the cell.
      • Hyperpolarization: The membrane potential temporarily becomes more negative than the resting membrane potential. This occurs as the potassium channels remain open for a brief time after the membrane reaches the resting potential.
      • Return to RMP: The membrane potential eventually returns to its resting state as the potassium channels close and the Na+/K+ pump restores the ion concentration gradients.

    Types of Membrane Potentials

    • Polarized state (RMP): A state of rest where the inside of the membrane is relatively more negative than the outside.
    • Depolarized state (depolarization): Reduction in membrane potential negativity, sometimes reversing the polarity and becoming positive.
    • Hyperpolarized state (hyperpolarization): An increase in membrane potential negativity, where the inside of the membrane becomes more negative than the value of the RMP.

    Excitability changes during Action Potential

    • Absolute Refractory Period: A period of time where the nerve is unresponsive to stimulation. It corresponds to the ascending limb of the action potential and the initial portion of the descending limb.
    • Relative Refractory Period: A period of time in which the nerve is excitable, with a stronger stimulus needed for excitation. This period of partial recovery corresponds to the remaining portion of the action potential's descending limb.

    Local Potentials (Graded Potentials)

    • Subthreshold stimulation of excitable nerve or muscle membrane that produce a graded response proportionate to the strength of the stimulus. These potentials decay with distance.
    • Important in short-distance signaling. localized stimuli.

    Nerve Conduction

    • Initiates at the axon hillock and travels along the axon.
    • Two types of conduction: point-to-point and saltatory.
    • Saltatory conduction in myelinated axons is faster and more energy efficient.

    Neuro-Muscular Transmission

    • Neurotransmitter Release: Acetylcholine is released into the synaptic cleft.
    • Destruction of Acetylcholine: Enzyme Acetylcholinesterase breaks it down, ending the stimulation.

    Myasthenia Gravis

    • Autoimmune neuromuscular junction disease.
    • Antibodies block or destroy acetylcholine receptors, leading to muscle weakness and paralysis.
    • Treatment involves medications to increase acetylcholine levels.

    Drugs That Influence Neurotransmission

    • Drugs that enhance or block neuromuscular transmission can affect the process.

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    Test your knowledge on nerve physiology concepts, including neuron structure, impulse conduction, and resting membrane potential. This quiz covers key characteristics and principles that define nerve function. Perfect for students studying biology or neuroscience!

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