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Questions and Answers
What primarily creates the resting membrane potential in a neuron?
What primarily creates the resting membrane potential in a neuron?
When a neuron becomes hyperpolarized, what is the effect on its membrane potential?
When a neuron becomes hyperpolarized, what is the effect on its membrane potential?
What is the main function of sodium-potassium pumps in neurons?
What is the main function of sodium-potassium pumps in neurons?
Which ions are primarily responsible for the polarization of a nerve cell's membrane?
Which ions are primarily responsible for the polarization of a nerve cell's membrane?
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What role do voltage-gated channels play in the transmission of a nerve impulse?
What role do voltage-gated channels play in the transmission of a nerve impulse?
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What occurs when the membrane potential decreases from the resting state?
What occurs when the membrane potential decreases from the resting state?
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What is the resting membrane potential value for a typical nerve cell?
What is the resting membrane potential value for a typical nerve cell?
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Which of the following best describes the term 'membrane potential'?
Which of the following best describes the term 'membrane potential'?
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What primarily contributes to the negative resting membrane potential in neurons?
What primarily contributes to the negative resting membrane potential in neurons?
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What role does the sodium potassium pump play in maintaining resting membrane potential?
What role does the sodium potassium pump play in maintaining resting membrane potential?
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What happens to the membrane potential when an action potential is triggered?
What happens to the membrane potential when an action potential is triggered?
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What defines a threshold stimulus in neurons?
What defines a threshold stimulus in neurons?
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How long does it typically take for a neuron to return to its resting state after an action potential?
How long does it typically take for a neuron to return to its resting state after an action potential?
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What happens to chloride ions (Cl-) in relation to the interior of the cell?
What happens to chloride ions (Cl-) in relation to the interior of the cell?
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During the depolarization phase of an action potential, what primarily occurs?
During the depolarization phase of an action potential, what primarily occurs?
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Which statement about ion movement in neurons is true?
Which statement about ion movement in neurons is true?
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Study Notes
Nerve Impulse
- Nerve impulse is an electrical signal, relying on ion flow across a neuron's membrane.
- It begins with a change in the electrical gradient across the plasma membrane.
Generation and Transmission of Nerve Impulses
- All living cells have an electrical charge difference across their neurolemma, creating an electrical voltage gradient (membrane potential).
- Nerve impulse is the electrochemical transmission of messages through neurons, traveling through dendrites or axons via voltage-gated ion channels in the neurolemma. These channels open and close in response to electrical voltage.
- Neurolemma is polarized, with the inside negatively charged relative to the outside due to ion distribution.
Ion Distribution
- Intracellular major positive ions are potassium (K+) and sodium (Na+). Extracellular major positive ions are sodium (Na+).
- Potassium (K+) concentration is significantly higher inside the cell than outside (30 times).
- Sodium (Na+) concentration is higher outside the cell than inside (approximately 10 times).
- Sodium-potassium pumps actively transport Na+ out of the cell and K+ into the cell, maintaining these concentration gradients.
- Channels in the membrane are specific to ions, allowing one type to pass while restricting others.
- Negative ions inside the neurolemma include chloride (Cl-), phosphate (PO4-2), sulfate (SO4-2), and intracellular proteins.
Resting Membrane Potential (RMP)
- RMP is the state of a nerve cell when not stimulated.
- The resting membrane is slightly permeable to ions (more permeable to K+ than Na+).
- RMP is -70 millivolts (mV).
- Neurons are excitable, responding to stimuli affecting membrane potential.
- Membrane hyperpolarization: membrane becomes more negative than RMP.
- Membrane depolarization: membrane becomes less negative than RMP.
- Sufficient depolarization triggers an action potential.
- At rest, K+ ions move out of the cell due to their concentration gradient. This creates the negative inner charge.
- Increased extracellular sodium (Na+) concentration, combined with the high K+ permeability of the membrane, results in the negative resting membrane potential.
- The sodium-potassium pump maintains the RMP by expelling 3 Na+ ions and bringing 2 K+ ions into the cell per ATP.
- Cl- tends to accumulate outside the cell, repelled by negatively charged cytoplasmic proteins.
Action Potential (AP)
- Action potential is triggered by a stimulus sufficient to depolarize the membrane to threshold.
- Sodium channels open rapidly, allowing Na+ influx (inside the cell), causing depolarization.
- Depolarization can reach up to +50mV.
- Then, sodium channels close, potassium channels open, allowing K+ efflux (out of the cell), leading to repolarization.
- Repolarization restores the resting membrane potential (takes 10-30 milliseconds).
- Threshold stimulus is required to produce an action potential; a weaker one will not result in a depolarization.
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Description
Test your knowledge on nerve impulses, their generation, and transmission through neurons. This quiz covers key concepts such as ion distribution, membrane potential, and the role of voltage-gated ion channels. Perfect for biology students looking to reinforce their understanding of cellular communication.