28 Questions
Which term describes the abnormal proliferation of cells?
Neoplasia
What is the clinical appearance of an abnormal growth called?
Cancer
Which type of growth does not invade surrounding tissue or spread to new locations in the body?
Benign
Which type of growth lacks invasion of the basement membrane but becomes malignant once invasion occurs?
Pre-malignant
Which type of growth interferes with and ultimately kills the organism?
Malignant
What is the process of gradual stepwise tumor development called?
Oncogenesis
Which type of neoplasm is a malignant neoplasm that originates from epithelium?
Carcinoma
Which step of oncogenesis involves the introduction of an irreversible genetic change?
Initiation
Which cells can be resistant to apoptosis?
Initiated cells
In terms of oncogenesis, what is the second step in the sequence of steps for carcinoma development?
Epidermal hypoplasia
Which of the following is a characteristic of a malignant neoplasm?
Frequent metastasis
Which of the following is a characteristic of a benign neoplasm?
Cohesive growth
Which of the following is a characteristic of a malignant neoplasm based on cytological features?
Marked anisokaryosis
Which of the following is a characteristic of a benign neoplasm based on cytological features?
Minimal to mild anisocytosis
Which type of neoplasm affects the lining epithelium?
Squamous cell carcinoma
Which type of neoplasm affects connective tissue?
Lipoma
Which phase of tumor development is characterized by genetic instability and increasing tumor cell heterogeneity?
Progression
Which phase of tumor development is characterized by the development of a preneoplastic lesion or a benign tumor?
Promotion
Which factor is responsible for driving proliferation of neoplastic cells during promotion?
Selective stimulation
Which characteristic is important for characterizing neoplasms and involves the absence of invasiveness to surrounding tissue?
Differentiation
Which type of neoplasm affects the muscle?
Fibrosarcoma
Which type of neoplasm affects the lining epithelium?
Adenocarcinoma
Which type of neoplasm affects the nervous system?
Oligodendroglioma
Which type of agent can cause mutagenesis during the initiation phase of oncogenesis?
All of the above
What is the main characteristic of promotors during the promotion phase of oncogenesis?
They are non-mutagenic
What is a hallmark of the progression phase of tumor development?
Both genetic instability and increasing tumor cell heterogeneity
Which type of neoplasm can become metastatic and is characterized by irreversible change?
Malignant neoplasm
What are the main factors responsible for selecting increasingly malignant clones of tumor cells during progression?
Both genetic and epigenetic changes
Test your knowledge on neoplasia, the process of abnormal cell proliferation and the formation of abnormal masses of tissue known as neoplasms. Learn about the different types of neoplasms, including benign and malignant growths, and the clinical appearance of cancer.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
