Neisseria gonorrhoeae Overview
30 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary shape of Neisseria gonorrhoeae?

  • Chain-shaped
  • Rod-shaped
  • Spiral-shaped
  • Cocci arranged in pairs (correct)

    • Neisseria gonorrhoeae can be found as a commensal organism in healthy individuals.

    False

    What type of media do Neisseria gonorrhoeae require for growth in laboratory conditions?

    Enriched media, such as chocolate agar or Modified Thayer-Martin medium.

    Neisseria gonorrhoeae is classified as a _____ organism requiring carbon dioxide for optimal growth.

    <p>facultative anaerobe</p> Signup and view all the answers

    Match the following terms with their descriptions:

    <p>Aerobes = Organisms that require oxygen for growth Diplococci = Bacteria shaped as pairs Oxidase positive = Organisms that possess cytochrome C enzyme Enriched media = Nutrient-rich media for specific bacteria growth</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Neisseria gonorrhoeae?

    <p>Gram-positive</p> Signup and view all the answers

    Only Neisseria gonorrhoeae causes disease in humans within the genus Neisseria.

    <p>False</p> Signup and view all the answers

    What is one of the diseases caused by Neisseria gonorrhoeae?

    <p>Gonorrhea</p> Signup and view all the answers

    The bacterial infection gonorrhea is most commonly transmitted through _____ contact.

    <p>sexual</p> Signup and view all the answers

    Which virulence factor is associated with Neisseria gonorrhoeae?

    <p>Pili for attachment</p> Signup and view all the answers

    Which of the following is NOT a treatment for uncomplicated gonococcal infection?

    <p>Tetracycline</p> Signup and view all the answers

    Nisseria is oxidase negative.

    <p>False</p> Signup and view all the answers

    What is the common manifestation of gonorrhea in prepubescent girls?

    <p>Vulvovaginitis</p> Signup and view all the answers

    Nisseria grows at _____ degrees Celsius in a CO2 enriched environment.

    <p>35-37</p> Signup and view all the answers

    Match the following treatments with their specific use cases:

    <p>Ceftriaxone = Uncomplicated gonococcal infection Azithromycin = Mixed infection with C. trachomatis Spectinomycin = Uncomplicated gonococcal infection Tetracycline = Mixed infection with C. trachomatis</p> Signup and view all the answers

    What percentage of infertility is associated with ectopic pregnancy due to infections?

    <p>20%</p> Signup and view all the answers

    Conjunctivitis in newborns is preventable with ocular prophylaxis.

    <p>True</p> Signup and view all the answers

    Name a method used to identify gonococcal colonies in a laboratory setting.

    <p>Culture on chocolate agar or MTM</p> Signup and view all the answers

    Secretory IgA1 is destroyed by _____ protease.

    <p>IgA1</p> Signup and view all the answers

    Which of the following is an infection that can occur in children during childbirth?

    <p>Ophthalmia neonatorum</p> Signup and view all the answers

    What is the primary method used for detecting N. meningitidis in a laboratory setting?

    <p>Smearing on oxidase reagent impregnated filter paper</p> Signup and view all the answers

    All strains of Neisseria gonorrhoeae are virulent.

    <p>False</p> Signup and view all the answers

    What is the role of IgA1 protease in the virulence of Neisseria gonorrhoeae?

    <p>It hydrolyzes secretory IgA1 and aids attachment to mucous membranes.</p> Signup and view all the answers

    Neisseria gonorrhoeae can cause _____ infections in both men and women.

    <p>urethral</p> Signup and view all the answers

    Match the Neisseria species with their respective acid production from sugar:

    <p>N. meningitidis = Glucose: +, Maltose: +, Sucrose: _ N. gonorrhoeae = Glucose: +, Maltose: _, Sucrose: _ N. flavescens = Glucose: _, Maltose: _, Sucrose: _ N. sicca = Glucose: +, Maltose: +, Sucrose: +</p> Signup and view all the answers

    Which of the following is NOT a disease caused by N. gonorrhoeae?

    <p>Tuberculosis</p> Signup and view all the answers

    Gonococci can cause asymptomatic infections in approximately 50% of females.

    <p>True</p> Signup and view all the answers

    What type of organism is Neisseria gonorrhoeae?

    <p>Bacteria</p> Signup and view all the answers

    The presence of _____ in Neisseria gonorrhoeae facilitates its attachment to mucosal cells.

    <p>pili</p> Signup and view all the answers

    Which of the following components is responsible for endotoxic effects in N. gonorrhoeae?

    <p>Lipoolysaccharides</p> Signup and view all the answers

    Study Notes

    Neisseria gonorrhoeae

    •  Neisseria gonorrhoeae (gonococci) cause gonorrhea (STD)
    •  Morphology: Gram-negative diplococci (kidney bean shape). Occur intracellularly and extracellularly in infected tissues
    •  Cultural characteristics: Aerobes, requiring enriched media (e.g., chocolate agar or Modified Thayer-Martin medium) containing heated blood, antibiotics to inhibit other organisms present in the specimen; incubated at 35-37°C and 5-10% CO2
    •  Biochemical activities: Oxidase-positive (due to cytochrome C)
    • Acid production from sugar: Glucose is positive for N. meningitidis and N. gonorrhoeae; maltose is positive for N. meningitidis; sucrose is negative for all species tested.
    •  Antigenic composition and virulence factors:
      • Pili: mediate attachment to mucosal cells and are antiphagocytic. Non-piliated strains are less virulent. There are 100 serotypes and antigenic variation due to chromosomal rearrangement.
      • Lipooligosaccharides (LOS): responsible for endotoxic effects
      • Outer membrane proteins (I, II, III): play a role in attachment
      • Porin A: present in some strains, inactivates C3b, making strains resistant to killing by antibodies and complement; leads to disseminated infections.
      • IgA1 protease: hydrolyzes secretory IgA1, aiding attachment to mucous membranes (colonization)
    •  Diseases caused by Neisseria gonorrhoeae:
      • Urogenital, pharyngeal, and rectal infections in males and females.
      • Conjunctivitis in adults and neonates. Untreated gonorrhea can lead to pelvic inflammatory disease (PID), tubal infertility, ectopic pregnancy, and chronic pelvic pain.
    •  Genital infection in men: urethritis, epididymitis. Infection can progress to chronic infections with scanty discharge.
    •  Genital infection in women: approximately 50% asymptomatic. Common symptoms include cervicitis, urethritis, salpingitis, pelvic inflammatory disease (PID), ectopic pregnancy, and infertility (20%). No infection of the adult vagina, due to normal vaginal acidity and flora.
    •  Anorectal and throat infections in heterosexual men and women.
    •  Infections in children: - Perinatal infections during childbirth can affect the neonatal conjunctiva, pharynx, respiratory tract, and anal canal. Preventable by newborn ocular prophylaxis. - In older children, gonorrhea should raise suspicion of sexual abuse. Vulvovaginitis (non cervicitis) is common in prepubescent girls.
    •  Repeated gonococcal infection: - Antigenic variation of pili and outer membrane proteins - Superficial nature of infection, limiting IgG protective action - Secretory IgA1 is destroyed by IgA1 protease

    Diagnosis

    •  Specimen: discharge from urethra, cervix, rectum, conjunctiva, throat, or synovial fluid
    •  Identification of colonies by: - Morphology: gram-negative diplococci - Biochemical reaction: oxidase-positive, acid production from glucose - Detection of gonococcal antigen using ELISA
    •  Culture: On chocolate agar or Modified Thayer-Martin (MTM) medium. Incubation at 35-37°C in 5-10% CO2
    •  Blood culture

    Treatment

    •  Penicillin G: Drug resistance reported in 1950.
    •  Ceftriaxone: uncomplicated gonococcal infections
    •  Spectinomycin or ciprofloxacin: Used if mixed infection with Chlamydia trachomatis
    •  Tetracycline or azithromycin: Used if mixed infection with Chlamydia trachomatis

    Prevention

    •  Condoms
    •  Treatment of patients
    •  Treatment of neonatal ophthalmia after birth with erythromycin or tetracycline eye drops and ointments

    Quiz Time

    •  Question 1: Is Nisseria oxidase negative? (Answer: False)
    •  Question 2: Does Nisseria grow at 35-37°C in 5-10% CO2? (Answer: True)

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Nisseria Gonorrhea PDF Template

    Description

    This quiz explores the characteristics and pathogenicity of Neisseria gonorrhoeae, the bacteria responsible for gonorrhea. Learn about its morphology, cultural requirements, biochemical activities, and virulence factors. Understand the significance of antibiotic resistance and its impact on treatment.

    More Like This

    Neisseria Bacteria Overview
    10 questions

    Neisseria Bacteria Overview

    SupportingDoppelganger avatar
    SupportingDoppelganger
    Neisseria Overview and Clinical Features
    52 questions

    Neisseria Overview and Clinical Features

    CleanlyBoston avatar
    CleanlyBoston
    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser