11 Questions
What is the primary purpose of the reticuloendothelial system (RES)?
To remove immune complexes from the circulation
Which of the following is NOT a route of parenteral administration?
Oral
What is the primary mechanism by which nonionic surfactants or polymers provide steric stabilization to nanoparticles?
By adsorbing onto the particle surface and producing strong repulsion between particles
Why might intravenously administered nanomedicines be prone to aggregation?
Due to the high ionic strength of the blood environment
Which of the following is NOT a component of the reticuloendothelial system (RES)?
Epithelial cells in the gastrointestinal tract
What is the primary function of electrostatic stabilization of nanoparticles?
To create a surface charge density that causes particles to repel each other
Which of the following statements about monocytes is correct?
Inflammatory monocytes rapidly enter tissues in response to infection, while patrolling monocytes crawl slowly along blood vessels.
Which of the following is NOT a function of macrophages?
Opsonization, the process of marking foreign particles for phagocytosis.
Which of the following factors does NOT influence the opsonization determinant of nanoparticles?
Shape of the nanoparticle.
What is the primary strategy used to impart 'stealth characteristics' to nanocarriers, allowing them to evade immune recognition?
Inhibiting opsonization through steric repulsion using poly(ethylene glycol) or PEG.
Which of the following is an example of a tissue-resident macrophage?
All of the above.
Explore the concept of nanostructure in biological systems and its relevance to parenteral administration. Understand the different routes of administration that do not involve absorption through the gastrointestinal tract, including IV, IM, SC, and transdermal routes.
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