Nanostructure in Biological Systems: Parenteral Administration
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Questions and Answers

What is the primary purpose of the reticuloendothelial system (RES)?

  • To induce aggregation of intravenously administered nanomedicines
  • To produce nanoparticle stabilization through electrostatic forces
  • To facilitate the absorption of drugs through the gastrointestinal tract
  • To remove immune complexes from the circulation (correct)
  • Which of the following is NOT a route of parenteral administration?

  • Subcutaneous (SC or SQ)
  • Intramuscular (IM)
  • Oral (correct)
  • Intravenous (IV)
  • What is the primary mechanism by which nonionic surfactants or polymers provide steric stabilization to nanoparticles?

  • By facilitating the absorption of the nanoparticles through the gastrointestinal tract
  • By inducing aggregation of the nanoparticles in the high ionic strength environment of the blood
  • By adsorbing onto the particle surface and producing strong repulsion between particles (correct)
  • By creating a high surface charge density that induces repulsion between particles
  • Why might intravenously administered nanomedicines be prone to aggregation?

    <p>Due to the high ionic strength of the blood environment</p> Signup and view all the answers

    Which of the following is NOT a component of the reticuloendothelial system (RES)?

    <p>Epithelial cells in the gastrointestinal tract</p> Signup and view all the answers

    What is the primary function of electrostatic stabilization of nanoparticles?

    <p>To create a surface charge density that causes particles to repel each other</p> Signup and view all the answers

    Which of the following statements about monocytes is correct?

    <p>Inflammatory monocytes rapidly enter tissues in response to infection, while patrolling monocytes crawl slowly along blood vessels.</p> Signup and view all the answers

    Which of the following is NOT a function of macrophages?

    <p>Opsonization, the process of marking foreign particles for phagocytosis.</p> Signup and view all the answers

    Which of the following factors does NOT influence the opsonization determinant of nanoparticles?

    <p>Shape of the nanoparticle.</p> Signup and view all the answers

    What is the primary strategy used to impart 'stealth characteristics' to nanocarriers, allowing them to evade immune recognition?

    <p>Inhibiting opsonization through steric repulsion using poly(ethylene glycol) or PEG.</p> Signup and view all the answers

    Which of the following is an example of a tissue-resident macrophage?

    <p>All of the above.</p> Signup and view all the answers

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