Nanogels and Polymeric Micelles in Drug Delivery

The Theranostic Strategy involves combining drug therapy with medical imaging tools to monitor pathological progress and therapeutic efficacy.

Magnetic Nanoparticles are not useful for visualizing tissues with magnetic resonance imaging (MRI).

Tailoring nanomedicine modules can effectively address the challenges of tumor heterogeneity and adaptive resistance.

Inorganic nanoparticles do not possess novel intrinsic physical properties according to the text.

Hyperthermia involves the generation of cold at the tumor site.

The joint delivery of therapeutic and diagnostic agents does not show promise in improving diagnostic accuracy according to the text.

Polymeric Micelles can only carry water-soluble drugs.

Dendrimers are difficult to synthesize in large quantities pure enough for clinical trials.

Liposomes are not easily modified and functionalized.

Carbon Nanotubes are not biocompatible.

Viral Nanoparticles cannot selectively target tumors.

There are five main methods of delivery discussed, which include Liposomes, Dendrimers, Carbon Nanotubes, Viral Nanoparticles, and Polymer Micelles.

Successful delivery of nucleic acids into target cells is one of the main challenges of gene therapy.

Cationic liposome/DNA complexes (Lipoplexes) are the least studied non-viral gene delivery systems.

Gene therapy is primarily intended to treat acquired genetic pathologies like cancer.

Increasing accumulation of α-glucosidase in tumor tissue is critical for the success of the targeted enzyme/prodrug strategy.

The development of a technology for curing brain disorders is not considered a medical need.

Treatment with short interference RNA (siRNA) is a method that is being explored to address medical needs in brain disorders.

Coating MIONs with liposomes can increase their blood circulation time.

Polyethylene glycol (PEG) completely avoids uptake by macrophages and does not activate complement systems.

PVP is considered a less promising alternative to PEG for modifying MNP.

The sustained and controlled delivery of imaging and therapeutic agents is the main purpose of liposomes.

Coating MIONs with liposomes decreases their colloidal stability in physiological solutions.

Modified MNP with PEG shows decreased stability in plasma.

PVP modification helps nanoparticles escape from macrophage systems, reducing their circulation time in vivo.

The targeted delivery of a prodrug-activating enzyme or its encoding gene to the tumor is done after administering a prodrug in DEPT.

The β-glucosidase/amygdalin system converts amygdalin to hydrogen cyanide to kill normal cells.

Magnetic DEPT involves applying an external magnetic field to deliver prodrugs to the tumor.

Administering amygdalin with a minimum concentration ratio of β-glucosidase-conjugated MNP in tumor tissue minimizes the nonspecific toxicity of hydrogen cyanide.

Directed Enzyme Prodrug Therapy (DEPT) is used to improve the tumor selectivity of cosmetics.