NAGM Hassan: General Principles of Lung Damage Pathogenesis
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Questions and Answers

What is one of the consequences of inhalation of high concentrations of HCl, NO2, NH3, or phosgene in the respiratory tract?

  • Rapid epithelial regeneration
  • Quick recovery of the alveolar zone
  • Immediate pulmonary edema
  • Initial minimal apparent damage (correct)

Which mechanism leads to delayed pulmonary edema after exposure to highly reactive molecules like ozone?

  • Direct injury to lung defense cells
  • Primary alveolar damage
  • Epoxide hydrolase activation
  • Cascade of secondary reaction products (correct)

How does metabolism contribute to the pathogenesis of lung injury?

  • Activation of protective enzymes
  • Involvement of cytochrome P450s and glutathione S-transferases (correct)
  • Inhibition of free radical reactions
  • Reduction in oxidative burden

What is a common factor contributing to oxidative burden in the respiratory system?

<p>Inhalation of tobacco smoke (B)</p> Signup and view all the answers

Which enzyme is NOT mentioned as being involved in xenobiotic metabolism related to lung injury pathogenesis?

<p>Catalase (B)</p> Signup and view all the answers

What initiates the delayed onset of lung damage after exposure to certain respirable substances?

<p>Alveolar epithelial barrier leakage (C)</p> Signup and view all the answers

Which of the following is a characteristic symptom of bronchoconstriction?

<p>All of the above (D)</p> Signup and view all the answers

What is a primary cause of bronchoconstriction in asthma?

<p>Increased reactivity of bronchial smooth muscle (C)</p> Signup and view all the answers

Which of the following is NOT a factor that contributes to airway reactivity?

<p>Destruction of alveolar walls (C)</p> Signup and view all the answers

Which cells play a crucial role in the inflammatory response and injury to the respiratory tract?

<p>Neutrophils, monocytes, and macrophages (D)</p> Signup and view all the answers

Which of the following is a potential source of oxidant species in the respiratory tract?

<p>All of the above (D)</p> Signup and view all the answers

What is a common feature of pneumotoxicants like ozone, nitrogen dioxide, and phosgene?

<p>They are highly reactive molecules (A)</p> Signup and view all the answers

Which factor primarily determines the region of the respiratory tract where a particle or aerosol will deposit?

<p>Particle size (B)</p> Signup and view all the answers

What is a potential consequence of emphysema?

<p>Impaired diffusion of oxygen and carbon dioxide (C)</p> Signup and view all the answers

Which statement about the lung's metabolic competence is correct?

<p>The lung contains most enzymes involved in xenobiotic biotransformation (B)</p> Signup and view all the answers

Which factor is decisive in determining how deeply a gas penetrates into the lung?

<p>Water solubility (A)</p> Signup and view all the answers

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