NAFLD and Cirrhosis Pathophysiology
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Questions and Answers

What is the main characteristic feature of HCC morphology compared to the surrounding liver?

  • It is more pale than the surrounding liver (correct)
  • It appears darker in color compared to the surrounding liver
  • It is more green due to the secretion of bile by malignant hepatocytes
  • It is firmer in texture than the surrounding liver

Which type of HCC morphology is associated with multiple large masses spread throughout the liver?

  • Well-differentiated
  • Diffuse (correct)
  • Poorly differentiated
  • Unifocal

What is the characteristic architectural feature of well-differentiated HCC?

  • Shows spindled sarcomatous appearance
  • Contains rapidly dividing anaplastic cells
  • Presence of portal triads in the tumor
  • Resembles normal hepatocytes with trabecular or pseudoglandular architecture (correct)

What is the main cause of intrahepatic metastasis in HCC?

<p>Vascular invasion (B)</p> Signup and view all the answers

At what stage of HCC does extrahepatic metastasis usually occur?

<p>Advanced stage (C)</p> Signup and view all the answers

Which blood test is used as a tumor marker for diagnosing HCC?

<p>Alpha-fetoprotein (AFP) (D)</p> Signup and view all the answers

What is considered an elevated level of Alpha-fetoprotein (AFP) suggestive of HCC?

<p>&gt;400 ng/ml (A)</p> Signup and view all the answers

Which form of liver cancer is the most common?

<p>Hepatocellular carcinoma (C)</p> Signup and view all the answers

In which individuals is hepatocellular carcinoma most commonly seen?

<p>Men over 60 years old (C)</p> Signup and view all the answers

Which of the following is NOT a major etiologic factor for hepatocellular carcinoma?

<p>Bacterial infections (A)</p> Signup and view all the answers

What is the main mechanism by which HBV can lead to hepatocellular carcinoma?

<p>Integration of HBV DNA into the host genome (D)</p> Signup and view all the answers

Which toxin is known to react with DNA to form mutagenic adducts that can lead to dysplasia and hepatocellular carcinoma?

<p>Aflatoxin B1 (C)</p> Signup and view all the answers

What is the most common treatment approach for hepatocellular carcinoma in its early stages?

<p>Surgery to remove tumor or liver transplant (B)</p> Signup and view all the answers

How does chronic alcoholism/cirrhosis contribute to the development of hepatocellular carcinoma?

<p>Causes excessive fatty acid synthesis and NADH accumulation (A)</p> Signup and view all the answers

Apart from HBV, which other virus is known to work exclusively with advanced cirrhosis in hepatocellular carcinoma?

<p>Hepatitis C Virus (A)</p> Signup and view all the answers

What is required to diagnose NAFLD based on the provided text?

<p>Presence of 3 out of 5 metabolic syndrome (A)</p> Signup and view all the answers

Which of the following is NOT a histologic feature of cirrhosis as mentioned in the text?

<p>Formation of normal liver tissue (B)</p> Signup and view all the answers

What is the role of HSC in the pathogenesis of cirrhosis mentioned in the text?

<p>Activate HSC to create fibrotic tissues via collagen (C)</p> Signup and view all the answers

What is the sequence of changes that abnormal nodules in cirrhosis go through according to the text?

<p>Hyperplastic, dysplastic, necrotic (C)</p> Signup and view all the answers

What is the function of beta-catenin in the pathogenesis of HCC as mentioned in the text?

<p>Regulates liver cell proliferation, differentiation, and apoptosis (D)</p> Signup and view all the answers

What consequence does continuous cell division have on DNA repair mechanisms according to the text?

<p>Damages DNA repair mechanisms leading to mutations accumulation (A)</p> Signup and view all the answers

What role does IL-6 play in the context provided in the text?

<p>Contributes to inflammation (C)</p> Signup and view all the answers

Which of the following is NOT a classification of HCC cells discussed in the text?

<p>(Best one) Differentiated (A)</p> Signup and view all the answers

Which oral manifestation is NOT typically associated with liver dysfunction?

<p>Leukoplakia (D)</p> Signup and view all the answers

What is a characteristic oral sign of advanced liver disease?

<p>Crusted perioral rash (B)</p> Signup and view all the answers

What is the common link between HCV and Oral Lichen Planus (OLP)?

<p>There is a strong association between HCV infection and OLP (B)</p> Signup and view all the answers

How does primary biliary cirrhosis (PBC) affect the salivary glands?

<p>It causes dry mouth due to hyposecretion (D)</p> Signup and view all the answers

What oral condition is NOT commonly found in patients with liver disease?

<p>Dentigerous cyst (C)</p> Signup and view all the answers

How does portal hypertension affect nutrient absorption in liver disease?

<p>It shunts blood away from the liver, impairing nutrient delivery (D)</p> Signup and view all the answers

What is a common reason for impaired salivary flow in chronic liver disease patients?

<p>Systemic diseases and certain medications (B)</p> Signup and view all the answers

'Dry gland syndrome' associated with primary biliary cirrhosis primarily affects which glands?

<p>Salivary and lacrimal glands (C)</p> Signup and view all the answers

What is the purpose of a liver biopsy in the context of liver cancer diagnosis?

<p>To test tissue for cancer cells (A)</p> Signup and view all the answers

Which treatment option is suitable for small liver tumors that cannot be removed with surgery or ablation?

<p>Radiation therapy (D)</p> Signup and view all the answers

What lifestyle changes are recommended for individuals with liver cancer?

<p>Maintain a healthy weight (C)</p> Signup and view all the answers

In the context of liver cancer treatment, what does ablation therapy involve?

<p>Burning tumors using extreme temperatures (A)</p> Signup and view all the answers

What is the main function of immunotherapy in treating liver cancer?

<p>To help immune system identify and fight cancer cells (B)</p> Signup and view all the answers

Which imaging scan is commonly used to visualize tumors in the liver?

<p>Magnetic resonance imaging (MRI) (A)</p> Signup and view all the answers

What is the purpose of embolization in liver cancer treatment?

<p>To implant a substance that stops blood flow toward the tumor (B)</p> Signup and view all the answers

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