Nabumetone Flashcards Overview

Questions and Answers

What is the therapeutic classification of Nabumetone?

Antibiotics

Opioids

Antirheumatics, nonsteroidal, anti-inflammatory agents (correct)

Steroids

What is the pharmacologic classification of Nabumetone?

N/A

What are the indications for Nabumetone?

Symptomatic management of rheumatoid arthritis and osteoarthritis

What action does Nabumetone perform?

Inhibits prostaglandin synthesis Signup and view all the answers

What are the contraindications/precautions for using Nabumetone?

Hypersensitivity; use with other NSAIDs, including aspirin, active GI bleeding or ulcer disease, peri-op pain from coronary artery bypass graft (CABG) surgery Signup and view all the answers

What are some adverse reactions/side effects of Nabumetone?

GI bleeding, abdominal pain, diarrhea, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic reactions including anaphylaxis, angioneurotic edema Signup and view all the answers

What interactions are important to note with Nabumetone?

Adverse GI effects with aspirin and other NSAIDs, increased hypoglycemic effects of insulin or oral hypoglycemic agents, higher risk of toxicity from methotrexate, higher risk of bleeding with certain other medications Signup and view all the answers

What is the recommended dosage of Nabumetone?

1000mg/day as a single dose or divided dose twice daily, may be higher up to 2000mg/day Signup and view all the answers

What nursing implications should be considered when administering Nabumetone?

Monitor patients at risk for hypersensitivity reactions, assess pain and range of motion, evaluate lab results for prolonged therapy, advise on administration with meals to reduce GI irritation Signup and view all the answers

Study Notes

Classification

Therapeutic classification includes antirheumatics and nonsteroidal anti-inflammatory agents.

Indications

Used for symptomatic management of rheumatoid arthritis and osteoarthritis.

Action

Nabumetone inhibits the synthesis of prostaglandins, which play a key role in inflammation and pain.

Contraindications/Precautions

Not suitable for individuals with hypersensitivity to nabumetone or other NSAIDs, active gastrointestinal bleeding, or ulcer disease.
Caution required in patients experiencing peri-operative pain from coronary artery bypass graft (CABG) surgery.

Adverse Reactions/Side Effects

Gastrointestinal issues such as GI bleeding, abdominal pain, and diarrhea are common.
Dermatological reactions can include exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
Miscellaneous reactions may involve allergic responses such as anaphylaxis and angioneurotic edema.

Drug Interactions

Concurrent use with aspirin or other NSAIDs increases the risk of gastrointestinal adverse effects.
Potassium supplements, corticosteroids, or alcohol can exacerbate GI issues.
Potential to enhance hypoglycemic effects when combined with insulin or oral hypoglycemics.
Increased toxicity risk when used with methotrexate and bleeding risk with anticoagulants, valproic acid, and specific antibiotics.

Dosage

Initial dosage can be 1000 mg/day, adjustable up to a maximum of 2000 mg/day as needed.
Lowest effective dose should be used during chronic therapy.

Nursing Implications

Assess patients with asthma, aspirin-induced allergies, and nasal polyps for hypersensitivity.
Monitor for respiratory issues and assess pain and range of motion regularly.
Lab evaluations of BUN, serum creatinine, CBC, and liver function are crucial in patients on prolonged therapy.
Use the lowest effective dose to minimize cardiovascular risks and administer with meals or antacids to reduce GI irritation.

Patient/Family Teaching

Advise taking medication with a full glass of water and to maintain an upright position for 15-30 minutes post-dose.
Stress the importance of adhering to prescribed dosing schedules to avoid missed or double doses.
Warn about potential photosensitivity and recommend sunscreen use, as well as caution with other medications and alcohol.
Instruct them to communicate any adverse effects or medication interactions to healthcare providers.

Evaluation/Desired Outcomes

Aim for reduced pain and improved joint mobility, with partial relief typically observed within one week.
Full effectiveness may take two weeks or more; patients unresponsive to one NSAID may benefit from alternatives.

Description

This quiz covers essential information about Nabumetone, including its therapeutic and pharmacologic classifications, indications, mechanisms of action, and contraindications. Perfect for students or professionals looking to enhance their pharmaceutical knowledge.