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Myoglobin Structure and Function

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Questions and Answers

What is the primary stabilizing force for the interior of myoglobin?

Hydrogen bond interactions

Hydrophobic interactions (correct)

Ionic interactions

Disulfide bond interactions

What function does the distal histidine (His E7) serve in myoglobin?

Stabilizing the heme-protein conjugate

Assisting with oxygen-binding (correct)

Binding directly to the iron in heme

Holding the heme in place

What accompanies the oxygenation of myoglobin?

Formation of disulfide bonds within the protein

Decrease in the number of alpha-helices in the protein structure

Increase in charged amino acids in the interior of the protein

Movement of the iron atom, His F8, and residues covalently linked to His F8 toward the plane of the ring (correct)

What is the effect of H+, CO2, and 2,3-bisphosphoglycerate on the oxygen binding curve of hemoglobin?

They decrease the binding of oxygen by shifting the equilibrium towards the low affinity form Signup and view all the answers

At what partial pressure of oxygen does the pO2 in lung capillary bed typically occur?

~ 100 mm Hg Signup and view all the answers

Why does myoglobin not serve as an effective vehicle for delivery of oxygen from lungs to peripheral tissues?

It releases its bound oxygen readily at low pressure, making it ineffective for delivery Signup and view all the answers

What is the main characteristic of hereditary persistence of fetal hemoglobin (HPFH)?

Continued production of adult-type hemoglobin in adulthood Signup and view all the answers

What is the effect of having one of the four gene copies not expressed in α thalassemia?

Decreased α subunit production leading to increased death Signup and view all the answers

What is the cause of sickle cell anemia?

Point mutation in Hbβ, leading to the formation of Hb S (Glu → Val at amino acid 6) Signup and view all the answers

What is the distinguishing characteristic of Hemoglobin Gun Hill?

Unstable mutant hemoglobin associated with mild compensated hemolysis Signup and view all the answers