10 Questions
What is the primary stabilizing force for the interior of myoglobin?
Hydrophobic interactions
What function does the distal histidine (His E7) serve in myoglobin?
Assisting with oxygen-binding
What accompanies the oxygenation of myoglobin?
Movement of the iron atom, His F8, and residues covalently linked to His F8 toward the plane of the ring
What is the effect of H+, CO2, and 2,3-bisphosphoglycerate on the oxygen binding curve of hemoglobin?
They decrease the binding of oxygen by shifting the equilibrium towards the low affinity form
At what partial pressure of oxygen does the pO2 in lung capillary bed typically occur?
~ 100 mm Hg
Why does myoglobin not serve as an effective vehicle for delivery of oxygen from lungs to peripheral tissues?
It releases its bound oxygen readily at low pressure, making it ineffective for delivery
What is the main characteristic of hereditary persistence of fetal hemoglobin (HPFH)?
Continued production of adult-type hemoglobin in adulthood
What is the effect of having one of the four gene copies not expressed in α thalassemia?
Decreased α subunit production leading to increased death
What is the cause of sickle cell anemia?
Point mutation in Hbβ, leading to the formation of Hb S (Glu → Val at amino acid 6)
What is the distinguishing characteristic of Hemoglobin Gun Hill?
Unstable mutant hemoglobin associated with mild compensated hemolysis
Test your knowledge about the structure and function of myoglobin, a monomeric heme protein found in skeletal and heart muscle. Explore its amino acid residues, alpha helix folds, hydrophobic interactions, and the role of charged amino acids.
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