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Questions and Answers
What is the primary stabilizing force for the interior of myoglobin?
What is the primary stabilizing force for the interior of myoglobin?
- Hydrogen bond interactions
- Hydrophobic interactions (correct)
- Ionic interactions
- Disulfide bond interactions
What function does the distal histidine (His E7) serve in myoglobin?
What function does the distal histidine (His E7) serve in myoglobin?
- Stabilizing the heme-protein conjugate
- Assisting with oxygen-binding (correct)
- Binding directly to the iron in heme
- Holding the heme in place
What accompanies the oxygenation of myoglobin?
What accompanies the oxygenation of myoglobin?
- Formation of disulfide bonds within the protein
- Decrease in the number of alpha-helices in the protein structure
- Increase in charged amino acids in the interior of the protein
- Movement of the iron atom, His F8, and residues covalently linked to His F8 toward the plane of the ring (correct)
What is the effect of H+, CO2, and 2,3-bisphosphoglycerate on the oxygen binding curve of hemoglobin?
What is the effect of H+, CO2, and 2,3-bisphosphoglycerate on the oxygen binding curve of hemoglobin?
At what partial pressure of oxygen does the pO2 in lung capillary bed typically occur?
At what partial pressure of oxygen does the pO2 in lung capillary bed typically occur?
Why does myoglobin not serve as an effective vehicle for delivery of oxygen from lungs to peripheral tissues?
Why does myoglobin not serve as an effective vehicle for delivery of oxygen from lungs to peripheral tissues?
What is the main characteristic of hereditary persistence of fetal hemoglobin (HPFH)?
What is the main characteristic of hereditary persistence of fetal hemoglobin (HPFH)?
What is the effect of having one of the four gene copies not expressed in α thalassemia?
What is the effect of having one of the four gene copies not expressed in α thalassemia?
What is the cause of sickle cell anemia?
What is the cause of sickle cell anemia?
What is the distinguishing characteristic of Hemoglobin Gun Hill?
What is the distinguishing characteristic of Hemoglobin Gun Hill?
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