Myocarditis: Definition and Causes

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Questions and Answers

What is myocarditis?

  • A condition where the muscular walls of the heart become enlarged
  • A condition where the blood vessels of the heart become blocked
  • A condition where the heart beats irregularly
  • A condition where the muscular walls of the heart become inflamed (correct)

What are some common causes of myocarditis in children?

  • Viral infections (correct)
  • Excessive exercise
  • Bacterial infections
  • Genetic predisposition

Which of the following viruses is NOT commonly involved in causing myocarditis in children?

  • Parvovirus
  • Adenovirus
  • Influenza virus
  • Hepatitis A virus (correct)

What can activate the innate immune response in myocarditis?

<p>Death of infected cells (C)</p> Signup and view all the answers

What is the role of Coxsackie-adenovirus receptor in myocarditis pathogenesis?

<p>It activates the innate immune response (A)</p> Signup and view all the answers

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Study Notes

Myocarditis Overview

  • Myocarditis is an inflammatory disease of the myocardium, the heart muscle.

Causes of Myocarditis in Children

  • Common causes of myocarditis in children include viral infections, specifically:
    • Coxsackievirus
    • Adenovirus
    • Parvovirus
    • Influenza virus
    • Epstein-Barr virus
  • Note: Enterovirus is NOT commonly involved in causing myocarditis in children.

Innate Immune Response

  • The innate immune response in myocarditis can be activated by:
    • Recognition of viral pathogen-associated molecular patterns (PAMPs)
    • Activation of pattern recognition receptors (PRRs)

Coxsackie-Adenovirus Receptor

  • The Coxsackie-adenovirus receptor (CAR) plays a crucial role in myocarditis pathogenesis by:
    • Facilitating viral entry into cardiac cells
    • Mediating viral-induced inflammation and cardiac damage

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