Podcast
Questions and Answers
What is the key structural change in myocardial concentric hypertrophy?
What is the key structural change in myocardial concentric hypertrophy?
In myocardial concentric hypertrophy, there is an increased diameter of myocardial fiber and enhanced wall thickness due to sarcomeres arranged in parallel.
How does eccentric hypertrophy differ from concentric hypertrophy?
How does eccentric hypertrophy differ from concentric hypertrophy?
Eccentric hypertrophy involves increased internal chamber size and decreased wall thickness, with sarcomeres arranged in series due to volume overload.
What physiological response occurs due to increased blood volume?
What physiological response occurs due to increased blood volume?
Increased blood volume leads to decreased glomerular filtration rate (GFR) and promotes water and sodium retention.
What role does erythropoietin (EPO) play in myocardial hypertrophy?
What role does erythropoietin (EPO) play in myocardial hypertrophy?
How does the body redistribute blood flow during myocardial hypertrophy?
How does the body redistribute blood flow during myocardial hypertrophy?
Describe the change in cellular function in response to increased tissue capability to utilize oxygen.
Describe the change in cellular function in response to increased tissue capability to utilize oxygen.
What is one consequence of excessive water and sodium retention due to heart overload?
What is one consequence of excessive water and sodium retention due to heart overload?
What mechanisms are involved in the compensatory response to myocardial hypertrophy?
What mechanisms are involved in the compensatory response to myocardial hypertrophy?
What role does myocardial contraction impairment play in heart failure?
What role does myocardial contraction impairment play in heart failure?
Identify two causes of myocardial destruction that contribute to heart failure.
Identify two causes of myocardial destruction that contribute to heart failure.
How does a myocardial infarction impact the risk of heart failure?
How does a myocardial infarction impact the risk of heart failure?
What is ventricular remodeling, and how can it contribute to heart failure?
What is ventricular remodeling, and how can it contribute to heart failure?
List one cytokine involved in myocardial damage and explain its effect.
List one cytokine involved in myocardial damage and explain its effect.
What is the significance of delayed repositioning of Ca2+ in relation to diastolic dysfunction?
What is the significance of delayed repositioning of Ca2+ in relation to diastolic dysfunction?
What characterizes acute heart failure in terms of cardiac output?
What characterizes acute heart failure in terms of cardiac output?
What is the difference between left heart failure and right heart failure?
What is the difference between left heart failure and right heart failure?
How does impaired dissociation of the myosin-actin complex affect cardiac function?
How does impaired dissociation of the myosin-actin complex affect cardiac function?
Explain how decreased potential energy during ventricular diastole contributes to diastolic dysfunction.
Explain how decreased potential energy during ventricular diastole contributes to diastolic dysfunction.
What conditions are associated with low-output heart failure?
What conditions are associated with low-output heart failure?
Describe the concept of ventricular compliance and its relation to diastolic dysfunction.
Describe the concept of ventricular compliance and its relation to diastolic dysfunction.
In what scenario would high-output heart failure occur?
In what scenario would high-output heart failure occur?
What are the key manifestations of low output syndrome in cardiac insufficiency?
What are the key manifestations of low output syndrome in cardiac insufficiency?
What differentiates systolic heart failure from diastolic heart failure?
What differentiates systolic heart failure from diastolic heart failure?
According to the New York Heart Association (NYHA) classification, what class is assigned to mild heart failure?
According to the New York Heart Association (NYHA) classification, what class is assigned to mild heart failure?
Identify the features associated with moderate heart failure.
Identify the features associated with moderate heart failure.
What is the primary mechanism of cardiac compensation in response to increased heart failure?
What is the primary mechanism of cardiac compensation in response to increased heart failure?
How do catecholamines affect myocardial contractility?
How do catecholamines affect myocardial contractility?
What role does myocardial remodeling play in chronic heart failure?
What role does myocardial remodeling play in chronic heart failure?
Describe the Frank-Starling law of the heart.
Describe the Frank-Starling law of the heart.
What factors stimulate the sympathetic nervous system in cardiac insufficiency?
What factors stimulate the sympathetic nervous system in cardiac insufficiency?
What role does myocardial hypertrophy play in cardiac compensation?
What role does myocardial hypertrophy play in cardiac compensation?
How does cardiac tonogenic dilation contribute to cardiac function?
How does cardiac tonogenic dilation contribute to cardiac function?
What is the relationship between stroke volume and heart rate in determining cardiac output?
What is the relationship between stroke volume and heart rate in determining cardiac output?
Why is there a limit to the compensatory increase in heart rate during cardiac insufficiency?
Why is there a limit to the compensatory increase in heart rate during cardiac insufficiency?
What is the primary role of creatine phosphate (CP) in myocardial energy metabolism?
What is the primary role of creatine phosphate (CP) in myocardial energy metabolism?
How does impaired pyruvic acid metabolism affect myocardial energy production?
How does impaired pyruvic acid metabolism affect myocardial energy production?
Explain how prolonged pressure or volume overload can affect myosin-ATPase activity.
Explain how prolonged pressure or volume overload can affect myosin-ATPase activity.
What role does extracellular Ca2+ play in excitation-contraction coupling?
What role does extracellular Ca2+ play in excitation-contraction coupling?
How does acidosis influence the influx of extracellular Ca2+?
How does acidosis influence the influx of extracellular Ca2+?
Describe how hyperkalemia affects the sensitivity of β-adrenergic receptors to norepinephrine.
Describe how hyperkalemia affects the sensitivity of β-adrenergic receptors to norepinephrine.
What happens to the sarcoplasmic reticulum (SR) during disordered calcium handling?
What happens to the sarcoplasmic reticulum (SR) during disordered calcium handling?
Why is the binding of calcium to troponin essential for muscle contraction?
Why is the binding of calcium to troponin essential for muscle contraction?
Flashcards
Low-output heart failure
Low-output heart failure
A type of heart failure where the heart's ability to pump blood effectively is reduced, leading to a decrease in cardiac output.
Acute heart failure
Acute heart failure
A type of heart failure characterized by a rapid onset and a sharp decrease in cardiac output within a short timeframe.
Chronic heart failure
Chronic heart failure
A type of heart failure characterized by chronic onset, often accompanied by compensatory mechanisms like increased blood volume and heart muscle remodeling.
Left heart failure
Left heart failure
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Right heart failure
Right heart failure
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High-output heart failure
High-output heart failure
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Systolic heart failure
Systolic heart failure
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Diastolic heart failure
Diastolic heart failure
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Myocardial destruction
Myocardial destruction
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Impaired myocardial energy metabolism
Impaired myocardial energy metabolism
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Dysfunction of excitation-contraction coupling
Dysfunction of excitation-contraction coupling
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Myocardial infarction
Myocardial infarction
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Apoptosis
Apoptosis
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Cardiac compensation
Cardiac compensation
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Increased heart rate
Increased heart rate
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Positive inotropic actions of catecholamine
Positive inotropic actions of catecholamine
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Cardiac tonogenic dilation
Cardiac tonogenic dilation
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Myocardial hypertrophy
Myocardial hypertrophy
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Cardiac output
Cardiac output
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Baroreceptors
Baroreceptors
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Sympathetic nervous system
Sympathetic nervous system
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Concentric hypertrophy
Concentric hypertrophy
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Eccentric hypertrophy
Eccentric hypertrophy
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Increased blood volume
Increased blood volume
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Redistributed blood flow
Redistributed blood flow
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Erythrocytosis
Erythrocytosis
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Increased tissue capability to utilize oxygen
Increased tissue capability to utilize oxygen
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Extracardiac compensation
Extracardiac compensation
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Neurohumoral mechanisms
Neurohumoral mechanisms
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Impairment of myocardial energy metabolism
Impairment of myocardial energy metabolism
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Creatine Phosphate (CP)?
Creatine Phosphate (CP)?
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What is Creatine Phosphate Kinase (CK)?
What is Creatine Phosphate Kinase (CK)?
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What is Excitation-Contraction Coupling?
What is Excitation-Contraction Coupling?
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What is a Voltage-Operated Calcium Channel (VOC)?
What is a Voltage-Operated Calcium Channel (VOC)?
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What is Sarcoplasmic Reticulum (SR)?
What is Sarcoplasmic Reticulum (SR)?
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What is Troponin?
What is Troponin?
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What is Myosin?
What is Myosin?
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Diastolic dysfunction
Diastolic dysfunction
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Ventricular compliance
Ventricular compliance
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Asynergic of contraction and relaxation
Asynergic of contraction and relaxation
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Low output syndrome
Low output syndrome
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Venous congestion syndrome
Venous congestion syndrome
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