Mycosis: Fungal Infection Overview
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Questions and Answers

Match the following clinical findings of mycetoma with their descriptions:

Tumefaction = Tumor like swelling Discharging sinuses = Openings draining pus Granules = Solid particles in discharge Lymphadenopathy = Swollen lymph nodes

Match the following treatments for mycetoma with their corresponding infections:

Amphotericin B = Madurella infections Itraconazole = Pseudallescheria boydii Flucytosine = Exophiala jeanselmei Miconazole = General antifungal treatment

Match the following symptoms of sporotrichosis with their descriptions:

Nodules = Swelling at the site of inoculation Ulcers = Open sores along lymphatic channels Lymphatic involvement = Spread along lymph vessels Systemic infections = Infection spreading throughout the body

Match the following treatments with their conditions:

<p>Saturated solution of potassium iodide = Sporotrichosis Long-term antifungal medications = Subcutaneous mycoses Surgical removal = Mycetoma Amphotericin B = Systemic infections</p> Signup and view all the answers

Match the following systemic mycosis terms with their definitions:

<p>Systemic mycosis = Deep fungal infections affecting multiple organs Histoplasmosis = Infection caused by Histoplasma capsulatum Pulmonary infiltrates = Lung issues seen on radiography Dimorphic = Existing in two forms</p> Signup and view all the answers

Match the following symptoms of acute pulmonary histoplasmosis with their characteristics:

<p>Fever = Elevated body temperature Chills = Shivering sensations Myalgias = Muscle pains Nonproductive cough = Cough without mucus</p> Signup and view all the answers

Match the following complications of subcutaneous mycoses with their potential consequences:

<p>Spread of infection = Involvement of deeper tissues Lymphadenopathy = Affected lymphatic system Cosmetic disfigurement = Scarring and visible abnormalities Systemic infections = Widespread body infection</p> Signup and view all the answers

Match the following conditions with the recommended antifungal treatments:

<p>Mycetoma = Long-term antifungal therapy Histoplasmosis = Amphotericin B or itraconazole Sporotrichosis = Oral itraconazole Subcutaneous mycoses = Combination of surgery and antifungals</p> Signup and view all the answers

Match the following conditions with their primary treatments:

<p>Acute pulmonary histoplasmosis = Supportive therapy and rest Coccidioidomycosis = Itraconazole for symptom reduction Blastomycosis = Amphotericin B Disseminated histoplasmosis = Amphotericin B</p> Signup and view all the answers

Match the fungal infections with their causative agents:

<p>Histoplasmosis = Histoplasma capsulatum Coccidioidomycosis = Coccidioides posadasii Blastomycosis = Blastomyces dermatitidis Valley fever = Coccidioides immitis</p> Signup and view all the answers

Match the symptoms with the respective condition:

<p>Chronic pulmonary histoplasmosis = Granulomatous nodules with calcification Coccidioidomycosis = Self-limited influenza-like illness Blastomycosis = Pulmonary infiltrate with various symptoms Disseminated histoplasmosis = Relapses despite therapy in AIDS patients</p> Signup and view all the answers

Match the treatments with the specific patient conditions:

<p>Mild to moderate histoplasmosis = Itraconazole Severe coccidioidomycosis = Amphotericin B Coccidioidal meningitis = Oral fluconazole Chronic blastomycosis = Amphotericin B</p> Signup and view all the answers

Match the symptoms commonly associated with each fungal infection:

<p>Histoplasmosis = Cough and malaise Coccidioidomycosis = Fever and arthralgia Blastomycosis = Night sweats and myalgias Valley fever = Headache and cough</p> Signup and view all the answers

Match the treatment protocols to the infections and related conditions:

<p>Coccidioidomycosis cases with severe symptoms = Amphotericin B AIDS patients with histoplasmosis = Maintenance therapy with itraconazole Chronic pneumonia due to blastomycosis = Amphotericin B Self-limited valley fever = Symptomatic support</p> Signup and view all the answers

Match the conditions with their descriptive features:

<p>Histoplasmosis = Nodules heal with calcification Coccidioidomycosis = Desert rheumatism Blastomycosis = Ulcerated verrucous granulomas Acute pulmonary histoplasmosis = Manifests more in men</p> Signup and view all the answers

Match the following infections with their notable complications:

<p>Chronic histoplasmosis = Reactivation process Coccidioidomycosis = Relapses if untreated Blastomycosis = Dissemination to skin and bones Histoplasmosis in AIDS = Prolonged treatment required</p> Signup and view all the answers

Match the type of mycosis with its description:

<p>Superficial Mycosis = Affects the outermost layer of the skin, hair, and nails Cutaneous Mycosis = Involves deeper layers of skin, hair, and nails Subcutaneous Mycosis = Affects skin, subcutaneous tissue, and sometimes bone Systemic Mycosis = Involves internal organs or the entire body</p> Signup and view all the answers

Match the type of fungal organism with its corresponding mycosis:

<p>Dermatophytoses = Caused by fungi that thrive on keratinized tissues Candidiasis = Caused by Candida species, a type of yeast Aspergillosis = Caused by Aspergillus species, a type of mold Histoplasmosis = Caused by Histoplasma capsulatum, found in contaminated soil</p> Signup and view all the answers

Match the superficial mycosis with its common example:

<p>Tinea Versicolor = Common superficial fungal infection affecting the skin Athlete's Foot = Common cutaneous infection affecting the feet Ringworm = Common cutaneous infection that can occur anywhere on the body Sporotrichosis = Involves deeper skin and subcutaneous tissue</p> Signup and view all the answers

Match the conditions with the type of mycosis they represent:

<p>Athlete's Foot = Cutaneous Mycosis Tinea Versicolor = Superficial Mycosis Sporotrichosis = Subcutaneous Mycosis Fungal pneumonia = Systemic Mycosis</p> Signup and view all the answers

Match the following fungal infections with their effects:

<p>Dermatophytoses = Infections on skin, hair, and nails Candidiasis = Overgrowth causing mucosal infections Aspergillosis = Causes respiratory infections Coccidioidomycosis = Infections from dimorphic fungi in arid regions</p> Signup and view all the answers

Match the fungal organism with its related health concern:

<p>Candida = Normal skin flora that can cause infections Aspergillus = Associated with respiratory issues Histoplasma = Found in bird or bat droppings Coccidioides = Inhabits arid and semi-arid regions</p> Signup and view all the answers

Match the mycosis category with its characteristics:

<p>Superficial Mycosis = Harmless and cosmetic Cutaneous Mycosis = Causes inflammation and discomfort Subcutaneous Mycosis = May require surgical intervention Systemic Mycosis = Life-threatening in immunocompromised individuals</p> Signup and view all the answers

Match the mycosis type with its primary feature:

<p>Superficial Mycosis = Limited to the skin's outer layer Cutaneous Mycosis = Affects deeper skin layers Subcutaneous Mycosis = Chronic and may affect tissue Systemic Mycosis = Spreads through the bloodstream</p> Signup and view all the answers

Match the following fungal allergies with their clinical presentations:

<p>Allergic rhinitis = Sneezing, runny nose, itchy eyes, nasal congestion Asthma = Wheezing, coughing, shortness of breath Skin allergies = Itchy rash, hives Sinusitis = Sinus congestion, pain, and pressure</p> Signup and view all the answers

Match the following pharmacological treatments with their respective conditions:

<p>Tinea Corporis = Miconazole cream (topical) 2%, apply thinly 12hourly for 5-7 days after clearing Tinea Capitis = Griseofulvin (PO): Adult 500 mg; Paediatric 10-20mg/kg 24hourly for 6-8 weeks Pityriasis Versicolor = Clotrimazole cream (topical) 12hourly for 2 weeks Tinea Pedis = Frequent change of socks/footwear, keeping spaces between toes dry</p> Signup and view all the answers

Match the following azole antifungals with their respective dosages:

<p>Itraconazole = 200mg 24hourly for 6-9months Terbinafine (PO) = 250mg 24hourly for 6-8weeks Fluconazole = 150-300mg once weekly for 6-12months Miconazole = 2% oral gel every 8hourly for 7days</p> Signup and view all the answers

Match the following mold species with their properties:

<p>Alternaria = Common outdoor mold Cladosporium = Common indoor mold Penicillium = Produces the antibiotic penicillin Aspergillus = Can cause respiratory issues</p> Signup and view all the answers

Match the following treatments with their specific forms of candidiasis:

<p>Clotrimazole vaginal pessaries = Vaginal candidiasis Miconazole cream 2% = Cutaneous candidiasis Fluconazole (PO) 150mg stat = Severe vaginal candidiasis Miconazole 2% oral gel = Oral candidiasis</p> Signup and view all the answers

Match the following treatment categories with their applications:

<p>Topical treatment = Miconazole cream for Tinea Capitis Oral treatment = Griseofulvin for Tinea Capitis Antihistamines = Symptomatic relief for allergies Immunotherapy = Long-term management of allergies</p> Signup and view all the answers

Match the following routes of administration to the corresponding antifungal treatments:

<p>Topical cream = Clotrimazole for cutaneous candidiasis Oral suspension = Nystatin for oral candidiasis PO (oral) = Fluconazole for GIT candidiasis Vaginal pessaries = Miconazole for vaginal candidiasis</p> Signup and view all the answers

Match the following tinea types with their common names:

<p>Tinea Corporis = Body ringworm Tinea Capitis = Scalp ringworm Tinea Pedis = Athlete's foot Tinea Cruris = Jock itch</p> Signup and view all the answers

Match the following treatments with their dosing schedules:

<p>Gentian violet = 24hourly for 14days Amikacin = 7.5mg/kg 12hourly for 5weeks Terbinafine cream = 24hourly for 14days Co-trimoxazole = 480mg–960mg 12hourly for 5weeks</p> Signup and view all the answers

Match the following symptoms with their possible complications:

<p>Chronic sinusitis = Long-lasting nasal congestion and pain Asthma exacerbations = Increased wheezing and shortness of breath Skin allergies = Persistent itchy rash and hives Sinusitis = Recurring sinus infections</p> Signup and view all the answers

Match the following conditions with their treatment:

<p>Mycetoma (Actinomycetoma) = Co-trimoxazole and Amikacin Eumycetoma = Itraconazole for 5weeks or longer Onychomycosis = Fluconazole (PO) 150-300mg weekly Chromoblastomycosis = Itraconazole (PO) 200mg for 6-9months</p> Signup and view all the answers

Match the following types of medications with their descriptions:

<p>Corticosteroids = Reduce inflammation and swelling Antihistamines = Block histamine action to relieve allergies Keratinolytics = Help in the treatment of fungal conditions Antifungals = Eliminate fungal infections</p> Signup and view all the answers

Match the following antifungal treatments to their application frequency:

<p>Miconazole cream 2% = 12hourly for 2weeks Fluconazole (PO) 150mg = 24hourly for 14days Clotrimazole vaginal pessaries = Insert one at night for 6days Terbinafine (PO) = 250mg 24hourly for 6-8weeks</p> Signup and view all the answers

Match the following prevention methods with their purposes:

<p>Frequent change of socks = Prevention of Tinea Pedis Using cotton clothing = Reduces moisture and irritation Keeping skin dry = Prevents fungal overgrowth Separating opposing skin surfaces = Speeds healing of skin infections</p> Signup and view all the answers

Match the following antifungal treatments with their alternative options:

<p>Miconazole vaginal pessaries = Clotrimazole vaginal pessaries Terbinafine (PO) = Itraconazole (PO) 200mg Nystatin oral suspension = Miconazole 2% oral gel Co-trimoxazole = Dapsone for Actinomycetoma</p> Signup and view all the answers

Match the following fungal infections with their characteristics:

<p>Paracoccidioidomycosis = Caused by Paracoccidioides brasiliensis Cryptococcosis = Caused by Cryptococcus neoformans and Cryptococcus gattii Opportunistic Mycoses = Fungal infections in individuals with weakened immune systems Candidiasis = Involves Candida and related endogenous opportunistic yeasts</p> Signup and view all the answers

Match the following treatments with the corresponding fungal infection:

<p>Itraconazole = Paracoccidioidomycosis Amphotericin B and flucytosine = Cryptococcal meningitis Ketoconazole = Paracoccidioidomycosis Fluconazole = Suppressive therapy for cryptococcosis in AIDS patients</p> Signup and view all the answers

Match the following symptoms with their respective infections:

<p>Chronic meningitis = Cryptococcosis Painful sores in oral mucosa = Paracoccidioidomycosis Disorientation and neck stiffness = Cryptococcosis Skin lesions = Opportunistic Mycoses</p> Signup and view all the answers

Match the following demographic characteristics with the fungal infection:

<p>Paracoccidioidomycosis = Primarily affects men aged 30-60 Cryptococcosis = More common in patients with HIV/AIDS Candidiasis = Common in immunocompromised individuals Opportunistic Mycoses = Typically affects individuals with underlying health conditions</p> Signup and view all the answers

Match the following secondary sites of infection with the respective disease:

<p>Paracoccidioidomycosis = Skin and mucocutaneous tissue Cryptococcosis = Central nervous system Candidiasis = Various mucosal sites Pneumocystis pneumonia = Lungs</p> Signup and view all the answers

Match the following characteristics with the fungal pathogens:

<p>Paracoccidioides brasiliensis = Inhaled and causes initial lung lesions Cryptococcus neoformans = Commonly occurs in immunocompetent persons but more frequent in immunosuppressed Cryptococcus gattii = Associated with apparently normal hosts Candida = Endogenous opportunistic yeast</p> Signup and view all the answers

Match the following findings with cryptococcosis:

<p>Increased cerebrospinal fluid pressure = Cryptococcosis Normal or low glucose in CSF = Cryptococcosis Elevated protein in CSF = Cryptococcosis Biopsy shows yeast forms = Cryptococcosis</p> Signup and view all the answers

Match the following treatment regimens with their descriptions:

<p>Suppressive therapy with fluconazole = Recommended for inadequately treated AIDS patients with cryptococcosis Combination therapy of amphotericin B and flucytosine = Standard treatment for cryptococcal meningitis 6-month course of itraconazole = Effective for confined paracoccidioidomycosis Amphotericin B alone = Potentially curative for non-AIDS cryptococcosis patients</p> Signup and view all the answers

Flashcards

Paracoccidioidomycosis

A fungal infection caused by Paracoccidioides brasiliensis, primarily affecting the lungs and spreading to other organs.

Itraconazole

An antifungal medication effective in treating paracoccidioidomycosis, particularly in confined lesions.

Opportunistic mycoses

Fungal infections that primarily affect individuals with weakened immune systems, such as those with HIV/AIDS.

Candidiasis

An opportunistic fungal infection caused by Candida species, affecting various body parts.

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Cryptococcosis

A fungal infection caused by Cryptococcus neoformans, more common in immunocompromised patients.

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Chronic meningitis

A major clinical manifestation of cryptococcosis, resembling brain tumors or abscesses.

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Amphotericin B

An antifungal used for severe cases of fungal infections, including cryptococcal meningitis.

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Flucytosine

An antifungal often used in combination with amphotericin B to treat cryptococcal meningitis.

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Common mold spores

Alternaria, Cladosporium, Penicillium, and Aspergillus are molds found indoors and outdoors.

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Candida albicans

A common yeast that can cause allergies in humans.

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Transmission of fungal spores

Fungal spores can be transmitted through inhalation, contact, or ingestion.

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Allergic rhinitis symptoms

Symptoms include sneezing, runny nose, itchy eyes, and nasal congestion.

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Asthma symptoms

Symptoms of asthma include wheezing, coughing, and shortness of breath.

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Tinea Corporis treatment

Topical treatments include benzoic acid, miconazole, or terbinafine for body ringworm.

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Prevention of Tinea Pedis

Change socks frequently, use cotton, and keep feet dry to prevent athlete’s foot.

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Immunotherapy for allergies

Allergy shots that may help manage severe fungal allergies.

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Mycetoma

A fungal infection characterized by tumor-like swelling, discharging sinuses, and granule-containing discharge.

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Treatment for Mycetoma

Involves surgical removal and antifungals like nystatin, miconazole, or amphotericin B, depending on the causing organism.

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Sporotrichosis

A fungal infection that leads to nodules and ulcers along lymphatic channels, often starting at the inoculation site.

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Treatment for Sporotrichosis

Best treated with oral itraconazole or potassium iodide, and amphotericin B for systemic cases.

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Systemic Mycosis

Serious fungal infections that spread throughout the body, potentially life-threatening for immunocompromised individuals.

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Histoplasmosis

A systemic mycosis caused by inhalation of Histoplasma capsulatum conidia, presenting as flu-like symptoms.

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Symptoms of Histoplasmosis

Includes fever, chills, myalgias, headaches, nonproductive cough, and may show hilar lymphadenopathy on X-ray.

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Complications of Mycoses

Infections can spread to deeper tissues, lymphatics may get involved, and significant cosmetic disfigurement may occur.

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Clotrimazole Cream

Topical medication for cutaneous candidiasis, 1% applied 12-hourly for 2 weeks.

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Miconazole Cream

Topical antifungal treatment, 2% applied 12-hourly for 2 weeks for cutaneous candidiasis.

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Terbinafine Cream

Topical antifungal applied once daily for 14 days for skin infections.

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Fluconazole (PO)

Oral antifungal treatment, 150mg taken daily for various candidiasis types, 14 days for GIT.

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Nystatin Oral Suspension

Antifungal for oral candidiasis, gurgle and swallow 6-hourly.

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Itraconazole (PO)

Oral antifungal, 200mg taken daily for fungal infections, 6-9 months for chromoblastomycosis.

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Onychomycosis Treatment

Fluconazole 150-300mg weekly for 6-12 months to treat nail fungal infections.

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Mycetoma Treatment (Actinomycetoma)

Combined treatment with co-trimoxazole and amikacin for 5 weeks for bacterial form.

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Acute pulmonary histoplasmosis

An infection that manifests with respiratory symptoms and resolves spontaneously in many cases.

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Devastating relapses

A common occurrence in AIDS patients with previously treatable fungal infections.

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Coccidioidomycosis

A fungal infection caused by Coccidioides species, often leading to valley fever symptoms.

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Valley fever

Self-limited influenza-like illness from coccidioidal infection.

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Blastomycosis

A chronic fungal infection starting in the lungs that may disseminate to other organs.

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Granulomatous lesions

Inflammatory response seen in infections like blastomycosis, characterized by granuloma formation.

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Mycosis

A disease caused by a fungal infection.

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Superficial Mycoses

Infections affecting the outermost layer of skin and hair, usually harmless.

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Cutaneous Mycoses

Infections that involve deeper layers of skin, causing discomfort.

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Subcutaneous Mycoses

Infections affecting deeper skin layers and tissues, may require surgery.

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Dermatophytoses

Infections caused by fungi that thrive on keratinized tissues.

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Aspergillosis

Infections caused by Aspergillus species, can affect the respiratory system.

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Study Notes

Mycosis: A Fungal Infection

  • Mycosis, also known as a fungal infection, is a disease caused by fungi.
  • Fungi are eukaryotic organisms, unlike bacteria, which have a cell wall made of chitin, not peptidoglycan.

Classification of Mycoses

  • Mycoses are classified based on the infection site and type of fungus.

1. Based on Site of Infection

  • Superficial Mycoses: Affect the outermost layer of skin and hair, usually harmless and cosmetic.
  • Cutaneous Mycoses: Affect the deeper layers of skin, hair, and nails. They can cause inflammation and discomfort.
  • Subcutaneous Mycoses: Affect the deeper skin and subcutaneous tissues. Often chronic and may need surgery.
  • Systemic Mycoses: Spread throughout the body, affecting multiple organs. Can be life-threatening, especially in immunocompromised individuals.

2. Based on Type of Fungal Organism

  • Dermatophytoses: Caused by dermatophytes, which thrive on keratinized tissues (skin, hair, and nails).
  • Candidiasis: Caused by Candida species, a type of yeast typically found on skin and mucous membranes but can overgrow and cause infection, especially in warm, moist areas.
  • Aspergillosis: Caused by Aspergillus species, a type of mold that causes respiratory infections and allergic reactions.
  • Histoplasmosis: Caused by Histoplasma capsulatum, a dimorphic fungus found in soil contaminated with bird or bat droppings.
  • Coccidioidomycosis: Caused by Coccidioides immitis and C. posadasii, dimorphic fungi found in arid and semi-arid regions of the southwestern United States and Mexico.

Major Category of Mycosis

  • Superficial Mycoses: Affect outer skin, hair, and nails, usually cosmetic.
  • Cutaneous Mycoses: Deeper skin layers, hair, and nails leading to inflammation, itching, and discomfort, sometimes progressing.
  • Subcutaneous Mycoses: Deeper skin and subcutaneous layers, potentially chronic, need surgical intervention.
  • Systemic Mycoses: Involves internal organs, life-threatening, typically caused by inhalation of fungal spores.
  • Opportunistic Mycoses: Affect immunocompromised individuals, often present in the form of systemic infections, involve aspergillosis and cryptococcosis.

Superficial Mycosis

  • Superficial mycoses primarily affect the outermost layers of skin and hair.

Causative Agents of Superficial Mycosis

  • Pityriasis versicolor: Caused by Malassezia furfur, a yeast-like fungus. Characterized by discolored skin patches.
  • Black piedra: Caused by Piedraia hortae, a fungus that forms black nodules on hair shafts.
  • White piedra: Caused by Trichosporon beigelii, a fungus that forms soft, white nodules on hair shafts.
  • Tinea nigra: Caused by Phaeoannellomyces werneckii, a fungus causing brown to black macules on palms or soles of feet.

Transmission of Superficial Mycosis

  • Pityriasis versicolor: Through person-to-person contact, contaminated clothing, or towels.
  • Black and white piedra: Through direct contact with infected hair or shared combs and brushes.
  • Tinea nigra: Through contact with contaminated soil or surfaces in warm, humid climates.

Clinical Presentation/Signs and Symptoms of Superficial Mycosis

  • Pityriasis versicolor: Patches of discolored skin, potentially lighter or darker than the surrounding skin.
  • Black piedra: Small, hard, black nodules on hair shafts.
  • White piedra: Soft, white nodules on hair shafts.
  • Tinea nigra: Brown to black macules on the palms or soles of the feet.

Superficial Mycosis - Complications/Note

  • Severe cases of pityriasis versicolor may lead to post-inflammatory hyperpigmentation.
  • Superficial mycoses are more common in warm and humid climates.
  • People with oily skin or weakened immune systems are at a higher risk.
  • Antifungal medications are typically applied topically to the affected areas.
  • Good hygiene practices, such as hand-washing and showering, can help prevent spread.

Cutaneous Mycosis

  • Cutaneous mycoses affect the deeper layers of the skin, hair, and nails.
  • Causative agents: Dermatophytes, Trichophyton species, Microsporum species, Epidermophyton species, Candida species
  • Transmission: Direct contact, sharing contaminated items (towels, clothing), environmental sources (contaminated soil or surfaces) are common means of transmission.
  • Clinical presentation: Includes tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot), and tinea unguium (onychomycosis) with varying symptoms.

Subcutaneous Mycosis

  • These mycoses affect deeper layers of skin and subcutaneous tissue.
  • Causative agents: Chromoblastomycosis, Mycetoma, Sporotrichosis
  • Transmission: Typically involves traumatic inoculation (through puncture wounds or cuts) with contaminated soil or plant materials.
  • Clinical presentation: Common findings include verrucous (wart-like) lesions.

Systemic Mycoses

  • These infections are life-threatening, encompassing the entire body.
  • Causative agents: Include histoplasmosis, coccidioidomycosis, and blastomycosis.

Opportunistic Mycoses

  • Fungal infections that mainly affect individuals with compromised immune systems.
  • Include candidiasis, cryptococcosis, aspergillosis, mucormycosis, pneumocystis pneumonia, and penicilliosis.
  • These organisms may be normally present but overgrow in impaired immune states.

Mycotoxicosis

  • Illnesses caused by ingesting Mycotoxins (toxic secondary metabolites produced by certain fungi).
  • Causative Agents: Aflatoxins (produced by Aspergillus flavus and A. parasiticus), Ochratoxins (Aspergillus and Penicillium species), Ergot alkaloids (Claviceps purpurea), Trichothecenes (Fusarium species), and Zearalenone (Fusarium species).
  • Transmission is primarily through ingesting contaminated food or feed.

Fungal Allergies

  • Allergies occur when the immune system overreacts to fungal spores or components.
  • Causative agents: Mold spores and yeast cells.

Treatment

  • Treatment methods vary greatly depending on the specific type of mycosis.

Complications

  • Mycotic infections can lead to disseminated disease or organ failure, or chronic infection.

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Description

This quiz explores the classification of mycosis, a fungal infection caused by various types of fungi. It covers different types based on infection sites and the types of fungal organisms involved. Perfect for students seeking to understand the complexities of fungal diseases.

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