Podcast
Questions and Answers
What is the main cause of human tuberculosis in developed countries?
What is the main cause of human tuberculosis in developed countries?
- Mycobacterium tuberculosis (correct)
- Non-tuberculous mycobacteria
- Mycobacterium bovis
- Mycobacterium marinum
Which characteristic does NOT describe Mycobacterium?
Which characteristic does NOT describe Mycobacterium?
- Spores forming (correct)
- Non-motile
- Aerobic
- Very thin rods
What is the estimated percentage of infected individuals who actually develop tuberculosis?
What is the estimated percentage of infected individuals who actually develop tuberculosis?
- 25-30%
- 15-20% (correct)
- 35-40%
- 5-10%
What is a common mode of transmission for tuberculosis?
What is a common mode of transmission for tuberculosis?
What is the prevalence of tuberculosis in the Philippines?
What is the prevalence of tuberculosis in the Philippines?
Which of these mycobacteria is associated with drug-resistant tuberculosis?
Which of these mycobacteria is associated with drug-resistant tuberculosis?
Which category does Mycobacterium bovis belong to?
Which category does Mycobacterium bovis belong to?
In what state is tuberculosis particularly dangerous for immune-compromised individuals?
In what state is tuberculosis particularly dangerous for immune-compromised individuals?
What unique component is found in the cell wall of Mycobacterium?
What unique component is found in the cell wall of Mycobacterium?
What characteristic makes Mycobacterium difficult to stain?
What characteristic makes Mycobacterium difficult to stain?
Which strain of Mycobacterium bovis is used for immunization against tuberculosis?
Which strain of Mycobacterium bovis is used for immunization against tuberculosis?
What is the property of Mycobacterium that allows them to resist decolorization with acidified alcohol?
What is the property of Mycobacterium that allows them to resist decolorization with acidified alcohol?
What occurs after the initial infection with Mycobacterium tuberculosis?
What occurs after the initial infection with Mycobacterium tuberculosis?
Which symptom is NOT commonly associated with pulmonary tuberculosis?
Which symptom is NOT commonly associated with pulmonary tuberculosis?
How do Mycobacterium bacilli typically enter the body?
How do Mycobacterium bacilli typically enter the body?
What type of immune response does the BCG vaccine aim to elicit?
What type of immune response does the BCG vaccine aim to elicit?
What is the most likely reason some patients develop miliary tuberculosis?
What is the most likely reason some patients develop miliary tuberculosis?
What describes Mycobacterium's classification in terms of Gram staining?
What describes Mycobacterium's classification in terms of Gram staining?
Which of the following organs can be involved in tuberculosis infection aside from the lungs?
Which of the following organs can be involved in tuberculosis infection aside from the lungs?
What immune response takes place when the body tries to eliminate Mycobacterium tuberculosis?
What immune response takes place when the body tries to eliminate Mycobacterium tuberculosis?
What is a common presenting symptom of miliary tuberculosis?
What is a common presenting symptom of miliary tuberculosis?
How is tuberculosis primarily diagnosed?
How is tuberculosis primarily diagnosed?
What do granulomas in the lungs primarily consist of?
What do granulomas in the lungs primarily consist of?
Which of the following is NOT a common symptom of primary active tuberculosis?
Which of the following is NOT a common symptom of primary active tuberculosis?
What is a disadvantage of the PPD test for tuberculosis?
What is a disadvantage of the PPD test for tuberculosis?
What is indicated by a positive reaction to the PPD skin test?
What is indicated by a positive reaction to the PPD skin test?
What does the term 'miliary' refer to in tuberculosis?
What does the term 'miliary' refer to in tuberculosis?
Which system can be affected by tuberculosis leading to meningitis?
Which system can be affected by tuberculosis leading to meningitis?
What does tissue necrosis caused by the hypersensitivity reaction in tuberculosis result in?
What does tissue necrosis caused by the hypersensitivity reaction in tuberculosis result in?
How are T-cells and macrophages involved in tuberculosis infection?
How are T-cells and macrophages involved in tuberculosis infection?
What is NOT a possible outcome when Mycobacterium antigen concentration is high?
What is NOT a possible outcome when Mycobacterium antigen concentration is high?
Which test simulates proteins found in M. tuberculosis for diagnostic purposes?
Which test simulates proteins found in M. tuberculosis for diagnostic purposes?
Which statement accurately describes the transmission of NTMs?
Which statement accurately describes the transmission of NTMs?
What is true regarding the isolation of NTM organisms?
What is true regarding the isolation of NTM organisms?
Which factor can complicate the interpretation of an NTM culture?
Which factor can complicate the interpretation of an NTM culture?
What does recent contact with an active TB patient suggest regarding NTMs?
What does recent contact with an active TB patient suggest regarding NTMs?
What is a notable characteristic of NTMs regarding their pathogenic potential?
What is a notable characteristic of NTMs regarding their pathogenic potential?
What does the PD Test specifically assess?
What does the PD Test specifically assess?
What characteristic makes the PD Test less subject to reader bias?
What characteristic makes the PD Test less subject to reader bias?
What key feature distinguishes the results of the PD Test from the effects of BCG vaccination?
What key feature distinguishes the results of the PD Test from the effects of BCG vaccination?
What reaction is observed in an infected individual after the PD Test?
What reaction is observed in an infected individual after the PD Test?
Which of the following best describes induration measured after the PD Test?
Which of the following best describes induration measured after the PD Test?
Approximately how many species of non-tuberculous mycobacteria (NTMs) are currently recognized?
Approximately how many species of non-tuberculous mycobacteria (NTMs) are currently recognized?
What is the primary mode of transmission for Mycobacterium tuberculosis?
What is the primary mode of transmission for Mycobacterium tuberculosis?
In which areas can non-tuberculous mycobacteria (NTMs) sometimes colonize healthy individuals?
In which areas can non-tuberculous mycobacteria (NTMs) sometimes colonize healthy individuals?
Flashcards
Tuberculosis (TB)
Tuberculosis (TB)
An airborne disease that's a leading killer among infectious diseases.
Mycobacterium tuberculosis complex
Mycobacterium tuberculosis complex
A group of bacteria causing TB, including M. tuberculosis (main culprit).
Mycobacterium tuberculosis
Mycobacterium tuberculosis
The primary bacteria responsible for most TB cases, especially in developed countries.
Mode of Transmission (TB)
Mode of Transmission (TB)
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Nontuberculous Mycobacteria (NTM)
Nontuberculous Mycobacteria (NTM)
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Aerobic Mycobacteria
Aerobic Mycobacteria
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Non-spore forming bacteria
Non-spore forming bacteria
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Non-motile bacteria
Non-motile bacteria
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N-glycolyl muramic acid
N-glycolyl muramic acid
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Acid-Fastness
Acid-Fastness
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Mycobacterium
Mycobacterium
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Lipid content
Lipid content
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Gram-positive
Gram-positive
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Mycobacterium bovis
Mycobacterium bovis
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BCG (Bacillus Calmette-Guerin)
BCG (Bacillus Calmette-Guerin)
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Intracellular Pathogen
Intracellular Pathogen
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Tuberculosis Diagnosis
Tuberculosis Diagnosis
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Tuberculin Test
Tuberculin Test
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Mycobacterium Infection
Mycobacterium Infection
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Granulomas
Granulomas
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Macrophages
Macrophages
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Tissue Necrosis
Tissue Necrosis
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Delayed Hypersensitivity
Delayed Hypersensitivity
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PD Test
PD Test
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Miliary Tuberculosis
Miliary Tuberculosis
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Common Symptoms of TB
Common Symptoms of TB
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Pulmonary TB Symptoms
Pulmonary TB Symptoms
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TB Disease Pathway
TB Disease Pathway
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Extra-pulmonary TB
Extra-pulmonary TB
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Tuberculin Skin Test (TST)
Tuberculin Skin Test (TST)
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Symptom Similarity
Symptom Similarity
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Immune System Function
Immune System Function
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PPD
PPD
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Delayed Hypersensitivity Reaction
Delayed Hypersensitivity Reaction
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Induration
Induration
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NTM (Nontuberculous Mycobacteria)
NTM (Nontuberculous Mycobacteria)
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Mode of NTM transmission
Mode of NTM transmission
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Erythema
Erythema
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Diagnosis of TB infection
Diagnosis of TB infection
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NTM Transmission
NTM Transmission
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NTM Isolation Significance
NTM Isolation Significance
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Positive NTM Culture - Complicated
Positive NTM Culture - Complicated
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Tuberculin Test - Positive
Tuberculin Test - Positive
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Tuberculin Test - Interpretation (≥10mm)
Tuberculin Test - Interpretation (≥10mm)
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Study Notes
Mycobacteria
- Tuberculosis is a highly curable but prevalent disease.
- It's the leading killer among infectious diseases in the Philippines.
- Many drug-resistant cases exist.
- Mycobacterium belong to a genus of aerobic, non-spore-forming, non-motile microorganisms.
- They are rod-shaped (0.2-0.6 μm x 1-10 μm) and may branch.
- Cell walls contain unusual N-glycolyl muramic acid (instead of N-acetyl).
- High lipid content creates a hydrophobic permeability barrier.
- Acid-fastness is a crucial property of mycobacteria, not usually stained by gram staining.
- Gram positive
- Mycobacteria generally grow slower than most human pathogens (20-36 hours for division).
- Colonies form visibly in 2-60 days.
Major Groups of Mycobacteria
- Mycobacteria are divided into two groups, based on differences in epidemiology and disease association.
- Mycobacterium tuberculosis complex: includes M. tuberculosis, M. caprae, M. bovis, M. microti, M. bovis BCG, and M. canettii, M. africanum, and M. pinnipedii.
- Nontuberculous mycobacteria (NTM): all species not in the complex.
Mycobacterium tuberculosis Complex
- Pathogenesis (M. tuberculosis): inhalation of a viable organism often leads to infection. The disease usually develops years later due to immune system breakdown.
- In some, infection becomes systemic and affects multiple organs.
- Pathogenesis (M. bovis): ingestion of infected cow's milk can lead to infection, and the M. bovis strain BCG is used for vaccination.
- BCG: attenuated strain of M. bovis, is used to immunize against tuberculosis.
Signs and Symptoms of Tuberculosis
- Symptoms can vary from asymptomatic to acutely symptomatic, often include lung-related signs or symptoms.
- General common presenting symptoms of pulmonary tuberculosis include low-grade fever, night sweats, fatigue, loss of appetite, and weight loss.
Diagnosis of Tuberculosis
- Tuberculin test (PPD): measures delayed hypersensitivity to tuberculin and is often used to diagnose TB infection; however not 100% accurate.
- QuantiFERON-TB Gold: new test approved by the FDA to diagnose latent or current TB infection.
Nontuberculous Mycobacteria (NTM)
- 130 recognized species.
- Ubiquitous in the environment.
- Infections are rarely transmitted person-to-person.
- 1959, Runyon's system classifies them into four groups (I-IV) based on growth characteristics and pigment production.
- Runyon group I (Photochromogens): require light for pigmentation.
- Runyon group II (Scotochromogens): produce pigment in the dark.
- Runyon group III (Nonphotochromogens): do not produce pigment under any condition.
- Runyon group IV (Rapid growers): exhibit rapid growth(visible in less than 7 days).
Other Relevant Topics
- Miliary (disseminated) tuberculosis occurs when infection spreads via the lymphatic system or bloodstream.
- Other organ involvement, such as the genitourinary tract, cervical lymph nodes, and nervous system, can be affected in some cases.
- Tuberculosis may mimic other conditions, including pneumonia, neoplasms, or fungal infections.
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