Mutation Origins and Types Quiz

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Questions and Answers

What is the ultimate source of variation and novelty in evolution?

  • Mutations (correct)
  • RNA
  • Protein
  • DNA

In eukaryotes, where can mutations occur but are not inherited?

  • Somatic cells (correct)
  • RNA
  • Germline cells
  • Protein

Which type of mutation usually leads to a dominant gain of function?

  • Structural mutation
  • Germline mutation
  • Loss of function mutation
  • Gain of function mutation (correct)

What does SNP stand for in genetics?

<p>Single Nucleotide Polymorphisms (D)</p> Signup and view all the answers

Which type of mutation refers to either an insertion or deletion?

<p>INDEL (C)</p> Signup and view all the answers

What type of mutation involves a change in the location of nucleotides?

<p>Inversion (D)</p> Signup and view all the answers

What is the repair pathway involved in fixing double strand breaks in DNA?

<p>Non-homologous end joining (NHEJ) (A)</p> Signup and view all the answers

Which type of radiation can cause T-T dimerization leading to deletions or insertions in DNA?

<p>UV light (B)</p> Signup and view all the answers

What type of agents can substitute for purines or pyrimidines during nucleic acid biosynthesis?

<p>Base analogs (D)</p> Signup and view all the answers

Which repair mechanism involves adding nucleotides to fill in gaps after alignment of DNA ends?

<p>Non-homologous end joining (NHEJ) (B)</p> Signup and view all the answers

Which mutagenic agent reacts with nucleic acids to cause mutations?

<p>Alkylating agents (A)</p> Signup and view all the answers

What is the high-energy source that can knock off electrons and cause mutations in DNA?

<p>UV light (D)</p> Signup and view all the answers

Which process is responsible for the base change due to the repositioning of hydrogen in a DNA molecule?

<p>Tautomerism (D)</p> Signup and view all the answers

What type of mutation occurs due to hydrolysis of a purine (A or G) in a DNA molecule?

<p>Depurination (A)</p> Signup and view all the answers

Which mutation type results from the removal of an amine group in either C or A, leading to U or hypoxanthine formation, respectively?

<p>Deamination (C)</p> Signup and view all the answers

Which mutation arises from denaturation of the new DNA strand during replication, followed by renaturation in a different location?

<p>Slipped strand mispairing (C)</p> Signup and view all the answers

What is the process that allows DNA replication past DNA lesions with low fidelity on undamaged templates?

<p>Translesion synthesis (A)</p> Signup and view all the answers

What is the term for the error-prone replication bypass process that often results in the insertion of wrong bases?

<p>Translesion synthesis (C)</p> Signup and view all the answers

What type of mutations result from intercalating agents?

<p>Frameshift mutations (A)</p> Signup and view all the answers

Which repair mechanism involves the excision of damaged DNA by a light-dependent enzyme?

<p>Photoreactivation (C)</p> Signup and view all the answers

What is the main activity of DNA polymerase I in excision repair?

<p>Excising damaged part (C)</p> Signup and view all the answers

Which type of mutation can alkylating agents cause?

<p>Point mutations (D)</p> Signup and view all the answers

What is the result of oxidative damage by oxygen radicals on DNA?

<p>Base modification leading to mispairing (A)</p> Signup and view all the answers

Which enzyme is responsible for repairing mismatched bases in DNA?

<p>DNA ligase (D)</p> Signup and view all the answers

What type of mutation causes a change in amino acid transcribed and alters protein function?

<p>Missense mutation (B)</p> Signup and view all the answers

Which type of mutation does NOT alter protein function and results in a shift in the reading frame?

<p>Frameshift mutation (B)</p> Signup and view all the answers

At a twofold degenerate site, how many possible changes are nonsynonymous?

<p>2 (A)</p> Signup and view all the answers

Which type of mutation results in no change in the amino acid transcribed?

<p>Neutral mutation (A)</p> Signup and view all the answers

What is the effect of a nonsense mutation?

<p>Normal codon to a stop codon (D)</p> Signup and view all the answers

What can cause a frameshift mutation?

<p>Insertion or deletion altering the reading frame (B)</p> Signup and view all the answers

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