Muscle Structure and Muscle Cells

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Questions and Answers

Which connective tissue layer directly surrounds individual muscle fibers?

  • Epimysium
  • Perimysium
  • Fascia
  • Endomysium (correct)

What is the primary function of an aponeurosis?

  • To provide a lubricating surface for tendons
  • To transmit nerve impulses to muscles
  • To attach muscles to bone or other tissues (correct)
  • To cushion joints between bones

Which of the following best describes a fascicle?

  • A type of myofilament
  • A layer of connective tissue around a muscle
  • A single muscle cell
  • A bundle of muscle fibers (correct)

If a researcher is studying the sarcolemma, which part of the muscle cell are they analyzing?

<p>The cell membrane (B)</p> Signup and view all the answers

What is the role of the sarcoplasmic reticulum in muscle cells?

<p>To store and release calcium ions (B)</p> Signup and view all the answers

Which of the following contains the active binding site for muscle contraction?

<p>Actin (B)</p> Signup and view all the answers

Which of the following represents the functional unit of muscle contraction?

<p>Sarcomere (D)</p> Signup and view all the answers

How do transverse tubules (T-tubules) contribute to muscle function?

<p>They allow action potentials to propagate deep inside the muscle cell. (D)</p> Signup and view all the answers

Which of the following is the role of a motor neuron in muscle contraction?

<p>To transmit impulses from the central nervous system to the muscle (C)</p> Signup and view all the answers

What is the primary difference between thick and thin filaments in myofibrils?

<p>Thick filaments are primarily composed of myosin, while thin filaments are primarily composed of actin. (D)</p> Signup and view all the answers

Which structure's primary function is to secrete neurotransmitters into the synaptic cleft?

<p>Synaptic knob (B)</p> Signup and view all the answers

What is the role of acetylcholine (ACh) at the neuromuscular junction (NMJ)?

<p>To trigger muscle contraction by binding to receptors and initiating depolarization (D)</p> Signup and view all the answers

In the sliding filament model of muscle contraction, what action directly leads to the shortening of the sarcomere?

<p>Actin and myosin filaments sliding past one another (C)</p> Signup and view all the answers

Which protein contains myosin-binding sites that are crucial for the formation of cross-bridges during muscle contraction?

<p>Actin (C)</p> Signup and view all the answers

What regulatory protein directly blocks the myosin-binding site on actin until muscle contraction is initiated?

<p>Tropomyosin (C)</p> Signup and view all the answers

What is the function of troponin in muscle contraction?

<p>Binds to calcium to initiate muscle contraction (C)</p> Signup and view all the answers

During high-frequency stimulation, if a muscle fiber doesn't fully relax between stimuli, what is the resulting phenomenon called?

<p>Summation (D)</p> Signup and view all the answers

What is the functional unit consisting of a motor neuron and all the muscle fibers it controls known as?

<p>Motor unit (C)</p> Signup and view all the answers

Which event directly allows myosin to bind to actin and initiate the power stroke?

<p>The binding of calcium to troponin (D)</p> Signup and view all the answers

Which process explains how increasing the intensity of stimulation to a muscle leads to a stronger contraction by activating more motor units?

<p>Recruitment (C)</p> Signup and view all the answers

The space between the neuron and the muscle fiber is called?

<p>Synaptic Cleft (B)</p> Signup and view all the answers

The enlargement at the end of an axon that secretes a neurotransmitter.

<p>Synaptic Knob (B)</p> Signup and view all the answers

A marathon runner primarily uses which type of muscle fiber to sustain their activity over a long period?

<p>Slow twitch fibers, relying on aerobic respiration (A)</p> Signup and view all the answers

What part of the muscle fiber that binds to neurotransmitters released by the motor neuron in a NMJ?

<p>Motor end plate (C)</p> Signup and view all the answers

What cellular process primarily fuels fast twitch muscle fibers during intense, short-duration activities like sprinting?

<p>Anaerobic glycolysis (C)</p> Signup and view all the answers

Weightlifters often experience muscle growth due to repetitive, high-intensity training. What is this process called?

<p>Hypertrophy (C)</p> Signup and view all the answers

After prolonged immobilization of a limb, what happens to the muscles due to lack of use?

<p>Atrophy (B)</p> Signup and view all the answers

Which characteristic is unique to visceral smooth muscle, enabling coordinated contractions in organs like the intestines?

<p>Ability to stimulate one another and display rhythmicity (C)</p> Signup and view all the answers

In the biceps curl exercise, which term describes the brachialis muscle as it performs the primary action of flexing the elbow?

<p>Agonist (prime mover) (D)</p> Signup and view all the answers

During knee extension, the hamstring muscles, which flex the knee, are acting in what capacity relative to the quadriceps?

<p>Antagonists (C)</p> Signup and view all the answers

During the cross-bridge cycle, what directly provides the energy that enables the myosin head to detach from actin and prepare for the next binding?

<p>Binding of a new ATP molecule. (D)</p> Signup and view all the answers

What is the primary role of acetylcholinesterase in muscle relaxation?

<p>Breaking down acetylcholine (ACh) in the neuromuscular junction. (A)</p> Signup and view all the answers

Why is ATP necessary for muscle relaxation?

<p>To pump calcium ions back into the sarcoplasmic reticulum and to break cross-bridges. (B)</p> Signup and view all the answers

Creatine phosphate is crucial in muscle contraction because it:

<p>Regenerates ATP from ADP and phosphate, providing a rapid energy source. (C)</p> Signup and view all the answers

What primarily contributes to the development of oxygen debt after vigorous exercise?

<p>The amount of oxygen needed to restore ATP and creatine phosphate levels in muscle, convert lactate to glucose and restore normal oxygen levels. (A)</p> Signup and view all the answers

What is the key difference between hemoglobin and myoglobin in terms of their function?

<p>Hemoglobin carries oxygen in red blood cells, while myoglobin stores oxygen in muscle tissue. (C)</p> Signup and view all the answers

What does the term 'threshold stimulus' refer to in the context of muscle contraction?

<p>The minimal stimulus required to initiate a muscle contraction. (C)</p> Signup and view all the answers

According to the 'all or none response' principle, what happens when a muscle fiber is stimulated to contract?

<p>The muscle fiber contracts to its full extent, regardless of the stimulus intensity above threshold. (B)</p> Signup and view all the answers

What characterizes a muscle twitch?

<p>A single, brief contraction of a muscle fiber in response to a stimulus. (A)</p> Signup and view all the answers

During muscle relaxation, what prevents myosin from binding to actin when nervous stimulation ceases and calcium ions are pumped back into the sarcoplasmic reticulum?

<p>Tropomyosin. (C)</p> Signup and view all the answers

Which connective tissue layer is LEAST directly involved in bundling groups of muscle fibers to form fascicles?

<p>Fascia (A)</p> Signup and view all the answers

How do transverse tubules enhance muscle contraction?

<p>By transmitting the action potential deep into the muscle fiber (B)</p> Signup and view all the answers

What is the functional significance of the arrangement of actin and myosin myofilaments within a sarcomere?

<p>It facilitates the sliding mechanism for muscle contraction. (C)</p> Signup and view all the answers

How do cisternae contribute to muscle cell function?

<p>They store and release calcium ions for muscle contraction. (C)</p> Signup and view all the answers

Which of the following describes the correct sequence of structural hierarchy in skeletal muscle, from smallest to largest?

<p>Myofilament, myofibril, muscle fiber, fascicle (D)</p> Signup and view all the answers

Which of the following is the best analogy for a sarcomere structure?

<p>A section of chain between two links (D)</p> Signup and view all the answers

A drug inhibits the function of the sarcoplasmic reticulum. What immediate effect would this have on muscle contraction?

<p>Inability of the muscle to relax (B)</p> Signup and view all the answers

How do aponeuroses differ structurally from tendons, and what functional advantage does this provide?

<p>Aponeuroses are sheet-like, distributing force over a wider area; tendons are cord-like, concentrating force. (B)</p> Signup and view all the answers

Which of the following sequences accurately describes the events of the cross-bridge cycle?

<p>Myosin head binds to actin using energy from ATP hydrolysis, pulls the actin filament, releases ADP and phosphate, binds another ATP for detachment. (A)</p> Signup and view all the answers

What role does acetylcholinesterase play in muscle relaxation?

<p>It breaks down acetylcholine in the neuromuscular junction. (A)</p> Signup and view all the answers

How does creatine phosphate function as an energy source during muscle contraction?

<p>It rapidly regenerates ATP from ADP and phosphate. (D)</p> Signup and view all the answers

What contributes most significantly to the development of oxygen debt (EPOC) after intense exercise?

<p>The amount of oxygen needed by the liver to convert accumulated lactate to glucose and to restore ATP and creatine phosphate levels in muscle. (A)</p> Signup and view all the answers

What is the key difference between hemoglobin and myoglobin?

<p>Hemoglobin transports oxygen in blood; myoglobin stores oxygen in muscle tissue. (B)</p> Signup and view all the answers

Which of the following accurately describes the sequence of events at the neuromuscular junction (NMJ) that initiates muscle contraction?

<p>Action potential travels down the axon, acetylcholine is released, acetylcholine binds to receptors on the motor end plate. (C)</p> Signup and view all the answers

How do troponin and tropomyosin interact to regulate muscle contraction in the absence of calcium?

<p>Tropomyosin blocks the myosin-binding sites on actin, preventing cross-bridge formation, while troponin binds to tropomyosin to maintain this blocking. (B)</p> Signup and view all the answers

During the sliding filament model of muscle contraction, what specific event is directly triggered by the binding of calcium ions?

<p>Troponin changes shape and pulls tropomyosin away from the myosin-binding sites on actin. (A)</p> Signup and view all the answers

Which statement accurately compares the roles of actin and myosin during muscle contraction?

<p>Actin forms the thin filaments and contains binding sites for myosin, which pulls the actin filaments towards the center of the sarcomere. (D)</p> Signup and view all the answers

An action potential reaches the synaptic knob. What directly results from this event?

<p>Calcium channels open, causing an influx of calcium ions into the synaptic knob. (C)</p> Signup and view all the answers

What would be the most immediate effect of a drug that blocks acetylcholinesterase at the neuromuscular junction?

<p>Rapid and repeated stimulation of the muscle fiber due to continued presence of acetylcholine in the synaptic cleft. (A)</p> Signup and view all the answers

Sarcomere shortening during muscle contraction requires which of the following?

<p>Actin and myosin filaments binding and sliding past one another (C)</p> Signup and view all the answers

If a muscle cell suddenly ran out of ATP, what immediate effect would this have on muscle relaxation?

<p>Actin and myosin would remain bound in a cross-bridge, preventing relaxation. (A)</p> Signup and view all the answers

What physiological process explains why the force of muscle contraction increases with higher intensity stimulation?

<p>Recruitment of additional motor units within the muscle. (A)</p> Signup and view all the answers

During intense exercise, a person might experience muscle fatigue and an oxygen debt. Which type of muscle fiber primarily contributes to this rapid fatigue?

<p>Fast-twitch fibers relying on anaerobic glycolysis. (A)</p> Signup and view all the answers

How does the arrangement of filaments in smooth muscle differ from that in skeletal muscle, and how does this affect its function?

<p>Smooth muscle has randomly arranged thick and thin filaments, allowing for contraction in all directions. (A)</p> Signup and view all the answers

Which characteristic of visceral smooth muscle is essential for coordinated functions like peristalsis in the digestive tract?

<p>Fibers can stimulate one another through gap junctions, displaying rhythmicity. (A)</p> Signup and view all the answers

Why is the cardiac muscle's interconnected network of cells important for its function in the heart?

<p>It ensures that the heart muscle contracts in a coordinated, wave-like manner for efficient pumping. (D)</p> Signup and view all the answers

During a bicep curl, the biceps brachii is the primary muscle responsible for flexing the elbow. What is the role of the triceps brachii in this movement?

<p>Antagonist, opposing the biceps brachii by extending the elbow. (B)</p> Signup and view all the answers

If a patient experiences muscle atrophy due to prolonged immobilization after a fracture, which cellular process is primarily responsible for the reduction in muscle size?

<p>Reduced protein synthesis and increased protein breakdown in muscle cells. (C)</p> Signup and view all the answers

In a scenario where a doctor is assessing a patient with suspected nerve damage affecting muscle function, which of the following observations would most strongly suggest damage to the motor neuron rather than the muscle itself?

<p>The muscle exhibits atrophy and an inability to contract even with stimulation. (D)</p> Signup and view all the answers

Flashcards

Axon

Nerve fiber transmitting electrical impulses from a neuron.

Tendon

Cord-like or band-like dense connective tissue connecting muscle to bone.

Synaptic knob

Enlargement at the axon's end, secreting neurotransmitters.

Aponeurosis

Sheets of connective tissue attaching muscles to bone, skin, or adjacent muscles.

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Synaptic vesicles

Sacs in the synaptic knob containing neurotransmitters.

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Fascia

Dense connective tissue layer that surrounds and separates each muscle.

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Epimysium

Connective tissue sheath surrounding the entire skeletal muscle.

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Synaptic cleft

Space between cells at a synapse.

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Perimysium

Connective tissue sheath enclosing a bundle of skeletal muscle fibers (a fascicle).

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Motor end plate

Muscle fiber portion binding neurotransmitters.

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Acetylcholine (ACh)

Neurotransmitter triggering muscle contraction.

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Endomysium

Connective tissue sheath surrounding each individual skeletal muscle fiber.

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Fascicle

A small bundle of skeletal muscle fibers.

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Sliding Filament Model

Muscles contract as actin/myosin filaments slide past each other.

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Sarcolemma

The cell membrane of a muscle fiber.

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Myosin

Forms thick filaments that pull on actin.

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Actin

Forms thin filaments that myosin pulls on.

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Sarcoplasm

Cytoplasm of a muscle cell, containing myofibrils, mitochondria and nuclei.

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Sarcoplasmic reticulum

Network of channels in a muscle fiber, similar to endoplasmic reticulum.

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Troponin

Binds calcium to initiate muscle contraction.

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Cross-bridge cycle

Myosin heads bind to actin, using ATP energy to pull actin filaments, then detach to repeat the process.

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Muscle relaxation

Nerve stimulation stops, acetylcholinesterase breaks down ACh, calcium ions are pumped back into the sarcoplasmic reticulum (using ATP), tropomyosin blocks binding sites, and ATP breaks cross-bridges.

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Creatine phosphate role

Creatine phosphate regenerates ATP by donating a phosphate group to ADP.

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Oxygen debt (EPOC)

The extra oxygen needed after exercise to convert lactate to glucose, restore ATP and creatine phosphate, and replenish oxygen stores.

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Hemoglobin vs. Myoglobin

Hemoglobin: Oxygen-carrying protein in red blood cells. Myoglobin: Oxygen-storing protein in muscle tissue.

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Threshold stimulus

The minimum stimulus needed to cause a muscle fiber contraction.

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All-or-none response

A muscle fiber contracts completely or not at all; each twitch generates the same force.

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Twitch

A single, brief contraction of a muscle fiber in response to a stimulus.

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Summation (Muscle)

When frequent stimuli prevent complete muscle relaxation, causing combined force.

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Tetany (Muscle)

Very short relaxation time due to a high frequency of stimulation.

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Motor Unit

A motor neuron and all the muscle fibers it controls.

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Recruitment (Muscle)

Increasing activated motor units to increase muscle contraction strength.

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Hypertrophy

Enlargement of a muscle due to repeated exercise.

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Atrophy

Decrease in muscle size and strength due to disuse.

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Origin (Muscle)

The less movable end of a skeletal muscle.

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Insertion (Muscle)

The more movable end of a skeletal muscle.

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Agonist (Prime Mover)

The muscle that is the primary actor in causing a movement.

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Synergists

Muscles that assist the prime mover.

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Sarcomere

Structural and functional contractile unit of a myofibril.

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Myofibril

Contractile fiber in striated muscle cells.

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Motor Neuron

Neuron that conducts impulses to an effector.

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Tropomyosin

Regulatory protein blocking myosin binding sites until contraction.

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Acetylcholine (ACh) function

Neurotransmitter released at NMJ; triggers muscle contraction.

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Myosin Function

Protein forming thick filaments that pull on actin.

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Actin Function

Protein forming thin filaments that myosin pulls on to cause movement.

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Sliding Filament Theory

Explains how muscles contract due to actin and myosin sliding.

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Troponin Function

Binds calcium to initiate the muscle contraction process.

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Actin and Myosin Movement

The actin and myosin filaments bind and slide past one another to create a contraction.

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Fast Twitch Fibers

Muscle fibers relying on anaerobic glycolysis for energy.

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Slow Twitch Fibers

Muscle fibers primarily using aerobic respiration for energy.

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Smooth Muscle Characteristics

Elongated cells lacking striations with random thick/thin filament arrangement.

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Multi-Unit Smooth Muscle

Smooth muscle with separated fibers stimulated by neurons/hormones.

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Visceral Smooth Muscle

Smooth muscle in sheets; found in hollow organ walls.

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Cardiac Muscle Characteristics

Branching, striated cells interconnected in 3D networks.

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Antagonists (Muscles)

Muscles that oppose the action of the prime mover.

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BIO 163 Muscle Identification

Knowing each muscle's location from the provided list with actions.

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Cross-bridge cycle steps

Myosin heads bind, use ATP energy to pull actin filaments inward, then detach to repeat.

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Muscle relaxation steps

Nerve signals stop, ACh breaks down, calcium returns to sarcoplasmic reticulum (using ATP), blocking binding sites, and ATP breaks cross-bridges.

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Study Notes

Muscles That Move the Thigh (Femur)

  • Gluteus Maximus extends thigh at hip
  • Gluteus Medius abducts thigh at hip

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