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Questions and Answers
What characterizes an isometric contraction?
What characterizes an isometric contraction?
During isotonic contractions, which statement is true?
During isotonic contractions, which statement is true?
What occurs when a muscle relaxes during an isotonic contraction?
What occurs when a muscle relaxes during an isotonic contraction?
What is the role of the force in an isometric contraction?
What is the role of the force in an isometric contraction?
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In the context of muscle contractions, what does 'stimulated muscle' refer to?
In the context of muscle contractions, what does 'stimulated muscle' refer to?
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Which statement best describes the relationship between load and muscle contraction?
Which statement best describes the relationship between load and muscle contraction?
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What typically happens to muscle tension during a prolonged isometric contraction?
What typically happens to muscle tension during a prolonged isometric contraction?
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Which of the following best differentiates isotonic from isometric contractions?
Which of the following best differentiates isotonic from isometric contractions?
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What is the main characteristic of isometric contractions?
What is the main characteristic of isometric contractions?
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What happens to sarcomeres during isometric contractions?
What happens to sarcomeres during isometric contractions?
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What typically causes muscle cramps?
What typically causes muscle cramps?
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Which inherited disorder is characterized by a loss of dystrophin?
Which inherited disorder is characterized by a loss of dystrophin?
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What is a significant risk associated with Duchenne muscular dystrophy?
What is a significant risk associated with Duchenne muscular dystrophy?
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How do cardiac muscle fibers differ from skeletal muscle fibers?
How do cardiac muscle fibers differ from skeletal muscle fibers?
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What contributes to muscle atrophy?
What contributes to muscle atrophy?
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What is the appearance of skeletal muscle fibers under a microscope?
What is the appearance of skeletal muscle fibers under a microscope?
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What role does myosin light chain kinase (MLCK) play in muscle contraction?
What role does myosin light chain kinase (MLCK) play in muscle contraction?
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What type of contraction results in movement of a load?
What type of contraction results in movement of a load?
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What is the effect of increased myosin phosphatase activity on muscle tension?
What is the effect of increased myosin phosphatase activity on muscle tension?
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How does ATP influence the activity of myosin ATPase?
How does ATP influence the activity of myosin ATPase?
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What is the consequence of decreased myosin ATPase activity?
What is the consequence of decreased myosin ATPase activity?
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What initiates the activation of myosin light chain kinase (MLCK)?
What initiates the activation of myosin light chain kinase (MLCK)?
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What characteristic of smooth muscle allows it to sustain contractions for extended periods without fatiguing?
What characteristic of smooth muscle allows it to sustain contractions for extended periods without fatiguing?
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How do smooth muscle myosin molecules differ from skeletal muscle myosin?
How do smooth muscle myosin molecules differ from skeletal muscle myosin?
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What is a key difference in calcium source during contraction between smooth muscle and skeletal muscle?
What is a key difference in calcium source during contraction between smooth muscle and skeletal muscle?
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Which of the following statements about smooth muscle is false?
Which of the following statements about smooth muscle is false?
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What initiates contraction in smooth muscle cells?
What initiates contraction in smooth muscle cells?
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What is a significant feature of smooth muscle cell arrangement?
What is a significant feature of smooth muscle cell arrangement?
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What triggers contraction in smooth muscle cells?
What triggers contraction in smooth muscle cells?
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Which process is involved in the relaxation of smooth muscle?
Which process is involved in the relaxation of smooth muscle?
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What energy characteristic distinguishes smooth muscle from other muscle types?
What energy characteristic distinguishes smooth muscle from other muscle types?
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What is the first step in the relaxation of smooth muscle?
What is the first step in the relaxation of smooth muscle?
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What type of muscle has smaller, spindle-shaped cells with a single nucleus?
What type of muscle has smaller, spindle-shaped cells with a single nucleus?
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What happens to cytosolic calcium levels when smooth muscle relaxes?
What happens to cytosolic calcium levels when smooth muscle relaxes?
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Which of the following features does not describe smooth muscle?
Which of the following features does not describe smooth muscle?
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What role does calmodulin (CaM) play in smooth muscle contraction?
What role does calmodulin (CaM) play in smooth muscle contraction?
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What triggers the release of Ca2+ from the sarcoplasmic reticulum?
What triggers the release of Ca2+ from the sarcoplasmic reticulum?
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What is the effect of calcium unbinding from calmodulin (CaM)?
What is the effect of calcium unbinding from calmodulin (CaM)?
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How is Ca2+ returned to the sarcoplasmic reticulum?
How is Ca2+ returned to the sarcoplasmic reticulum?
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What effect does an increase in extracellular calcium (ECF) have on smooth muscle contraction?
What effect does an increase in extracellular calcium (ECF) have on smooth muscle contraction?
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Which component is involved in the signaling pathway for smooth muscle contraction?
Which component is involved in the signaling pathway for smooth muscle contraction?
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Which ion's levels must decrease for smooth muscle to relax?
Which ion's levels must decrease for smooth muscle to relax?
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Study Notes
Muscle Contractions
- Isometric Contraction: Muscle contracts without shortening; force created does not move the load.
- Isotonic Contraction: Muscle shortens while contracting, resulting in movement of the load.
- Series Elastic Elements: Sarcomeres shorten while elastic elements stretch; minimal change in overall muscle length.
Muscle Disorders
- Muscle Cramps: Sustained, painful contractions often due to overuse or disuse, leading to atrophy.
- Duchenne Muscular Dystrophy: Inherited disorder caused by absence of dystrophin, leading to progressive muscle weakness; often fatal by age 30 due to respiratory failure.
Muscle Cell Types
- Skeletal Muscle: Large, multinucleate fibers appear striated under a microscope; responsible for voluntary movements.
- Cardiac Muscle: Smaller, branched, uninucleate fibers connected by intercalated disks; striated and involuntary, found in the heart.
- Smooth Muscle: Small, spindle-shaped cells with one nucleus; contracts and relaxes slowly, sustaining long-term contractions without fatiguing.
Smooth Muscle Mechanics
- Contraction Initiation: Calcium ions (Ca2+) from extracellular fluid (ECF) and sarcoplasmic reticulum; does not require an action potential.
- Troponin Absence: Ca2+ triggers contraction through a cascade effect, involving phosphorylation of myosin light chains.
- Relaxation Process: Involves dephosphorylation of myosin light chains; removal of Ca2+ from the cytosol initiates relaxation.
Muscle Fiber Structure
- Smooth Muscle Structure: Actin filaments attach to dense bodies; myosin molecules have hinged heads along their length, facilitating contraction.
- Intermediate Filaments: Form a cytoskeleton within smooth muscle, providing structural support during contraction.
Calcium Dynamics in Smooth Muscle
- Calcium Role: Increased cytosolic Ca2+ signals contraction; its removal is essential for relaxation.
- Calmodulin (CaM): Binds to Ca2+ to activate myosin light chain kinase (MLCK), promoting contraction.
- Myosin Phosphatase: Dephosphorylates myosin light chains, reducing myosin ATPase activity and muscle tension.
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Description
Test your knowledge on muscle tension and relaxation. This quiz covers key concepts related to the development of muscle tension in various conditions. Ideal for students studying exercise physiology or related fields.