Muscle Physiology Quiz
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Questions and Answers

Fast skeletal muscle fibers are primarily adapted for which type of activity?

  • Sustained low-intensity exercise
  • Endurance activities over long periods
  • Short, rapid muscle contractions (correct)
  • Aerobic metabolism

Which of the following is NOT a characteristic of red (slow) muscle fibers?

  • Predominant use of anaerobic metabolism (correct)
  • High concentration of myoglobin
  • Low glycogen stores
  • Extensive blood supply

Which factor does NOT contribute to muscle fatigue?

  • Depletion of ATP and glycogen stores
  • Increased intracellular Ca2+ (correct)
  • Depletion of acetylcholine at the motor end plate
  • Decreased blood supply

What is the primary neurotransmitter released at the motor end plate?

<p>Acetylcholine (A)</p> Signup and view all the answers

During isometric contraction, which of the following is true?

<p>Tension is constant (C)</p> Signup and view all the answers

Which answer corresponds to question number 10?

<p>C (B)</p> Signup and view all the answers

What is the answer for question number 58?

<p>C (A)</p> Signup and view all the answers

Identify the answer for question number 19.

<p>A (D)</p> Signup and view all the answers

Which answer is associated with question number 41?

<p>D (B)</p> Signup and view all the answers

Determine the answer for question number 62.

<p>C (C)</p> Signup and view all the answers

Identify the correct answer for question number 82.

<p>D (A)</p> Signup and view all the answers

Which statement about the human cell membrane is accurate?

<p>It is a bilipid layer with integral proteins scattered throughout. (D)</p> Signup and view all the answers

What is the main extracellular cation found in the human body?

<p>Sodium (B)</p> Signup and view all the answers

Which function is NOT attributed to proteins in the cell membrane?

<p>Storing genetic information (D)</p> Signup and view all the answers

What is the correct concentration of NaCl for isotonic saline?

<p>0.9% (C)</p> Signup and view all the answers

Glucose transport across the cell membrane primarily occurs through which method?

<p>Secondary active co-transport with sodium ions (A)</p> Signup and view all the answers

Which of the following accurately describes the sodium-potassium pump?

<p>It pumps 3 sodium ions out of the cell and 2 potassium ions into the cell. (C)</p> Signup and view all the answers

Which fluid compartment is not directly measurable using substances?

<p>Intracellular fluid (D)</p> Signup and view all the answers

What characterizes voltage-gated channels?

<p>They open or close in response to membrane potential changes. (D)</p> Signup and view all the answers

What is the structural unit of a nerve?

<p>Neuron (A)</p> Signup and view all the answers

Which cells form the outer layer of a myelinated nerve fiber?

<p>Schwann cells (B)</p> Signup and view all the answers

What causes the resting membrane potential?

<p>Unequal distribution of ions in ICF and ECF (C)</p> Signup and view all the answers

What causes the absolute refractory period in a nerve fiber?

<p>Is due to inactivation of Na+ channels (B)</p> Signup and view all the answers

Which statement about the Na+-K+ pump is incorrect?

<p>Is inactive at rest because the membrane is absolutely impermeable to sodium ions (A)</p> Signup and view all the answers

Which characteristic does NOT apply to the local response of a nerve fiber?

<p>Obeys the all-or-none law (A)</p> Signup and view all the answers

At what membrane potential is the firing level of a stimulated nerve fiber reached?

<p>Is reached at a membrane potential of -65 mV (B)</p> Signup and view all the answers

Which statement correctly describes the relative refractory period?

<p>Is due to inactivation of some voltage-gated Na+ channels while K+ channels are opened (C)</p> Signup and view all the answers

What is the characteristic of the myelin sheath of a nerve?

<p>It behaves as a good conductor (A)</p> Signup and view all the answers

What does chronaxie signify in neurophysiology?

<p>It is the time taken by a current twice the rheobase to excite the nerve (A)</p> Signup and view all the answers

What is true about the strength-duration curve of a nerve?

<p>It depicts a relationship between stimulus duration and amplitude of response (D)</p> Signup and view all the answers

Which of the following is NOT a correct statement regarding the sodium-potassium pump?

<p>It pumps Na+ into the nerve fibers (A)</p> Signup and view all the answers

What is the result of inhibiting Na+/K+ ATPase in a neuron?

<p>Resting potential falls to zero (D)</p> Signup and view all the answers

The local response in a nerve fiber can be characterized by which of the following?

<p>It obeys the 'all or none' rule (B)</p> Signup and view all the answers

During the absolute refractory period, which statement is true?

<p>Na+ channels are inactive (D)</p> Signup and view all the answers

Which statement about nerve resting membrane potential is accurate?

<p>It depends on K+ permeability being greater than Na+ (B)</p> Signup and view all the answers

Which defines the local response of a nerve fiber?

<p>It is triggered by a cathode current of threshold intensity (B)</p> Signup and view all the answers

What is a consequence of an increased extracellular sodium concentration?

<p>The resting potential becomes more negative (C)</p> Signup and view all the answers

What occurs when there is an increase in body temperature?

<p>Increased cutaneous blood flow (B)</p> Signup and view all the answers

Which is a response of the body when exposed to cold?

<p>Activation of the sympathetic nervous system (B), Vasoconstriction of cutaneous blood vessels (D)</p> Signup and view all the answers

What happens to blood flow during exercise?

<p>Decreased renal blood flow (C)</p> Signup and view all the answers

On exposure to a hot humid atmosphere, which change occurs?

<p>Vasoconstriction in skin blood vessels (D)</p> Signup and view all the answers

Which statement about body temperature is correct?

<p>In females, it decreases by 0.5°C in the menstrual cycle's second half (D)</p> Signup and view all the answers

Which condition does NOT happen during heat stroke?

<p>Shivering (C)</p> Signup and view all the answers

What generally causes obesity?

<p>Hyperphagia (A)</p> Signup and view all the answers

Which statement about obesity is incorrect?

<p>Is solely due to genetic factors (A)</p> Signup and view all the answers

What effect does leptin have on feeding?

<p>Inhibits feeding when secreted by adipocytes (C)</p> Signup and view all the answers

Which factor is least likely to lead to a decrease in food intake?

<p>Increased body temperature (D)</p> Signup and view all the answers

What is the approximate average hydrostatic pressure in systemic capillaries?

<p>35 mmHg (C)</p> Signup and view all the answers

Which component is primarily responsible for oncotic pressure?

<p>Plasma proteins (D)</p> Signup and view all the answers

The capillary membrane is most impermeable to which substance?

<p>Proteins (A)</p> Signup and view all the answers

In which condition does lung compliance generally increase?

<p>Emphysema (D)</p> Signup and view all the answers

Which disorder is commonly associated with reduced chest compliance?

<p>All of the above (D)</p> Signup and view all the answers

Flashcards

Cell membrane structure

The cell membrane is primarily composed of two layers of lipids, forming a bilayer structure. It acts as a barrier between the cell's interior and the external environment.

Main Extracellular Cation

Sodium (Na+) is the primary ion found outside of cells, in the extracellular fluid. It plays a critical role in maintaining osmotic balance and nerve impulse transmission.

Functions of membrane proteins

Proteins embedded within the cell membrane perform various functions, including facilitating transport of molecules, acting as receptors for signaling, and catalyzing biochemical reactions.

Isotonic saline concentration

Isotonic saline is a solution containing 0.9% NaCl, mimicking the concentration of salts in the body's fluids. It's used in medical settings to maintain fluid balance.

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Glucose transport across the cell membrane

Glucose, a sugar, enters cells through a process called secondary active co-transport. This means it's coupled with the movement of sodium ions, which provides energy for transport.

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Sodium-potassium pump

The sodium-potassium pump is a protein that actively transports sodium ions out of the cell and potassium ions into the cell. This process requires energy and maintains the resting membrane potential.

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Integral proteins functions

Integral proteins are embedded within the cell membrane and play crucial roles in various functions, including transporting molecules, receiving signals, and facilitating chemical reactions.

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Factors affecting diffusion rate

The rate at which substances diffuse across the cell membrane is inversely proportional to the thickness of the membrane. Thicker membranes slow down diffusion.

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Isometric Contraction

A type of muscle contraction where the muscle length remains constant while tension increases. Think holding a heavy object.

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What is the neurotransmitter at the motor end plate?

The neurotransmitter involved in stimulating muscle contraction at the neuromuscular junction.

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What makes fast skeletal muscle fibers different?

Fast skeletal muscle fibers are specialized for rapid, powerful contractions. They rely on glycolysis for energy production.

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What is the 'All or None' law?

The principle that a single muscle fiber will contract completely or not at all, based on whether the stimulus exceeds its threshold.

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What are causes of muscle fatigue?

Muscle fatigue is a decline in muscle performance due to factors like ATP depletion, glycogen depletion, and decreased blood supply.

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What is the structural unit of a nerve?

The structural unit of a nerve is a neuron. It's the basic building block responsible for transmitting nerve impulses.

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What forms the outer layer of a myelinated nerve fiber?

The outer layer of a myelinated nerve fiber is composed of Schwann cells, which wrap around the axon and provide insulation.

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What causes the resting membrane potential?

The resting membrane potential is caused by an unequal distribution of ions between the inside (ICF) and outside (ECF) of the cell. This difference in charge is essential for nerve function.

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What happens during the absolute refractory period?

The absolute refractory period is a time when a nerve can't be stimulated again, regardless of the strength of the stimulus. This is due to the inactivation of sodium channels.

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What is the role of the Na+-K+ pump?

The Na+-K+ pump actively pumps sodium (Na+) ions out of the cell and potassium (K+) ions into the cell, maintaining the electrochemical gradient and resting membrane potential. It requires energy from ATP.

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What is the local response in a nerve fiber?

The local response is a graded potential that occurs in a localized area of the nerve fiber. It can be summed and is not subject to the all-or-none law.

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What is the firing level in a nerve fiber?

The firing level, or threshold, is reached when the membrane potential reaches a specific voltage, typically around -55mV. This initiates the action potential.

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What happens during the relative refractory period?

The relative refractory period is a time when the nerve is less sensitive to stimulation, but can still be stimulated if the stimulus is strong enough. This is due to the partial inactivation of sodium channels and the opening of potassium channels.

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What is the cell membrane?

The cell membrane is a selectively permeable barrier that surrounds cells. It's composed of a phospholipid bilayer, which acts as a barrier to many molecules, with embedded proteins that facilitate transport and communication.

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What is the main extracellular cation?

Sodium (Na+) is the primary ion found outside of cells, in the extracellular fluid. It plays a crucial role in maintaining osmotic balance and nerve impulse transmission.

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What are the functions of membrane proteins?

Proteins embedded within the cell membrane perform various functions, including facilitating transport of molecules, acting as receptors for signaling, and catalyzing biochemical reactions.

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What is isotonic saline?

Isotonic saline is a solution containing 0.9% NaCl, mimicking the concentration of salts in the body's fluids. It's used in medical settings to maintain fluid balance.

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How does glucose enter cells?

Glucose, a sugar, enters cells through a process called secondary active co-transport. This means it's coupled with the movement of sodium ions, which provides energy for transport.

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What is the sodium-potassium pump?

The sodium-potassium pump is a protein that actively transports sodium ions out of the cell and potassium ions into the cell. This process requires energy and maintains the resting membrane potential.

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What are the functions of integral proteins?

Integral proteins are embedded within the cell membrane and play crucial roles in various functions, including transporting molecules, receiving signals, and facilitating chemical reactions.

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Factors affecting diffusion rate across the membrane?

The rate at which substances diffuse across the cell membrane is inversely proportional to the thickness of the membrane. Thicker membranes slow down diffusion.

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What is the function of the myelin sheath?

The myelin sheath is a fatty layer that covers nerve fibers. It allows for faster transmission of nerve impulses by reducing the resistance to ion flow. This allows the signal to travel quickly and efficiently.

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What is Chronaxie?

Chronaxie is the minimum duration time required to stimulate a nerve when the intensity of the stimulus is twice the rheobase (minimum intensity needed for stimulation). It is a measure of nerve excitability.

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What is the strength-duration curve?

The strength-duration curve shows the relationship between the strength (intensity) of a stimulus and the duration (time) required to elicit an action potential in a nerve fiber.

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What is the resting membrane potential?

The resting membrane potential is the electrical potential difference between the inside and outside of a cell. It is typically negative (-70mV) and is maintained by the sodium-potassium pump.

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What is the local response?

The local response is a graded potential that occurs in the dendrites and cell body of a neuron. It is not an all-or-none response, meaning its amplitude can vary depending on the strength of the stimulus. It can summate with other local responses.

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What is the absolute refractory period?

The absolute refractory period is a period after an action potential during which a nerve cell cannot generate another action potential, no matter how strong the stimulus.

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What is an anelectrotonic response?

An anelectrotonic response is a decrease in membrane potential caused by a decrease in the sodium ion concentration in the extracellular fluid. This leads to an increase in nerve excitability.

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How is the local response in a nerve fiber generated?

The local response in a single nerve fiber can be elicited by a cathode current of threshold intensity. It is associated with increased potassium permeability and is dependent on the intensity of the stimulus. If the membrane potential reaches a certain threshold level (-65mV), it can trigger an action potential.

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How does the sodium concentration differ inside and outside the nerve cell?

During the resting state, the extracellular sodium concentration is higher than its intracellular concentration. This concentration gradient is maintained by the sodium-potassium pump and contributes to the resting membrane potential.

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Cold exposure effects

The body's response to cold temperatures involves the activation of the sympathetic nervous system, which triggers shivering and increased thyroid hormone secretion.

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Vasodilation in heat

Heat stress causes the body to initiate vasodilation in skin blood vessels, leading to increased blood flow and heat dissipation.

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Obesity's causes and effects

Obesity is a condition characterized by excessive body weight, often caused by overeating and genetic predisposition. It increases the risk of gallbladder diseases.

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Leptin's role in feeding

Leptin, secreted by fat cells (adipocytes), plays a role in regulating appetite and food intake. It signals the brain to decrease hunger and decrease food consumption.

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Capillary hydrostatic pressure

The average hydrostatic pressure in systemic capillaries is the pressure exerted by blood against the capillary walls.

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Oncotic pressure

The oncotic pressure is primarily determined by the concentration of plasma proteins, particularly albumin. These proteins attract water, pulling fluid into the bloodstream.

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Capillary permeability

The capillary membrane is mainly impermeable to large molecules, such as proteins, which are too large to pass through the tiny gaps.

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Normal lung compliance

Lung compliance refers to the ability of the lungs to expand in response to changes in pressure. A normal compliance value is approximately 0.2 L/cmH2O.

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Factors affecting lung compliance

Increased elastic forces within lung tissues, as seen in diseases like lung fibrosis, can increase the resistance of the lungs to inflation.

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Conditions impacting lung compliance

Emphysema, a condition that damages lung tissue, increases lung compliance due to the destruction of elastic fibers.

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Decreased chest compliance

Scoliosis, fractured ribs, and paralysis of respiratory muscles can all decrease chest compliance by making it harder for the chest wall to expand.

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Lung recoil

The recoil tendency of the lungs is due to the elastic forces of the lung tissue and the surface tension of the fluid lining the alveoli.

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Compliance of blood vessels

Compliance of large blood vessels is a measure of their ability to stretch and expand in response to changes in pressure. Veins are more compliant than arteries because their walls are thinner and more elastic.

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Vein pressure-volume relationship

The pressure-volume curve of veins shows that a large increase in blood volume is associated with a relatively small change in pressure. This reflects their high compliance.

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Factors influencing vascular compliance

Activation of the sympathetic nervous system can decrease the compliance of blood vessels, making them less stretchy and reducing blood flow.

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Study Notes

Physiology MCQs

  • Human cell membrane: Is a bilipid layer membrane. It primarily consists of lipid molecules, not carbohydrates. It's impermeable to lipid-soluble molecules and has integral proteins on its surface.
  • Main extracellular cation: Sodium.
  • Proteins in cell membrane: Act as carriers, channels, and receptors.
  • Isotonic saline: Sodium chloride (NaCl) solution with a concentration of 0.9%.
  • Glucose transport: Occurs via secondary active co-transport with sodium ions.
  • Sodium-potassium pump: An example of primary active transport, not secondary. It pumps 3 sodium ions out of the nerve fiber and 2 potassium ions into it.
  • Integral proteins: Act as carriers, receptors, and enzymes.
  • Diffusion rate: Is indirectly proportional to the membrane thickness.
  • Connexon: An important component of gap junctions.
  • Body weight composition: Primarily water, with significant amounts of proteins, fats, and minerals.
  • ICF vs. ECF: Intracellular fluid (ICF) contains a higher concentration of potassium (K+) and phosphate ions compared to extracellular fluid (ECF).
  • Body fluid compartments: Can be measured directly using substances, except total body water.
  • Voltage-gated channels: Open or close in response to changes in membrane potential.
  • Diffusion rate factors: Depends on the total cross-sectional area of the membrane, temperature, and concentration gradient.
  • Ligand-gated channels: Open or close when a molecule (e.g., hormone or neurotransmitter) binds to them.
  • Active transport: Occurs against electrochemical gradients and requires energy.
  • Osmosis: Is a passive process that moves water across a semipermeable membrane from an area of low solute concentration to high solute concentration.
  • Secondary active transport: Involves the movement of two substances, one molecule moves down its concentration gradient and the other moves against its concentration gradient.
  • Diffusion rate factors: The rate of diffusion increases with larger membrane surface area, higher temperature, and greater lipid solubility of the molecule.
  • Reflex arc components: Afferent neuron, sensory receptor, effector organ, and sometimes efferent ganglion.
  • Nerve structural unit: The neuron.
  • Myelinated nerve fiber outer layer: Schwann cells.
  • Resting membrane potential cause: Unequal distribution of ions across the cell membrane, particularly sodium (Na+) and potassium (K+).
  • Absolute refractory period: A period of time after an action potential where the neuron cannot be stimulated to fire another action potential. It occurs due to inactivation of voltage-gated Na+ channels.
  • Sodium-potassium pump activity: Active at rest, essential for maintaining ion gradients, and it couples 3 Na+ ions out of the nerve fiber to 2 K+ ions in.
  • Firing level: The membrane potential (-65mV) at which a nerve fiber will fire an action potential.
  • Relative refractory period: The period when the neurons membrane is more difficult to depolarize than normal.
  • Saltatory conduction: Fast propagation of action potentials along myelinated nerve fibers, "jumping" from node to node.
  • Nerve excitability increase: Hypercalcemia and increased potassium permeability can increase nerve excitability.
  • Absolute refractory period: Occurs after depolarization; a period where the membrane cannot be stimulated to fire another action potential.
  • Local response in nerve fiber: Doesn't obey the all-or-none principle, and can be summated.
  • Repolarization: Opening of potassium (K+) channels allows potassium to leave the cell and return the membrane to its resting potential.
  • Concerning voltage-gated sodium channels: The inactivation gate closes when the membrane reaches the firing level.
  • Acetylcholine action at neuromuscular junction: It triggers postsynaptic depolarization after release from the neuromuscular junction. It is broken down by acetylcholinesterase to prevent continual stimulation.
  • Muscle stimulation factors: Includes action potential propagation inward along T-tubules, releasing Ca2+, binding to troponin, and causing contraction.
  • Muscle relaxation factors: Decreasing Ca2+ concentration, detaching myosin heads from actin, and returning the muscle to a relaxed state.
  • Muscle fatigue causes: Include depletion of acetylcholine at the motor end plate, and insufficient ATP/creatine Phosphate/glycogen supplies.
  • All-or-none principle: Applies to individual nerve fibers or muscle cells, but not to whole tissues or organs.
  • Mechanisms of neuromuscular transmission: Acetylcholine is released, receptor binding occurs, and an action potential is generated in the muscle fiber. Inhibited by Curare.
  • Isometric contraction: Maintaining constant muscle length while contracting; tension increases.
  • Isotonic contraction: Maintaining constant tension while muscles shorten.
  • Myelin sheath function: Acts as an insulator, speeding up the transmission of nerve impulses. It has gaps (nodes of Ranvier), enabling saltatory conduction.
  • Chronaxie: Measures a muscle or nerve fibre's excitability; it's the minimum duration of a stimulus needed to stimulate a reaction at twice the rheobase current.
  • Strength-duration curve: Illustrates the relationship between the duration of a stimulus and its intensity required to produce a response. Subthreshold stimuli have no effect.
  • Resting membrane potential determinants: Selective permeability of the membrane to different ions, and the activity of the sodium-potassium pump.
  • Nerve excitability and stimuli: Nerve excitability increases with a more negative membrane potential.
  • Na⁺ influx during stimulus: Increases the membrane potential, making the resting membrane potential more positive.
  • Action potential propagation: Faster for myelinated than unmyelinated nerve fibers due to saltatory conduction.
  • Biophysics
    • Hydrostatic pressure in systemic capillaries: Roughly 35mmHg
    • Oncotic pressure determinants: Plasma proteins
    • Capillary membrane permeability: Freely permeable to ions.
    • Lymphatic obstruction effect: Decreases interstitial fluid volume.
    • Lung compliance implications: Increase and decrease are associated with various lung conditions.
    • Compliance of large arterial blood vessels: The initial linear relationship between volume and pressure is due to stretching of the elastic fibers. Compliance increases with more stretching of the elastic fibers.
    • Vein distensibility: Significantly higher than arteries.
    • Starling's law and cardiac muscle: The degree of contraction is proportional to the degree of stretching during filling.
    • Force-velocity relationship in skeletal muscle: Isotonic and isometric contraction types.
    • Laminar blood flow: Characterized by smooth, layered flow of blood through vessels.
    • Murmur: Abnormal heart sounds.
  • Metabolism
    • Basal metabolic rate (BMR): Metabolic rate at rest. It is higher in men, and lower during pregnancy and old age, as a result of decreased metabolism and less activity.
    • Energy equivalent of oxygen: For carbs it is 5 Kcal/L, for fats 4.1 Kcal/L, for proteins 4.7 Kcal/L, and in a mixed diet 4.2 Kcal/L
    • Physical heat of food measurement: Indirect calorimetry.
    • Respiratory quotient (RQ): Ratio of carbon dioxide produced to oxygen consumed during metabolism.
    • Decrease in RQ: Results from different metabolic pathways; e.g., shifting from carbohydrate metabolism to fat metabolism during starvation.
    • Respiratory quotient (RQ) of 0.7: Suggests a high-fat diet. A low RQ signifies use of fats, a normal one carbohydrates as fuel.

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Test your knowledge on muscle physiology with this engaging quiz! Questions cover fast and slow muscle fibers, muscle fatigue, and neurotransmitters at the motor end plate. Perfect for students looking to enhance their understanding of how muscles function during various activities.

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